Research graph
References from L-System Transporters Control Uptake and Toxicity of Methylmercury Cysteine Complexes in Larval Zebrafish. Local targets link to admitted publications; unresolved targets remain external evidence.
Neurotoxicity of organomercurial compounds
10.1007/bf03033386 · 2003 · External reference
The toxicology of mercury and its chemical compounds
10.1080/10408440600845619 · 2006 · External reference
Minamata Disease: Methylmercury poisoning in Japan caused by environmental pollution
10.3109/10408449509089885 · 1995 · External reference
Neurodevelopmental effects of maternal nutritional status and exposure to methylmercury from eating fish during pregnancy
10.1016/j.neuro.2008.06.001 · 2008 · External reference
Cognitive deficit in 7-year old children with prenatal exposure to methylmercury
10.1016/s0892-0362(97)00097-4 · 1997 · External reference
Environmental exposure to mercury and its toxicopathologic implications for public health
10.1002/tox.10116 · 2003 · External reference
Methylmercury-thiol uptake into cultured brain capillary endothelial cells on amino acid system L
10.1016/s0022-3565(25)24557-8 · 1995 · External reference
Transport of a neurotoxicant by molecular mimicry: the methylmercury-L-cysteine complex is a substrate for the human L-type large neutral amino acid transporter (LAT) 1 and LAT2
10.1042/bj20020841 · 2002 · External reference
Methylmercury transport across the blood-brain barrier by an amino acid carrier
10.1152/ajpregu.1992.262.5.r761 · 1992 · External reference
Methylmercury transport across the placenta via neutral amino acid carrier
10.1007/s002040050279 · 1996 · External reference
γ-glutamyl transpeptidase and l-cysteine regulate methylmercury uptake by HepG2 cells, a human hepatoma cell line
10.1006/taap.2000.9018 · 2000 · External reference
Methylmercury uptake into BeWo cells depends on LAT2-4F2hc, a system L amino acid transporter
10.3390/ijms18081730 · 2017 · External reference
Molecular mimicry in mercury toxicology
10.1021/tx0503449 · 2006 · External reference
Inorganic molecular toxicology and chelation therapy of heavy metals and metalloids
10.1016/s1872-0854(07)02005-x · 2008 · External reference
Heterodimeric amino acid transporters: Molecular biology and pathological and pharmacological relevance
10.2174/1389200013338324 · 2001 · External reference
Structure of the human LAT1-4F2hc heteromeric amino acid transporter complex
10.1038/s41586-019-1011-z · 2019 · External reference
Cryo-EM structure of the human L-type amino acid transporter 1 in complex with glycoprotein CD98hc
10.1038/s41594-019-0237-7 · 2019 · External reference
Mechanism of substrate transport and inhibition of the human LAT1-4F2hc amino acid transporter
10.1038/s41421-021-00247-4 · 2021 · External reference
Structural insights into the substrate transport mechanism of the amino acid transporter complex
10.1016/j.jbc.2025.110569 · 2025 · External reference
Structural basis of anticancer drug recognition and amino acid transport by LAT1
10.1038/s41467-025-56903-w · 2025 · External reference
Expression cloning and characterization of a transporter for large neutral amino acids activated by the heavy chain of 4F2 antigen (CD98)
10.1074/jbc.273.37.23629 · 1998 · External reference
Identification of a membrane protein, LAT-2, that co-expresses with 4F2 heavy chain, an L-type amino acid transport activity with broad specificity for small and large zwitterionic amino acids
10.1074/jbc.274.28.19738 · 1999 · External reference
Amino acid transporters ASCT2 and LAT1 in cancer: Partners in crime?
10.1016/j.semcancer.2005.04.005 · 2005 · External reference
Uptake and efflux of methylmercury in vitro: Comparison of transport mechanisms in C6, B35 and RBE4 cells
10.1016/j.tiv.2009.06.018 · 2009 · External reference
Effect of amino acids on brain uptake of methyl mercury
10.1016/0041-008x(80)90093-9 · 1980 · External reference
Effects of combined administration of thiol compounds and methylmercury chloride on mercury distribution in rats
10.1016/0006-2952(85)90328-4 · 1985 · External reference
Elemental and chemically specific X-ray fluorescence imaging of biological systems
10.1021/cr4007297 · 2014 · External reference
Chemical form matters: Differential accumulation of mercury following inorganic and organic mercury exposures in zebrafish larvae
10.1021/cb200287c · 2012 · External reference
Dynamic accumulation and redistribution of methylmercury in the lens of developing zebrafish embryos and larvae
10.1007/s00775-010-0674-6 · 2010 · External reference
Interaction of mercury and selenium in the larval stage zebrafish vertebrate model
10.1039/c5mt00145e · 2015 · External reference
Localizing organomercury uptake and accumulation in zebrafish larvae at the tissue and cellular level
10.1073/pnas.0803147105 · 2008 · External reference
Methylmercury targets photoreceptor outer segments
10.1021/cb4004805 · 2013 · External reference
Distribution of selenium in zebrafish larvae after exposure to organic and inorganic selenium forms
10.1039/c5mt00279f · 2016 · External reference
An all-electron numerical method for solving the local density functional for polyatomic molecules
10.1063/1.458452 · 1990 · External reference
From molecules to solids with the DMol3 approach
10.1063/1.1316015 · 2000 · External reference
M11-L: A local density functional that provides improved accuracy for electronic structure calculations in chemistry and physics
10.1021/jz201525m · 2012 · External reference
Drosophotoxicology: Elucidating kinetic and dynamic pathways of methylmercury toxicity in a Drosophila model
10.3389/fgene.2019.00666 · 2019 · External reference
Arsenic-selenium and mercury-selenium bonds in biology
10.1016/j.ccr.2006.07.018 · 2007 · External reference
Selenium and selenocysteine: roles in cancer, health, and development
10.1016/j.tibs.2013.12.007 · 2014 · External reference
Mercury toxicity and the mitigating role of selenium
10.1007/s10393-008-0204-y · 2008 · External reference
Do two wrongs make a right? Persistent uncertainties regarding environmental selenium–mercury interactions
10.1021/acs.est.0c01894 · 2020 · External reference
Disruption of selenium transport and function is a major contributor to mercury toxicity in zebrafish larvae
10.1039/c8mt00315g · 2019 · External reference
Selenium protection against mercury toxicity: high binding affinity of methylmercury by selenium-containing ligands in comparison with sulfur-containing ligands
10.1016/s0006-3061(00)80288-4 · 1978 · External reference
Mercury speciation and stable isotopes in emperor penguins: First evidence for biochemical demethylation of methylmercury to mercury-dithiolate and mercury-tetraselenolate complexes
10.1016/j.jhazmat.2024.136499 · 2025 · External reference
Nuclear magnetic resonance studies of the solution chemistry of metal complexes 20. Ligand-exchange kinetics of methylmercury(II)-thiol complexes
10.1021/ic00177a016 · 1984 · External reference
Tissue-specific Nrf2 signaling protects against methylmercury toxicity in Drosophila neuromuscular development
10.1007/s00204-020-02879-z · 2020 · External reference
Establishment and characterization of mammalian cell lines stably expressing human L-type amino acid transporters
10.1254/jphs.08232fp · 2008 · External reference
Human L-type amino acid transporter 1 (LAT1): characterization of function and expression in tumor cell lines
10.1016/s0005-2736(01)00384-4 · 2001 · External reference
Environmental exposure to mercury and its toxicopathologic implications for public health
10.1002/tox.10116 · ExternalCitation · doi-reference
γ-glutamyl transpeptidase and l-cysteine regulate methylmercury uptake by HepG2 cells, a human hepatoma cell line
10.1006/taap.2000.9018 · ExternalCitation · doi-reference
Neurotoxicity of organomercurial compounds
10.1007/bf03033386 · ExternalCitation · doi-reference
Tissue-specific Nrf2 signaling protects against methylmercury toxicity in Drosophila neuromuscular development
10.1007/s00204-020-02879-z · ExternalCitation · doi-reference
Methylmercury transport across the placenta via neutral amino acid carrier
10.1007/s002040050279 · ExternalCitation · doi-reference
Dynamic accumulation and redistribution of methylmercury in the lens of developing zebrafish embryos and larvae
10.1007/s00775-010-0674-6 · ExternalCitation · doi-reference
Mercury toxicity and the mitigating role of selenium
10.1007/s10393-008-0204-y · ExternalCitation · doi-reference
Effects of combined administration of thiol compounds and methylmercury chloride on mercury distribution in rats
10.1016/0006-2952(85)90328-4 · ExternalCitation · doi-reference
Effect of amino acids on brain uptake of methyl mercury
10.1016/0041-008x(80)90093-9 · ExternalCitation · doi-reference
Arsenic-selenium and mercury-selenium bonds in biology
10.1016/j.ccr.2006.07.018 · ExternalCitation · doi-reference
Structural insights into the substrate transport mechanism of the amino acid transporter complex
10.1016/j.jbc.2025.110569 · ExternalCitation · doi-reference
Mercury speciation and stable isotopes in emperor penguins: First evidence for biochemical demethylation of methylmercury to mercury-dithiolate and mercury-tetraselenolate complexes
10.1016/j.jhazmat.2024.136499 · ExternalCitation · doi-reference
Neurodevelopmental effects of maternal nutritional status and exposure to methylmercury from eating fish during pregnancy
10.1016/j.neuro.2008.06.001 · ExternalCitation · doi-reference
Amino acid transporters ASCT2 and LAT1 in cancer: Partners in crime?
10.1016/j.semcancer.2005.04.005 · ExternalCitation · doi-reference
Selenium and selenocysteine: roles in cancer, health, and development
10.1016/j.tibs.2013.12.007 · ExternalCitation · doi-reference
Uptake and efflux of methylmercury in vitro: Comparison of transport mechanisms in C6, B35 and RBE4 cells
10.1016/j.tiv.2009.06.018 · ExternalCitation · doi-reference
Human L-type amino acid transporter 1 (LAT1): characterization of function and expression in tumor cell lines
10.1016/s0005-2736(01)00384-4 · ExternalCitation · doi-reference
Selenium protection against mercury toxicity: high binding affinity of methylmercury by selenium-containing ligands in comparison with sulfur-containing ligands
10.1016/s0006-3061(00)80288-4 · ExternalCitation · doi-reference
Methylmercury-thiol uptake into cultured brain capillary endothelial cells on amino acid system L
10.1016/s0022-3565(25)24557-8 · ExternalCitation · doi-reference
Cognitive deficit in 7-year old children with prenatal exposure to methylmercury
10.1016/s0892-0362(97)00097-4 · ExternalCitation · doi-reference
Inorganic molecular toxicology and chelation therapy of heavy metals and metalloids
10.1016/s1872-0854(07)02005-x · ExternalCitation · doi-reference
Do two wrongs make a right? Persistent uncertainties regarding environmental selenium–mercury interactions
10.1021/acs.est.0c01894 · ExternalCitation · doi-reference
Chemical form matters: Differential accumulation of mercury following inorganic and organic mercury exposures in zebrafish larvae
10.1021/cb200287c · ExternalCitation · doi-reference
Methylmercury targets photoreceptor outer segments
10.1021/cb4004805 · ExternalCitation · doi-reference
Elemental and chemically specific X-ray fluorescence imaging of biological systems
10.1021/cr4007297 · ExternalCitation · doi-reference
Nuclear magnetic resonance studies of the solution chemistry of metal complexes 20. Ligand-exchange kinetics of methylmercury(II)-thiol complexes
10.1021/ic00177a016 · ExternalCitation · doi-reference
M11-L: A local density functional that provides improved accuracy for electronic structure calculations in chemistry and physics
10.1021/jz201525m · ExternalCitation · doi-reference
Molecular mimicry in mercury toxicology
10.1021/tx0503449 · ExternalCitation · doi-reference
Mechanism of substrate transport and inhibition of the human LAT1-4F2hc amino acid transporter
10.1038/s41421-021-00247-4 · ExternalCitation · doi-reference
Structural basis of anticancer drug recognition and amino acid transport by LAT1
10.1038/s41467-025-56903-w · ExternalCitation · doi-reference
Structure of the human LAT1-4F2hc heteromeric amino acid transporter complex
10.1038/s41586-019-1011-z · ExternalCitation · doi-reference
Cryo-EM structure of the human L-type amino acid transporter 1 in complex with glycoprotein CD98hc
10.1038/s41594-019-0237-7 · ExternalCitation · doi-reference
Interaction of mercury and selenium in the larval stage zebrafish vertebrate model
10.1039/c5mt00145e · ExternalCitation · doi-reference
Distribution of selenium in zebrafish larvae after exposure to organic and inorganic selenium forms
10.1039/c5mt00279f · ExternalCitation · doi-reference
Disruption of selenium transport and function is a major contributor to mercury toxicity in zebrafish larvae
10.1039/c8mt00315g · ExternalCitation · doi-reference
Transport of a neurotoxicant by molecular mimicry: the methylmercury-L-cysteine complex is a substrate for the human L-type large neutral amino acid transporter (LAT) 1 and LAT2
10.1042/bj20020841 · ExternalCitation · doi-reference
From molecules to solids with the DMol3 approach
10.1063/1.1316015 · ExternalCitation · doi-reference
An all-electron numerical method for solving the local density functional for polyatomic molecules
10.1063/1.458452 · ExternalCitation · doi-reference
Localizing organomercury uptake and accumulation in zebrafish larvae at the tissue and cellular level
10.1073/pnas.0803147105 · ExternalCitation · doi-reference
Expression cloning and characterization of a transporter for large neutral amino acids activated by the heavy chain of 4F2 antigen (CD98)
10.1074/jbc.273.37.23629 · ExternalCitation · doi-reference
Identification of a membrane protein, LAT-2, that co-expresses with 4F2 heavy chain, an L-type amino acid transport activity with broad specificity for small and large zwitterionic amino acids
10.1074/jbc.274.28.19738 · ExternalCitation · doi-reference
The toxicology of mercury and its chemical compounds
10.1080/10408440600845619 · ExternalCitation · doi-reference
Methylmercury transport across the blood-brain barrier by an amino acid carrier
10.1152/ajpregu.1992.262.5.r761 · ExternalCitation · doi-reference
Establishment and characterization of mammalian cell lines stably expressing human L-type amino acid transporters
10.1254/jphs.08232fp · ExternalCitation · doi-reference
Heterodimeric amino acid transporters: Molecular biology and pathological and pharmacological relevance
10.2174/1389200013338324 · ExternalCitation · doi-reference
Minamata Disease: Methylmercury poisoning in Japan caused by environmental pollution
10.3109/10408449509089885 · ExternalCitation · doi-reference
Drosophotoxicology: Elucidating kinetic and dynamic pathways of methylmercury toxicity in a Drosophila model
10.3389/fgene.2019.00666 · ExternalCitation · doi-reference
Methylmercury uptake into BeWo cells depends on LAT2-4F2hc, a system L amino acid transporter
10.3390/ijms18081730 · ExternalCitation · doi-reference
