Research graph
References from Recent Advances in the Production and Biosynthesis of Oleanane-Type Pentacyclic Triterpenoids. Local targets link to admitted publications; unresolved targets remain external evidence.
The pharmaceutical industry and natural products: historical status and new trends
10.1007/s11101-014-9367-z · 2015 · External reference
Manipulation of GES and ERG20 for geraniol overproduction in Saccharomyces cerevisiae
10.1016/j.ymben.2017.03.005 · 2017 · External reference
Dynamic control of ERG20 expression combined with minimized endogenous downstream metabolism contributes to the improvement of geraniol production in Saccharomyces cerevisiae
10.1186/s12934-017-0641-9 · 2017 · External reference
Biosynthesis and engineering of isoprenoid small molecules
10.1007/s00253-006-0593-1 · 2007 · External reference
Artemisinin-Based Combination Therapies in East Africa: A Systematic Review of Quality, Clinical Efficacy, and Regulatory Progress Towards Sustainable Malaria Control
10.1111/tmi.70072 · 2026 · External reference
Efficient production of lycopene in Saccharomyces cerevisiae by enzyme engineering and increasing membrane flexibility and NAPDH production
10.1007/s00253-018-9449-8 · 2019 · External reference
Lycopene in citrus fruit: biochemical mechanisms, molecular insights and health implications
10.1080/10408398.2026.2625334 · 2026 · External reference
Structure and Activity of Pentacyclic Triterpenes Codrugs. A Review
10.2174/1389557521666210105110848 · 2021 · External reference
Therapeutic Potential of Ursolic Acid in Cancer and Diabetic Neuropathy Diseases
10.3390/ijms222212162 · 2021 · External reference
Development and Evaluation of Oleanolic Acid Dosage Forms and Its Derivatives
10.1155/2020/1308749 · 2020 · External reference
Application of multiple strategies to enhance oleanolic acid biosynthesis by engineered Saccharomyces cerevisiae
10.1016/j.biortech.2024.130716 · 2024 · External reference
Self-controlled in silico gene knockdown strategies to enhance the sustainable production of heterologous terpenoid by Saccharomyces cerevisiae
10.1016/j.ymben.2024.04.005 · 2024 · External reference
Enhancing oleanolic acid production in engineered Saccharomyces cerevisiae
10.1016/j.biortech.2018.02.096 · 2018 · External reference
Combinatorial metabolic engineering enables the efficient production of ursolic acid and oleanolic acid in Saccharomyces cerevisiae
10.1016/j.biortech.2023.128819 · 2023 · External reference
Biosynthesis of ursolic acid and oleanolic acid in Saccharomyces cerevisiae
10.1002/aic.16370 · 2018 · External reference
Construction of oleanolic acid-producing Saccharomyces cerevisiae cells
10.19540/j.cnki.cjcmm.20250216.105 · 2025 · External reference
Producing aglycons of ginsenosides in bakers’ yeast
10.1038/srep03698 · 2014 · External reference
Metabolic engineering of Yarrowia lipolytica for heterologous oleanolic acid production
10.1016/j.ces.2020.115529 · 2020 · External reference
Engineering of Yarrowia lipolytica for the production of plant triterpenoids: Asiatic, madecassic, and arjunolic acids
10.1016/j.mec.2022.e00197 · 2022 · External reference
Two CYP716A subfamily cytochrome P450 monooxygenases of sweet basil play similar but nonredundant roles in ursane- and oleanane-type pentacyclic triterpene biosynthesis
10.1111/nph.14412 · 2017 · External reference
Cytochrome P450 Monooxygenase/Cytochrome P450 Reductase Bi-Enzymatic System Isolated From Ilex asprella for Regio-Specific Oxidation of Pentacyclic Triterpenoids
10.3389/fpls.2022.831401 · 2022 · External reference
Establishing cell suitability for high-level production of licorice triterpenoids in yeast
10.1016/j.apsb.2024.04.032 · 2024 · External reference
Controlling Chemo- and Regioselectivity of a Plant P450 in Yeast Cell toward Rare Licorice Triterpenoid Biosynthesis
10.1021/acscatal.0c00128 · 2020 · External reference
Efficient production of glycyrrhetinic acid in metabolically engineered Saccharomyces cerevisiae via an integrated strategy
10.1186/s12934-019-1138-5 · 2019 · External reference
Low temperature promotes the production and efflux of terpenoids in yeast
10.1016/j.biortech.2024.130376 · 2024 · External reference
Boosting 11-oxo-β-amyrin and glycyrrhetinic acid synthesis in Saccharomyces cerevisiae via pairing novel oxidation and reduction system from legume plants
10.1016/j.ymben.2017.11.009 · 2018 · External reference
Triterpene functional genomics in licorice for identification of CYP72A154 involved in the biosynthesis of glycyrrhizin
10.1105/tpc.110.082685 · 2011 · External reference
Molecular study on the role of vacuolar transporters in glycyrrhetinic acid production in engineered Saccharomyces cerevisiae
10.1016/j.bbamem.2022.183890 · 2022 · External reference
Oxidosqualene cyclase and CYP716 enzymes contribute to triterpene structural diversity in the medicinal tree banaba
10.1111/nph.15606 · 2019 · External reference
De Novo Biosynthesis of Oleanane-Type Ginsenosides in Saccharomyces cerevisiae Using Two Types of Glycosyltransferases from Panax ginseng
10.1021/acs.jafc.1c07526 · 2022 · External reference
A cellulose synthase-derived enzyme catalyses 3-O-glucuronosylation in saponin biosynthesis
10.1038/s41467-020-19399-0 · 2020 · External reference
Biosynthesis of Soyasapogenol B by Engineered Saccharomyces cerevisiae
10.1007/s12010-021-03599-5 · 2021 · External reference
Combinatorial Biosynthesis of Legume Natural and Rare Triterpenoids in Engineered Yeast
10.1093/pcp/pct015 · 2013 · External reference
Identification of a novel cytochrome P450 enzyme that catalyzes the C-2α hydroxylation of pentacyclic triterpenoids and its application in yeast cell factories
10.1016/j.ymben.2018.10.001 · 2019 · External reference
Biosynthesis analysis of hederagenin pathway and its construction in yeast cells
10.19540/j.cnki.cjcmm.20180307.008 · 2018 · External reference
Transcriptomic Analysis of Kalopanax septemlobus and Characterization of KsBAS, CYP716A94 and CYP72A397 Genes Involved in Hederagenin Saponin Biosynthesis
10.1093/pcp/pcx188 · 2018 · External reference
Unraveling the role of cytochrome P450 enzymes in oleanane triterpenoid biosynthesis in arjuna tree
10.1111/tpj.16942 · 2024 · External reference
Combinatorial optimization and spatial remodeling of CYPs to control product profile
10.1016/j.ymben.2023.09.004 · 2023 · External reference
De Novo Biosynthesis of the Oleanane-Type Triterpenoids of Tunicosaponins in Yeast
10.1021/acssynbio.1c00065 · 2021 · External reference
Extraction characteristics and kinetic studies of oleanolic and ursolic acids from Hedyotis diffusa under ultrasound-assisted extraction conditions
10.1016/j.seppur.2014.04.029 · 2014 · External reference
Simultaneous quantification of oleanolic acid, ursolic acid, betulinic acid and lupeol in different populations of five Swertia species by using HPTLC-densitometry: Comparison of different extraction methods and solvent selection
10.1016/j.indcrop.2018.12.089 · 2019 · External reference
Extraction of anti-cancer damnacanthal from roots of Morinda citrifolia by subcritical water
10.1016/j.seppur.2007.01.004 · 2007 · External reference
Ultrasound-assisted extraction of triterpenoids from Chaenomeles speciosa leaves: Process optimization, adsorptive enrichment, chemical profiling, and protection against ulcerative colitis
10.1016/j.ultsonch.2024.107136 · 2024 · External reference
Comparison of simultaneous distillation extraction and solid-phase microextraction for the determination of volatile flavor components
10.1016/s0021-9673(01)01187-6 · 2001 · External reference
Continuous microwave-assisted isoflavone extraction system: Design and performance evaluation
10.1016/j.biortech.2009.11.039 · 2010 · External reference
Supercritical Fluid Chromatography, Pressurized Liquid Extraction, and Supercritical Fluid Extraction
10.1021/ac0605703 · 2006 · External reference
Supercritical carbon dioxide extraction of seed oil from yellow horn (Xanthoceras sorbifolia Bunge.) and its anti-oxidant activity
10.1016/j.biortech.2009.11.082 · 2010 · External reference
Supercritical CO2 extraction of grappa volatile compounds
10.1111/j.1365-2621.2009.01999.x · 2009 · External reference
Optimization of Total Saponin Extraction from Polyscias fruticosa Roots Using the Ultrasonic-Assisted Method and Response Surface Methodology
10.3390/pr10102034 · 2022 · External reference
Determination of Oleanolic and Ursolic Acids in Hedyotis diffusa Using Hyphenated Ultrasound-Assisted Supercritical Carbon Dioxide Extraction and Chromatography
10.1155/2015/450547 · 2015 · External reference
Micropropagation and in vitro elicitation of licorice (Glycyrrhiza spp.)
10.1007/s11627-017-9832-7 · 2017 · External reference
Establishment and triterpenoid production of Ocimum basilicum cambial meristematic cells
10.1007/s11240-020-01942-y · 2020 · External reference
First Total Synthesis and Bioactivity Study of Dumortierinoside A and Concinnoside D: Two Representative D/E-Ring Simultaneously Functionalized Oleanane-Type Triterpene Saponins
10.1021/jacsau.5c00574 · 2025 · External reference
Design, synthesis, and antitumor activity of novel oleanolic acid analogues targeting EGFR
10.1080/10286020.2023.2206572 · 2023 · External reference
Isoxazole and Pyrazole Derivatives of 28-Oxo-Allobetulone Target Viral Membrane Glycoprotein Hemagglutinin
10.1111/cbdd.70099 · 2025 · External reference
Triterpenoid biosynthesis and engineering in plants
10.3389/fpls.2011.00025 · 2011 · External reference
Biochemical analysis of a multifunctional cytochrome P450 (CYP51) enzyme required for synthesis of antimicrobial triterpenes in plants
10.1073/pnas.1309157110 · 2013 · External reference
Metabolic Engineering of Pichia pastoris for High-Level Production of Lycopene
10.1021/acssynbio.3c00294 · 2023 · External reference
Nrf2 the rescue: Effects of the antioxidative/electrophilic response on the liver
10.1016/j.taap.2010.01.013 · 2010 · External reference
Oleanolic acid activates Nrf2 and protects from acetaminophen hepatotoxicity via Nrf2-dependent and Nrf2-independent processes
10.1016/j.bcp.2008.12.028 · 2009 · External reference
Hederagenin as a triterpene template for the development of new antitumor compounds
10.1016/j.ejmech.2015.10.006 · 2015 · External reference
Pharmacological overview of hederagenin and its derivatives
10.1039/d3md00296a · 2023 · External reference
Hederagenin inhibits high glucose-induced fibrosis in human renal cells by suppression of NLRP3 inflammasome activation through reducing cathepsin B expression
10.1111/cbdd.14332 · 2023 · External reference
Selected Pentacyclic Triterpenoids and Their Derivatives as Biologically Active Compounds
10.3390/molecules30153106 · 2025 · External reference
Antihyperalgesic Activity of Quillaic Acid Obtained from Quillaja saponaria Mol
10.2174/1568026619666190509115741 · 2019 · External reference
In vitro evaluation and molecular docking of QS-21 and quillaic acid from Quillaja saponaria Molina as gastric cancer agents
10.1038/s41598-020-67442-3 · 2020 · External reference
Oleanolic acid
10.1016/j.phytochem.2011.12.022 · 2012 · External reference
iTRAQ-based quantitative proteomic analysis in liver of Pomacea canaliculata induced by oleanolic acid stress
10.1002/ps.6987 · 2022 · External reference
Anticancer activity of oleanolic acid and its derivatives: Recent advances in evidence, target profiling and mechanisms of action
10.1016/j.biopha.2021.112397 · 2022 · External reference
Study of the oleanolic and ursolic acid contents of some species of the Lamiaceae
10.1016/j.bse.2005.12.004 · 2006 · External reference
Mass spectrometry of labelled triterpenoids: Thermospray and electron impact ionization analysis
10.1002/(sici)1099-1565(199609)7:5<237::aid-pca310>3.0.co;2-m · 1996 · External reference
Protective effects of ursolic acid and oleanolic acid in leukemic cells
10.1016/j.mrfmmm.2006.03.008 · 2006 · External reference
A systematic comparison of triterpenoid biosynthetic enzymes for the production of oleanolic acid in Saccharomyces cerevisiae
10.1371/journal.pone.0231980 · 2020 · External reference
Minor Hydroxylated Triterpenoids Produced in Engineered Yeast by the Enzymes OSC and CYP716s from the Plant Enkianthus chinensis and Their Anti-Inflammatory and Hepatoprotective Activities
10.1021/acs.jnatprod.3c01291 · 2024 · External reference
10.1111/nph.18239
10.1111/nph.18239 · External reference
Sustainable production of rare oleanane-type ginsenoside Ro with an artificial glycosylation pathway in Saccharomyces cerevisiae
10.1039/d2gc02639b · 2022 · External reference
Maslinic acid exerts anticancer effects by targeting cancer hallmarks
10.1016/j.phymed.2022.154631 · 2023 · External reference
Maslinic Acid: A New Compound for the Treatment of Multiple Organ Diseases
10.3390/molecules27248732 · 2022 · External reference
Maslinic acid induces autophagy and ferroptosis via transcriptomic and metabolomic reprogramming in prostate cancer cells
10.3389/fphar.2024.1453447 · 2024 · External reference
Maslinic acid alleviates alcoholic liver injury in mice and regulates intestinal microbiota via the gut-liver axis
10.1002/jsfa.13624 · 2024 · External reference
Roles of three cytochrome P450 monooxygenases in triterpene biosynthesis and their potential impact on growth and development
10.1093/plphys/kiae399 · 2024 · External reference
Functional Identification of HhUGT74AG11-A Key Glycosyltransferase Involved in Biosynthesis of Oleanane-Type Saponins in Hedera helix
10.3390/ijms25074067 · 2024 · External reference
Hederagenin improves Alzheimer’s disease through PPARα/TFEB-mediated autophagy
10.1016/j.phymed.2023.154711 · 2023 · External reference
Advances in the anti-tumor potential of hederagenin and its analogs
10.1016/j.ejphar.2023.176073 · 2023 · External reference
MeJA-responsive transcription factors AeMYB9/73 promote oleanolic acid and hederagenin accumulation in Aralia elata
10.1016/j.plantsci.2025.112887 · 2026 · External reference
Arjunolic acid, a peroxisome proliferator-activated receptor α agonist, regresses cardiac fibrosis by inhibiting non-canonical TGF-β signaling
10.1074/jbc.m117.788299 · 2017 · External reference
Arjunolic acid: A new multifunctional therapeutic promise of alternative medicine
10.1016/j.biochi.2013.01.016 · 2013 · External reference
Arjunolic acid protects the intestinal epithelial barrier, ameliorating Crohn’s disease-like colitis by restoring gut microbiota composition and inactivating TLR4 signalling
10.1016/j.phymed.2023.155223 · 2024 · External reference
Supramolecular Assembly of Triterpenoids: Current State and Biomedical Perspectives
10.1002/agt2.70081 · 2025 · External reference
Development of an efficient chromatographic method for the extraction and separation of arjunolic acid and asiatic acid from the heartwood of Terminalia arjuna
10.1016/j.microc.2025.112778 · 2025 · External reference
Development of a minimal saponin vaccine adjuvant based on QS-21
10.1038/nchem.1963 · 2014 · External reference
Review of pharmacological effects of Glycyrrhiza sp. and its bioactive compounds
10.1002/ptr.2362 · 2008 · External reference
Glycyrrhetinic acid: a promising scaffold for the discovery of anticancer agents
10.1080/17460441.2021.1956901 · 2021 · External reference
Glycyrrhetinic Acid Mediated Drug Delivery Carriers for Hepatocellular Carcinoma Therapy
10.1021/acs.molpharmaceut.5b00677 · 2016 · External reference
Functional specialization of UDP-glycosyltransferase 73P12 in licorice to produce a sweet triterpenoid saponin, glycyrrhizin
10.1111/tpj.14409 · 2019 · External reference
Chemical and biological characterization of oleanane triterpenoids from soy
10.3390/molecules14082959 · 2009 · External reference
Potential Anti-tumor Effects and Apoptosis-inducing Mechanisms of Saponins: A Review
10.2174/0115680266315197241015101801 · 2025 · External reference
Triterpenoids from Glycine max decrease invasiveness and induce caspase-mediated cell death in human SNB19 glioma cells
10.1023/a:1024043104803 · 2003 · External reference
Total soy saponins improve the antioxidant capacity of the myocardium and exercise ability in exhausted rats
10.1016/j.jshs.2015.09.005 · 2016 · External reference
Inhibitory effect of soy saponins on the activity of β-lactamases, including New Delhi metallo-β-lactamase 1
10.1007/s13197-018-3091-4 · 2018 · External reference
Effects of long-term soaking on nutraceutical and taste characteristic components in Thai soybeans
10.1016/j.lwt.2019.108432 · 2019 · External reference
Wetting properties of Saponaria officinalis saponins
10.1016/j.colsurfa.2019.123980 · 2020 · External reference
Bridging the Gaps between Plant and Human Health: A Systematic Review of Soyasaponins
10.1021/acs.jafc.1c04819 · 2021 · External reference
The Basic Helix–Loop–Helix Transcription Factor GubHLH3 Positively Regulates Soyasaponin Biosynthetic Genes in Glycyrrhiza uralensis
10.1093/pcp/pcy046 · 2018 · External reference
Biosynthesis of DDMP saponins in soybean is regulated by a distinct UDP-glycosyltransferase
10.1111/nph.15588 · 2019 · External reference
The Sg-1 Glycosyltransferase Locus Regulates Structural Diversity of Triterpenoid Saponins of Soybean
10.1105/tpc.111.095174 · 2012 · External reference
Disruption of a licorice cellulose synthase-derived glycosyltransferase gene demonstrates its in planta role in soyasaponin biosynthesis
10.1007/s00299-023-03095-6 · 2024 · External reference
Engineering the oleaginous yeast Yarrowia lipolytica for β-farnesene overproduction
10.1002/biot.202100097 · 2021 · External reference
Metabolic Engineering of Saccharomyces cerevisiae to Overproduce Squalene
10.1021/acs.jafc.9b07419 · 2020 · External reference
Truncation of LPD1 promoter and adaptive evolution increase cytosolic acetyl-CoA supply in yeast
10.1016/j.synbio.2025.10.013 · 2026 · External reference
Post-translational events and modifications regulating plant enzymes involved in isoprenoid precursor biosynthesis
10.1016/j.plantsci.2012.12.008 · 2013 · External reference
Production of the antimalarial drug precursor artemisinic acid in engineered yeast
10.1038/nature04640 · 2006 · External reference
Combined overexpression of genes of the ergosterol biosynthetic pathway leads to accumulation of sterols in Saccharomyces cerevisiae
10.1016/s1567-1356(03)00126-0 · 2003 · External reference
Refactoring β-amyrin synthesis in Saccharomyces cerevisiae
10.1002/aic.14950 · 2015 · External reference
Production of 11-Oxo-β-Amyrin in Saccharomyces cerevisiae at High Efficiency by Fine-Tuning the Expression Ratio of CYP450:CPR
10.1021/acs.jafc.2c08261 · 2023 · External reference
Enhanced β-Amyrin Synthesis in Saccharomyces cerevisiae by Coupling An Optimal Acetyl-CoA Supply Pathway
10.1021/acs.jafc.9b00653 · 2019 · External reference
Outline of the biosynthesis and regulation of ergosterol in yeast
10.1007/s11274-019-2673-2 · 2019 · External reference
Dynamic plasmid copy number control for synthetic biology
10.1016/j.tibtech.2023.08.004 · 2024 · External reference
Dynamic Regulation Engineering of Plasmid Copy Number Based on CRISPRi in Saccharomyces cerevisiae
10.3390/fermentation12040177 · 2026 · External reference
CRISPR/Cas9-based iterative multi-copy integration for improved metabolite yields in Saccharomyces cerevisiae
10.1016/j.synbio.2025.02.016 · 2025 · External reference
Combining Gal4p-mediated expression enhancement and directed evolution of isoprene synthase to improve isoprene production in Saccharomyces cerevisiae
10.1016/j.ymben.2016.12.011 · 2017 · External reference
Improved squalene production through increasing lipid contents in Saccharomyces cerevisiae
10.1002/bit.26595 · 2018 · External reference
Lipid engineering combined with systematic metabolic engineering of Saccharomyces cerevisiae for high-yield production of lycopene
10.1016/j.ymben.2018.11.009 · 2019 · External reference
The yeast peroxisome: A dynamic storage depot and subcellular factory for squalene overproduction
10.1016/j.ymben.2019.11.001 · 2020 · External reference
Peroxisomes as dynamic organelles: peroxisome abundance in yeast
10.1111/j.1742-4658.2010.07740.x · 2010 · External reference
Enhancing antibody folding and secretion by tailoring the Saccharomyces cerevisiae endoplasmic reticulum
10.1186/s12934-016-0488-5 · 2016 · External reference
Enhanced membrane protein expression by engineering increased intracellular membrane production
10.1186/1475-2859-12-122 · 2013 · External reference
An endoplasmic reticulum-engineered yeast platform for overproduction of triterpenoids
10.1016/j.ymben.2017.02.007 · 2017 · External reference
Heterologous biosynthesis of taraxerol by engineered Saccharomyces cerevisiae
10.1093/femsle/fnac070 · 2022 · External reference
Engineering enzyme microenvironments for enhanced biocatalysis
10.1039/c8cs00085a · 2018 · External reference
Fine-Tuning the Micro-Environment to Optimize the Catalytic Activity of Enzymes Immobilized in Multivariate Metal–Organic Frameworks
10.1021/jacs.1c07107 · 2021 · External reference
Functional expression of eukaryotic cytochrome P450s in yeast
10.1002/bit.27630 · 2021 · External reference
Mechanism and engineering of endoplasmic reticulum-localized membrane protein folding in Saccharomyces cerevisiae
10.1016/j.ymben.2025.03.006 · 2025 · External reference
Boosting 11-oxo-β-amyrin and glycyrrhetinic acid synthesis in Saccharomyces cerevisiae via pairing novel oxidation and reduction system from legume plants
10.1016/j.ymben.2017.11.009 · 2018 · External reference
Specific Glycosylation System Enables the High-Level and Sustainable Production of Glycyrrhetinic Acid 3-O-monoglucuronide and Glycyrrhizin in Engineered Saccharomyces cerevisiae
10.1021/acssuschemeng.3c06260 · 2024 · External reference
Engineering amino acid residues of pentacyclic triterpene synthases for improving the activity
10.1007/s00253-024-13030-8 · 2024 · External reference
Identification of universal selectivity-determining positions in cytochrome P450 monooxygenases by systematic sequence-based literature mining
10.1002/prot.24840 · 2015 · External reference
Implementing N-terminomics and machine learning to probe Nt-arginylation
10.1038/s41467-025-66883-6 · 2026 · External reference
Synthetic Engineering of Microbes for Production of Terpenoid Food Ingredients
10.1021/acs.jafc.5c01724 · 2025 · External reference
Optimization of a cytochrome P450 oxidation system for enhancing protopanaxadiol production in Saccharomyces cerevisiae
10.1002/bit.25934 · 2016 · External reference
Heterologous biosynthesis of (+)-nootkatone in unconventional yeast Yarrowia lipolytica
10.1016/j.bej.2018.05.023 · 2018 · External reference
Glycerol improves heterologous biosynthesis of betulinic acid in engineered Yarrowia lipolytica
10.1016/j.ces.2018.10.052 · 2019 · External reference
Co-localizing key pathway enzymes by protein scaffold to enhance geraniol production in Escherichia coli
10.1016/j.indcrop.2023.117144 · 2023 · External reference
Modular enzyme assembly for enhanced cascade biocatalysis and metabolic flux
10.1038/s41467-019-12247-w · 2019 · External reference
Aided-efflux and high production of β-amyrin realized by β-cyclodextrin in situ synthesized on surface of Saccharomyces cerevisiae
10.1002/bit.28327 · 2023 · External reference
In Silico Prediction and Mining of Exporters for Secretory Bioproduction of Terpenoids in Saccharomyces cerevisiae
10.1021/acssynbio.2c00673 · 2023 · External reference
[Optimization of synthetic pathway and fermentation process of yeast cell factories for production of oleanoic acid]
10.4268/cjcmm20141410 · 2014 · External reference
Insight into neofunctionalization of 2,3-oxidosqualene cyclases in B,C-ring-opened triterpene biosynthesis in quinoa
10.1111/nph.19345 · 2024 · External reference
Site-directed mutagenesis identified the key active site residues of 2,3-oxidosqualene cyclase HcOSC6 responsible for cucurbitacins biosynthesis in Hemsleya chinensis
10.3389/fpls.2023.1138893 · 2023 · External reference
Large-scale mining of plant genomes unlocks the diversity of oxidosqualene cyclases
10.1038/s41589-025-02034-8 · 2026 · External reference
UniKP: a unified framework for the prediction of enzyme kinetic parameters
10.1038/s41467-023-44113-1 · 2023 · External reference
CRISPR/Cas9-Mediated Targeted Mutagenesis of CYP93E2Modulates the Triterpene Saponin Biosynthesis in Medicago truncatula
10.3389/fpls.2021.690231 · 2021 · External reference
Automation and machine learning drive rapid optimization of isoprenol production in Pseudomonas putida
10.1038/s41467-025-66304-8 · 2025 · External reference
Machine-learning guided elucidation of contribution of individual steps in the mevalonate pathway and construction of a yeast platform strain for terpenoid production
10.1016/j.ymben.2022.10.004 · 2022 · External reference
Redox metabolism for improving whole-cell P450-catalysed terpenoid biosynthesis
10.1080/07388551.2021.1990210 · 2022 · External reference
Protein design: the experts speak
10.1038/s41587-023-02111-0 · 2024 · External reference
Mass spectrometry of labelled triterpenoids: Thermospray and electron impact ionization analysis
10.1002/(sici)1099-1565(199609)7:5<237::aid-pca310>3.0.co;2-m · ExternalCitation · doi-reference
Supramolecular Assembly of Triterpenoids: Current State and Biomedical Perspectives
10.1002/agt2.70081 · ExternalCitation · doi-reference
Refactoring β-amyrin synthesis in Saccharomyces cerevisiae
10.1002/aic.14950 · ExternalCitation · doi-reference
Biosynthesis of ursolic acid and oleanolic acid in Saccharomyces cerevisiae
10.1002/aic.16370 · ExternalCitation · doi-reference
Engineering the oleaginous yeast Yarrowia lipolytica for β-farnesene overproduction
10.1002/biot.202100097 · ExternalCitation · doi-reference
Optimization of a cytochrome P450 oxidation system for enhancing protopanaxadiol production in Saccharomyces cerevisiae
10.1002/bit.25934 · ExternalCitation · doi-reference
Improved squalene production through increasing lipid contents in Saccharomyces cerevisiae
10.1002/bit.26595 · ExternalCitation · doi-reference
Functional expression of eukaryotic cytochrome P450s in yeast
10.1002/bit.27630 · ExternalCitation · doi-reference
Aided-efflux and high production of β-amyrin realized by β-cyclodextrin in situ synthesized on surface of Saccharomyces cerevisiae
10.1002/bit.28327 · ExternalCitation · doi-reference
Maslinic acid alleviates alcoholic liver injury in mice and regulates intestinal microbiota via the gut-liver axis
10.1002/jsfa.13624 · ExternalCitation · doi-reference
Identification of universal selectivity-determining positions in cytochrome P450 monooxygenases by systematic sequence-based literature mining
10.1002/prot.24840 · ExternalCitation · doi-reference
iTRAQ-based quantitative proteomic analysis in liver of Pomacea canaliculata induced by oleanolic acid stress
10.1002/ps.6987 · ExternalCitation · doi-reference
Review of pharmacological effects of Glycyrrhiza sp. and its bioactive compounds
10.1002/ptr.2362 · ExternalCitation · doi-reference
Biosynthesis and engineering of isoprenoid small molecules
10.1007/s00253-006-0593-1 · ExternalCitation · doi-reference
Efficient production of lycopene in Saccharomyces cerevisiae by enzyme engineering and increasing membrane flexibility and NAPDH production
10.1007/s00253-018-9449-8 · ExternalCitation · doi-reference
Engineering amino acid residues of pentacyclic triterpene synthases for improving the activity
10.1007/s00253-024-13030-8 · ExternalCitation · doi-reference
Disruption of a licorice cellulose synthase-derived glycosyltransferase gene demonstrates its in planta role in soyasaponin biosynthesis
10.1007/s00299-023-03095-6 · ExternalCitation · doi-reference
The pharmaceutical industry and natural products: historical status and new trends
10.1007/s11101-014-9367-z · ExternalCitation · doi-reference
Establishment and triterpenoid production of Ocimum basilicum cambial meristematic cells
10.1007/s11240-020-01942-y · ExternalCitation · doi-reference
Outline of the biosynthesis and regulation of ergosterol in yeast
10.1007/s11274-019-2673-2 · ExternalCitation · doi-reference
Micropropagation and in vitro elicitation of licorice (Glycyrrhiza spp.)
10.1007/s11627-017-9832-7 · ExternalCitation · doi-reference
Biosynthesis of Soyasapogenol B by Engineered Saccharomyces cerevisiae
10.1007/s12010-021-03599-5 · ExternalCitation · doi-reference
Inhibitory effect of soy saponins on the activity of β-lactamases, including New Delhi metallo-β-lactamase 1
10.1007/s13197-018-3091-4 · ExternalCitation · doi-reference
Establishing cell suitability for high-level production of licorice triterpenoids in yeast
10.1016/j.apsb.2024.04.032 · ExternalCitation · doi-reference
Molecular study on the role of vacuolar transporters in glycyrrhetinic acid production in engineered Saccharomyces cerevisiae
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