Research graph
References from Selenium Supplementation Attenuates NET DNA-Mediated Intestinal Epithelial Pyroptosis and Intestinal Barrier Injury in MRSA Enteritis via Upregulating Selenoprotein S. Local targets link to admitted publications; unresolved targets remain external evidence.
Methicillin-Resistant Staphylococcus aureus (MRSA): Resistance, Prevalence, and Coping Strategies
10.3390/antibiotics14080771 · 2025 · External reference
Epidemiological Study on Case Definition of Methicillin-Resistant Staphylococcus aureus Enteritis
10.2147/idr.s459708 · 2024 · External reference
Protective effect of 13-methylberberine against mouse enteritis caused by MRSA
10.1016/j.jep.2022.115994 · 2023 · External reference
Establishment and application of nano-liposomes system for targeted therapy of methicillin-resistant Staphylococcus aureus enteritis
10.1016/j.mtbio.2025.102380 · 2025 · External reference
Ginsenoside Rh4 inhibits colorectal cancer via the modulation of gut microbiota-mediated bile acid metabolism
10.1016/j.jare.2024.06.028 · 2025 · External reference
Unravelling the collateral damage of antibiotics on gut bacteria
10.1038/s41586-021-03986-2 · 2021 · External reference
Selenium-enriched Cardamine violifolia protects against sepsis-induced intestinal injury by regulating mitochondrial fusion in weaned pigs
10.1007/s11427-022-2274-7 · 2023 · External reference
Dietary nano-selenium alleviated intestinal damage of juvenile grass carp (Ctenopharyngodon idella) induced by high-fat diet: Insight from intestinal morphology, tight junction, inflammation, anti-oxidization and intestinal microbiota
10.1016/j.aninu.2021.07.001 · 2022 · External reference
Surface chemistry engineered selenium nanoparticles as bactericidal and immuno-modulating dual-functional agents for combating methicillin-resistant Staphylococcus aureus Infection
10.1016/j.drup.2024.101102 · 2024 · External reference
Biosynthesis and antibacterial activity of selenium nanoparticles using Pseudomonas aeruginosa and Bacillus pumilus RMO6
10.1186/s11671-026-04484-y · 2026 · External reference
Selenium nanoparticles biosynthesized by Eurotium cristatum with antimicrobial activity
10.26599/fshw.2024.9250158 · 2025 · External reference
Biogenic Selenium Nanoparticles from Lactiplantibacillus plantarum as a Potent Antimicrobial Agent Against Methicillin-Resistant Staphylococcus aureus
10.3390/pharmaceutics18010014 · 2026 · External reference
Selenoprotein S is a marker but not a regulator of endoplasmic reticulum stress in intestinal epithelial cells
10.1016/j.freeradbiomed.2013.11.001 · 2014 · External reference
Selenoprotein S maintains intestinal homeostasis in ulcerative colitis by inhibiting necroptosis of colonic epithelial cells through modulation of macrophage polarization
10.7150/thno.97005 · 2024 · External reference
The diverse roles of neutrophils from protection to pathogenesis
10.1038/s41590-024-02006-5 · 2024 · External reference
Mitochondria sense bacterial lactate and drive release of neutrophil extracellular traps
10.1016/j.chom.2025.02.003 · 2025 · External reference
Neutrophils in Atopic Dermatitis
10.1007/s12016-024-09004-3 · 2024 · External reference
Staphylococcus aureus induces neutrophil extracellular traps (NETs) and neutralizes their bactericidal potential
10.1016/j.csbj.2021.06.012 · 2021 · External reference
Staphylococcus aureus biofilm extracellular DNA neutralizes the antimicrobial activity of histone H3
10.1038/s41522-026-00979-9 · 2026 · External reference
Oral exposure to Staphylococcus aureus enterotoxin B could promote the Ovalbumin-induced food allergy by enhancing the activation of DCs and T cells
10.3389/fimmu.2023.1250458 · 2023 · External reference
Reuterin-producing Limosilactobacillus reuteri with glycerol metabolism ameliorates Staphylococcus aureus-induced intestinal inflammation and dysfunction without gut microbiota dependent
10.26599/fshw.2024.9250360 · 2026 · External reference
The Host CYP1A1-Microbiota Metabolic Axis Promotes Gut Barrier Disruption in Methicillin-Resistant Staphylococcus aureus-Induced Abdominal Sepsis
10.3389/fmicb.2022.802409 · 2022 · External reference
Staphylococcus aureus manipulates osteocytes to cause persistent chronic osteomyelitis and antibiotic resistance via pyroptosis pathway suppression
10.1016/j.drup.2025.101295 · 2026 · External reference
GSDME promotes MASLD by regulating pyroptosis, Drp1 citrullination-dependent mitochondrial dynamic, and energy balance in intestine and liver
10.1038/s41418-024-01343-0 · 2024 · External reference
Meningitic Escherichia coli disrupts the blood-brain barrier through pyroptosis and tight junction degradation and NLRP6 deficiency aggravates infection outcomes
10.1016/j.micres.2025.128388 · 2026 · External reference
Excessive pyroptosis mediates the exacerbation of pneumonia caused by low-lethality influenza virus and secondary MRSA co-infection
10.1038/s41420-026-03031-z · 2026 · External reference
Pyroptosis Drives the Impairment of Colonic Barrier Integrity During Toxoplasma Gondii Chronic Infection
10.1111/imm.70023 · 2026 · External reference
The Barrier Disruption and Pyroptosis of Intestinal Epithelial Cells Caused by Perfringolysin O (PFO) from Clostridium perfringens
10.3390/cells13131140 · 2024 · External reference
Roles of selenoprotein S in reactive oxygen species-dependent neutrophil extracellular trap formation induced by selenium-deficient arteritis
10.1016/j.redox.2021.102003 · 2021 · External reference
In vitro and in silico analyses reveal the toxicity of metolachlor to grass carp hepatocytes and the antagonism of melatonin
10.1016/j.pestbp.2024.105930 · 2024 · External reference
lnc-3215 Suppression Leads to Calcium Overload in Selenium Deficiency-Induced Chicken Heart Lesion via the lnc-3215-miR-1594-TNN2 Pathway
10.1016/j.omtn.2019.08.003 · 2019 · External reference
Piezo1-directed neutrophil extracellular traps regulate macrophage differentiation during influenza virus infection
10.1038/s41419-025-07395-5 · 2025 · External reference
Genomic characterization of healthcare-associated ST5MRSA causing severe pseudomembranous enteritis in intensive care unit
10.1186/s12879-025-10573-7 · 2025 · External reference
Loss of Mptx2 alters bacteria composition and intestinal homeostasis potentially by impairing autophagy
10.1038/s42003-024-05785-7 · 2024 · External reference
Pathways of Methicillin-Resistant Staphylococcus aureus in Animal Model: New Insights Regarding Public Health
10.2147/idr.s252332 · 2020 · External reference
Equine neutrophils selectively release neutrophil extracellular traps in response to chemical and bacterial agonists
10.3389/fvets.2025.1512343 · 2025 · External reference
Neutrophils Expressing Programmed Death-Ligand 1 Play an Indispensable Role in Effective Bacterial Elimination and Resolving Inflammation in Methicillin-Resistant Staphylococcus aureus Infection
10.3390/pathogens13050401 · 2024 · External reference
Neutrophil Extracellular Traps: Mechanisms of Formation and Role in Health and Disease
10.1134/s0006297914120025 · 2014 · External reference
Neutrophil, neutrophil extracellular traps and endothelial cell dysfunction in sepsis
10.1002/ctm2.1170 · 2023 · External reference
Cathepsin C from extracellular histone-induced M1 alveolar macrophages promotes NETosis during lung ischemia-reperfusion injury
10.1016/j.redox.2024.103231 · 2024 · External reference
Increased Circulating Extracellular Superoxide Dismutase Attenuates Platelet-Neutrophil Interactions
10.1165/rcmb.2024-0292oc · 2025 · External reference
Phenol-soluble Modulin a Peptide Toxins from aggressive Staphylococcus aureus induce rapid Formation of neutrophil extracellular Traps through a reactive Oxygen species-independent Pathway
10.3389/fimmu.2017.00257 · 2017 · External reference
Lipoproteins from Staphylococcus aureus Drive Neutrophil Extracellular Trap Formation in a TLR2/1-and PAD-Dependent Manner
10.4049/jimmunol.2100283 · 2021 · External reference
Antioxidant Strategies to Modulate NETosis and the Release of Neutrophil Extracellular Traps during Chronic Inflammation
10.3390/antiox12020478 · 2023 · External reference
Agonist signaling drives neutrophil subpopulations to promote/inhibit colorectal cancer liver metastasis
10.1038/s41467-025-67579-7 · 2026 · External reference
Histones of Neutrophil Extracellular Traps Directly Disrupt the Permeability and Integrity of the Intestinal Epithelial Barrier
10.1093/ibd/izac256 · 2023 · External reference
Hesperetin attenuates sepsis-induced intestinal barrier injury by regulating neutrophil extracellular trap formation via the ROS/autophagy signaling pathway
10.1039/d2fo02707k · 2023 · External reference
Neutrophil extracellular traps promote intestinal barrier dysfunction by regulating macrophage polarization during trauma/hemorrhagic shock via the TGF-β signaling pathway
10.1016/j.cellsig.2023.110941 · 2024 · External reference
Who and how, DNA sensors in NETs-driven inflammation
10.3389/fimmu.2023.1190177 · 2023 · External reference
Cytosolic escape of mitochondrial DNA triggers cGAS-STING-NLRP3 axis-dependent nucleus pulposus cell pyroptosis
10.1038/s12276-022-00729-9 · 2022 · External reference
ATP Facilitates Staphylococcal Enterotoxin O Induced Neutrophil IL-1β Secretion via NLRP3 Inflammasome Dependent Pathways
10.3389/fimmu.2021.649235 · 2021 · External reference
Selenoprotein S ablation-mediated pyroptosis contributes to liver damage resulting from selenium deficiency in chickens
10.1016/j.psj.2025.105269 · 2025 · External reference
Dietary Selenium deficiency activates the NLRP3 inflammasome to induce gallbladder pyroptosis by regulating glycolysis and histone lactylation through ROS/HIF-1α pathway
10.1016/j.jnutbio.2025.110118 · 2026 · External reference
The protective effects of selenium against NLRP3-mediated inflammation and pyroptosis: mechanisms and the potential health benefits
10.1007/s10534-025-00754-x · 2026 · External reference
Thioredoxin reductase 3 suppression promotes colitis and carcinogenesis via activating pyroptosis and necrosis
10.1007/s00018-022-04155-y · 2022 · External reference
Molecular mechanisms of NLRP3 inflammasome activation
10.1038/s12276-026-01656-9 · 2026 · External reference
A Review of the Neutrophil Extracellular Traps (NETs) from Cow, Sheep and Goat Models
10.3390/ijms22158046 · 2021 · External reference
PRRSV Infection Induces Gasdermin D-Driven Pyroptosis of Porcine Alveolar Macrophages through NLRP3 Inflammasome Activation
10.1128/jvi.02127-21 · 2022 · External reference
The NLRP3 molecule is responsible for mediating the pyroptosis of intestinal mucosa cells and plays a crucial role in salmonellosis enteritis in chicks
10.1016/j.molimm.2024.02.009 · 2024 · External reference
Selenium Deficiency in Chickens Induces Intestinal Mucosal Injury by Affecting the Mucosa Morphology, SIgA Secretion, and GSH-Px Activity
10.1007/s12011-019-02017-6 · 2020 · External reference
Gender-specific differences in the expression of selenoproteins in mammals
10.1055/s-2005-862874 · 2005 · External reference
Selenium controls the sex-specific immune response and selenoprotein expression during the acute-phase response in mice
10.1042/bj20091868 · 2010 · External reference
Sex-specific NLRP3 activation in neutrophils promotes neutrophil recruitment and NETosis in the murine model of diffuse alveolar hemorrhage
10.3389/fimmu.2024.1466234 · 2024 · External reference
Sex differences in neutrophil biology
10.1093/jleuko/qiaf161 · 2025 · External reference
Neutrophil, neutrophil extracellular traps and endothelial cell dysfunction in sepsis
10.1002/ctm2.1170 · ExternalCitation · doi-reference
Thioredoxin reductase 3 suppression promotes colitis and carcinogenesis via activating pyroptosis and necrosis
10.1007/s00018-022-04155-y · ExternalCitation · doi-reference
The protective effects of selenium against NLRP3-mediated inflammation and pyroptosis: mechanisms and the potential health benefits
10.1007/s10534-025-00754-x · ExternalCitation · doi-reference
Selenium-enriched Cardamine violifolia protects against sepsis-induced intestinal injury by regulating mitochondrial fusion in weaned pigs
10.1007/s11427-022-2274-7 · ExternalCitation · doi-reference
Selenium Deficiency in Chickens Induces Intestinal Mucosal Injury by Affecting the Mucosa Morphology, SIgA Secretion, and GSH-Px Activity
10.1007/s12011-019-02017-6 · ExternalCitation · doi-reference
Neutrophils in Atopic Dermatitis
10.1007/s12016-024-09004-3 · ExternalCitation · doi-reference
Dietary nano-selenium alleviated intestinal damage of juvenile grass carp (Ctenopharyngodon idella) induced by high-fat diet: Insight from intestinal morphology, tight junction, inflammation, anti-oxidization and intestinal microbiota
10.1016/j.aninu.2021.07.001 · ExternalCitation · doi-reference
Neutrophil extracellular traps promote intestinal barrier dysfunction by regulating macrophage polarization during trauma/hemorrhagic shock via the TGF-β signaling pathway
10.1016/j.cellsig.2023.110941 · ExternalCitation · doi-reference
Mitochondria sense bacterial lactate and drive release of neutrophil extracellular traps
10.1016/j.chom.2025.02.003 · ExternalCitation · doi-reference
Staphylococcus aureus induces neutrophil extracellular traps (NETs) and neutralizes their bactericidal potential
10.1016/j.csbj.2021.06.012 · ExternalCitation · doi-reference
Surface chemistry engineered selenium nanoparticles as bactericidal and immuno-modulating dual-functional agents for combating methicillin-resistant Staphylococcus aureus Infection
10.1016/j.drup.2024.101102 · ExternalCitation · doi-reference
Staphylococcus aureus manipulates osteocytes to cause persistent chronic osteomyelitis and antibiotic resistance via pyroptosis pathway suppression
10.1016/j.drup.2025.101295 · ExternalCitation · doi-reference
Selenoprotein S is a marker but not a regulator of endoplasmic reticulum stress in intestinal epithelial cells
10.1016/j.freeradbiomed.2013.11.001 · ExternalCitation · doi-reference
Ginsenoside Rh4 inhibits colorectal cancer via the modulation of gut microbiota-mediated bile acid metabolism
10.1016/j.jare.2024.06.028 · ExternalCitation · doi-reference
Protective effect of 13-methylberberine against mouse enteritis caused by MRSA
10.1016/j.jep.2022.115994 · ExternalCitation · doi-reference
Dietary Selenium deficiency activates the NLRP3 inflammasome to induce gallbladder pyroptosis by regulating glycolysis and histone lactylation through ROS/HIF-1α pathway
10.1016/j.jnutbio.2025.110118 · ExternalCitation · doi-reference
Meningitic Escherichia coli disrupts the blood-brain barrier through pyroptosis and tight junction degradation and NLRP6 deficiency aggravates infection outcomes
10.1016/j.micres.2025.128388 · ExternalCitation · doi-reference
The NLRP3 molecule is responsible for mediating the pyroptosis of intestinal mucosa cells and plays a crucial role in salmonellosis enteritis in chicks
10.1016/j.molimm.2024.02.009 · ExternalCitation · doi-reference
Establishment and application of nano-liposomes system for targeted therapy of methicillin-resistant Staphylococcus aureus enteritis
10.1016/j.mtbio.2025.102380 · ExternalCitation · doi-reference
lnc-3215 Suppression Leads to Calcium Overload in Selenium Deficiency-Induced Chicken Heart Lesion via the lnc-3215-miR-1594-TNN2 Pathway
10.1016/j.omtn.2019.08.003 · ExternalCitation · doi-reference
In vitro and in silico analyses reveal the toxicity of metolachlor to grass carp hepatocytes and the antagonism of melatonin
10.1016/j.pestbp.2024.105930 · ExternalCitation · doi-reference
Selenoprotein S ablation-mediated pyroptosis contributes to liver damage resulting from selenium deficiency in chickens
10.1016/j.psj.2025.105269 · ExternalCitation · doi-reference
Roles of selenoprotein S in reactive oxygen species-dependent neutrophil extracellular trap formation induced by selenium-deficient arteritis
10.1016/j.redox.2021.102003 · ExternalCitation · doi-reference
Cathepsin C from extracellular histone-induced M1 alveolar macrophages promotes NETosis during lung ischemia-reperfusion injury
10.1016/j.redox.2024.103231 · ExternalCitation · doi-reference
Cytosolic escape of mitochondrial DNA triggers cGAS-STING-NLRP3 axis-dependent nucleus pulposus cell pyroptosis
10.1038/s12276-022-00729-9 · ExternalCitation · doi-reference
Molecular mechanisms of NLRP3 inflammasome activation
10.1038/s12276-026-01656-9 · ExternalCitation · doi-reference
GSDME promotes MASLD by regulating pyroptosis, Drp1 citrullination-dependent mitochondrial dynamic, and energy balance in intestine and liver
10.1038/s41418-024-01343-0 · ExternalCitation · doi-reference
Piezo1-directed neutrophil extracellular traps regulate macrophage differentiation during influenza virus infection
10.1038/s41419-025-07395-5 · ExternalCitation · doi-reference
Excessive pyroptosis mediates the exacerbation of pneumonia caused by low-lethality influenza virus and secondary MRSA co-infection
10.1038/s41420-026-03031-z · ExternalCitation · doi-reference
Agonist signaling drives neutrophil subpopulations to promote/inhibit colorectal cancer liver metastasis
10.1038/s41467-025-67579-7 · ExternalCitation · doi-reference
Staphylococcus aureus biofilm extracellular DNA neutralizes the antimicrobial activity of histone H3
10.1038/s41522-026-00979-9 · ExternalCitation · doi-reference
Unravelling the collateral damage of antibiotics on gut bacteria
10.1038/s41586-021-03986-2 · ExternalCitation · doi-reference
The diverse roles of neutrophils from protection to pathogenesis
10.1038/s41590-024-02006-5 · ExternalCitation · doi-reference
Loss of Mptx2 alters bacteria composition and intestinal homeostasis potentially by impairing autophagy
10.1038/s42003-024-05785-7 · ExternalCitation · doi-reference
Hesperetin attenuates sepsis-induced intestinal barrier injury by regulating neutrophil extracellular trap formation via the ROS/autophagy signaling pathway
10.1039/d2fo02707k · ExternalCitation · doi-reference
Selenium controls the sex-specific immune response and selenoprotein expression during the acute-phase response in mice
10.1042/bj20091868 · ExternalCitation · doi-reference
Gender-specific differences in the expression of selenoproteins in mammals
10.1055/s-2005-862874 · ExternalCitation · doi-reference
Histones of Neutrophil Extracellular Traps Directly Disrupt the Permeability and Integrity of the Intestinal Epithelial Barrier
10.1093/ibd/izac256 · ExternalCitation · doi-reference
Sex differences in neutrophil biology
10.1093/jleuko/qiaf161 · ExternalCitation · doi-reference
Pyroptosis Drives the Impairment of Colonic Barrier Integrity During Toxoplasma Gondii Chronic Infection
10.1111/imm.70023 · ExternalCitation · doi-reference
PRRSV Infection Induces Gasdermin D-Driven Pyroptosis of Porcine Alveolar Macrophages through NLRP3 Inflammasome Activation
10.1128/jvi.02127-21 · ExternalCitation · doi-reference
Neutrophil Extracellular Traps: Mechanisms of Formation and Role in Health and Disease
10.1134/s0006297914120025 · ExternalCitation · doi-reference
Increased Circulating Extracellular Superoxide Dismutase Attenuates Platelet-Neutrophil Interactions
10.1165/rcmb.2024-0292oc · ExternalCitation · doi-reference
Biosynthesis and antibacterial activity of selenium nanoparticles using Pseudomonas aeruginosa and Bacillus pumilus RMO6
10.1186/s11671-026-04484-y · ExternalCitation · doi-reference
Genomic characterization of healthcare-associated ST5MRSA causing severe pseudomembranous enteritis in intensive care unit
10.1186/s12879-025-10573-7 · ExternalCitation · doi-reference
Pathways of Methicillin-Resistant Staphylococcus aureus in Animal Model: New Insights Regarding Public Health
10.2147/idr.s252332 · ExternalCitation · doi-reference
Epidemiological Study on Case Definition of Methicillin-Resistant Staphylococcus aureus Enteritis
10.2147/idr.s459708 · ExternalCitation · doi-reference
Selenium nanoparticles biosynthesized by Eurotium cristatum with antimicrobial activity
10.26599/fshw.2024.9250158 · ExternalCitation · doi-reference
Reuterin-producing Limosilactobacillus reuteri with glycerol metabolism ameliorates Staphylococcus aureus-induced intestinal inflammation and dysfunction without gut microbiota dependent
10.26599/fshw.2024.9250360 · ExternalCitation · doi-reference
Phenol-soluble Modulin a Peptide Toxins from aggressive Staphylococcus aureus induce rapid Formation of neutrophil extracellular Traps through a reactive Oxygen species-independent Pathway
10.3389/fimmu.2017.00257 · ExternalCitation · doi-reference
ATP Facilitates Staphylococcal Enterotoxin O Induced Neutrophil IL-1β Secretion via NLRP3 Inflammasome Dependent Pathways
10.3389/fimmu.2021.649235 · ExternalCitation · doi-reference
Who and how, DNA sensors in NETs-driven inflammation
10.3389/fimmu.2023.1190177 · ExternalCitation · doi-reference
Oral exposure to Staphylococcus aureus enterotoxin B could promote the Ovalbumin-induced food allergy by enhancing the activation of DCs and T cells
10.3389/fimmu.2023.1250458 · ExternalCitation · doi-reference
Sex-specific NLRP3 activation in neutrophils promotes neutrophil recruitment and NETosis in the murine model of diffuse alveolar hemorrhage
10.3389/fimmu.2024.1466234 · ExternalCitation · doi-reference
The Host CYP1A1-Microbiota Metabolic Axis Promotes Gut Barrier Disruption in Methicillin-Resistant Staphylococcus aureus-Induced Abdominal Sepsis
10.3389/fmicb.2022.802409 · ExternalCitation · doi-reference
Equine neutrophils selectively release neutrophil extracellular traps in response to chemical and bacterial agonists
10.3389/fvets.2025.1512343 · ExternalCitation · doi-reference
Methicillin-Resistant Staphylococcus aureus (MRSA): Resistance, Prevalence, and Coping Strategies
10.3390/antibiotics14080771 · ExternalCitation · doi-reference
Antioxidant Strategies to Modulate NETosis and the Release of Neutrophil Extracellular Traps during Chronic Inflammation
10.3390/antiox12020478 · ExternalCitation · doi-reference
The Barrier Disruption and Pyroptosis of Intestinal Epithelial Cells Caused by Perfringolysin O (PFO) from Clostridium perfringens
10.3390/cells13131140 · ExternalCitation · doi-reference
A Review of the Neutrophil Extracellular Traps (NETs) from Cow, Sheep and Goat Models
10.3390/ijms22158046 · ExternalCitation · doi-reference
Neutrophils Expressing Programmed Death-Ligand 1 Play an Indispensable Role in Effective Bacterial Elimination and Resolving Inflammation in Methicillin-Resistant Staphylococcus aureus Infection
10.3390/pathogens13050401 · ExternalCitation · doi-reference
Biogenic Selenium Nanoparticles from Lactiplantibacillus plantarum as a Potent Antimicrobial Agent Against Methicillin-Resistant Staphylococcus aureus
10.3390/pharmaceutics18010014 · ExternalCitation · doi-reference
Lipoproteins from Staphylococcus aureus Drive Neutrophil Extracellular Trap Formation in a TLR2/1-and PAD-Dependent Manner
10.4049/jimmunol.2100283 · ExternalCitation · doi-reference
Selenoprotein S maintains intestinal homeostasis in ulcerative colitis by inhibiting necroptosis of colonic epithelial cells through modulation of macrophage polarization
10.7150/thno.97005 · ExternalCitation · doi-reference
