Research graph
References from Integrated AI-Driven Multi-Objective Optimization of Sulfamoylbenzamide-Based HBV Capsid Assembly Modulators: Discovery of <b>11B-6</b> with Superior Potency and Drug-like Properties. Local targets link to admitted publications; unresolved targets remain external evidence.
Hepatitis B Virus Taxonomy and Hepatitis B Virus Genotypes
10.3748/wjg.v13.i1.14 · 2007 · External reference
Unresolved reference
External reference
Targeting HBV with RNA Interference: Paths to Cure
10.1126/scitranslmed.adv3678 · 2025 · External reference
Targeting Hepatitis B Virus cccDNA Levels: Recent Progress in Seeking Small Molecule Drug Candidates
10.1016/j.drudis.2023.103617 · 2023 · External reference
Hepatitis B Virus Capsid: The Core in Productive Entry and Covalently Closed Circular DNA Formation
10.3390/v15030642 · 2023 · External reference
Nucleoporin 153 Arrests the Nuclear Import of Hepatitis B Virus Capsids in the Nuclear Basket
10.1371/journal.ppat.1000741 · 2010 · External reference
Discovery and Optimization of Benzenesulfonamides-Based Hepatitis B Virus Capsid Modulators via Contemporary Medicinal Chemistry Strategies
10.1016/j.ejmech.2020.112714 · 2020 · External reference
Medicinal Chemistry Strategies in the Discovery and Optimization of HBV Core Protein Allosteric Modulators (2018−2022 Update)
10.1016/j.cclet.2023.108349 · 2023 · External reference
Antiviral Activity and Pharmacokinetics of the Hepatitis B Virus (HBV) Capsid Assembly Modulator GLS4 in Patients with Chronic HBV Infection
10.1093/cid/ciaa961 · 2021 · External reference
Discovery of Linvencorvir (RG7907), a Hepatitis B Virus Core Protein Allosteric Modulator, for the Treatment of Chronic HBV Infection
10.1021/acs.jmedchem.3c00173 · 2023 · External reference
A Novel Hepatitis B Virus Capsid Assembly Modulator QL-007 Inhibits HBV Replication and Infection through Altering Capsid Assembly
10.1016/j.antiviral.2023.105715 · 2023 · External reference
Efficacy of NVR 3-778, Alone and In Combination With Pegylated Interferon, vs Entecavir In uPA/SCID Mice With Humanized Livers and HBV Infection
10.1053/j.gastro.2017.10.017 · 2018 · External reference
Design, Synthesis, and Structure-Activity Relationship of a Bicyclic HBV Capsid Assembly Modulator Chemotype Leading to the Identification of Clinical Candidate AB-506
10.1016/j.bmcl.2023.129456 · 2023 · External reference
The Discovery and Preclinical Profile of ALG-000184, a Prodrug of the Potent Hepatitis B Virus Capsid Assembly Modulator ALG-001075
10.1021/acs.jmedchem.4c01814 · 2024 · External reference
Design, Synthesis, and Biological Evaluation of Highly Potent Boronic Acid (Boronate Ester)-Bearing Heteroaryldihydropyrimidine Derivatives as HBV Capsid Assembly Modulators
10.1021/acs.jmedchem.5c01837 · 2025 · External reference
Nomenclature of HBV Core Protein-Targeting Antivirals
10.1038/s41575-022-00700-z · 2022 · External reference
Effect of Plasma Protein Binding on the Anti-Hepatitis B Virus Activity and Pharmacokinetic Properties of NVR 3-778
10.1128/aac.01497-18 · 2018 · External reference
Antiviral Activity, Safety, and Pharmacokinetics of Capsid Assembly Modulator NVR 3-778 in Patients with Chronic HBV Infection
10.1053/j.gastro.2018.12.023 · 2019 · External reference
Design, Synthesis, and Biological Evaluation of Novel Sulfamoylbenzamide Derivatives as HBV Capsid Assembly Modulators
10.1016/j.bioorg.2022.106192 · 2022 · External reference
Design, Synthesis and Biological Evaluation of Novel Dihydrobenzodioxine Derivatives as HBV Capsid Protein Inhibitors
10.1016/j.bioorg.2022.106052 · 2022 · External reference
Design, Synthesis, and Biological Evaluation of Novel Thioureidobenzamide (TBA) Derivatives as HBV Capsid Assembly Modulators
10.1021/acs.jmedchem.3c01022 · 2023 · External reference
Discovery and Mechanism Verification of First-In-Class Hydrophobic Tagging-Based Degraders of HBV Core Protein
10.1016/j.apsb.2025.02.033 · 2025 · External reference
Multisite Occupancy and Multidimensional Optimization: Design and Evaluation of Piperazine-Thioureidobenzamide Derivatives as Potent HBV Capsid Assembly Modulators
10.1021/acs.jmedchem.5c02347 · 2025 · External reference
DeepFrag: A Deep Convolutional Neural Network for Fragment-Based Lead Optimization
10.1039/d1sc00163a · 2021 · External reference
DeepFrag: An Open-Source Browser App for Deep-Learning Lead Optimization
10.1021/acs.jcim.1c00103 · 2021 · External reference
DeepDTAF: A Deep Learning Method to Predict Protein-Ligand Binding Affinity
10.1093/bib/bbab072 · 2021 · External reference
Chemprop: A Machine Learning Package for Chemical Property Prediction
10.1021/acs.jcim.3c01250 · 2024 · External reference
Heteroaryldihydropyrimidine (HAP) and Sulfamoylbenzamide (SBA) Inhibit Hepatitis B Virus Replication by Different Molecular Mechanisms
10.1038/srep42374 · 2017 · External reference
Molecular Mechanism of Capsid Disassembly in Hepatitis B Virus
10.1073/pnas.2102530118 · 2021 · External reference
A Patent Review of Hepatitis B Virus Core Protein Allosteric Modulators (2019-Present)
10.1080/13543776.2025.2467699 · 2025 · External reference
Fragment Library Design: Efficiently Hunting Drugs in Chemical Space
10.1016/j.ddtec.2010.11.010 · 2010 · External reference
Sulfamoylbenzamide-Based Capsid Assembly Modulators for Selective Inhibition of Hepatitis B Viral Replication
10.1021/acsmedchemlett.0c00606 · 2021 · External reference
Design, Synthesis and Evaluation of Heteroaryldihydropyrimidine Analogues Bearing Spiro Ring as Hepatitis B Virus Capsid Protein Inhibitors
10.1016/j.ejmech.2021.113780 · 2021 · External reference
Hepatitis B and D Viruses Exploit Sodium Taurocholate Co-Transporting Polypeptide for Species-Specific Entry into Hepatocytes
10.1053/j.gastro.2013.12.024 · 2014 · External reference
A Novel Method to Precisely Quantify Hepatitis B Virus Covalently Closed Circular (ccc)DNA Formation and Maintenance
10.1016/j.antiviral.2020.104865 · 2020 · External reference
Discovery and Structure Activity Relationship of Glyoxamide Derivatives as Anti-Hepatitis B Virus Agents
10.1016/j.bmc.2020.115952 · 2021 · External reference
Inducible Expression of Human Hepatitis B Virus (HBV) in Stably Transfected Hepatoblastoma Cells: A Novel System for Screening Potential Inhibitors of HBV Replication
10.1128/aac.41.8.1715 · 1997 · External reference
Antiviral Activities and Cellular Toxicities of Modified 2′,3′-Dideoxy-2′,3′-Didehydrocytidine Analogues
10.1128/aac.46.12.3854-3860.2002 · 2002 · External reference
Development of a Quantitative Real-Time Detection Assay for Hepatitis B Virus DNA and Comparison with Two Commercial Assays
10.1128/jcm.38.8.2897-2901.2000 · 2000 · External reference
Rapid and Robust Continuous Purification of High-Titer Hepatitis B Virus for In Vitro and In Vivo Applications
10.3390/v13081503 · 2021 · External reference
A Mid-Throughput HBV Replication Inhibition Assay Capable of Detecting Ribonuclease H Inhibitors
10.1016/j.jviromet.2021.114127 · 2021 · External reference
High-Resolution Crystal Structure of a Hepatitis B Virus Replication Inhibitor Bound to the Viral Core Protein
10.1073/pnas.1513803112 · 2015 · External reference
XDS
10.1107/s0907444909047337 · 2010 · External reference
Xia2 : An Expert System for Macromolecular Crystallography Data Reduction
10.1107/s0021889809045701 · 2010 · External reference
PHENIX : A Comprehensive Python-Based System for Macromolecular Structure Solution
10.1107/s0907444909052925 · 2010 · External reference
Coot : Model-Building Tools for Molecular Graphics
10.1107/s0907444904019158 · 2004 · External reference
Unresolved reference
External reference
A Novel Method to Precisely Quantify Hepatitis B Virus Covalently Closed Circular (ccc)DNA Formation and Maintenance
10.1016/j.antiviral.2020.104865 · ExternalCitation · doi-reference
A Novel Hepatitis B Virus Capsid Assembly Modulator QL-007 Inhibits HBV Replication and Infection through Altering Capsid Assembly
10.1016/j.antiviral.2023.105715 · ExternalCitation · doi-reference
Discovery and Mechanism Verification of First-In-Class Hydrophobic Tagging-Based Degraders of HBV Core Protein
10.1016/j.apsb.2025.02.033 · ExternalCitation · doi-reference
Design, Synthesis and Biological Evaluation of Novel Dihydrobenzodioxine Derivatives as HBV Capsid Protein Inhibitors
10.1016/j.bioorg.2022.106052 · ExternalCitation · doi-reference
Design, Synthesis, and Biological Evaluation of Novel Sulfamoylbenzamide Derivatives as HBV Capsid Assembly Modulators
10.1016/j.bioorg.2022.106192 · ExternalCitation · doi-reference
Discovery and Structure Activity Relationship of Glyoxamide Derivatives as Anti-Hepatitis B Virus Agents
10.1016/j.bmc.2020.115952 · ExternalCitation · doi-reference
Design, Synthesis, and Structure-Activity Relationship of a Bicyclic HBV Capsid Assembly Modulator Chemotype Leading to the Identification of Clinical Candidate AB-506
10.1016/j.bmcl.2023.129456 · ExternalCitation · doi-reference
Medicinal Chemistry Strategies in the Discovery and Optimization of HBV Core Protein Allosteric Modulators (2018−2022 Update)
10.1016/j.cclet.2023.108349 · ExternalCitation · doi-reference
Fragment Library Design: Efficiently Hunting Drugs in Chemical Space
10.1016/j.ddtec.2010.11.010 · ExternalCitation · doi-reference
Targeting Hepatitis B Virus cccDNA Levels: Recent Progress in Seeking Small Molecule Drug Candidates
10.1016/j.drudis.2023.103617 · ExternalCitation · doi-reference
Discovery and Optimization of Benzenesulfonamides-Based Hepatitis B Virus Capsid Modulators via Contemporary Medicinal Chemistry Strategies
10.1016/j.ejmech.2020.112714 · ExternalCitation · doi-reference
Design, Synthesis and Evaluation of Heteroaryldihydropyrimidine Analogues Bearing Spiro Ring as Hepatitis B Virus Capsid Protein Inhibitors
10.1016/j.ejmech.2021.113780 · ExternalCitation · doi-reference
A Mid-Throughput HBV Replication Inhibition Assay Capable of Detecting Ribonuclease H Inhibitors
10.1016/j.jviromet.2021.114127 · ExternalCitation · doi-reference
DeepFrag: An Open-Source Browser App for Deep-Learning Lead Optimization
10.1021/acs.jcim.1c00103 · ExternalCitation · doi-reference
Chemprop: A Machine Learning Package for Chemical Property Prediction
10.1021/acs.jcim.3c01250 · ExternalCitation · doi-reference
Discovery of Linvencorvir (RG7907), a Hepatitis B Virus Core Protein Allosteric Modulator, for the Treatment of Chronic HBV Infection
10.1021/acs.jmedchem.3c00173 · ExternalCitation · doi-reference
Design, Synthesis, and Biological Evaluation of Novel Thioureidobenzamide (TBA) Derivatives as HBV Capsid Assembly Modulators
10.1021/acs.jmedchem.3c01022 · ExternalCitation · doi-reference
The Discovery and Preclinical Profile of ALG-000184, a Prodrug of the Potent Hepatitis B Virus Capsid Assembly Modulator ALG-001075
10.1021/acs.jmedchem.4c01814 · ExternalCitation · doi-reference
Design, Synthesis, and Biological Evaluation of Highly Potent Boronic Acid (Boronate Ester)-Bearing Heteroaryldihydropyrimidine Derivatives as HBV Capsid Assembly Modulators
10.1021/acs.jmedchem.5c01837 · ExternalCitation · doi-reference
Multisite Occupancy and Multidimensional Optimization: Design and Evaluation of Piperazine-Thioureidobenzamide Derivatives as Potent HBV Capsid Assembly Modulators
10.1021/acs.jmedchem.5c02347 · ExternalCitation · doi-reference
Sulfamoylbenzamide-Based Capsid Assembly Modulators for Selective Inhibition of Hepatitis B Viral Replication
10.1021/acsmedchemlett.0c00606 · ExternalCitation · doi-reference
Nomenclature of HBV Core Protein-Targeting Antivirals
10.1038/s41575-022-00700-z · ExternalCitation · doi-reference
Heteroaryldihydropyrimidine (HAP) and Sulfamoylbenzamide (SBA) Inhibit Hepatitis B Virus Replication by Different Molecular Mechanisms
10.1038/srep42374 · ExternalCitation · doi-reference
DeepFrag: A Deep Convolutional Neural Network for Fragment-Based Lead Optimization
10.1039/d1sc00163a · ExternalCitation · doi-reference
Hepatitis B and D Viruses Exploit Sodium Taurocholate Co-Transporting Polypeptide for Species-Specific Entry into Hepatocytes
10.1053/j.gastro.2013.12.024 · ExternalCitation · doi-reference
Efficacy of NVR 3-778, Alone and In Combination With Pegylated Interferon, vs Entecavir In uPA/SCID Mice With Humanized Livers and HBV Infection
10.1053/j.gastro.2017.10.017 · ExternalCitation · doi-reference
Antiviral Activity, Safety, and Pharmacokinetics of Capsid Assembly Modulator NVR 3-778 in Patients with Chronic HBV Infection
10.1053/j.gastro.2018.12.023 · ExternalCitation · doi-reference
High-Resolution Crystal Structure of a Hepatitis B Virus Replication Inhibitor Bound to the Viral Core Protein
10.1073/pnas.1513803112 · ExternalCitation · doi-reference
Molecular Mechanism of Capsid Disassembly in Hepatitis B Virus
10.1073/pnas.2102530118 · ExternalCitation · doi-reference
A Patent Review of Hepatitis B Virus Core Protein Allosteric Modulators (2019-Present)
10.1080/13543776.2025.2467699 · ExternalCitation · doi-reference
DeepDTAF: A Deep Learning Method to Predict Protein-Ligand Binding Affinity
10.1093/bib/bbab072 · ExternalCitation · doi-reference
Antiviral Activity and Pharmacokinetics of the Hepatitis B Virus (HBV) Capsid Assembly Modulator GLS4 in Patients with Chronic HBV Infection
10.1093/cid/ciaa961 · ExternalCitation · doi-reference
Xia2 : An Expert System for Macromolecular Crystallography Data Reduction
10.1107/s0021889809045701 · ExternalCitation · doi-reference
Coot : Model-Building Tools for Molecular Graphics
10.1107/s0907444904019158 · ExternalCitation · doi-reference
XDS
10.1107/s0907444909047337 · ExternalCitation · doi-reference
PHENIX : A Comprehensive Python-Based System for Macromolecular Structure Solution
10.1107/s0907444909052925 · ExternalCitation · doi-reference
Targeting HBV with RNA Interference: Paths to Cure
10.1126/scitranslmed.adv3678 · ExternalCitation · doi-reference
Effect of Plasma Protein Binding on the Anti-Hepatitis B Virus Activity and Pharmacokinetic Properties of NVR 3-778
10.1128/aac.01497-18 · ExternalCitation · doi-reference
Inducible Expression of Human Hepatitis B Virus (HBV) in Stably Transfected Hepatoblastoma Cells: A Novel System for Screening Potential Inhibitors of HBV Replication
10.1128/aac.41.8.1715 · ExternalCitation · doi-reference
Antiviral Activities and Cellular Toxicities of Modified 2′,3′-Dideoxy-2′,3′-Didehydrocytidine Analogues
10.1128/aac.46.12.3854-3860.2002 · ExternalCitation · doi-reference
Development of a Quantitative Real-Time Detection Assay for Hepatitis B Virus DNA and Comparison with Two Commercial Assays
10.1128/jcm.38.8.2897-2901.2000 · ExternalCitation · doi-reference
Nucleoporin 153 Arrests the Nuclear Import of Hepatitis B Virus Capsids in the Nuclear Basket
10.1371/journal.ppat.1000741 · ExternalCitation · doi-reference
Rapid and Robust Continuous Purification of High-Titer Hepatitis B Virus for In Vitro and In Vivo Applications
10.3390/v13081503 · ExternalCitation · doi-reference
Hepatitis B Virus Capsid: The Core in Productive Entry and Covalently Closed Circular DNA Formation
10.3390/v15030642 · ExternalCitation · doi-reference
Hepatitis B Virus Taxonomy and Hepatitis B Virus Genotypes
10.3748/wjg.v13.i1.14 · ExternalCitation · doi-reference
