Research graph
References from Second-Generation AOH1996 Analogues with Enhanced Pharmacological Properties for Targeting PCNA. Local targets link to admitted publications; unresolved targets remain external evidence.
How Does the Proliferating Cell Nuclear Antigen Modulate Binding Specificity to Multiple Partner Proteins?
10.1021/acs.jcim.7b00171 · 2017 · External reference
Proliferating cell nuclear antigen (PCNA): a dancer with many partners
10.1242/jcs.00653 · 2003 · External reference
Targeting proliferating cell nuclear antigen (PCNA) for cancer therapy
10.1016/bs.apha.2024.04.002 · 2024 · External reference
Crystal structure of the eukaryotic DNA polymerase processivity factor PCNA
10.1016/0092-8674(94)90014-0 · 1994 · External reference
Structural basis for novel interactions between human translesion synthesis polymerases and proliferating cell nuclear antigen
10.1074/jbc.m809745200 · 2009 · External reference
A Transition-State Perspective on Y-Family DNA Polymerase eta Fidelity in Comparison with X-Family DNA Polymerases lambda and beta
10.1021/acs.biochem.9b00087 · 2019 · External reference
Essential interaction between the fission yeast DNA polymerase delta subunit Cdc27 and Pcn1 (PCNA) mediated through a C-terminal p21(Cip1)-like PCNA binding motif
10.1093/emboj/19.5.1108 · 2000 · External reference
Targeting cytosolic proliferating cell nuclear antigen in neutrophil-dominated inflammation
10.3389/fimmu.2012.00311 · 2012 · External reference
The bacterial DNA sliding clamp, β-clamp: structure, interactions, dynamics and drug discovery
10.1007/s00018-024-05252-w · 2024 · External reference
Extracellular vesicles deposit PCNA to rejuvenate aged bone marrow-derived mesenchymal stem cells and slow age-related degeneration
10.1126/scitranslmed.aaz8697 · 2021 · External reference
PCNA: a silent housekeeper or a potential therapeutic target?
10.1016/j.tips.2014.02.004 · 2014 · External reference
A cancer-associated PCNA expressed in breast cancer has implications as a potential biomarker
10.1073/pnas.0604614103 · 2006 · External reference
Structurally distinct ubiquitin- and sumo-modified PCNA: implications for their distinct roles in the DNA damage response
10.1016/j.str.2015.02.008 · 2015 · External reference
Structural insights into the function of ZRANB3 in replication stress response
10.1038/ncomms15847 · 2017 · External reference
The discovery of labile methyl esters on proliferating cell nuclear antigen by MS/MS
10.1002/pmic.200600142 · 2006 · External reference
Isolation and characterization of a DNA synthesome from a neuroblastoma cell line
10.1016/j.jpedsurg.2005.03.054 · 2005 · External reference
Human hepatocellular carcinoma expresses specific PCNA isoforms: an in vivo and in vitro evaluation
10.1038/labinvest.2008.50 · 2008 · External reference
Elevated expression of cancer-associated proliferating cell nuclear antigen in high-grade prostatic intraepithelial neoplasia and prostate cancer
10.1002/pros.21291 · 2011 · External reference
PCNA binding through a conserved motif
10.1002/(sici)1521-1878(199803)20:3<195::aid-bies2>3.0.co;2-r · 1998 · External reference
A million peptide motifs for the molecular biologist
10.1016/j.molcel.2014.05.032 · 2014 · External reference
Checkpoint activation by Spd1: a competition-based system relying on tandem disordered PCNA binding motifs
10.1093/nar/gkae011 · 2024 · External reference
Targeting the “Undruggable”: Small-Molecule Inhibitors of Proliferating Cell Nuclear Antigen (PCNA) in the Spotlight in Cancer Therapy
10.1021/acs.jmedchem.4c00526 · 2025 · External reference
DNA Sliding Clamps as Therapeutic Targets
10.3389/fmolb.2018.00087 · 2018 · External reference
The Anticancer Activity of a First-in-class Small-molecule Targeting PCNA
10.1158/1078-0432.ccr-18-0592 · 2018 · External reference
Targeting Proliferating Cell Nuclear Antigen (PCNA) as an Effective Strategy to Inhibit Tumor Cell Proliferation
10.2174/1568009620666200115162814 · 2020 · External reference
Identification of small molecule proliferating cell nuclear antigen (PCNA) inhibitor that disrupts interactions with PIP-box proteins and inhibits DNA replication
10.1074/jbc.m112.353201 · 2012 · External reference
A small molecule inhibitor of monoubiquitinated Proliferating Cell Nuclear Antigen (PCNA) inhibits repair of interstrand DNA cross-link, enhances DNA double strand break, and sensitizes cancer cells to cisplatin
10.1074/jbc.m113.520429 · 2014 · External reference
Discovery of Inhibitors for Proliferating Cell Nuclear Antigen Using a Computational-Based Linked-Multiple-Fragment Screen
10.1021/acsomega.9b02079 · 2019 · External reference
Small-molecule targeting of proliferating cell nuclear antigen chromatin association inhibits tumor cell growth
10.1124/mol.112.077735 · 2012 · External reference
Additive effects of a small molecular PCNA inhibitor PCNA-I1S and DNA damaging agents on growth inhibition and DNA damage in prostate and lung cancer cells
10.1371/journal.pone.0223894 · 2019 · External reference
Screening for novel chemical scaffolds targeting PCNA identifies the Hsp90alpha inhibitor SNX-2112
10.1016/j.crstbi.2026.100183 · 2026 · External reference
Small molecule targeting of transcription-replication conflict for selective chemotherapy
10.1016/j.chembiol.2023.07.001 · 2023 · External reference
Transcription-replication conflicts: how they occur and how they are resolved
10.1038/nrm.2016.88 · 2016 · External reference
The potential of PCNA inhibition as a therapeutic strategy in cervical cancer
10.1002/jmv.29244 · 2023 · External reference
AOH1996 targets mitochondrial dynamics and metabolism in leukemic stem cells via mitochondrial PCNA inhibition
10.1186/s40164-024-00586-4 · 2024 · External reference
Selective reduction of aromatic nitro compounds with stannous chloride in non-acidic and non-aqueous medium
10.1016/s0040-4039(01)80041-1 · 1985 · External reference
Nonpolar Solvent a Key for Highly Regioselective SNAr Reaction in the Case of 2,4-Difluoronitrobenzene
10.1021/op500120z · 2014 · External reference
The Phosphonation of Aromatic Compounds with Phosphorus Pentasulfide
10.1021/ja01600a058 · 1956 · External reference
Thiation with 2,4-Bis(4-Methoxyphenyl)-1,3,2,4- Dithiadiphosphetane 2,4-Disulfide: N-Methylthiopyrrolidone
1984 · External reference
Selective thyroid hormone receptor beta agonists with oxadiazolone acid isosteres
10.1016/j.bmcl.2020.127465 · 2020 · External reference
Metabolic Hydrolysis of Aromatic Amides in Selected Rat, Minipig, and Human In Vitro Systems
10.1038/s41598-018-20464-4 · 2018 · External reference
Design of drugs involving the concepts and theories of drug metabolism and pharmacokinetics
10.1002/(sici)1098-1128(199605)16:3<243::aid-med2>3.0.co;2-z · 1996 · External reference
Crystal structure of 4-methyl- N -propylbenzenesulfonamide
10.1107/s2056989020007756 · 2020 · External reference
Novel Peptide Therapeutic Approaches for Cancer Treatment
10.3390/cells10112908 · 2021 · External reference
Synthesis and Anticancer Evaluation of PCNA Inhibitor AOH1996 Analogs in Cancer Cell Cultures
10.3390/molecules31050862 · 2026 · External reference
Abstract 6989: Advancing AOH1996: Enhanced anticancer activity of next-generation small molecule PCNA inhibitors
10.1158/1538-7445.am2025-6989 · 2025 · External reference
Structural studies of several clinically important oncology drugs in complex with human serum albumin
10.1016/j.bbagen.2013.06.032 · 2013 · External reference
Local delivery of stabilized chondroitinase ABC degrades chondroitin sulfate proteoglycans in stroke-injured rat brains
10.1016/j.jconrel.2019.01.033 · 2019 · External reference
Structural basis of non-steroidal anti-inflammatory drug diclofenac binding to human serum albumin
10.1111/cbdd.12583 · 2015 · External reference
Mini-review: Targeted radiopharmaceuticals incorporating reversible, low molecular weight albumin binders
10.1016/j.nucmedbio.2019.01.006 · 2019 · External reference
Fatty liver is an independent predictor of early carotid atherosclerosis
10.1016/j.jhep.2016.02.023 · 2016 · External reference
Limiting angiogenesis to modulate scar formation
10.1016/j.addr.2018.02.010 · 2019 · External reference
Molecular aspects of ligand binding to serum albumin
10.1016/s0031-6997(25)06849-8 · 1981 · External reference
Crystal structure of human serum albumin complexed with fatty acid reveals an asymmetric distribution of binding sites
10.1038/1869 · 1998 · External reference
Harnessing albumin as a carrier for cancer therapies
10.1016/j.addr.2018.07.011 · 2018 · External reference
A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs
1986 · External reference
In vitro sulfoxidation of thioether compounds by human cytochrome P450 and flavin-containing monooxygenase isoforms with particular reference to the CYP2C subfamily
10.1124/dmd.32.3.333 · 2004 · External reference
Base-excision repair pathway regulates transcription-replication conflicts in pancreatic ductal adenocarcinoma
10.1016/j.celrep.2024.114820 · 2024 · External reference
Therapeutic Targeting of Oncogene-Induced Transcription-Replication Conflicts in Pancreatic Ductal Adenocarcinoma
10.1053/j.gastro.2025.02.038 · 2025 · External reference
Phaser crystallographic software
10.1107/s0021889807021206 · 2007 · External reference
PHENIX: An R package to estimate a size-controlled phenotypic integration index
10.3732/apps.1400104 · 2015 · External reference
Features and development of Coot
10.1107/s0907444910007493 · 2010 · External reference
Sulforhodamine B colorimetric assay for cytotoxicity screening
10.1038/nprot.2006.179 · 2006 · External reference
High Risk alpha-HPV E6 Impairs Translesion Synthesis by Blocking POLeta Induction
10.3390/cancers13010028 · 2020 · External reference
C2-symmetric bis(oxazolinato)lanthanide catalysts for enantioselective intramolecular hydroamination/cyclization
10.1021/ja0364672 · 2003 · External reference
Nickel-Catalyzed Kumada Coupling of Boc-Activated Aromatic Amines via Nondirected Selective Aryl C-N Bond Cleavage
10.1021/acs.orglett.9b00242 · 2019 · External reference
Design of drugs involving the concepts and theories of drug metabolism and pharmacokinetics
10.1002/(sici)1098-1128(199605)16:3<243::aid-med2>3.0.co;2-z · ExternalCitation · doi-reference
PCNA binding through a conserved motif
10.1002/(sici)1521-1878(199803)20:3<195::aid-bies2>3.0.co;2-r · ExternalCitation · doi-reference
The potential of PCNA inhibition as a therapeutic strategy in cervical cancer
10.1002/jmv.29244 · ExternalCitation · doi-reference
The discovery of labile methyl esters on proliferating cell nuclear antigen by MS/MS
10.1002/pmic.200600142 · ExternalCitation · doi-reference
Elevated expression of cancer-associated proliferating cell nuclear antigen in high-grade prostatic intraepithelial neoplasia and prostate cancer
10.1002/pros.21291 · ExternalCitation · doi-reference
The bacterial DNA sliding clamp, β-clamp: structure, interactions, dynamics and drug discovery
10.1007/s00018-024-05252-w · ExternalCitation · doi-reference
Crystal structure of the eukaryotic DNA polymerase processivity factor PCNA
10.1016/0092-8674(94)90014-0 · ExternalCitation · doi-reference
Targeting proliferating cell nuclear antigen (PCNA) for cancer therapy
10.1016/bs.apha.2024.04.002 · ExternalCitation · doi-reference
Limiting angiogenesis to modulate scar formation
10.1016/j.addr.2018.02.010 · ExternalCitation · doi-reference
Harnessing albumin as a carrier for cancer therapies
10.1016/j.addr.2018.07.011 · ExternalCitation · doi-reference
Structural studies of several clinically important oncology drugs in complex with human serum albumin
10.1016/j.bbagen.2013.06.032 · ExternalCitation · doi-reference
Selective thyroid hormone receptor beta agonists with oxadiazolone acid isosteres
10.1016/j.bmcl.2020.127465 · ExternalCitation · doi-reference
Base-excision repair pathway regulates transcription-replication conflicts in pancreatic ductal adenocarcinoma
10.1016/j.celrep.2024.114820 · ExternalCitation · doi-reference
Small molecule targeting of transcription-replication conflict for selective chemotherapy
10.1016/j.chembiol.2023.07.001 · ExternalCitation · doi-reference
Screening for novel chemical scaffolds targeting PCNA identifies the Hsp90alpha inhibitor SNX-2112
10.1016/j.crstbi.2026.100183 · ExternalCitation · doi-reference
Local delivery of stabilized chondroitinase ABC degrades chondroitin sulfate proteoglycans in stroke-injured rat brains
10.1016/j.jconrel.2019.01.033 · ExternalCitation · doi-reference
Fatty liver is an independent predictor of early carotid atherosclerosis
10.1016/j.jhep.2016.02.023 · ExternalCitation · doi-reference
Isolation and characterization of a DNA synthesome from a neuroblastoma cell line
10.1016/j.jpedsurg.2005.03.054 · ExternalCitation · doi-reference
A million peptide motifs for the molecular biologist
10.1016/j.molcel.2014.05.032 · ExternalCitation · doi-reference
Mini-review: Targeted radiopharmaceuticals incorporating reversible, low molecular weight albumin binders
10.1016/j.nucmedbio.2019.01.006 · ExternalCitation · doi-reference
Structurally distinct ubiquitin- and sumo-modified PCNA: implications for their distinct roles in the DNA damage response
10.1016/j.str.2015.02.008 · ExternalCitation · doi-reference
PCNA: a silent housekeeper or a potential therapeutic target?
10.1016/j.tips.2014.02.004 · ExternalCitation · doi-reference
Molecular aspects of ligand binding to serum albumin
10.1016/s0031-6997(25)06849-8 · ExternalCitation · doi-reference
Selective reduction of aromatic nitro compounds with stannous chloride in non-acidic and non-aqueous medium
10.1016/s0040-4039(01)80041-1 · ExternalCitation · doi-reference
A Transition-State Perspective on Y-Family DNA Polymerase eta Fidelity in Comparison with X-Family DNA Polymerases lambda and beta
10.1021/acs.biochem.9b00087 · ExternalCitation · doi-reference
How Does the Proliferating Cell Nuclear Antigen Modulate Binding Specificity to Multiple Partner Proteins?
10.1021/acs.jcim.7b00171 · ExternalCitation · doi-reference
Targeting the “Undruggable”: Small-Molecule Inhibitors of Proliferating Cell Nuclear Antigen (PCNA) in the Spotlight in Cancer Therapy
10.1021/acs.jmedchem.4c00526 · ExternalCitation · doi-reference
Nickel-Catalyzed Kumada Coupling of Boc-Activated Aromatic Amines via Nondirected Selective Aryl C-N Bond Cleavage
10.1021/acs.orglett.9b00242 · ExternalCitation · doi-reference
Discovery of Inhibitors for Proliferating Cell Nuclear Antigen Using a Computational-Based Linked-Multiple-Fragment Screen
10.1021/acsomega.9b02079 · ExternalCitation · doi-reference
The Phosphonation of Aromatic Compounds with Phosphorus Pentasulfide
10.1021/ja01600a058 · ExternalCitation · doi-reference
C2-symmetric bis(oxazolinato)lanthanide catalysts for enantioselective intramolecular hydroamination/cyclization
10.1021/ja0364672 · ExternalCitation · doi-reference
Nonpolar Solvent a Key for Highly Regioselective SNAr Reaction in the Case of 2,4-Difluoronitrobenzene
10.1021/op500120z · ExternalCitation · doi-reference
Crystal structure of human serum albumin complexed with fatty acid reveals an asymmetric distribution of binding sites
10.1038/1869 · ExternalCitation · doi-reference
Human hepatocellular carcinoma expresses specific PCNA isoforms: an in vivo and in vitro evaluation
10.1038/labinvest.2008.50 · ExternalCitation · doi-reference
Structural insights into the function of ZRANB3 in replication stress response
10.1038/ncomms15847 · ExternalCitation · doi-reference
Sulforhodamine B colorimetric assay for cytotoxicity screening
10.1038/nprot.2006.179 · ExternalCitation · doi-reference
Transcription-replication conflicts: how they occur and how they are resolved
10.1038/nrm.2016.88 · ExternalCitation · doi-reference
Metabolic Hydrolysis of Aromatic Amides in Selected Rat, Minipig, and Human In Vitro Systems
10.1038/s41598-018-20464-4 · ExternalCitation · doi-reference
Therapeutic Targeting of Oncogene-Induced Transcription-Replication Conflicts in Pancreatic Ductal Adenocarcinoma
10.1053/j.gastro.2025.02.038 · ExternalCitation · doi-reference
A cancer-associated PCNA expressed in breast cancer has implications as a potential biomarker
10.1073/pnas.0604614103 · ExternalCitation · doi-reference
Identification of small molecule proliferating cell nuclear antigen (PCNA) inhibitor that disrupts interactions with PIP-box proteins and inhibits DNA replication
10.1074/jbc.m112.353201 · ExternalCitation · doi-reference
A small molecule inhibitor of monoubiquitinated Proliferating Cell Nuclear Antigen (PCNA) inhibits repair of interstrand DNA cross-link, enhances DNA double strand break, and sensitizes cancer cells to cisplatin
10.1074/jbc.m113.520429 · ExternalCitation · doi-reference
Structural basis for novel interactions between human translesion synthesis polymerases and proliferating cell nuclear antigen
10.1074/jbc.m809745200 · ExternalCitation · doi-reference
Essential interaction between the fission yeast DNA polymerase delta subunit Cdc27 and Pcn1 (PCNA) mediated through a C-terminal p21(Cip1)-like PCNA binding motif
10.1093/emboj/19.5.1108 · ExternalCitation · doi-reference
Checkpoint activation by Spd1: a competition-based system relying on tandem disordered PCNA binding motifs
10.1093/nar/gkae011 · ExternalCitation · doi-reference
Phaser crystallographic software
10.1107/s0021889807021206 · ExternalCitation · doi-reference
Features and development of Coot
10.1107/s0907444910007493 · ExternalCitation · doi-reference
Crystal structure of 4-methyl- N -propylbenzenesulfonamide
10.1107/s2056989020007756 · ExternalCitation · doi-reference
Structural basis of non-steroidal anti-inflammatory drug diclofenac binding to human serum albumin
10.1111/cbdd.12583 · ExternalCitation · doi-reference
In vitro sulfoxidation of thioether compounds by human cytochrome P450 and flavin-containing monooxygenase isoforms with particular reference to the CYP2C subfamily
10.1124/dmd.32.3.333 · ExternalCitation · doi-reference
Small-molecule targeting of proliferating cell nuclear antigen chromatin association inhibits tumor cell growth
10.1124/mol.112.077735 · ExternalCitation · doi-reference
Extracellular vesicles deposit PCNA to rejuvenate aged bone marrow-derived mesenchymal stem cells and slow age-related degeneration
10.1126/scitranslmed.aaz8697 · ExternalCitation · doi-reference
The Anticancer Activity of a First-in-class Small-molecule Targeting PCNA
10.1158/1078-0432.ccr-18-0592 · ExternalCitation · doi-reference
Abstract 6989: Advancing AOH1996: Enhanced anticancer activity of next-generation small molecule PCNA inhibitors
10.1158/1538-7445.am2025-6989 · ExternalCitation · doi-reference
AOH1996 targets mitochondrial dynamics and metabolism in leukemic stem cells via mitochondrial PCNA inhibition
10.1186/s40164-024-00586-4 · ExternalCitation · doi-reference
Proliferating cell nuclear antigen (PCNA): a dancer with many partners
10.1242/jcs.00653 · ExternalCitation · doi-reference
Additive effects of a small molecular PCNA inhibitor PCNA-I1S and DNA damaging agents on growth inhibition and DNA damage in prostate and lung cancer cells
10.1371/journal.pone.0223894 · ExternalCitation · doi-reference
Targeting Proliferating Cell Nuclear Antigen (PCNA) as an Effective Strategy to Inhibit Tumor Cell Proliferation
10.2174/1568009620666200115162814 · ExternalCitation · doi-reference
Targeting cytosolic proliferating cell nuclear antigen in neutrophil-dominated inflammation
10.3389/fimmu.2012.00311 · ExternalCitation · doi-reference
DNA Sliding Clamps as Therapeutic Targets
10.3389/fmolb.2018.00087 · ExternalCitation · doi-reference
High Risk alpha-HPV E6 Impairs Translesion Synthesis by Blocking POLeta Induction
10.3390/cancers13010028 · ExternalCitation · doi-reference
Novel Peptide Therapeutic Approaches for Cancer Treatment
10.3390/cells10112908 · ExternalCitation · doi-reference
Synthesis and Anticancer Evaluation of PCNA Inhibitor AOH1996 Analogs in Cancer Cell Cultures
10.3390/molecules31050862 · ExternalCitation · doi-reference
PHENIX: An R package to estimate a size-controlled phenotypic integration index
10.3732/apps.1400104 · ExternalCitation · doi-reference
