Research graph
References from Practical Synthesis of Methyl <i>N</i> 2-( <i>tert</i> -butoxycarbonyl)- <i>N</i> 4-(1-( <i>tert</i> -butyl)-1 <i>H</i> -pyrazol-4-yl)- <i>L</i> -asparaginyl- <i>L</i> -phenylalaninate Utilizing Continuous-Flow Technology. Local targets link to admitted publications; unresolved targets remain external evidence.
Peptide Therapeutics 2.0
10.3390/molecules25102293 · 2020 · External reference
Trends in peptide drug discovery
10.1038/s41573-020-00135-8 · 2021 · External reference
Peptide-based therapeutics: challenges and solutions
10.1007/s00044-024-03269-1 · 2024 · External reference
Recent developments in the reduction of aromatic and aliphatic nitro compounds to amines
10.1021/acs.oprd.6b00205 · 2018 · External reference
Selective hydrogenation for fine chemicals: recent trends and new developments
10.1002/adsc.200390000 · 2003 · External reference
Catalytic static mixer-enabled hydrogenation of a key fenebrutinib intermediate: real-time analysis for a stable and scalable process
10.1021/acs.oprd.1c00258 · 2021 · External reference
Catalytic transfer hydrogenation
10.1021/cr60291a003 · 1974 · External reference
Ten key issues in modern flow chemistry
10.1039/c0cc05060a · 2011 · External reference
The hitchhiker’s guide to flow chemistry
10.1021/acs.chemrev.7b00183 · 2017 · External reference
Fixed bed continuous hydrogenations in trickle flow mode: A pharmaceutical industry perspective
10.1021/acs.oprd.2c00034 · 2022 · External reference
Recent progress in continuous-flow hydrogenation
10.1002/cssc.202000778 · 2020 · External reference
Process intensification for the continuous flow hydrogenation of ethyl nicotinate
10.1021/op500208j · 2014 · External reference
Heterogeneous catalytic hydrogenation reactions in continuous-flow reactors
10.1002/cssc.201000354 · 2011 · External reference
Membrane reactor based on hybrid nanomaterials for process intensification of catalytic hydrogenation reaction: an example of reduction of the environmental footprint of chemical synthesis from a batch to a continuous flow chemistry process
10.3303/cet1647062 · 2016 · External reference
The expanding utility of continuous flow hydrogenation
10.1039/c5ob01067e · 2015 · External reference
Improved continuous flow processing: benzimidazole ring formation via catalytic hydrogenation of an aromatic nitro compound
10.1021/op400179f · 2014 · External reference
Recent developments in the use of flow hydrogenation in the field of medicinal chemistry
10.5772/65518 · 2017 · External reference
Hydrogenation of nitroarenes in continuous flow with TPP/Raney Ni
10.1007/s41981-021-00156-3 · 2021 · External reference
Synthesis of a crizotinib intermediate via highly efficient catalytic hydrogenation in continuous flow
10.1021/acs.oprd.0c00302 · 2020 · External reference
Catalytic hydrogenation of N-4-nitrophenyl nicotinamide in a micro-packed bed reactor
10.1039/c7gc03469e · 2018 · External reference
Fast gas–liquid–solid reactions in monoliths: A case study of nitro-aromatic hydrogenation
10.1016/j.cattod.2005.06.028 · 2005 · External reference
Gas-liquid hydrogenation in continuous flow–The effect of mass transfer and residence time in powder packed-bed and catalyst-coated reactors
10.1016/j.cej.2019.122292 · 2020 · External reference
Modeling and Simulation of the Hydrogenation of α-Methylstyrene on Catalytically Active Metal Foams as Tubular Reactor Packing
10.1155/2016/7082381 · 2016 · External reference
Evaluation of reactor concepts for the continuous production of fine chemicals using the selective hydrogenation of cinnamaldehyde over palladium catalysts
10.1016/j.cattod.2013.12.051 · 2015 · External reference
Structuring hybrid palladium nanoparticles in metallic monolithic reactors for continuous-flow three-phase alkyne hydrogenation
10.1039/c6re00114a · 2016 · External reference
Using PAT to understand, control, and rapidly scale up the production of a hydrogenation reaction and isolation of pharmaceutical intermediate
10.1021/op500285x · 2015 · External reference
In situ monitoring of catalytic three-phase enantioselective hydrogenation using FTIR/ATR spectroscopy
10.1016/j.apcata.2003.12.019 · 2004 · External reference
Catalytic three-phase diastereoselective hydrogenation of o-toluic and 2-methyl nicotinic acid derivatives: In situ FTIR/ATR investigation
10.1016/j.vibspec.2007.04.003 · 2007 · External reference
Process analytical technology (PAT): applications to flow processes for active pharmaceutical ingredient (API) development
10.1039/d2re00004k · 2022 · External reference
Amide bonds meet flow chemistry: a journey into methodologies and sustainable evolution
10.1002/cssc.202102708 · 2022 · External reference
Recent advances in the solid-and solution-phase synthesis of peptides and proteins using microflow technology
10.1021/acs.oprd.2c00074 · 2022 · External reference
A fully automated flow-based approach for accelerated peptide synthesis
10.1038/nchembio.2318 · 2017 · External reference
Deep learning for prediction and optimization of fast-flow peptide synthesis
10.1021/acscentsci.0c00979 · 2020 · External reference
Evaluation of sponge metal catalysts in a trickle bed reactor for the continuous hydrogenation of an aliphatic nitro intermediate
10.1021/acs.oprd.9b00447 · 2020 · External reference
Run Parameters for a Continuous Hydrogenation Process Using ACMC-Pd To Replace Commercial Batch Reactor Processes
10.1021/acs.oprd.8b00286 · 2018 · External reference
Hydrogenation of aromatic nitrogroups with precious metal powder catalysts: influence of modifier on selectivity and activity
10.1007/s11244-010-9545-1 · 2010 · External reference
Studying the Three-Phase Hydrogenation of Nitrobenzene to Aniline in the Presense of a Ruthenium Catalyst
10.1134/s2070050418040049 · 2018 · External reference
Liquid phase hydrogenation of nitrobenzene
10.1016/j.apcata.2015.04.002 · 2015 · External reference
Site-selective thiolation of (multi) halogenated heteroarenes
10.1021/jacs.0c01630 · 2020 · External reference
Dual transition metal electrocatalysis: direct decarboxylative alkenylation of aliphatic carboxylic acids
10.1021/jacs.3c08839 · 2023 · External reference
Peptide couplings by reactive extrusion: solid-tolerant and free from carcinogenic, mutagenic and reprotoxic chemicals
10.1021/acssuschemeng.8b04509 · 2018 · External reference
Selective hydrogenation for fine chemicals: recent trends and new developments
10.1002/adsc.200390000 · ExternalCitation · doi-reference
Heterogeneous catalytic hydrogenation reactions in continuous-flow reactors
10.1002/cssc.201000354 · ExternalCitation · doi-reference
Recent progress in continuous-flow hydrogenation
10.1002/cssc.202000778 · ExternalCitation · doi-reference
Amide bonds meet flow chemistry: a journey into methodologies and sustainable evolution
10.1002/cssc.202102708 · ExternalCitation · doi-reference
Peptide-based therapeutics: challenges and solutions
10.1007/s00044-024-03269-1 · ExternalCitation · doi-reference
Hydrogenation of aromatic nitrogroups with precious metal powder catalysts: influence of modifier on selectivity and activity
10.1007/s11244-010-9545-1 · ExternalCitation · doi-reference
Hydrogenation of nitroarenes in continuous flow with TPP/Raney Ni
10.1007/s41981-021-00156-3 · ExternalCitation · doi-reference
In situ monitoring of catalytic three-phase enantioselective hydrogenation using FTIR/ATR spectroscopy
10.1016/j.apcata.2003.12.019 · ExternalCitation · doi-reference
Liquid phase hydrogenation of nitrobenzene
10.1016/j.apcata.2015.04.002 · ExternalCitation · doi-reference
Fast gas–liquid–solid reactions in monoliths: A case study of nitro-aromatic hydrogenation
10.1016/j.cattod.2005.06.028 · ExternalCitation · doi-reference
Evaluation of reactor concepts for the continuous production of fine chemicals using the selective hydrogenation of cinnamaldehyde over palladium catalysts
10.1016/j.cattod.2013.12.051 · ExternalCitation · doi-reference
Gas-liquid hydrogenation in continuous flow–The effect of mass transfer and residence time in powder packed-bed and catalyst-coated reactors
10.1016/j.cej.2019.122292 · ExternalCitation · doi-reference
Catalytic three-phase diastereoselective hydrogenation of o-toluic and 2-methyl nicotinic acid derivatives: In situ FTIR/ATR investigation
10.1016/j.vibspec.2007.04.003 · ExternalCitation · doi-reference
The hitchhiker’s guide to flow chemistry
10.1021/acs.chemrev.7b00183 · ExternalCitation · doi-reference
Synthesis of a crizotinib intermediate via highly efficient catalytic hydrogenation in continuous flow
10.1021/acs.oprd.0c00302 · ExternalCitation · doi-reference
Catalytic static mixer-enabled hydrogenation of a key fenebrutinib intermediate: real-time analysis for a stable and scalable process
10.1021/acs.oprd.1c00258 · ExternalCitation · doi-reference
Fixed bed continuous hydrogenations in trickle flow mode: A pharmaceutical industry perspective
10.1021/acs.oprd.2c00034 · ExternalCitation · doi-reference
Recent advances in the solid-and solution-phase synthesis of peptides and proteins using microflow technology
10.1021/acs.oprd.2c00074 · ExternalCitation · doi-reference
Recent developments in the reduction of aromatic and aliphatic nitro compounds to amines
10.1021/acs.oprd.6b00205 · ExternalCitation · doi-reference
Run Parameters for a Continuous Hydrogenation Process Using ACMC-Pd To Replace Commercial Batch Reactor Processes
10.1021/acs.oprd.8b00286 · ExternalCitation · doi-reference
Evaluation of sponge metal catalysts in a trickle bed reactor for the continuous hydrogenation of an aliphatic nitro intermediate
10.1021/acs.oprd.9b00447 · ExternalCitation · doi-reference
Deep learning for prediction and optimization of fast-flow peptide synthesis
10.1021/acscentsci.0c00979 · ExternalCitation · doi-reference
Peptide couplings by reactive extrusion: solid-tolerant and free from carcinogenic, mutagenic and reprotoxic chemicals
10.1021/acssuschemeng.8b04509 · ExternalCitation · doi-reference
Catalytic transfer hydrogenation
10.1021/cr60291a003 · ExternalCitation · doi-reference
Site-selective thiolation of (multi) halogenated heteroarenes
10.1021/jacs.0c01630 · ExternalCitation · doi-reference
Dual transition metal electrocatalysis: direct decarboxylative alkenylation of aliphatic carboxylic acids
10.1021/jacs.3c08839 · ExternalCitation · doi-reference
Improved continuous flow processing: benzimidazole ring formation via catalytic hydrogenation of an aromatic nitro compound
10.1021/op400179f · ExternalCitation · doi-reference
Process intensification for the continuous flow hydrogenation of ethyl nicotinate
10.1021/op500208j · ExternalCitation · doi-reference
Using PAT to understand, control, and rapidly scale up the production of a hydrogenation reaction and isolation of pharmaceutical intermediate
10.1021/op500285x · ExternalCitation · doi-reference
A fully automated flow-based approach for accelerated peptide synthesis
10.1038/nchembio.2318 · ExternalCitation · doi-reference
Trends in peptide drug discovery
10.1038/s41573-020-00135-8 · ExternalCitation · doi-reference
Ten key issues in modern flow chemistry
10.1039/c0cc05060a · ExternalCitation · doi-reference
The expanding utility of continuous flow hydrogenation
10.1039/c5ob01067e · ExternalCitation · doi-reference
Structuring hybrid palladium nanoparticles in metallic monolithic reactors for continuous-flow three-phase alkyne hydrogenation
10.1039/c6re00114a · ExternalCitation · doi-reference
Catalytic hydrogenation of N-4-nitrophenyl nicotinamide in a micro-packed bed reactor
10.1039/c7gc03469e · ExternalCitation · doi-reference
Process analytical technology (PAT): applications to flow processes for active pharmaceutical ingredient (API) development
10.1039/d2re00004k · ExternalCitation · doi-reference
Studying the Three-Phase Hydrogenation of Nitrobenzene to Aniline in the Presense of a Ruthenium Catalyst
10.1134/s2070050418040049 · ExternalCitation · doi-reference
Modeling and Simulation of the Hydrogenation of α-Methylstyrene on Catalytically Active Metal Foams as Tubular Reactor Packing
10.1155/2016/7082381 · ExternalCitation · doi-reference
Membrane reactor based on hybrid nanomaterials for process intensification of catalytic hydrogenation reaction: an example of reduction of the environmental footprint of chemical synthesis from a batch to a continuous flow chemistry process
10.3303/cet1647062 · ExternalCitation · doi-reference
Peptide Therapeutics 2.0
10.3390/molecules25102293 · ExternalCitation · doi-reference
Recent developments in the use of flow hydrogenation in the field of medicinal chemistry
10.5772/65518 · ExternalCitation · doi-reference
