Research graph
References from Hsc70-Mediated Targeting Chimeras for Targeted Protein Degradation via Chaperone-Mediated Autophagy. Local targets link to admitted publications; unresolved targets remain external evidence.
Waste DisposalAn Attractive Strategy for Cancer Therapy
10.1126/science.aam7340 · 2017 · External reference
Targeted Protein Degradation for Cancer Therapy
10.1038/s41568-025-00817-8 · 2025 · External reference
Targeting the Undruggables The Power of Protein Degraders
10.1016/j.scib.2024.03.056 · 2024 · External reference
Transforming Targeted Cancer Therapy with PROTACs: A Forward-Looking Perspective
10.1016/j.coph.2021.02.009 · 2021 · External reference
Chemistries of Bifunctional PROTAC Degraders
10.1039/d2cs00220e · 2022 · External reference
PROTAC Targeted Protein Degraders: The Past Is Prologue
10.1038/s41573-021-00371-6 · 2022 · External reference
Targeted Protein Degradation: From Mechanisms to Clinic
10.1038/s41580-024-00729-9 · 2024 · External reference
The PROTAC Gold Rush
10.1038/s41587-021-01173-2 · 2022 · External reference
Protein Degraders Enter the ClinicA New Approach to Cancer Therapy
10.1038/s41571-023-00736-3 · 2023 · External reference
Acquired Resistance to BET-PROTACs (Proteolysis-Targeting Chimeras) Caused by Genomic Alterations in Core Components of E3 Ligase Complexes
10.1158/1535-7163.mct-18-1129 · 2019 · External reference
Proteolysis-Targeting Chimeras in Drug Development: A Safety Perspective
10.1111/bph.15014 · 2020 · External reference
Lysosome-Targeting Chimaeras for Degradation of Extracellular Proteins
10.1038/s41586-020-2545-9 · 2020 · External reference
Elucidating the Cellular Determinants of Targeted Membrane Protein Degradation by Lysosome-Targeting Chimeras
10.1126/science.adf6249 · 2023 · External reference
LYTACs That Engage the Asialoglycoprotein Receptor for Targeted Protein Degradation
10.1038/s41589-021-00770-1 · 2021 · External reference
Degradation of Lipid Droplets by Chimeric Autophagy-Tethering Compounds
10.1038/s41422-021-00532-7 · 2021 · External reference
Allele-Selective Lowering of Mutant HTT Protein by HTT−LC3 Linker Compounds
10.1038/s41586-019-1722-1 · 2019 · External reference
AUTACs: Cargo-Specific Degraders Using Selective Autophagy
10.1016/j.molcel.2019.09.009 · 2019 · External reference
Bispecific Aptamer Chimeras Enable Targeted Protein Degradation on Cell Membranes
10.1002/anie.202102170 · 2021 · External reference
Development of Antibody-Based PROTACs for the Degradation of the Cell-Surface Immune Checkpoint Protein PD-L1
10.1021/jacs.0c10008 · 2021 · External reference
The Coming of Age of Chaperone-Mediated Autophagy
10.1038/s41580-018-0001-6 · 2018 · External reference
Harnessing Chaperone-Mediated Autophagy for the Selective Degradation of Mutant Huntingtin Protein
10.1038/nbt.1608 · 2010 · External reference
Rapid and Reversible Knockdown of Endogenous Proteins by Peptide-Directed Lysosomal Degradation
10.1038/nn.3637 · 2014 · External reference
Discovery of a Potent and Selective Degrader for USP7
10.1002/ange.202204395 · 2022 · External reference
Discovery of PRMT3 Degrader for the Treatment of Acute Leukemia
10.1002/advs.202405963 · 2024 · External reference
HSP70 Interactome-Mediated Proteolysis Targeting Chimera (HSP70-PROTAC) for Ferroptosis-Driven Cancer Treatment
10.1002/advs.202513655 · 2026 · External reference
The HSP70 Chaperone Machinery: J Proteins as Drivers of Functional Specificity
10.1038/nrm2941 · 2010 · External reference
Allosteric Drugs: The Interaction of Antitumor Compound MKT-077 with Human Hsp70 Chaperones
10.1016/j.jmb.2011.06.003 · 2011 · External reference
Synthesis and Initial Evaluation of YM-08, a Blood-Brain Barrier Permeable Derivative of the Heat Shock Protein 70 (Hsp70) Inhibitor MKT-077, Which Reduces Tau Levels
10.1021/cn300210g · 2013 · External reference
Activation of Hsp70 Reduces Neurotoxicity by Promoting Polyglutamine Protein Degradation
10.1038/nchembio.1140 · 2013 · External reference
Activatable Near-Infrared Versatile Fluorescent and Chemiluminescent Dyes Based on the Dicyanomethylene-4H-pyran Scaffold: From Design to Imaging and Theranostics
10.1002/anie.202311764 · 2024 · External reference
A New Target Class for Drug Development
10.1038/s41573-019-0030-7 · 2019 · External reference
Functions of Bromodomain-Containing Proteins and Their Roles in Homeostasis and Cancer
10.1038/nrm.2016.143 · 2017 · External reference
Selective Inhibition of BET Bromodomains
10.1038/nature09504 · 2010 · External reference
DRUG DEVELOPMENT. Phthalimide conjugation as a strategy for in vivo target protein degradation
10.1126/science.aab1433 · 2015 · External reference
Novel Adenosine-Derived Inhibitors of 70 kDa Heat Shock Protein, Discovered through Structure-Based Design
10.1021/jm801627a · 2009 · External reference
Chaperone-Mediated Autophagy and Endosomal Microautophagy: Jointed by a Chaperone
10.1074/jbc.r117.818237 · 2018 · External reference
Chloroquine Inhibits Autophagic Flux by Decreasing Autophagosome-Lysosome Fusion
10.1080/15548627.2018.1474314 · 2018 · External reference
In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2
10.1126/science.1092472 · 2004 · External reference
Design of Chemically Stable, Potent, and Efficacious MDM2 Inhibitors That Exploit the Retro-Mannich Ring-Opening-Cyclization Reaction Mechanism in Spiro-oxindoles
10.1021/jm501541j · 2014 · External reference
Discovery of MD-265: A Potent MDM2 Degrader That Achieves Complete Tumor Regression and Improves Long-Term Survival of Mice with Leukemia
10.1021/acs.jmedchem.4c01818 · 2024 · External reference
MDM2 inhibition sensitizes neuroblastoma to chemotherapy-induced apoptotic cell death
10.1158/1535-7163.mct-06-0305 · 2006 · External reference
A Membrane Protein Display Platform for Receptor Interactome Discovery
10.1073/pnas.2025451118 · 2021 · External reference
Extracellular Targeted Protein Degradation: An Emerging Modality for Drug Discovery
10.1038/s41573-023-00833-z · 2024 · External reference
PD-L1 as a Biomarker of Response to Immune-Checkpoint Inhibitors
10.1038/s41571-021-00473-5 · 2021 · External reference
Unresolved reference
External reference
NFAT control of immune function: New Frontiers for an Abiding Trooper
10.12688/f1000research.13426.1 · 2018 · External reference
Imaging TCR-dependent NFAT-mediated T-cell activation with positron emission tomography in vivo
10.1038/sj.neo.7900204 · 2001 · External reference
Covalently Engineered Nanobody Chimeras for Targeted Membrane Protein Degradation
10.1021/jacs.1c08521 · 2021 · External reference
Fluorescent Dyad for Cooperative Recognition of Copper Cation and Halogen Anion
10.1016/j.tetlet.2013.01.119 · 2013 · External reference
A small molecule inhibitor of ATPase activity of HSP70 induces apoptosis and has antitumor activities
10.1016/j.chembiol.2015.02.004 · 2015 · External reference
Probing the effect of an inhibitor of an ATPase domain of Hsc70 on clathrin-mediated endocytosis
10.1039/c4mb00695j · 2015 · External reference
Discovery of PRMT3 Degrader for the Treatment of Acute Leukemia
10.1002/advs.202405963 · ExternalCitation · doi-reference
HSP70 Interactome-Mediated Proteolysis Targeting Chimera (HSP70-PROTAC) for Ferroptosis-Driven Cancer Treatment
10.1002/advs.202513655 · ExternalCitation · doi-reference
Discovery of a Potent and Selective Degrader for USP7
10.1002/ange.202204395 · ExternalCitation · doi-reference
Bispecific Aptamer Chimeras Enable Targeted Protein Degradation on Cell Membranes
10.1002/anie.202102170 · ExternalCitation · doi-reference
Activatable Near-Infrared Versatile Fluorescent and Chemiluminescent Dyes Based on the Dicyanomethylene-4H-pyran Scaffold: From Design to Imaging and Theranostics
10.1002/anie.202311764 · ExternalCitation · doi-reference
A small molecule inhibitor of ATPase activity of HSP70 induces apoptosis and has antitumor activities
10.1016/j.chembiol.2015.02.004 · ExternalCitation · doi-reference
Transforming Targeted Cancer Therapy with PROTACs: A Forward-Looking Perspective
10.1016/j.coph.2021.02.009 · ExternalCitation · doi-reference
Allosteric Drugs: The Interaction of Antitumor Compound MKT-077 with Human Hsp70 Chaperones
10.1016/j.jmb.2011.06.003 · ExternalCitation · doi-reference
AUTACs: Cargo-Specific Degraders Using Selective Autophagy
10.1016/j.molcel.2019.09.009 · ExternalCitation · doi-reference
Targeting the Undruggables The Power of Protein Degraders
10.1016/j.scib.2024.03.056 · ExternalCitation · doi-reference
Fluorescent Dyad for Cooperative Recognition of Copper Cation and Halogen Anion
10.1016/j.tetlet.2013.01.119 · ExternalCitation · doi-reference
Discovery of MD-265: A Potent MDM2 Degrader That Achieves Complete Tumor Regression and Improves Long-Term Survival of Mice with Leukemia
10.1021/acs.jmedchem.4c01818 · ExternalCitation · doi-reference
Synthesis and Initial Evaluation of YM-08, a Blood-Brain Barrier Permeable Derivative of the Heat Shock Protein 70 (Hsp70) Inhibitor MKT-077, Which Reduces Tau Levels
10.1021/cn300210g · ExternalCitation · doi-reference
Development of Antibody-Based PROTACs for the Degradation of the Cell-Surface Immune Checkpoint Protein PD-L1
10.1021/jacs.0c10008 · ExternalCitation · doi-reference
Covalently Engineered Nanobody Chimeras for Targeted Membrane Protein Degradation
10.1021/jacs.1c08521 · ExternalCitation · doi-reference
Design of Chemically Stable, Potent, and Efficacious MDM2 Inhibitors That Exploit the Retro-Mannich Ring-Opening-Cyclization Reaction Mechanism in Spiro-oxindoles
10.1021/jm501541j · ExternalCitation · doi-reference
Novel Adenosine-Derived Inhibitors of 70 kDa Heat Shock Protein, Discovered through Structure-Based Design
10.1021/jm801627a · ExternalCitation · doi-reference
Selective Inhibition of BET Bromodomains
10.1038/nature09504 · ExternalCitation · doi-reference
Harnessing Chaperone-Mediated Autophagy for the Selective Degradation of Mutant Huntingtin Protein
10.1038/nbt.1608 · ExternalCitation · doi-reference
Activation of Hsp70 Reduces Neurotoxicity by Promoting Polyglutamine Protein Degradation
10.1038/nchembio.1140 · ExternalCitation · doi-reference
Rapid and Reversible Knockdown of Endogenous Proteins by Peptide-Directed Lysosomal Degradation
10.1038/nn.3637 · ExternalCitation · doi-reference
Functions of Bromodomain-Containing Proteins and Their Roles in Homeostasis and Cancer
10.1038/nrm.2016.143 · ExternalCitation · doi-reference
The HSP70 Chaperone Machinery: J Proteins as Drivers of Functional Specificity
10.1038/nrm2941 · ExternalCitation · doi-reference
Degradation of Lipid Droplets by Chimeric Autophagy-Tethering Compounds
10.1038/s41422-021-00532-7 · ExternalCitation · doi-reference
Targeted Protein Degradation for Cancer Therapy
10.1038/s41568-025-00817-8 · ExternalCitation · doi-reference
PD-L1 as a Biomarker of Response to Immune-Checkpoint Inhibitors
10.1038/s41571-021-00473-5 · ExternalCitation · doi-reference
Protein Degraders Enter the ClinicA New Approach to Cancer Therapy
10.1038/s41571-023-00736-3 · ExternalCitation · doi-reference
A New Target Class for Drug Development
10.1038/s41573-019-0030-7 · ExternalCitation · doi-reference
PROTAC Targeted Protein Degraders: The Past Is Prologue
10.1038/s41573-021-00371-6 · ExternalCitation · doi-reference
Extracellular Targeted Protein Degradation: An Emerging Modality for Drug Discovery
10.1038/s41573-023-00833-z · ExternalCitation · doi-reference
The Coming of Age of Chaperone-Mediated Autophagy
10.1038/s41580-018-0001-6 · ExternalCitation · doi-reference
Targeted Protein Degradation: From Mechanisms to Clinic
10.1038/s41580-024-00729-9 · ExternalCitation · doi-reference
Allele-Selective Lowering of Mutant HTT Protein by HTT−LC3 Linker Compounds
10.1038/s41586-019-1722-1 · ExternalCitation · doi-reference
Lysosome-Targeting Chimaeras for Degradation of Extracellular Proteins
10.1038/s41586-020-2545-9 · ExternalCitation · doi-reference
The PROTAC Gold Rush
10.1038/s41587-021-01173-2 · ExternalCitation · doi-reference
LYTACs That Engage the Asialoglycoprotein Receptor for Targeted Protein Degradation
10.1038/s41589-021-00770-1 · ExternalCitation · doi-reference
Imaging TCR-dependent NFAT-mediated T-cell activation with positron emission tomography in vivo
10.1038/sj.neo.7900204 · ExternalCitation · doi-reference
Probing the effect of an inhibitor of an ATPase domain of Hsc70 on clathrin-mediated endocytosis
10.1039/c4mb00695j · ExternalCitation · doi-reference
Chemistries of Bifunctional PROTAC Degraders
10.1039/d2cs00220e · ExternalCitation · doi-reference
A Membrane Protein Display Platform for Receptor Interactome Discovery
10.1073/pnas.2025451118 · ExternalCitation · doi-reference
Chaperone-Mediated Autophagy and Endosomal Microautophagy: Jointed by a Chaperone
10.1074/jbc.r117.818237 · ExternalCitation · doi-reference
Chloroquine Inhibits Autophagic Flux by Decreasing Autophagosome-Lysosome Fusion
10.1080/15548627.2018.1474314 · ExternalCitation · doi-reference
Proteolysis-Targeting Chimeras in Drug Development: A Safety Perspective
10.1111/bph.15014 · ExternalCitation · doi-reference
In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2
10.1126/science.1092472 · ExternalCitation · doi-reference
DRUG DEVELOPMENT. Phthalimide conjugation as a strategy for in vivo target protein degradation
10.1126/science.aab1433 · ExternalCitation · doi-reference
Waste DisposalAn Attractive Strategy for Cancer Therapy
10.1126/science.aam7340 · ExternalCitation · doi-reference
Elucidating the Cellular Determinants of Targeted Membrane Protein Degradation by Lysosome-Targeting Chimeras
10.1126/science.adf6249 · ExternalCitation · doi-reference
MDM2 inhibition sensitizes neuroblastoma to chemotherapy-induced apoptotic cell death
10.1158/1535-7163.mct-06-0305 · ExternalCitation · doi-reference
Acquired Resistance to BET-PROTACs (Proteolysis-Targeting Chimeras) Caused by Genomic Alterations in Core Components of E3 Ligase Complexes
10.1158/1535-7163.mct-18-1129 · ExternalCitation · doi-reference
NFAT control of immune function: New Frontiers for an Abiding Trooper
10.12688/f1000research.13426.1 · ExternalCitation · doi-reference
