Research graph
References from Species-Dependent Citrus–Simvastatin Interaction Profiles in an Acute Rat Model: Integrating Drug Disposition, Hepatic Redox, and Complementary Computational Analysis. Local targets link to admitted publications; unresolved targets remain external evidence.
Phytochemical and Antioxidant Profile of Citrus Peel Extracts in Relation to Different Extraction Parameters
10.1080/10942912.2024.2304274 · 2024 · External reference
Polymethoxyflavones from Citrus Peel: Advances in Extraction Methods, Biological Properties, and Potential Applications
10.1080/10408398.2022.2156476 · 2024 · External reference
Flavonoids as Modulators of Metabolic Enzymes and Drug Transporters
10.1111/nyas.13384 · 2017 · External reference
Physiologically Based Pharmacokinetics Modeling and Transporter Proteomics to Predict Systemic and Local Liver and Muscle Disposition of Statins
10.1002/psp4.13139 · 2024 · External reference
The Drug Transporter–Metabolism Alliance: Uncovering and Defining the Interplay
10.1021/mp900253n · 2009 · External reference
Pharmacokinetic and Pharmacodynamic Alterations of 3-Hydroxy-3-Methylglutaryl Coenzyme A (HMG-CoA) Reductase Inhibitors: Drug–Drug Interactions and Interindividual Differences in Transporter and Metabolic Enzyme Functions
10.1016/j.pharmthera.2006.03.003 · 2006 · External reference
Organic Anion Transporting Polypeptide 1B1: A Genetically Polymorphic Transporter of Major Importance for Hepatic Drug Uptake
10.1124/pr.110.002857 · 2011 · External reference
Statin-Associated Liver Dysfunction and Muscle Injury: Epidemiology, Mechanisms, and Management Strategies
10.2147/ijgm.s460305 · 2024 · External reference
Impacts of Pharmacokinetic Gene Polymorphisms on Steady-State Plasma Concentrations of Simvastatin in Thai Population
10.1111/cts.70225 · 2025 · External reference
Interaction of Statins with Grapefruit Juice
2023 · External reference
Physiologically Based Pharmacokinetic Modeling of Bergamottin and 6,7-Dihydroxybergamottin to Describe CYP3A4-Mediated Grapefruit–Drug Interactions
10.1002/cpt.2968 · 2023 · External reference
Statins Trigger Mitochondrial Reactive Oxygen Species-Induced Apoptosis in Glycolytic Skeletal Muscle
10.1089/ars.2014.6190 · 2016 · External reference
Statins: Adverse Reactions, Oxidative Stress and Metabolic Interactions
10.1016/j.pharmthera.2018.10.004 · 2019 · External reference
Combating Oxidative Stress Disorders with Citrus Flavonoid: Naringenin
10.1016/j.lfs.2018.07.017 · 2018 · External reference
Toxicological and Pharmacokinetic Evaluation of Concomitant Intake of Grapefruit Juice and Simvastatin in Rats after Repeated Treatment over 28 Days
10.1055/s-0029-1185534 · 2009 · External reference
Effects of Silymarin on the in Vivo Pharmacokinetics of Simvastatin and Its Active Metabolite in Rats
10.3390/molecules24091666 · 2019 · External reference
Food–Drug Interactions: Effect of Capsaicin on the Pharmacokinetics of Simvastatin and Its Active Metabolite in Rats
10.1016/j.fct.2012.11.045 · 2013 · External reference
SwissADME: A Free Web Tool to Evaluate Pharmacokinetics, Drug-Likeness and Medicinal Chemistry Friendliness of Small Molecules
10.1038/srep42717 · 2017 · External reference
Experimental and Computational Approaches to Estimate Solubility and Permeability in Drug Discovery and Development Settings
10.1016/s0169-409x(00)00129-0 · 2001 · External reference
Webina: An Open-Source Library and Web App That Runs AutoDock Vina Entirely in the Web Browser
10.1093/bioinformatics/btaa579 · 2020 · External reference
AutoDock Vina: Improving the Speed and Accuracy of Docking with a New Scoring Function, Efficient Optimization, and Multithreading
10.1002/jcc.21334 · 2010 · External reference
UCSF ChimeraX: Structure Visualization for Researchers, Educators, and Developers
10.1002/pro.3943 · 2021 · External reference
Valorization of Taiwan’s Citrus depressa Hayata Peels as a Source of Nobiletin and Tangeretin Using Simple Ultrasonic-Assisted Extraction
10.1016/j.crfs.2022.01.013 · 2022 · External reference
Extraction of Nobiletin and Tangeretin from Peels of Shekwasha and Ponkan Using [C2mim][(MeO)(H)PO2] and Centrifugation
10.1177/1934578x19845816 · 2019 · External reference
Methylated Flavonoids Have Greatly Improved Intestinal Absorption and Metabolic Stability
10.1124/dmd.106.011122 · 2006 · External reference
Pharmacokinetics and Metabolism of Naringin and Active Metabolite Naringenin in Rats, Dogs, Humans, and the Differences Between Species
10.3389/fphar.2020.00364 · 2020 · External reference
The Chemistry Behind Antioxidant Capacity Assays
10.1021/jf030723c · 2005 · External reference
Antioxidant Properties, Radical Scavenging Activity and Biomolecule Protection Capacity of Flavonoid Naringenin and Its Glycoside Naringin: A Comparative Study
10.1002/jsfa.3959 · 2010 · External reference
Insights into Molecular Mechanism of Action of Citrus Flavonoids Hesperidin and Naringin on Lipid Bilayers Using Spectroscopic, Calorimetric, Microscopic and Theoretical Studies
10.1016/j.molliq.2021.118411 · 2022 · External reference
Chemical Structures, Bioactivities and Molecular Mechanisms of Citrus Polymethoxyflavones
10.1016/j.jff.2017.11.036 · 2018 · External reference
Mechanisms of Enhanced Oral Availability of CYP3A4 Substrates by Grapefruit Constituents. Decreased Enterocyte CYP3A4 Concentration and Mechanism-Based Inactivation by Furanocoumarins
10.1124/dmd.25.11.1228 · 1997 · External reference
Fruit Juice Inhibition of Uptake Transport: A New Type of Food–Drug Interaction
10.1111/j.1365-2125.2010.03722.x · 2010 · External reference
Identification of the Residue in Human CYP3A4 That Is Covalently Modified by Bergamottin and the Reactive Intermediate That Contributes to the Grapefruit Juice Effect
10.1124/dmd.112.044560 · 2012 · External reference
Two Major Grapefruit Juice Components Differ in Time to Onset of Intestinal CYP3A4 Inhibition
10.1124/jpet.104.076836 · 2005 · External reference
Effects of Bioflavonoids on Hepatic P450 Activities
10.3109/00498259509061876 · 1995 · External reference
Polymethoxylated Flavones in Orange Juice Are Inhibitors of P-Glycoprotein but Not Cytochrome P450 3A4
10.1016/s0022-3565(24)39224-9 · 2000 · External reference
In Vitro Metabolism of Nobiletin, a Polymethoxy-Flavonoid, by Human Liver Microsomes and Cytochrome P450
10.3109/00498254.2011.593208 · 2011 · External reference
Pharmacokinetics, Bioavailability, Tissue Distribution and Excretion of Tangeretin in Rat
10.1016/j.jfda.2017.08.003 · 2018 · External reference
Comparative Uptake of Statins by Hepatic Organic Anion Transporting Polypeptides
10.1016/j.ejps.2025.107073 · 2025 · External reference
SLCO1B1 Polymorphism Markedly Affects the Pharmacokinetics of Simvastatin Acid
10.1097/01.fpc.0000230416.82349.90 · 2006 · External reference
Regulation of the Mevalonate Pathway
10.1038/343425a0 · 1990 · External reference
Feedback Regulation of Cholesterol Synthesis: Sterol-Accelerated Ubiquitination and Degradation of HMG CoA Reductase
10.1038/cr.2008.61 · 2008 · External reference
A Furanocoumarin-Free Grapefruit Juice Establishes Furanocoumarins as the Mediators of the Grapefruit Juice–Felodipine Interaction
10.1093/ajcn/83.5.1097 · 2006 · External reference
Grapefruit Juice–Felodipine Interaction: Mechanism, Predictability, and Effect of Naringin
10.1038/clpt.1993.84 · 1993 · External reference
Inhibition of Hepatic Uptake Transporters by Flavonoids
10.1016/j.ejps.2012.02.014 · 2012 · External reference
Unmasking the Dynamic Interplay Between Intestinal P-Glycoprotein and CYP3A4
10.1124/jpet.300.3.1036 · 2002 · External reference
Grapefruit Juice–Simvastatin Interaction: Effect on Serum Concentrations of Simvastatin, Simvastatin Acid, and HMG-CoA Reductase Inhibitors
10.1016/s0009-9236(98)90130-8 · 1998 · External reference
Activation of Pregnane X Receptor and Induction of MDR1 by Dietary Phytochemicals
10.1021/jf073350e · 2008 · External reference
Nobiletin, Sinensetin, and Tangeretin Are the Main Perpetrators in Clementines Provoking Food–Drug Interactions in Vitro
10.1016/j.foodchem.2020.126578 · 2020 · External reference
Atorvastatin Induced Hepatic Oxidative Stress and Apoptotic Damage via MAPKs, Mitochondria, Calpain and Caspase12 Dependent Pathways
10.1016/j.fct.2015.05.016 · 2015 · External reference
High-Content Screening of Drug-Induced Mitochondrial Impairment in Hepatic Cells: Effects of Statins
10.1007/s00204-014-1334-3 · 2015 · External reference
Nobiletin Ameliorates Hepatic Lipid Deposition, Oxidative Stress, and Inflammation by Mechanisms That Involve the Nrf2/NF-κB Axis in Nonalcoholic Fatty Liver Disease
10.1021/acs.jafc.3c06498 · 2023 · External reference
Nobiletin Intake Attenuates Hepatic Lipid Profiling and Oxidative Stress in HFD-Induced Nonalcoholic-Fatty-Liver-Disease Mice
10.3390/molecules28062570 · 2023 · External reference
Structural Mechanism for Statin Inhibition of HMG-CoA Reductase
10.1126/science.1059344 · 2001 · External reference
Discovery of New Druggable Sites in the Anti-Cholesterol Target HMG-CoA Reductase by Computational Alanine Scanning Mutagenesis
10.1007/s00894-014-2178-8 · 2014 · External reference
Ligand Efficiency: A Useful Metric for Lead Selection
10.1016/s1359-6446(04)03069-7 · 2004 · External reference
The Role of Ligand Efficiency Metrics in Drug Discovery
10.1038/nrd4163 · 2014 · External reference
Nobiletin Inhibits Hepatic Lipogenesis via Activation of AMP-Activated Protein Kinase
10.1155/2018/7420265 · 2018 · External reference
Efficacy of Nobiletin in Improving Hypercholesterolemia and Nonalcoholic Fatty Liver Disease in High-Cholesterol Diet-Fed Mice
10.4162/nrp.2021.15.4.431 · 2021 · External reference
Inhibitory Effects of Tangeretin and trans-Ethyl Caffeate on the HMG-CoA Reductase Activity: Potential Agents for Reducing Cholesterol Levels
10.1016/j.sjbs.2020.06.010 · 2020 · External reference
The Lipid-Modulating Effect of Tangeretin on the Inhibition of Angiopoietin-Like 3 (ANGPTL3) Gene Expression Through Regulation of LXRα Activation in Hepatic Cells
10.3390/ijms22189853 · 2021 · External reference
Hepatic Lipidomics Analysis Reveals the Antiobesity and Cholesterol-Lowering Effects of Tangeretin in High-Fat Diet-Fed Rats
10.1021/acs.jafc.0c01778 · 2020 · External reference
Citrus Polymethoxyflavones Regulate against Aging-Associated Diseases: Advances in Biological Mechanisms Responsible for Their Regulation
10.1021/acs.jafc.4c08004 · 2024 · External reference
Physiologically Based Pharmacokinetic Modeling of Bergamottin and 6,7-Dihydroxybergamottin to Describe CYP3A4-Mediated Grapefruit–Drug Interactions
10.1002/cpt.2968 · ExternalCitation · doi-reference
AutoDock Vina: Improving the Speed and Accuracy of Docking with a New Scoring Function, Efficient Optimization, and Multithreading
10.1002/jcc.21334 · ExternalCitation · doi-reference
Antioxidant Properties, Radical Scavenging Activity and Biomolecule Protection Capacity of Flavonoid Naringenin and Its Glycoside Naringin: A Comparative Study
10.1002/jsfa.3959 · ExternalCitation · doi-reference
UCSF ChimeraX: Structure Visualization for Researchers, Educators, and Developers
10.1002/pro.3943 · ExternalCitation · doi-reference
Physiologically Based Pharmacokinetics Modeling and Transporter Proteomics to Predict Systemic and Local Liver and Muscle Disposition of Statins
10.1002/psp4.13139 · ExternalCitation · doi-reference
High-Content Screening of Drug-Induced Mitochondrial Impairment in Hepatic Cells: Effects of Statins
10.1007/s00204-014-1334-3 · ExternalCitation · doi-reference
Discovery of New Druggable Sites in the Anti-Cholesterol Target HMG-CoA Reductase by Computational Alanine Scanning Mutagenesis
10.1007/s00894-014-2178-8 · ExternalCitation · doi-reference
Valorization of Taiwan’s Citrus depressa Hayata Peels as a Source of Nobiletin and Tangeretin Using Simple Ultrasonic-Assisted Extraction
10.1016/j.crfs.2022.01.013 · ExternalCitation · doi-reference
Inhibition of Hepatic Uptake Transporters by Flavonoids
10.1016/j.ejps.2012.02.014 · ExternalCitation · doi-reference
Comparative Uptake of Statins by Hepatic Organic Anion Transporting Polypeptides
10.1016/j.ejps.2025.107073 · ExternalCitation · doi-reference
Food–Drug Interactions: Effect of Capsaicin on the Pharmacokinetics of Simvastatin and Its Active Metabolite in Rats
10.1016/j.fct.2012.11.045 · ExternalCitation · doi-reference
Atorvastatin Induced Hepatic Oxidative Stress and Apoptotic Damage via MAPKs, Mitochondria, Calpain and Caspase12 Dependent Pathways
10.1016/j.fct.2015.05.016 · ExternalCitation · doi-reference
Nobiletin, Sinensetin, and Tangeretin Are the Main Perpetrators in Clementines Provoking Food–Drug Interactions in Vitro
10.1016/j.foodchem.2020.126578 · ExternalCitation · doi-reference
Pharmacokinetics, Bioavailability, Tissue Distribution and Excretion of Tangeretin in Rat
10.1016/j.jfda.2017.08.003 · ExternalCitation · doi-reference
Chemical Structures, Bioactivities and Molecular Mechanisms of Citrus Polymethoxyflavones
10.1016/j.jff.2017.11.036 · ExternalCitation · doi-reference
Combating Oxidative Stress Disorders with Citrus Flavonoid: Naringenin
10.1016/j.lfs.2018.07.017 · ExternalCitation · doi-reference
Insights into Molecular Mechanism of Action of Citrus Flavonoids Hesperidin and Naringin on Lipid Bilayers Using Spectroscopic, Calorimetric, Microscopic and Theoretical Studies
10.1016/j.molliq.2021.118411 · ExternalCitation · doi-reference
Pharmacokinetic and Pharmacodynamic Alterations of 3-Hydroxy-3-Methylglutaryl Coenzyme A (HMG-CoA) Reductase Inhibitors: Drug–Drug Interactions and Interindividual Differences in Transporter and Metabolic Enzyme Functions
10.1016/j.pharmthera.2006.03.003 · ExternalCitation · doi-reference
Statins: Adverse Reactions, Oxidative Stress and Metabolic Interactions
10.1016/j.pharmthera.2018.10.004 · ExternalCitation · doi-reference
Inhibitory Effects of Tangeretin and trans-Ethyl Caffeate on the HMG-CoA Reductase Activity: Potential Agents for Reducing Cholesterol Levels
10.1016/j.sjbs.2020.06.010 · ExternalCitation · doi-reference
Grapefruit Juice–Simvastatin Interaction: Effect on Serum Concentrations of Simvastatin, Simvastatin Acid, and HMG-CoA Reductase Inhibitors
10.1016/s0009-9236(98)90130-8 · ExternalCitation · doi-reference
Polymethoxylated Flavones in Orange Juice Are Inhibitors of P-Glycoprotein but Not Cytochrome P450 3A4
10.1016/s0022-3565(24)39224-9 · ExternalCitation · doi-reference
Experimental and Computational Approaches to Estimate Solubility and Permeability in Drug Discovery and Development Settings
10.1016/s0169-409x(00)00129-0 · ExternalCitation · doi-reference
Ligand Efficiency: A Useful Metric for Lead Selection
10.1016/s1359-6446(04)03069-7 · ExternalCitation · doi-reference
Hepatic Lipidomics Analysis Reveals the Antiobesity and Cholesterol-Lowering Effects of Tangeretin in High-Fat Diet-Fed Rats
10.1021/acs.jafc.0c01778 · ExternalCitation · doi-reference
Nobiletin Ameliorates Hepatic Lipid Deposition, Oxidative Stress, and Inflammation by Mechanisms That Involve the Nrf2/NF-κB Axis in Nonalcoholic Fatty Liver Disease
10.1021/acs.jafc.3c06498 · ExternalCitation · doi-reference
Citrus Polymethoxyflavones Regulate against Aging-Associated Diseases: Advances in Biological Mechanisms Responsible for Their Regulation
10.1021/acs.jafc.4c08004 · ExternalCitation · doi-reference
The Chemistry Behind Antioxidant Capacity Assays
10.1021/jf030723c · ExternalCitation · doi-reference
Activation of Pregnane X Receptor and Induction of MDR1 by Dietary Phytochemicals
10.1021/jf073350e · ExternalCitation · doi-reference
The Drug Transporter–Metabolism Alliance: Uncovering and Defining the Interplay
10.1021/mp900253n · ExternalCitation · doi-reference
Regulation of the Mevalonate Pathway
10.1038/343425a0 · ExternalCitation · doi-reference
Grapefruit Juice–Felodipine Interaction: Mechanism, Predictability, and Effect of Naringin
10.1038/clpt.1993.84 · ExternalCitation · doi-reference
Feedback Regulation of Cholesterol Synthesis: Sterol-Accelerated Ubiquitination and Degradation of HMG CoA Reductase
10.1038/cr.2008.61 · ExternalCitation · doi-reference
The Role of Ligand Efficiency Metrics in Drug Discovery
10.1038/nrd4163 · ExternalCitation · doi-reference
SwissADME: A Free Web Tool to Evaluate Pharmacokinetics, Drug-Likeness and Medicinal Chemistry Friendliness of Small Molecules
10.1038/srep42717 · ExternalCitation · doi-reference
Toxicological and Pharmacokinetic Evaluation of Concomitant Intake of Grapefruit Juice and Simvastatin in Rats after Repeated Treatment over 28 Days
10.1055/s-0029-1185534 · ExternalCitation · doi-reference
Polymethoxyflavones from Citrus Peel: Advances in Extraction Methods, Biological Properties, and Potential Applications
10.1080/10408398.2022.2156476 · ExternalCitation · doi-reference
Phytochemical and Antioxidant Profile of Citrus Peel Extracts in Relation to Different Extraction Parameters
10.1080/10942912.2024.2304274 · ExternalCitation · doi-reference
Statins Trigger Mitochondrial Reactive Oxygen Species-Induced Apoptosis in Glycolytic Skeletal Muscle
10.1089/ars.2014.6190 · ExternalCitation · doi-reference
A Furanocoumarin-Free Grapefruit Juice Establishes Furanocoumarins as the Mediators of the Grapefruit Juice–Felodipine Interaction
10.1093/ajcn/83.5.1097 · ExternalCitation · doi-reference
Webina: An Open-Source Library and Web App That Runs AutoDock Vina Entirely in the Web Browser
10.1093/bioinformatics/btaa579 · ExternalCitation · doi-reference
SLCO1B1 Polymorphism Markedly Affects the Pharmacokinetics of Simvastatin Acid
10.1097/01.fpc.0000230416.82349.90 · ExternalCitation · doi-reference
Impacts of Pharmacokinetic Gene Polymorphisms on Steady-State Plasma Concentrations of Simvastatin in Thai Population
10.1111/cts.70225 · ExternalCitation · doi-reference
Fruit Juice Inhibition of Uptake Transport: A New Type of Food–Drug Interaction
10.1111/j.1365-2125.2010.03722.x · ExternalCitation · doi-reference
Flavonoids as Modulators of Metabolic Enzymes and Drug Transporters
10.1111/nyas.13384 · ExternalCitation · doi-reference
Methylated Flavonoids Have Greatly Improved Intestinal Absorption and Metabolic Stability
10.1124/dmd.106.011122 · ExternalCitation · doi-reference
Identification of the Residue in Human CYP3A4 That Is Covalently Modified by Bergamottin and the Reactive Intermediate That Contributes to the Grapefruit Juice Effect
10.1124/dmd.112.044560 · ExternalCitation · doi-reference
Mechanisms of Enhanced Oral Availability of CYP3A4 Substrates by Grapefruit Constituents. Decreased Enterocyte CYP3A4 Concentration and Mechanism-Based Inactivation by Furanocoumarins
10.1124/dmd.25.11.1228 · ExternalCitation · doi-reference
Two Major Grapefruit Juice Components Differ in Time to Onset of Intestinal CYP3A4 Inhibition
10.1124/jpet.104.076836 · ExternalCitation · doi-reference
Unmasking the Dynamic Interplay Between Intestinal P-Glycoprotein and CYP3A4
10.1124/jpet.300.3.1036 · ExternalCitation · doi-reference
Organic Anion Transporting Polypeptide 1B1: A Genetically Polymorphic Transporter of Major Importance for Hepatic Drug Uptake
10.1124/pr.110.002857 · ExternalCitation · doi-reference
Structural Mechanism for Statin Inhibition of HMG-CoA Reductase
10.1126/science.1059344 · ExternalCitation · doi-reference
Nobiletin Inhibits Hepatic Lipogenesis via Activation of AMP-Activated Protein Kinase
10.1155/2018/7420265 · ExternalCitation · doi-reference
Extraction of Nobiletin and Tangeretin from Peels of Shekwasha and Ponkan Using [C2mim][(MeO)(H)PO2] and Centrifugation
10.1177/1934578x19845816 · ExternalCitation · doi-reference
Statin-Associated Liver Dysfunction and Muscle Injury: Epidemiology, Mechanisms, and Management Strategies
10.2147/ijgm.s460305 · ExternalCitation · doi-reference
In Vitro Metabolism of Nobiletin, a Polymethoxy-Flavonoid, by Human Liver Microsomes and Cytochrome P450
10.3109/00498254.2011.593208 · ExternalCitation · doi-reference
Effects of Bioflavonoids on Hepatic P450 Activities
10.3109/00498259509061876 · ExternalCitation · doi-reference
Pharmacokinetics and Metabolism of Naringin and Active Metabolite Naringenin in Rats, Dogs, Humans, and the Differences Between Species
10.3389/fphar.2020.00364 · ExternalCitation · doi-reference
The Lipid-Modulating Effect of Tangeretin on the Inhibition of Angiopoietin-Like 3 (ANGPTL3) Gene Expression Through Regulation of LXRα Activation in Hepatic Cells
10.3390/ijms22189853 · ExternalCitation · doi-reference
Effects of Silymarin on the in Vivo Pharmacokinetics of Simvastatin and Its Active Metabolite in Rats
10.3390/molecules24091666 · ExternalCitation · doi-reference
Nobiletin Intake Attenuates Hepatic Lipid Profiling and Oxidative Stress in HFD-Induced Nonalcoholic-Fatty-Liver-Disease Mice
10.3390/molecules28062570 · ExternalCitation · doi-reference
Efficacy of Nobiletin in Improving Hypercholesterolemia and Nonalcoholic Fatty Liver Disease in High-Cholesterol Diet-Fed Mice
10.4162/nrp.2021.15.4.431 · ExternalCitation · doi-reference
