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References from Discovery of Pyranochromone Derivatives as TLR4-MD2 Inhibitors for Alleviating Osteoarthritis. Local targets link to admitted publications; unresolved targets remain external evidence.
Toll-like receptor 4 (TLR4) modulation by synthetic and natural compounds: an update
10.1021/jm401006s · 2014 · External reference
Toll-like receptor signaling
10.1038/nri1391 · 2004 · External reference
Assembly and localization of Toll-like receptor signaling complexes
10.1038/nri3713 · 2014 · External reference
A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
10.1038/41131 · 1997 · External reference
MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4
10.1084/jem.189.11.1777 · 1999 · External reference
MD-2
10.1016/j.imbio.2006.05.010 · 2006 · External reference
TLR-signaling networks: an integration of adaptor molecules, kinases, and cross-talk
10.1177/0022034510381264 · 2011 · External reference
Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction
10.1038/35092578 · 2001 · External reference
Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway
10.1126/science.1087262 · 2003 · External reference
TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway
10.1038/ni986 · 2003 · External reference
The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling
10.1038/nri2079 · 2007 · External reference
A universal role for MyD88 in TLR/IL-1R-mediated signaling
10.1016/s0968-0004(02)02145-x · 2002 · External reference
Crystal structure of human IRAK1
10.2210/pdb6bfn/pdb · 2017 · External reference
Toll-like receptor 4 (TLR4) inhibitors: Current research and prospective
10.1016/j.ejmech.2022.114291 · 2022 · External reference
Targeting TLR4 signaling to blunt viral-mediated acute lung injury
10.3389/fimmu.2021.705080 · 2021 · External reference
Platelet signaling at the nexus of innate immunity and rheumatoid arthritis
10.3389/fimmu.2022.977828 · 2022 · External reference
TLR4 signaling in osteoarthritis-finding targets for candidate DMOADs
10.1038/nrrheum.2014.209 · 2015 · External reference
New MD2 inhibitors derived from curcumin with improved anti-inflammatory activity
10.1016/j.ejmech.2018.02.008 · 2018 · External reference
Chalcone derivatives ameliorate lipopolysaccharide-induced acute lung injury and inflammation by targeting MD2
10.1038/s41401-021-00764-8 · 2022 · External reference
Discovery of caffeic acid phenethyl ester derivatives as novel myeloid differentiation protein 2 inhibitors for treatment of acute lung injury
10.1016/j.ejmech.2017.11.066 · 2018 · External reference
Discovery of a new inhibitor of myeloid differentiation 2 from cinnamamide derivatives with anti-inflammatory activity in sepsis and acute lung injury
10.1021/acs.jmedchem.5b01574 · 2016 · External reference
Design, synthesis and anti-rheumatoid arthritis evaluation of double-ring conjugated enones
10.1016/j.bioorg.2021.104701 · 2021 · External reference
Aryl quinolinyl hydrazone derivatives as anti-inflammatory agents that inhibit TLR4 activation in the macrophages
10.1016/j.ejps.2019.04.016 · 2019 · External reference
Design, synthesis and biological evaluation of novel arylpropionic esters for the treatment of acute kidney injury
10.1016/j.bioorg.2020.104455 · 2020 · External reference
Convenient synthesis of antisepsis agent TAK-242 by novel optical resolution through diastereomeric N-acylated sulfonamide derivative
10.1016/j.tet.2007.02.127 · 2007 · External reference
Discovery of novel small molecule TLR4 inhibitors as potent anti-inflammatory agents
10.1016/j.ejmech.2018.05.033 · 2018 · External reference
Discovery of 3-bromoflavone derivative D5 as a novel TLR4-MD2 antagonist for the treatment of acute lung injury and sepsis
10.1016/j.molstruc.2024.139375 · 2024 · External reference
In vitro cytotoxic activity of isolated compounds from Malaysian Calophyllum species
10.1007/s00044-016-1606-y · 2016 · External reference
Antimicrobial assessment of resins from Calophyllum antillanum and Calophyllum inophyllum
10.1002/ptr.5506 · 2015 · External reference
Constituents of the Cuban Endemic Species Calophyllum pinetorum
10.1021/np800079c · 2008 · External reference
Antifungal chromans inhibiting the mitochondrial respiratory chain of pea seeds and new xanthones from Calophyllum caledonicum
10.1055/s-2003-818004 · 2003 · External reference
HIV-1 inhibitory compounds from Calophyllum brasiliense leaves
10.1248/bpb.27.1471 · 2004 · External reference
Pyranochromones with anti-inflammatory activities in arthritis from Calophyllum membranaceum
10.1021/acs.jnatprod.2c00157 · 2022 · External reference
Pyranocoumarin-enriched extract from the leaves of Calophyllum membranaceum alleviates LPS-induced acute lung injury in mice by inhibiting the TLR4/MD2 interaction
10.1016/j.fitote.2025.106796 · 2025 · External reference
The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex
10.1038/nature07830 · 2009 · External reference
Matrix Metalloproteinase 3: A Promoting and Destabilizing Factor in the Pathogenesis of Disease and Cell Differentiation
10.3389/fphys.2021.663978 · 2021 · External reference
Overview of MMP-13 as a Promising Target for the Treatment of Osteoarthritis
10.3390/ijms22041742 · 2021 · External reference
Antimicrobial assessment of resins from Calophyllum antillanum and Calophyllum inophyllum
10.1002/ptr.5506 · ExternalCitation · doi-reference
In vitro cytotoxic activity of isolated compounds from Malaysian Calophyllum species
10.1007/s00044-016-1606-y · ExternalCitation · doi-reference
Design, synthesis and biological evaluation of novel arylpropionic esters for the treatment of acute kidney injury
10.1016/j.bioorg.2020.104455 · ExternalCitation · doi-reference
Design, synthesis and anti-rheumatoid arthritis evaluation of double-ring conjugated enones
10.1016/j.bioorg.2021.104701 · ExternalCitation · doi-reference
Discovery of caffeic acid phenethyl ester derivatives as novel myeloid differentiation protein 2 inhibitors for treatment of acute lung injury
10.1016/j.ejmech.2017.11.066 · ExternalCitation · doi-reference
New MD2 inhibitors derived from curcumin with improved anti-inflammatory activity
10.1016/j.ejmech.2018.02.008 · ExternalCitation · doi-reference
Discovery of novel small molecule TLR4 inhibitors as potent anti-inflammatory agents
10.1016/j.ejmech.2018.05.033 · ExternalCitation · doi-reference
Toll-like receptor 4 (TLR4) inhibitors: Current research and prospective
10.1016/j.ejmech.2022.114291 · ExternalCitation · doi-reference
Aryl quinolinyl hydrazone derivatives as anti-inflammatory agents that inhibit TLR4 activation in the macrophages
10.1016/j.ejps.2019.04.016 · ExternalCitation · doi-reference
Pyranocoumarin-enriched extract from the leaves of Calophyllum membranaceum alleviates LPS-induced acute lung injury in mice by inhibiting the TLR4/MD2 interaction
10.1016/j.fitote.2025.106796 · ExternalCitation · doi-reference
MD-2
10.1016/j.imbio.2006.05.010 · ExternalCitation · doi-reference
Discovery of 3-bromoflavone derivative D5 as a novel TLR4-MD2 antagonist for the treatment of acute lung injury and sepsis
10.1016/j.molstruc.2024.139375 · ExternalCitation · doi-reference
Convenient synthesis of antisepsis agent TAK-242 by novel optical resolution through diastereomeric N-acylated sulfonamide derivative
10.1016/j.tet.2007.02.127 · ExternalCitation · doi-reference
A universal role for MyD88 in TLR/IL-1R-mediated signaling
10.1016/s0968-0004(02)02145-x · ExternalCitation · doi-reference
Discovery of a new inhibitor of myeloid differentiation 2 from cinnamamide derivatives with anti-inflammatory activity in sepsis and acute lung injury
10.1021/acs.jmedchem.5b01574 · ExternalCitation · doi-reference
Pyranochromones with anti-inflammatory activities in arthritis from Calophyllum membranaceum
10.1021/acs.jnatprod.2c00157 · ExternalCitation · doi-reference
Toll-like receptor 4 (TLR4) modulation by synthetic and natural compounds: an update
10.1021/jm401006s · ExternalCitation · doi-reference
Constituents of the Cuban Endemic Species Calophyllum pinetorum
10.1021/np800079c · ExternalCitation · doi-reference
Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction
10.1038/35092578 · ExternalCitation · doi-reference
A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
10.1038/41131 · ExternalCitation · doi-reference
The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex
10.1038/nature07830 · ExternalCitation · doi-reference
TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway
10.1038/ni986 · ExternalCitation · doi-reference
Toll-like receptor signaling
10.1038/nri1391 · ExternalCitation · doi-reference
The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling
10.1038/nri2079 · ExternalCitation · doi-reference
Assembly and localization of Toll-like receptor signaling complexes
10.1038/nri3713 · ExternalCitation · doi-reference
TLR4 signaling in osteoarthritis-finding targets for candidate DMOADs
10.1038/nrrheum.2014.209 · ExternalCitation · doi-reference
Chalcone derivatives ameliorate lipopolysaccharide-induced acute lung injury and inflammation by targeting MD2
10.1038/s41401-021-00764-8 · ExternalCitation · doi-reference
Antifungal chromans inhibiting the mitochondrial respiratory chain of pea seeds and new xanthones from Calophyllum caledonicum
10.1055/s-2003-818004 · ExternalCitation · doi-reference
MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4
10.1084/jem.189.11.1777 · ExternalCitation · doi-reference
Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway
10.1126/science.1087262 · ExternalCitation · doi-reference
TLR-signaling networks: an integration of adaptor molecules, kinases, and cross-talk
10.1177/0022034510381264 · ExternalCitation · doi-reference
HIV-1 inhibitory compounds from Calophyllum brasiliense leaves
10.1248/bpb.27.1471 · ExternalCitation · doi-reference
Crystal structure of human IRAK1
10.2210/pdb6bfn/pdb · ExternalCitation · doi-reference
Targeting TLR4 signaling to blunt viral-mediated acute lung injury
10.3389/fimmu.2021.705080 · ExternalCitation · doi-reference
Platelet signaling at the nexus of innate immunity and rheumatoid arthritis
10.3389/fimmu.2022.977828 · ExternalCitation · doi-reference
Matrix Metalloproteinase 3: A Promoting and Destabilizing Factor in the Pathogenesis of Disease and Cell Differentiation
10.3389/fphys.2021.663978 · ExternalCitation · doi-reference
Overview of MMP-13 as a Promising Target for the Treatment of Osteoarthritis
10.3390/ijms22041742 · ExternalCitation · doi-reference
