Research graph
References from Discovery of Long-Acting Bifunctional Compounds with Muscarinic M3 and Histamine H1 Receptor Antagonism for the Treatment of Rhinitis. Local targets link to admitted publications; unresolved targets remain external evidence.
Allergic rhinitis: a review
10.1001/jama.2024.0530 · 2024 · External reference
Binding characteristics of cetirizine and levocetirizine to human H1 histamine receptors: contribution of Lys191 and Thr194
10.1016/s0026-895x(24)12872-6 · 2002 · External reference
Histamine H1 receptors identified in mammalian brain membranes with [3H]mepyramine
10.1073/pnas.75.12.6290 · 1978 · External reference
Decreased histamine H1 receptors in the frontal cortex of brains from patients with chronic schizophrenia
10.1016/0006-3223(91)90290-3 · 1991 · External reference
Interactions of recombinant human histamine H1R, H2R, H3R, and H4R receptors with 34 antidepressants and antipsychotics
10.1007/s00210-011-0704-0 · 2012 · External reference
Antimuscarinic effects of antihistamines: quantitative evaluation by receptor-binding assay
10.1016/s0021-5198(19)43508-7 · 1987 · External reference
The target residence time of antihistamines determines their antagonism of the G protein-coupled histamine H1 receptor
10.3389/fphar.2017.00667 · 2017 · External reference
The long duration of action of the second generation antihistamine bilastine coincides with its long residence time at the histamine H1 receptor
10.1016/j.ejphar.2018.09.011 · 2018 · External reference
Route to prolonged residence time at the histamine H1 receptor: growing from desloratadine to rupatadine
10.1021/acs.jmedchem.9b00447 · 2019 · External reference
Studies on the novel antiallergic agent HSR-609: its penetration into the central nervous system in mice and guinea pigs and its selectivity for the histamine H1 receptor
10.1254/jjp.60.291 · 1997 · External reference
International Union of Basic and Clinical Pharmacology. XCVIII. Histamine receptors
10.1124/pr.114.010249 · 2015 · External reference
Ebastine in the light of CONGA recommendations for the development of third-generation antihistamines
10.2147/jaa.s3108 · 2009 · External reference
A current appreciation of sites for pharmacological intervention in allergic conjunctivitis: effects of new topical ocular drugs
10.1111/j.1600-0420.1999.tb01171.x · 1999 · External reference
Review of rhinitis: classification, types, pathophysiology
10.3390/jcm10143183 · 2021 · External reference
Allergic and mixed rhinitis: diagnosis and natural evolution
10.3390/jcm8112019 · 2019 · External reference
Role of parasympathetic nerves and muscarinic receptors in allergy and asthma
10.1159/000336498 · 2012 · External reference
Pathophysiology of allergic and nonallergic rhinitis
10.1513/pats.201008-057rn · 2011 · External reference
Enhanced chemosensory sensitivity in patients with idiopathic rhinitis and its reversal by nasal capsaicin treatment
10.1016/j.jaci.2017.03.014 · 2017 · External reference
Capsaicin treatment reduces nasal hyperreactivity and transient receptor potential cation channel subfamily V, receptor 1 (TRPV1) overexpression in patients with idiopathic rhinitis
10.1016/j.jaci.2013.08.026 · 2014 · External reference
Autonomic nervous system dysfunction and sinonasal symptoms
10.1177/2152656718764233 · 2018 · External reference
Transient receptor potential vanilloid 1 channels control acetylcholine/2-arachidonoylglicerol coupling in the striatum
10.1016/j.neuroscience.2010.02.058 · 2010 · External reference
Ipratropium bromide nasal spray in non-allergic rhinitis: a systematic review and meta-analysis
10.1002/lary.30706 · 2023 · External reference
Intranasal anticholinergics for treatment of chronic rhinitis: systematic review and meta-analysis
10.1002/lary.30306 · 2023 · External reference
Intranasal antihistamine is superior to oral H1 antihistamine as an add-on therapy to intranasal corticosteroid for treating allergic rhinitis
10.1016/j.anai.2020.06.038 · 2020 · External reference
Effects of H1 antihistamine addition to intranasal corticosteroid for allergic rhinitis: a systematic review and meta-analysis
10.1002/alr.22166 · 2018 · External reference
Intranasal versus oral treatments for allergic rhinitis: a systematic review with meta-analysis
10.1016/j.jaip.2024.09.001 · 2024 · External reference
Efficacy and safety of intranasal medications for allergic rhinitis: network meta-analysis
10.1111/all.16384 · 2025 · External reference
Evidence-based use of antihistamines for treatment of allergic conditions
10.1016/j.anai.2023.07.019 · 2023 · External reference
The efficacy of intranasal antihistamines in the treatment of allergic rhinitis
10.1016/j.anai.2010.08.010 · 2011 · External reference
Ipratropium bromide nasal spray 0.03% provides additional relief from rhinorrhea when combined with terfenadine in perennial rhinitis patients; a randomized, double-blind, active-controlled trial
10.2500/105065898780707919 · 1998 · External reference
Use of ipratropium bromide nasal spray in chronic treatment of nonallergic perennial rhinitis, alone and in combination with other perennial rhinitis medications
10.1016/s0091-6749(95)70216-4 · 1995 · External reference
Pharmacotherapeutic medication adherence in patients with allergic rhinitis: a systematic review and meta-analysis
10.1007/s11882-026-01280-7 · 2026 · External reference
The efficacy of a novel smart watch on medicine adherence and symptom control of allergic rhinitis patients: pilot study
10.1016/j.waojou.2022.100739 · 2023 · External reference
Effect of medication dosing frequency on adherence in chronic diseases
2009 · External reference
Dosing frequency and medication adherence in chronic disease
10.18553/jmcp.2012.18.7.527 · 2012 · External reference
Effects of 101BHG-D01, a novel M receptor antagonism, on allergic rhinitis in animal models and its mechanism
10.1016/j.ejphar.2023.175902 · 2023 · External reference
Antagonism of M3 alleviates type 2 inflammation in allergic rhinitis mice
10.1177/19458924221137977 · 2023 · External reference
Effects of first and second generation antihistamines on muscarinic induced mucus gland cell ion transport
10.1186/1471-2210-5-8 · 2005 · External reference
Muscarinic M2 antagonists: anthranilamide derivatives with exceptional selectivity and in vivo activity
10.1016/j.bmc.2003.11.005 · 2004 · External reference
Diphenyl sulfoxides as selective antagonists of the muscarinic M2 receptor
10.1016/s0960-894x(00)00438-8 · 2000 · External reference
Diphenylsulfone muscarinic antagonists: piperidine derivatives with high M2 selectivity and improved potency
10.1016/s0960-894x(00)00437-6 · 2000 · External reference
Discovery and optimization of diarylsulfone-based dual M3-Antagonists and β2-Agonists (MABAs) as inhaled bronchodilators
10.1016/j.ejmech.2026.119082 · 2026 · External reference
Discovery of a novel class of inhaled dual pharmacology muscarinic antagonist and β2 agonist (MABA) for the treatment of chronic obstructive pulmonary disease (COPD)
10.1016/j.bmcl.2021.127975 · 2021 · External reference
Design, synthesis, and evaluation of a new fluorescent ligand for the M2 muscarinic acetylcholine receptor
10.1021/acsmedchemlett.4c00592 · 2025 · External reference
An efficient method for the oxidation of sulfides to sulfones
10.1016/s0040-4039(00)73291-6 · 1994 · External reference
Unresolved reference
External reference
Substituted 2-(R)-methyl piperazines as muscarinic M2 selective ligands
10.1016/s0960-894x(02)00023-9 · 2002 · External reference
The high-pressure SNAr reaction of N-p-fluorobenzyl-2-chlorobenzimidazole with amines; an approach to norastemizole and analogues
10.1016/s0040-4039(99)00290-7 · 1999 · External reference
Structure−activity relationship studies reveal new astemizole analogues active against Plasmodium falciparum in vitro
10.1021/acsmedchemlett.1c00328 · 2021 · External reference
Clinical development of histamine H4 receptor antagonists
10.1007/164_2016_130 · 2017 · External reference
Synthesis and structure−activity relationships of indole and benzimidazole piperazines as histamine H4 receptor antagonists
10.1016/j.bmcl.2004.08.035 · 2004 · External reference
Synthesis and antihistamine evaluations of novel loratadine analogues
10.1016/j.bmcl.2011.06.012 · 2011 · External reference
A redox-relay Heck approach to substituted tetrahydrofurans
10.1021/acs.orglett.3c00769 · 2023 · External reference
Preclinical evaluation of long-acting muscarinic antagonists: comparison of tiotropium and investigational drugs
10.1124/jpet.109.152470 · 2009 · External reference
Pharmacological characterization of GSK573719 (umeclidinium): a novel, long-acting, inhaled antagonist of the muscarinic cholinergic receptors for treatment of pulmonary diseases
10.1124/jpet.112.202051 · 2013 · External reference
Characterization of aclidinium bromide, a novel inhaled muscarinic antagonist, with long duration of action and a favorable pharmacological profile
10.1124/jpet.109.151639 · 2009 · External reference
Application of parallel multiparametric cell-based FLIPR detection assays for the identification of modulators of the muscarinic acetylcholine receptor 4 (M4)
10.1177/1087057115581770 · 2015 · External reference
Analysis of apparent noncompetitive responses to competitive H1-histamine receptor antagonists in fluorescent imaging plate reader-based calcium assays
10.1177/108705719900400506 · 1999 · External reference
A muscarinic view on Gq
10.1007/s00210-013-0895-7 · 2013 · External reference
Muscarinic acetylcholine receptors: novel opportunities for drug development
10.1038/nrd4295 · 2014 · External reference
Structure of the human histamine H1 receptor complex with doxepin
10.1038/nature10236 · 2011 · External reference
Molecular mechanism of antihistamines recognition and regulation of the histamine H1 receptor
10.1038/s41467-023-44477-4 · 2024 · External reference
Controlling the selectivity of aminergic GPCR ligands from the extracellular vestibule
10.1016/j.bioorg.2021.104832 · 2021 · External reference
Structure and dynamics of the M3 muscarinic acetylcholine receptor
10.1038/nature10867 · 2012 · External reference
Differential regulation of bilastine affinity for human histamine H1 receptors by Lys179 and Lys191 via its binding enthalpy and entropy
10.3390/ijms22041655 · 2021 · External reference
Detailed analysis of biased histamine H4 receptor signalling by JNJ 7777120 analogues
10.1111/bph.12117 · 2013 · External reference
Mapping histamine H4 receptor−ligand binding modes
10.1039/c2md20212c · 2013 · External reference
Structural basis of ligand recognition and design of antihistamines targeting histamine H4 receptor
10.1038/s41467-024-46840-5 · 2024 · External reference
Evaluation of the contribution of the nasal cavity and gastrointestinal tract to drug absorption following nasal application to rats
10.1248/bpb.30.608 · 2007 · External reference
The identification of indacaterol as an ultralong-acting inhaled β2-adrenoceptor agonist
10.1021/jm100068m · 2010 · External reference
Pharmacological properties of revefenacin (TD-4208), a novel, nebulized long-acting, and lung selective muscarinic antagonist, at human recombinant muscarinic receptors and in rat, guinea pig, and human isolated airway tissues
10.1002/prp2.400 · 2018 · External reference
Pharmacokinetics of ipratropium bromide after single dose inhalation and oral and intravenous administration
10.1007/bf00609193 · 1989 · External reference
Tiotropium (Spiriva): a once-daily inhaled anticholinergic medication for chronic obstructive pulmonary disease
10.1080/08998280.2004.11927996 · 2004 · External reference
Revefenacin absorption, metabolism, and excretion in healthy subjects and pharmacological activity of its major metabolite
10.1124/dmd.120.000103 · 2020 · External reference
Revisiting the hERG safety margin after 20 years of routine hERG screening
10.1016/j.vascn.2020.106900 · 2020 · External reference
Effects of nasal capsaicin pretreatment and cryosurgery on sneezing reflexes, neurogenic plasma extravasation, sensory and sympathetic neurons
10.3109/00016488509108596 · 1985 · External reference
Study on the dye leakage response of nasal mucosa following topical, capsaicin challenge in guinea pigs
10.3109/00016489209137438 · 1992 · External reference
Changes in nasal airway resistance and secretory response in the guinea pig after nasal challenge with capsaicin and histamine
10.1007/bf00628428 · 1994 · External reference
Effects of 4-DAMP on allergic rhinitis in guinea pigs and its potential mechanism
10.21037/atm-22-2998 · 2022 · External reference
Validation of guinea pig model of allergic rhinitis by oral and topical drugs
10.1016/j.intimp.2008.06.010 · 2008 · External reference
Anti-tumor necrosis factor-alpha treatment reduces allergic responses in an allergic rhinitis mouse model
10.1111/j.1398-9995.2010.02476.x · 2011 · External reference
Xanthii Fructus inhibits allergic response in the ovalbumin-sensitized mouse allergic rhinitis model
10.4103/0973-1296.166058 · 2015 · External reference
Characterization of a novel high-dose ovalbumin-induced murine model of allergic sinonasal inflammation
10.1002/alr.21768 · 2016 · External reference
Anti-allergic and anti-inflammatory effects of bakuchiol on ovalbumin-induced allergic rhinitis in mice
10.1007/s12010-023-04675-8 · 2023 · External reference
Management of rhinitis: allergic and non-allergic
10.4168/aair.2011.3.3.148 · 2011 · External reference
Intranasal antihistamines in the treatment of idiopathic non-allergic rhinitis: a systematic review and meta-analysis
10.4193/rhin21.380 · 2023 · External reference
Sneezing and rubbing counts in allergic rhinitis mouse models are a reliable indicator of type 2 immune response
10.21053/ceo.2019.02005 · 2020 · External reference
Effect of proparacaine in a mouse model of allergic rhinitis
10.1016/j.jaci.2016.12.290 · 2017 · External reference
Mechanisms and clinical implications of glucocorticosteroids in the treatment of allergic rhinitis
10.1111/j.1365-2249.2009.04010.x · 2009 · External reference
Serum level of interleukin-4 in patients with perennial allergic rhinitis during allergen-specific immunotherapy
10.1046/j.1365-3083.1996.d01-269.x · 1996 · External reference
IL-33: biological properties, functions, and roles in airway disease
10.1111/imr.12552 · 2017 · External reference
The role of IL-33 and its receptor ST2 in human nasal epithelium with allergic rhinitis
10.1111/j.1365-2222.2011.03867.x · 2012 · External reference
The role of the level of interleukin-33 in the therapeutic outcomes of immunotherapy in patients with allergic rhinitis
10.1055/s-0037-1605596 · 2018 · External reference
Investigating nasal interleukin (IL)-33 after the Allergic Rhinitis Clinical Investigator Collaborative (AR-CIC) nasal allergen challenge
10.1016/j.anai.2026.03.004 · 2026 · External reference
Preseasonal prophylactic treatment with antihistamines suppresses IL-5 but not IL-33 mRNA expression in the nasal mucosa of patients with seasonal allergic rhinitis caused by Japanese cedar pollen
10.3109/00016489.2011.644804 · 2012 · External reference
Differential regulation of allergic airway inflammation by acetylcholine
10.3389/fimmu.2022.893844 · 2022 · External reference
Cholinergic sensing of allergen exposure by airway epithelium promotes type 2 immunity in the lungs
10.1016/j.jaci.2023.10.031 · 2024 · External reference
Overview on the Pathomechanisms of allergic rhinitis
10.5415/apallergy.2011.1.3.157 · 2011 · External reference
Thymic stromal lymphopoietin is a critical mediator of IL-13-driven allergic inflammation
10.1002/eji.200939302 · 2009 · External reference
Single dose topical corticosteroid inhibits IL-5 and IL-13 in nasal lavage following grass pollen challenge
10.1111/j.1398-9995.2005.00928.x · 2005 · External reference
Dexamethasone suppresses allergic rhinitis and amplifies CD4+Foxp3+ regulatory T cells in vitro
10.1002/alr.21579 · 2015 · External reference
The release of IL-31 and IL-13 after nasal allergen challenge and their relation to nasal symptoms
10.1186/2045-7022-2-13 · 2012 · External reference
Murine allergic rhinitis and nasal Th2 activation are mediated via TSLP- and IL-33-signaling pathways
10.1093/intimm/dxv055 · 2016 · External reference
Mast cell regulation of epithelial TSLP expression plays an important role in the development of allergic rhinitis
10.1002/eji.200737809 · 2008 · External reference
The influence of TSLP on the allergic response
10.1038/mi.2009.134 · 2010 · External reference
Epithelial cell-derived cytokines: more than just signaling the alarm
10.1172/jci124606 · 2019 · External reference
Functions of thymic stromal lymphopoietin in immunity and disease
10.1007/s12026-012-8264-z · 2012 · External reference
IL-17A-associated IKK-α signaling induced TSLP production in epithelial cells of COPD patients
10.1038/s12276-018-0158-2 · 2018 · External reference
Pharmacological characterization of the human histamine H2 receptor stably expressed in Chinese hamster ovary cells
10.1111/j.1476-5381.1994.tb13157.x · 1994 · External reference
Evaluation of histamine H1-H2-and H3-receptor ligands at the human histamine H4 receptor: identification of 4-methylhistamine as the first potent and selective H4 receptor agonist
10.1124/jpet.105.087965 · 2005 · External reference
Guanosine 5′-(γ-[35S]thio)triphosphate autoradiography allows selective detection of histamine H3 receptor-dependent G protein activation in rat brain tissue sections
10.1046/j.1471-4159.1998.71020808.x · 1998 · External reference
N-Desmethylclozapine, an allosteric agonist at muscarinic 1 receptor, potentiates N-methyl-d-aspartate receptor activity
10.1073/pnas.1835612100 · 2003 · External reference
Dual Effects of Muscarinic M2 Acetylcholine Receptors on the Synthesis of Cyclic AMP in CHO cells: Dependence on time, receptor density and receptor agonists
10.1038/sj.bjp.0703931 · 2001 · External reference
PD 102807, a novel muscarinic M4 receptor antagonist, discriminates between striatal and cortical muscarinic receptors coupled to cyclic AMP
10.1016/s0024-3205(99)00488-9 · 1999 · External reference
International Union of Pharmacology. XVII. Classification of muscarinic acetylcholine receptors
10.1016/s0031-6997(24)01362-0 · 1998 · External reference
Cross-site and cross-platform variability of automated patch clamp assessments of drug effects on human cardiac currents in recombinant cells
10.1038/s41598-020-62344-w · 2020 · External reference
Allergic rhinitis: a review
10.1001/jama.2024.0530 · ExternalCitation · doi-reference
Dexamethasone suppresses allergic rhinitis and amplifies CD4+Foxp3+ regulatory T cells in vitro
10.1002/alr.21579 · ExternalCitation · doi-reference
Characterization of a novel high-dose ovalbumin-induced murine model of allergic sinonasal inflammation
10.1002/alr.21768 · ExternalCitation · doi-reference
Effects of H1 antihistamine addition to intranasal corticosteroid for allergic rhinitis: a systematic review and meta-analysis
10.1002/alr.22166 · ExternalCitation · doi-reference
Mast cell regulation of epithelial TSLP expression plays an important role in the development of allergic rhinitis
10.1002/eji.200737809 · ExternalCitation · doi-reference
Thymic stromal lymphopoietin is a critical mediator of IL-13-driven allergic inflammation
10.1002/eji.200939302 · ExternalCitation · doi-reference
Intranasal anticholinergics for treatment of chronic rhinitis: systematic review and meta-analysis
10.1002/lary.30306 · ExternalCitation · doi-reference
Ipratropium bromide nasal spray in non-allergic rhinitis: a systematic review and meta-analysis
10.1002/lary.30706 · ExternalCitation · doi-reference
Pharmacological properties of revefenacin (TD-4208), a novel, nebulized long-acting, and lung selective muscarinic antagonist, at human recombinant muscarinic receptors and in rat, guinea pig, and human isolated airway tissues
10.1002/prp2.400 · ExternalCitation · doi-reference
Clinical development of histamine H4 receptor antagonists
10.1007/164_2016_130 · ExternalCitation · doi-reference
Pharmacokinetics of ipratropium bromide after single dose inhalation and oral and intravenous administration
10.1007/bf00609193 · ExternalCitation · doi-reference
Changes in nasal airway resistance and secretory response in the guinea pig after nasal challenge with capsaicin and histamine
10.1007/bf00628428 · ExternalCitation · doi-reference
Interactions of recombinant human histamine H1R, H2R, H3R, and H4R receptors with 34 antidepressants and antipsychotics
10.1007/s00210-011-0704-0 · ExternalCitation · doi-reference
A muscarinic view on Gq
10.1007/s00210-013-0895-7 · ExternalCitation · doi-reference
Pharmacotherapeutic medication adherence in patients with allergic rhinitis: a systematic review and meta-analysis
10.1007/s11882-026-01280-7 · ExternalCitation · doi-reference
Anti-allergic and anti-inflammatory effects of bakuchiol on ovalbumin-induced allergic rhinitis in mice
10.1007/s12010-023-04675-8 · ExternalCitation · doi-reference
Functions of thymic stromal lymphopoietin in immunity and disease
10.1007/s12026-012-8264-z · ExternalCitation · doi-reference
Decreased histamine H1 receptors in the frontal cortex of brains from patients with chronic schizophrenia
10.1016/0006-3223(91)90290-3 · ExternalCitation · doi-reference
The efficacy of intranasal antihistamines in the treatment of allergic rhinitis
10.1016/j.anai.2010.08.010 · ExternalCitation · doi-reference
Intranasal antihistamine is superior to oral H1 antihistamine as an add-on therapy to intranasal corticosteroid for treating allergic rhinitis
10.1016/j.anai.2020.06.038 · ExternalCitation · doi-reference
Evidence-based use of antihistamines for treatment of allergic conditions
10.1016/j.anai.2023.07.019 · ExternalCitation · doi-reference
Investigating nasal interleukin (IL)-33 after the Allergic Rhinitis Clinical Investigator Collaborative (AR-CIC) nasal allergen challenge
10.1016/j.anai.2026.03.004 · ExternalCitation · doi-reference
Controlling the selectivity of aminergic GPCR ligands from the extracellular vestibule
10.1016/j.bioorg.2021.104832 · ExternalCitation · doi-reference
Muscarinic M2 antagonists: anthranilamide derivatives with exceptional selectivity and in vivo activity
10.1016/j.bmc.2003.11.005 · ExternalCitation · doi-reference
Synthesis and structure−activity relationships of indole and benzimidazole piperazines as histamine H4 receptor antagonists
10.1016/j.bmcl.2004.08.035 · ExternalCitation · doi-reference
Synthesis and antihistamine evaluations of novel loratadine analogues
10.1016/j.bmcl.2011.06.012 · ExternalCitation · doi-reference
Discovery of a novel class of inhaled dual pharmacology muscarinic antagonist and β2 agonist (MABA) for the treatment of chronic obstructive pulmonary disease (COPD)
10.1016/j.bmcl.2021.127975 · ExternalCitation · doi-reference
Discovery and optimization of diarylsulfone-based dual M3-Antagonists and β2-Agonists (MABAs) as inhaled bronchodilators
10.1016/j.ejmech.2026.119082 · ExternalCitation · doi-reference
The long duration of action of the second generation antihistamine bilastine coincides with its long residence time at the histamine H1 receptor
10.1016/j.ejphar.2018.09.011 · ExternalCitation · doi-reference
Effects of 101BHG-D01, a novel M receptor antagonism, on allergic rhinitis in animal models and its mechanism
10.1016/j.ejphar.2023.175902 · ExternalCitation · doi-reference
Validation of guinea pig model of allergic rhinitis by oral and topical drugs
10.1016/j.intimp.2008.06.010 · ExternalCitation · doi-reference
Capsaicin treatment reduces nasal hyperreactivity and transient receptor potential cation channel subfamily V, receptor 1 (TRPV1) overexpression in patients with idiopathic rhinitis
10.1016/j.jaci.2013.08.026 · ExternalCitation · doi-reference
Effect of proparacaine in a mouse model of allergic rhinitis
10.1016/j.jaci.2016.12.290 · ExternalCitation · doi-reference
Enhanced chemosensory sensitivity in patients with idiopathic rhinitis and its reversal by nasal capsaicin treatment
10.1016/j.jaci.2017.03.014 · ExternalCitation · doi-reference
Cholinergic sensing of allergen exposure by airway epithelium promotes type 2 immunity in the lungs
10.1016/j.jaci.2023.10.031 · ExternalCitation · doi-reference
Intranasal versus oral treatments for allergic rhinitis: a systematic review with meta-analysis
10.1016/j.jaip.2024.09.001 · ExternalCitation · doi-reference
Transient receptor potential vanilloid 1 channels control acetylcholine/2-arachidonoylglicerol coupling in the striatum
10.1016/j.neuroscience.2010.02.058 · ExternalCitation · doi-reference
Revisiting the hERG safety margin after 20 years of routine hERG screening
10.1016/j.vascn.2020.106900 · ExternalCitation · doi-reference
The efficacy of a novel smart watch on medicine adherence and symptom control of allergic rhinitis patients: pilot study
10.1016/j.waojou.2022.100739 · ExternalCitation · doi-reference
Antimuscarinic effects of antihistamines: quantitative evaluation by receptor-binding assay
10.1016/s0021-5198(19)43508-7 · ExternalCitation · doi-reference
PD 102807, a novel muscarinic M4 receptor antagonist, discriminates between striatal and cortical muscarinic receptors coupled to cyclic AMP
10.1016/s0024-3205(99)00488-9 · ExternalCitation · doi-reference
Binding characteristics of cetirizine and levocetirizine to human H1 histamine receptors: contribution of Lys191 and Thr194
10.1016/s0026-895x(24)12872-6 · ExternalCitation · doi-reference
International Union of Pharmacology. XVII. Classification of muscarinic acetylcholine receptors
10.1016/s0031-6997(24)01362-0 · ExternalCitation · doi-reference
An efficient method for the oxidation of sulfides to sulfones
10.1016/s0040-4039(00)73291-6 · ExternalCitation · doi-reference
The high-pressure SNAr reaction of N-p-fluorobenzyl-2-chlorobenzimidazole with amines; an approach to norastemizole and analogues
10.1016/s0040-4039(99)00290-7 · ExternalCitation · doi-reference
Use of ipratropium bromide nasal spray in chronic treatment of nonallergic perennial rhinitis, alone and in combination with other perennial rhinitis medications
10.1016/s0091-6749(95)70216-4 · ExternalCitation · doi-reference
Diphenylsulfone muscarinic antagonists: piperidine derivatives with high M2 selectivity and improved potency
10.1016/s0960-894x(00)00437-6 · ExternalCitation · doi-reference
Diphenyl sulfoxides as selective antagonists of the muscarinic M2 receptor
10.1016/s0960-894x(00)00438-8 · ExternalCitation · doi-reference
Substituted 2-(R)-methyl piperazines as muscarinic M2 selective ligands
10.1016/s0960-894x(02)00023-9 · ExternalCitation · doi-reference
Route to prolonged residence time at the histamine H1 receptor: growing from desloratadine to rupatadine
10.1021/acs.jmedchem.9b00447 · ExternalCitation · doi-reference
A redox-relay Heck approach to substituted tetrahydrofurans
10.1021/acs.orglett.3c00769 · ExternalCitation · doi-reference
Structure−activity relationship studies reveal new astemizole analogues active against Plasmodium falciparum in vitro
10.1021/acsmedchemlett.1c00328 · ExternalCitation · doi-reference
Design, synthesis, and evaluation of a new fluorescent ligand for the M2 muscarinic acetylcholine receptor
10.1021/acsmedchemlett.4c00592 · ExternalCitation · doi-reference
The identification of indacaterol as an ultralong-acting inhaled β2-adrenoceptor agonist
10.1021/jm100068m · ExternalCitation · doi-reference
The influence of TSLP on the allergic response
10.1038/mi.2009.134 · ExternalCitation · doi-reference
Structure of the human histamine H1 receptor complex with doxepin
10.1038/nature10236 · ExternalCitation · doi-reference
Structure and dynamics of the M3 muscarinic acetylcholine receptor
10.1038/nature10867 · ExternalCitation · doi-reference
Muscarinic acetylcholine receptors: novel opportunities for drug development
10.1038/nrd4295 · ExternalCitation · doi-reference
IL-17A-associated IKK-α signaling induced TSLP production in epithelial cells of COPD patients
10.1038/s12276-018-0158-2 · ExternalCitation · doi-reference
Molecular mechanism of antihistamines recognition and regulation of the histamine H1 receptor
10.1038/s41467-023-44477-4 · ExternalCitation · doi-reference
Structural basis of ligand recognition and design of antihistamines targeting histamine H4 receptor
10.1038/s41467-024-46840-5 · ExternalCitation · doi-reference
Cross-site and cross-platform variability of automated patch clamp assessments of drug effects on human cardiac currents in recombinant cells
10.1038/s41598-020-62344-w · ExternalCitation · doi-reference
Dual Effects of Muscarinic M2 Acetylcholine Receptors on the Synthesis of Cyclic AMP in CHO cells: Dependence on time, receptor density and receptor agonists
10.1038/sj.bjp.0703931 · ExternalCitation · doi-reference
Mapping histamine H4 receptor−ligand binding modes
10.1039/c2md20212c · ExternalCitation · doi-reference
Serum level of interleukin-4 in patients with perennial allergic rhinitis during allergen-specific immunotherapy
10.1046/j.1365-3083.1996.d01-269.x · ExternalCitation · doi-reference
Guanosine 5′-(γ-[35S]thio)triphosphate autoradiography allows selective detection of histamine H3 receptor-dependent G protein activation in rat brain tissue sections
10.1046/j.1471-4159.1998.71020808.x · ExternalCitation · doi-reference
The role of the level of interleukin-33 in the therapeutic outcomes of immunotherapy in patients with allergic rhinitis
10.1055/s-0037-1605596 · ExternalCitation · doi-reference
N-Desmethylclozapine, an allosteric agonist at muscarinic 1 receptor, potentiates N-methyl-d-aspartate receptor activity
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