Research graph
References from Region-Resolved Label-Free Raman Profiling of Perturbation Responses in Intestinal Organoids. Local targets link to admitted publications; unresolved targets remain external evidence.
Human organoids: New strategies and methods for analyzing human development and disease
10.1016/j.cell.2022.06.051 · 2022 · External reference
Human organoids in basic research and clinical applications
10.1038/s41392-022-01024-9 · 2022 · External reference
Organoids: development and applications in disease models, drug discovery, precision medicine, and regenerative medicine
10.1002/mco2.735 · 2024 · External reference
2D and 3D cell cultures - a comparison of different types of cancer cell cultures
10.5114/aoms.2016.63743 · 2018 · External reference
Three-dimensional in vitro culture models in oncology research
10.1186/s13578-022-00887-3 · 2022 · External reference
An integrated transcriptomic cell atlas of human neural organoids
10.1038/s41586-024-08172-8 · 2024 · External reference
Spatiotemporal, optogenetic control of gene expression in organoids
10.1038/s41592-023-01986-w · 2023 · External reference
Non-invasive label-free imaging analysis pipeline for in situ characterization of 3D brain organoids
10.1038/s41598-024-72038-2 · 2024 · External reference
Drug screening at single-organoid resolution via bioprinting and interferometry
10.1038/s41467-023-38832-8 · 2023 · External reference
Multimodal spatiotemporal phenotyping of human retinal organoid development
10.1038/s41587-023-01747-2 · 2023 · External reference
An integrated organoid omics map extends modeling potential of kidney disease
10.1038/s41467-023-39740-7 · 2023 · External reference
Human organoids with an autologous tissue-resident immune compartment
10.1038/s41586-024-07791-5 · 2024 · External reference
Human cerebral organoids recapitulate gene expression programs of fetal neocortex development
10.1073/pnas.1520760112 · 2015 · External reference
Inflation-collapse dynamics drive patterning and morphogenesis in intestinal organoids
10.1016/j.stem.2021.04.002 · 2021 · External reference
Multiscale 3D phenotyping of human cerebral organoids
10.1038/s41598-020-78130-7 · 2020 · External reference
Patient-derived tumor organoids: a new avenue for preclinical research and precision medicine in oncology
10.1038/s12276-024-01272-5 · 2024 · External reference
Present Application and Perspectives of Organoid Imaging Technology
10.3390/bioengineering9030121 · 2022 · External reference
Organoid assessment technologies
10.1002/ctm2.1499 · 2023 · External reference
Viability Analysis and High-Content Live-Cell Imaging for Drug Testing in Prostate Cancer Xenograft-Derived Organoids
10.3390/cells12101377 · 2023 · External reference
Organoid Imaging: Seeing Development and Function
10.1146/annurev-cellbio-120320-035146 · 2022 · External reference
Pathology-oriented multiplexing enables integrative disease mapping
10.1038/s41586-025-09225-2 · 2025 · External reference
Immunofluorescent staining of cancer spheroids and fine-needle aspiration-derived organoids
10.1016/j.xpro.2021.100578 · 2021 · External reference
A Perspective on Expanding Our Understanding of Cancer Treatments by Integrating Approaches from the Biological and Physical Sciences
10.1177/2472555220915830 · 2020 · External reference
Development of an automated 3D high content cell screening platform for organoid phenotyping
10.1016/j.slasd.2024.100182 · 2024 · External reference
Long-term three-dimensional high-resolution imaging of live unlabeled small intestinal organoids via low-coherence holotomography
10.1038/s12276-024-01312-0 · 2024 · External reference
Organoids in image-based phenotypic chemical screens
10.1038/s12276-021-00641-8 · 2021 · External reference
scTrends: A living review of commercial single-cell and spatial ’omic technologies
10.1016/j.xgen.2024.100723 · 2024 · External reference
Single-cell sequencing and organoids: applications in organ development and disease
10.1186/s43556-025-00364-6 · 2025 · External reference
High-Throughput Imaging Assay for Drug Screening of 3D Prostate Cancer Organoids
10.1177/24725552211020668 · 2021 · External reference
Label-free Molecular Imaging and Analysis by Raman Spectroscopy
10.1267/ahc.18019 · 2018 · External reference
Label-free 3D molecular imaging of living tissues using Raman spectral projection tomography
10.1038/s41467-024-51616-y · 2024 · External reference
Current Trends of Raman Spectroscopy in Clinic Settings: Opportunities and Challenges
10.1002/advs.202300668 · 2024 · External reference
In vivo surface-enhanced Raman scattering techniques: nanoprobes, instrumentation, and applications
10.1038/s41377-024-01718-5 · 2025 · External reference
Biomedical SERS - the current state and future trends
10.1039/d4cs00090k · 2024 · External reference
Developments in spontaneous and coherent Raman scattering microscopic imaging for biomedical applications
10.1039/c5cs00564g · 2016 · External reference
Fundamentals and Applications of Raman-Based Techniques for the Design and Development of Active Biomedical Materials
10.1002/adma.202210807 · 2024 · External reference
In Situ Spectral Monitoring of mRNA Translation in Embryonic Stem Cells during Differentiation in Vitro
10.1021/ac0498720 · 2004 · External reference
The Emerging Role of Raman Spectroscopy as an Omics Approach for Metabolic Profiling and Biomarker Detection toward Precision Medicine
10.1021/acs.chemrev.2c00897 · 2023 · External reference
Prediction of single-cell RNA expression profiles in live cells by Raman microscopy with Raman2RNA
10.1038/s41587-023-02082-2 · 2024 · External reference
Label-Free Detection of Biochemical Changes during Cortical Organoid Maturation via Raman Spectroscopy and Machine Learning
10.1021/acs.analchem.4c05661 · 2025 · External reference
Cisplatin-Induced Metabolic Responses Measured with Raman Spectroscopy in Cancer Cells, Spheroids, and Canine-Derived Organoids
10.1021/acsami.4c08629 · 2024 · External reference
Quantitative chemometric phenotyping of three-dimensional liver organoids by Raman spectral imaging
10.1016/j.crmeth.2023.100440 · 2023 · External reference
Label-free live-cell imaging with confocal Raman microscopy
10.1016/j.bpj.2011.12.027 · 2012 · External reference
In vivo organoid growth monitoring by stimulated Raman histology
10.1038/s44303-024-00019-1 · 2024 · External reference
Deep learning and artificial intelligence methods for Raman and surface-enhanced Raman scattering
10.1016/j.trac.2019.115796 · 2020 · External reference
Recent Advances in Raman Spectral Classification with Machine Learning
10.3390/s26010341 · 2026 · External reference
Application of the Dynamical Network Biomarker Theory to Raman Spectra
10.3390/biom12121730 · 2022 · External reference
Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts
10.1038/nature09637 · 2011 · External reference
Characterizing the effects of triclosan and triclocarban on the intestinal epithelial homeostasis using small intestinal organoids
10.1016/j.jhazmat.2024.135734 · 2024 · External reference
Raman spectroscopy and regenerative medicine: a review
10.1038/s41536-017-0014-3 · 2017 · External reference
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
10.1038/nature07935 · 2009 · External reference
Self-organized intestinal epithelial monolayers in crypt and villus-like domains show effective barrier function
10.1038/s41598-019-46497-x · 2019 · External reference
Studies on Stress-Induced Changes at the Subcellular Level by Raman Microspectroscopic Mapping
10.1021/ac060205b · 2006 · External reference
Raman identification of single nucleotides flowing through permeable plasmonic films
10.1038/s41467-025-64165-9 · 2025 · External reference
Multi-Excitation Raman Spectroscopy for Label-Free, Strain-Level Characterization of Bacterial Pathogens in Artificial Sputum Media
10.1021/acs.analchem.1c02501 · 2022 · External reference
Raman spectroscopy: techniques and applications in the life sciences
10.1364/aop.9.000315 · 2017 · External reference
Electrode- and Label-Free Assessment of Electrophysiological Firing Rates through Cytochrome C Monitoring via Raman Spectroscopy
10.1021/acssensors.4c03133 · 2025 · External reference
Fundamentals and Applications of Raman-Based Techniques for the Design and Development of Active Biomedical Materials
10.1002/adma.202210807 · ExternalCitation · doi-reference
Current Trends of Raman Spectroscopy in Clinic Settings: Opportunities and Challenges
10.1002/advs.202300668 · ExternalCitation · doi-reference
Organoid assessment technologies
10.1002/ctm2.1499 · ExternalCitation · doi-reference
Organoids: development and applications in disease models, drug discovery, precision medicine, and regenerative medicine
10.1002/mco2.735 · ExternalCitation · doi-reference
Label-free live-cell imaging with confocal Raman microscopy
10.1016/j.bpj.2011.12.027 · ExternalCitation · doi-reference
Human organoids: New strategies and methods for analyzing human development and disease
10.1016/j.cell.2022.06.051 · ExternalCitation · doi-reference
Quantitative chemometric phenotyping of three-dimensional liver organoids by Raman spectral imaging
10.1016/j.crmeth.2023.100440 · ExternalCitation · doi-reference
Characterizing the effects of triclosan and triclocarban on the intestinal epithelial homeostasis using small intestinal organoids
10.1016/j.jhazmat.2024.135734 · ExternalCitation · doi-reference
Development of an automated 3D high content cell screening platform for organoid phenotyping
10.1016/j.slasd.2024.100182 · ExternalCitation · doi-reference
Inflation-collapse dynamics drive patterning and morphogenesis in intestinal organoids
10.1016/j.stem.2021.04.002 · ExternalCitation · doi-reference
Deep learning and artificial intelligence methods for Raman and surface-enhanced Raman scattering
10.1016/j.trac.2019.115796 · ExternalCitation · doi-reference
scTrends: A living review of commercial single-cell and spatial ’omic technologies
10.1016/j.xgen.2024.100723 · ExternalCitation · doi-reference
Immunofluorescent staining of cancer spheroids and fine-needle aspiration-derived organoids
10.1016/j.xpro.2021.100578 · ExternalCitation · doi-reference
In Situ Spectral Monitoring of mRNA Translation in Embryonic Stem Cells during Differentiation in Vitro
10.1021/ac0498720 · ExternalCitation · doi-reference
Studies on Stress-Induced Changes at the Subcellular Level by Raman Microspectroscopic Mapping
10.1021/ac060205b · ExternalCitation · doi-reference
Multi-Excitation Raman Spectroscopy for Label-Free, Strain-Level Characterization of Bacterial Pathogens in Artificial Sputum Media
10.1021/acs.analchem.1c02501 · ExternalCitation · doi-reference
Label-Free Detection of Biochemical Changes during Cortical Organoid Maturation via Raman Spectroscopy and Machine Learning
10.1021/acs.analchem.4c05661 · ExternalCitation · doi-reference
The Emerging Role of Raman Spectroscopy as an Omics Approach for Metabolic Profiling and Biomarker Detection toward Precision Medicine
10.1021/acs.chemrev.2c00897 · ExternalCitation · doi-reference
Cisplatin-Induced Metabolic Responses Measured with Raman Spectroscopy in Cancer Cells, Spheroids, and Canine-Derived Organoids
10.1021/acsami.4c08629 · ExternalCitation · doi-reference
Electrode- and Label-Free Assessment of Electrophysiological Firing Rates through Cytochrome C Monitoring via Raman Spectroscopy
10.1021/acssensors.4c03133 · ExternalCitation · doi-reference
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
10.1038/nature07935 · ExternalCitation · doi-reference
Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts
10.1038/nature09637 · ExternalCitation · doi-reference
Organoids in image-based phenotypic chemical screens
10.1038/s12276-021-00641-8 · ExternalCitation · doi-reference
Patient-derived tumor organoids: a new avenue for preclinical research and precision medicine in oncology
10.1038/s12276-024-01272-5 · ExternalCitation · doi-reference
Long-term three-dimensional high-resolution imaging of live unlabeled small intestinal organoids via low-coherence holotomography
10.1038/s12276-024-01312-0 · ExternalCitation · doi-reference
In vivo surface-enhanced Raman scattering techniques: nanoprobes, instrumentation, and applications
10.1038/s41377-024-01718-5 · ExternalCitation · doi-reference
Human organoids in basic research and clinical applications
10.1038/s41392-022-01024-9 · ExternalCitation · doi-reference
Drug screening at single-organoid resolution via bioprinting and interferometry
10.1038/s41467-023-38832-8 · ExternalCitation · doi-reference
An integrated organoid omics map extends modeling potential of kidney disease
10.1038/s41467-023-39740-7 · ExternalCitation · doi-reference
Label-free 3D molecular imaging of living tissues using Raman spectral projection tomography
10.1038/s41467-024-51616-y · ExternalCitation · doi-reference
Raman identification of single nucleotides flowing through permeable plasmonic films
10.1038/s41467-025-64165-9 · ExternalCitation · doi-reference
Raman spectroscopy and regenerative medicine: a review
10.1038/s41536-017-0014-3 · ExternalCitation · doi-reference
Human organoids with an autologous tissue-resident immune compartment
10.1038/s41586-024-07791-5 · ExternalCitation · doi-reference
An integrated transcriptomic cell atlas of human neural organoids
10.1038/s41586-024-08172-8 · ExternalCitation · doi-reference
Pathology-oriented multiplexing enables integrative disease mapping
10.1038/s41586-025-09225-2 · ExternalCitation · doi-reference
Multimodal spatiotemporal phenotyping of human retinal organoid development
10.1038/s41587-023-01747-2 · ExternalCitation · doi-reference
Prediction of single-cell RNA expression profiles in live cells by Raman microscopy with Raman2RNA
10.1038/s41587-023-02082-2 · ExternalCitation · doi-reference
Spatiotemporal, optogenetic control of gene expression in organoids
10.1038/s41592-023-01986-w · ExternalCitation · doi-reference
Self-organized intestinal epithelial monolayers in crypt and villus-like domains show effective barrier function
10.1038/s41598-019-46497-x · ExternalCitation · doi-reference
Multiscale 3D phenotyping of human cerebral organoids
10.1038/s41598-020-78130-7 · ExternalCitation · doi-reference
Non-invasive label-free imaging analysis pipeline for in situ characterization of 3D brain organoids
10.1038/s41598-024-72038-2 · ExternalCitation · doi-reference
In vivo organoid growth monitoring by stimulated Raman histology
10.1038/s44303-024-00019-1 · ExternalCitation · doi-reference
Developments in spontaneous and coherent Raman scattering microscopic imaging for biomedical applications
10.1039/c5cs00564g · ExternalCitation · doi-reference
Biomedical SERS - the current state and future trends
10.1039/d4cs00090k · ExternalCitation · doi-reference
Human cerebral organoids recapitulate gene expression programs of fetal neocortex development
10.1073/pnas.1520760112 · ExternalCitation · doi-reference
Organoid Imaging: Seeing Development and Function
10.1146/annurev-cellbio-120320-035146 · ExternalCitation · doi-reference
A Perspective on Expanding Our Understanding of Cancer Treatments by Integrating Approaches from the Biological and Physical Sciences
10.1177/2472555220915830 · ExternalCitation · doi-reference
High-Throughput Imaging Assay for Drug Screening of 3D Prostate Cancer Organoids
10.1177/24725552211020668 · ExternalCitation · doi-reference
Three-dimensional in vitro culture models in oncology research
10.1186/s13578-022-00887-3 · ExternalCitation · doi-reference
Single-cell sequencing and organoids: applications in organ development and disease
10.1186/s43556-025-00364-6 · ExternalCitation · doi-reference
Label-free Molecular Imaging and Analysis by Raman Spectroscopy
10.1267/ahc.18019 · ExternalCitation · doi-reference
Raman spectroscopy: techniques and applications in the life sciences
10.1364/aop.9.000315 · ExternalCitation · doi-reference
Present Application and Perspectives of Organoid Imaging Technology
10.3390/bioengineering9030121 · ExternalCitation · doi-reference
Application of the Dynamical Network Biomarker Theory to Raman Spectra
10.3390/biom12121730 · ExternalCitation · doi-reference
Viability Analysis and High-Content Live-Cell Imaging for Drug Testing in Prostate Cancer Xenograft-Derived Organoids
10.3390/cells12101377 · ExternalCitation · doi-reference
Recent Advances in Raman Spectral Classification with Machine Learning
10.3390/s26010341 · ExternalCitation · doi-reference
2D and 3D cell cultures - a comparison of different types of cancer cell cultures
10.5114/aoms.2016.63743 · ExternalCitation · doi-reference
