Research graph
References from Discovery of Novel 2-(2-Benzimidazole)-Substituted Tetrahydrofur-ans as Potent and Selective NaV1.8 Inhibitors for the Treatment of Pain. Local targets link to admitted publications; unresolved targets remain external evidence.
Explainable fNIRS-based pain decoding under pharmacological conditions via deep transfer learning approach
10.1117/1.nph.11.4.045015 · 2024 · External reference
Efficacy of Anti-inflammatory Treatment Versus Rescue Analgesia After Arthroscopic Partial Meniscectomy in Nonarthritic Knees: A 3-Arm Controlled Study
10.1177/2325967121991545 · 2021 · External reference
The changing role of non-opioid analgesic techniques in the management of postoperative pain
10.1213/01.ane.0000177099.28914.a7 · 2005 · External reference
The Role of Voltage-Gated Sodium Channels in Pain Signaling
10.1152/physrev.00052.2017 · 2019 · External reference
Distribution and function of voltage-gated sodium channels in the nervous system
10.1080/19336950.2017.1380758 · 2017 · External reference
Voltage-Gated Sodium Channel Dysfunctions in Neurological Disorders
10.3390/life13051191 · 2023 · External reference
NaV1.8 in small dorsal root ganglion neurons contributes to vincristine-induced mechanical allodynia
10.1093/brain/awae071 · 2024 · External reference
NaV1.8 expression is not restricted to nociceptors in mouse peripheral nervous system
10.1016/j.pain.2012.04.022 · 2012 · External reference
Gain-of-function NaV1.8 mutations in painful neuropathy
10.1073/pnas.1216080109 · 2012 · External reference
Advances in the discovery of selective NaV1.8 inhibitors for pain management
10.1016/j.ejmech.2025.118326 · 2026 · External reference
The effects of A-803467 on cardiac NaV1.5 channels
10.1016/j.ejphar.2015.02.019 · 2015 · External reference
A-803467, a potent and selective NaV1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat
10.1073/pnas.0611364104 · 2007 · External reference
The discovery and optimization of benzimidazoles as selective NaV1.8 blockers for the treatment of pain
10.1016/j.bmc.2018.12.002 · 2019 · External reference
Recent progress in sodium channel modulators for pain
10.1016/j.bmcl.2014.06.038 · 2014 · External reference
A Phase 1, Randomized, Double-Blind, Placebo-Controlled, Crossover Study to Evaluate the Pharmacodynamic Effects of VX-150, a Highly Selective NaV1.8 Inhibitor, in Healthy Male Adults
10.1093/pm/pnab032 · 2021 · External reference
Clinical Efficacy and Safety Profile of Suzetrigine: A Novel Non-opioid Analgesic Targeting NaV1.8 Sodium Channel
10.7759/cureus.96054 · 2025 · External reference
Unresolved reference
External reference
Selective Inhibition of NaV1.8 with VX-548 for Acute Pain
10.1056/nejmoa2209870 · 2023 · External reference
Sensory neuron sodium channels as pain targets; from cocaine to Journavx (VX-548, suzetrigine)
10.1085/jgp.202513778 · 2025 · External reference
Gender difference in the pharmacokinetics and metabolism of VX-548 in rats
10.1002/bdd.2387 · 2024 · External reference
Unresolved reference
External reference
Persistent NaV1.1 and NaV1.6 currents drive spinal locomotor functions through nonlinear dynamics
10.1016/j.celrep.2023.113085 · 2023 · External reference
Epilepsy-associated SCN2A (NaV1.2) variants exhibit diverse and complex functional properties
10.1085/jgp.202313375 · 2023 · External reference
In vitro and in vivo metabolism of 3-Methoxyeticyclidine in human liver microsomes, a zebrafish model, and two human urine samples based on liquid chromatography-high-resolution mass spectrometry
10.1002/dta.3488 · 2024 · External reference
The role of the methoxy group in approved drugs
10.1016/j.ejmech.2024.116364 · 2024 · External reference
Cyrene as a bio-based solvent for HATU mediated amide coupling
10.1039/c8ob00653a · 2018 · External reference
Unresolved reference
External reference
Applications of Lawesson’s reagent in the synthesis of naturally occurring steroids and terpenoids
10.1080/10286020.2017.1295229 · 2017 · External reference
Ligand-Free Copper-Catalyzed Synthesis of Substituted Benzimidazoles, 2-Aminobenzimidazoles, 2-Aminobenzothiazoles, and Benzoxazoles
10.1021/jo901813g · 2009 · External reference
Highly Efficient Halide Perovskite Light-Emitting Diodes via Molecular Passivation
10.1002/anie.202100243 · 2021 · External reference
Synthesis and Antifungal Activity of 1,2,4-Oxadiazole Derivatives
10.3390/molecules30081851 · 2025 · External reference
C−H Borylation of Diphenylamines through Adamantane-1-carbonyl Auxiliary by BBr3
10.1021/acs.orglett.0c02552 · 2020 · External reference
Mechanochemical Synthesis of Primary Amides
10.1021/acs.joc.1c02350 · 2021 · External reference
Synthesis and anti-endoplasmic reticulum stress activity of N-substituted-2-arylcarbonylhydrazinecarbothioamides
10.1007/s00044-019-02442-1 · 2019 · External reference
Ammonia-borane as a Catalyst for the Direct Amidation of Carboxylic Acids
10.1021/acs.orglett.1c00591 · 2021 · External reference
Synthesis and Application of 2,6-Bis(trifluoromethyl)-4-pyridyl Phosphanes: The Most Electron-Poor Aryl Phosphanes with Moderate Bulkiness
10.1002/anie.201104588 · 2011 · External reference
Enantioselective synthesis of arylmethoxyacetic acid derivatives
10.1016/s0957-4166(03)00023-5 · 2003 · External reference
N-Aroylsulfonamide-Photofragmentation (ASAP)-A Versatile Route to Biaryls
10.1002/ejoc.202100955 · 2021 · External reference
Unresolved reference
External reference
Unresolved reference
External reference
Deciphering the potential involvement of PXMP2 and PEX11B in hydrogen peroxide permeation across the peroxisomal membrane reveals a role for PEX11B in protein sorting
10.1016/j.bbamem.2019.05.013 · 2019 · External reference
Patch-clamp technique to characterize ion channels in enlarged individual endolysosomes
10.1038/nprot.2017.036 · 2017 · External reference
Fluoromaticity: The Molecular Orbital Contributions of Fluorine Substituents to the π-Systems of Aromatic Rings
10.1021/acsomega.1c04175 · 2021 · External reference
Unresolved reference
External reference
Selective spider toxins reveal a role for the NaV1.1 channel in mechanical pain
10.1038/nature17976 · 2016 · External reference
Multiple NaV1.5 isoforms are functionally expressed in the brain and present distinct expression patterns compared with cardiac NaV1.5
10.3892/mmr.2017.6654 · 2017 · External reference
Investigating the Role of NaV1.5 in Somatosensory Mechanosensation
10.1016/j.bpj.2015.11.552 · 2016 · External reference
Effects of a BMI1008 mixture on postoperative pain in a rat model of incisional pain
10.1371/journal.pone.0257267 · 2021 · External reference
Synthesis and Application of 2,6-Bis(trifluoromethyl)-4-pyridyl Phosphanes: The Most Electron-Poor Aryl Phosphanes with Moderate Bulkiness
10.1002/anie.201104588 · ExternalCitation · doi-reference
Highly Efficient Halide Perovskite Light-Emitting Diodes via Molecular Passivation
10.1002/anie.202100243 · ExternalCitation · doi-reference
Gender difference in the pharmacokinetics and metabolism of VX-548 in rats
10.1002/bdd.2387 · ExternalCitation · doi-reference
In vitro and in vivo metabolism of 3-Methoxyeticyclidine in human liver microsomes, a zebrafish model, and two human urine samples based on liquid chromatography-high-resolution mass spectrometry
10.1002/dta.3488 · ExternalCitation · doi-reference
N-Aroylsulfonamide-Photofragmentation (ASAP)-A Versatile Route to Biaryls
10.1002/ejoc.202100955 · ExternalCitation · doi-reference
Synthesis and anti-endoplasmic reticulum stress activity of N-substituted-2-arylcarbonylhydrazinecarbothioamides
10.1007/s00044-019-02442-1 · ExternalCitation · doi-reference
Deciphering the potential involvement of PXMP2 and PEX11B in hydrogen peroxide permeation across the peroxisomal membrane reveals a role for PEX11B in protein sorting
10.1016/j.bbamem.2019.05.013 · ExternalCitation · doi-reference
The discovery and optimization of benzimidazoles as selective NaV1.8 blockers for the treatment of pain
10.1016/j.bmc.2018.12.002 · ExternalCitation · doi-reference
Recent progress in sodium channel modulators for pain
10.1016/j.bmcl.2014.06.038 · ExternalCitation · doi-reference
Investigating the Role of NaV1.5 in Somatosensory Mechanosensation
10.1016/j.bpj.2015.11.552 · ExternalCitation · doi-reference
Persistent NaV1.1 and NaV1.6 currents drive spinal locomotor functions through nonlinear dynamics
10.1016/j.celrep.2023.113085 · ExternalCitation · doi-reference
The role of the methoxy group in approved drugs
10.1016/j.ejmech.2024.116364 · ExternalCitation · doi-reference
Advances in the discovery of selective NaV1.8 inhibitors for pain management
10.1016/j.ejmech.2025.118326 · ExternalCitation · doi-reference
The effects of A-803467 on cardiac NaV1.5 channels
10.1016/j.ejphar.2015.02.019 · ExternalCitation · doi-reference
NaV1.8 expression is not restricted to nociceptors in mouse peripheral nervous system
10.1016/j.pain.2012.04.022 · ExternalCitation · doi-reference
Enantioselective synthesis of arylmethoxyacetic acid derivatives
10.1016/s0957-4166(03)00023-5 · ExternalCitation · doi-reference
Mechanochemical Synthesis of Primary Amides
10.1021/acs.joc.1c02350 · ExternalCitation · doi-reference
C−H Borylation of Diphenylamines through Adamantane-1-carbonyl Auxiliary by BBr3
10.1021/acs.orglett.0c02552 · ExternalCitation · doi-reference
Ammonia-borane as a Catalyst for the Direct Amidation of Carboxylic Acids
10.1021/acs.orglett.1c00591 · ExternalCitation · doi-reference
Fluoromaticity: The Molecular Orbital Contributions of Fluorine Substituents to the π-Systems of Aromatic Rings
10.1021/acsomega.1c04175 · ExternalCitation · doi-reference
Ligand-Free Copper-Catalyzed Synthesis of Substituted Benzimidazoles, 2-Aminobenzimidazoles, 2-Aminobenzothiazoles, and Benzoxazoles
10.1021/jo901813g · ExternalCitation · doi-reference
Selective spider toxins reveal a role for the NaV1.1 channel in mechanical pain
10.1038/nature17976 · ExternalCitation · doi-reference
Patch-clamp technique to characterize ion channels in enlarged individual endolysosomes
10.1038/nprot.2017.036 · ExternalCitation · doi-reference
Cyrene as a bio-based solvent for HATU mediated amide coupling
10.1039/c8ob00653a · ExternalCitation · doi-reference
Selective Inhibition of NaV1.8 with VX-548 for Acute Pain
10.1056/nejmoa2209870 · ExternalCitation · doi-reference
A-803467, a potent and selective NaV1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat
10.1073/pnas.0611364104 · ExternalCitation · doi-reference
Gain-of-function NaV1.8 mutations in painful neuropathy
10.1073/pnas.1216080109 · ExternalCitation · doi-reference
Applications of Lawesson’s reagent in the synthesis of naturally occurring steroids and terpenoids
10.1080/10286020.2017.1295229 · ExternalCitation · doi-reference
Distribution and function of voltage-gated sodium channels in the nervous system
10.1080/19336950.2017.1380758 · ExternalCitation · doi-reference
Epilepsy-associated SCN2A (NaV1.2) variants exhibit diverse and complex functional properties
10.1085/jgp.202313375 · ExternalCitation · doi-reference
Sensory neuron sodium channels as pain targets; from cocaine to Journavx (VX-548, suzetrigine)
10.1085/jgp.202513778 · ExternalCitation · doi-reference
NaV1.8 in small dorsal root ganglion neurons contributes to vincristine-induced mechanical allodynia
10.1093/brain/awae071 · ExternalCitation · doi-reference
A Phase 1, Randomized, Double-Blind, Placebo-Controlled, Crossover Study to Evaluate the Pharmacodynamic Effects of VX-150, a Highly Selective NaV1.8 Inhibitor, in Healthy Male Adults
10.1093/pm/pnab032 · ExternalCitation · doi-reference
Explainable fNIRS-based pain decoding under pharmacological conditions via deep transfer learning approach
10.1117/1.nph.11.4.045015 · ExternalCitation · doi-reference
The Role of Voltage-Gated Sodium Channels in Pain Signaling
10.1152/physrev.00052.2017 · ExternalCitation · doi-reference
Efficacy of Anti-inflammatory Treatment Versus Rescue Analgesia After Arthroscopic Partial Meniscectomy in Nonarthritic Knees: A 3-Arm Controlled Study
10.1177/2325967121991545 · ExternalCitation · doi-reference
The changing role of non-opioid analgesic techniques in the management of postoperative pain
10.1213/01.ane.0000177099.28914.a7 · ExternalCitation · doi-reference
Effects of a BMI1008 mixture on postoperative pain in a rat model of incisional pain
10.1371/journal.pone.0257267 · ExternalCitation · doi-reference
Voltage-Gated Sodium Channel Dysfunctions in Neurological Disorders
10.3390/life13051191 · ExternalCitation · doi-reference
Synthesis and Antifungal Activity of 1,2,4-Oxadiazole Derivatives
10.3390/molecules30081851 · ExternalCitation · doi-reference
Multiple NaV1.5 isoforms are functionally expressed in the brain and present distinct expression patterns compared with cardiac NaV1.5
10.3892/mmr.2017.6654 · ExternalCitation · doi-reference
Clinical Efficacy and Safety Profile of Suzetrigine: A Novel Non-opioid Analgesic Targeting NaV1.8 Sodium Channel
10.7759/cureus.96054 · ExternalCitation · doi-reference
