Research graph
References from Photoredox-Catalyzed Radical Heterocyclization of Heteroatom-Tethered Alkenes with α-Iodonium Diazo Compounds. Local targets link to admitted publications; unresolved targets remain external evidence.
Lactones: Classification, synthesis, biological activities, and industrial applications
10.1016/j.tet.2021.132001 · 2021 · External reference
A Review of the Pharmacological Activities and Recent Synthetic Advances of γ-Butyrolactones
10.3390/ijms22052769 · 2021 · External reference
Analysis of the Structural Diversity, Substitution Patterns, and Frequency of Nitrogen Heterocycles among U.S. FDA Approved Pharmaceuticals
10.1021/jm501100b · 2014 · External reference
An Update on the Nitrogen Heterocycle Compositions and Properties of U.S. FDA-Approved Pharmaceuticals (2013–2023)
10.1021/acs.jmedchem.4c01122 · 2024 · External reference
Recent advances in copper-catalysed radical-involved asymmetric 1,2-difunctionalization of alkenes
10.1039/c9cs00681h · 2020 · External reference
Radical Strategy for the Transition-Metal-Catalyzed Synthesis of γ-Lactones: A Review
10.1055/s-0040-1707835 · 2020 · External reference
Recent advances in cascade radical cyclization of radical acceptors for the synthesis of carbo- and heterocycles
10.1039/d0qo01453b · 2021 · External reference
Radical Cascade Cyclization of Alkene-Tethered Compounds: Versatile Approach towards Ring-Fused Polycyclic Structures
10.1002/ajoc.202300101 · 2023 · External reference
Diazotrifluoroethyl Radical in Photoinduced [3 + 2] Cycloadditions
10.1021/acs.orglett.5c05142 · 2026 · External reference
Electrophotocatalytic Radical Cyclizations
10.1002/adsc.70313 · 2026 · External reference
Radical–Radical Cyclization Cascades of Barbiturates Triggered by Electron-Transfer Reduction of Amide-Type Carbonyls
10.1021/jacs.6b04086 · 2016 · External reference
Organoelectrocatalysis Enables Direct Cyclopropanation of Methylene Compounds
10.1021/jacs.1c12762 · 2022 · External reference
Ketone–Olefin Coupling of Aliphatic and Aromatic Carbonyls Catalyzed by Excited-State Acridine Radicals
10.1021/jacs.2c04822 · 2022 · External reference
Methyl Ketones as Alkyl Halide Surrogates: A Deacylative Halogenation Approach for Strategic Functional Group Conversions
10.1021/jacs.3c08176 · 2023 · External reference
Photocatalytic Tandem Radical Cyclization Enables Expeditious Total Synthesis of Epoxyhinokiol Analogues for Anticancer Activity Evaluation
10.1021/acs.orglett.3c03811 · 2024 · External reference
Biocatalytic Metal Hydrogen Atom Transfer for Asymmetric Olefin–Olefin Coupling
10.1021/jacs.6c01998 · 2026 · External reference
Catalytic Olefin Hydroamination with Aminium Radical Cations: A Photoredox Method for Direct C–N Bond Formation
10.1021/ja5056774 · 2014 · External reference
Diastereoselective Synthesis of CF3- and CF2H- Substituted Spiroethers from Aryl-Fused Cycloalkenylalkanols by Photoredox Catalysis
10.1021/acs.joc.6b00953 · 2016 · External reference
Iminyl-Radicals by Oxidation of α-Imino-oxy Acids: Photoredox-Neutral Alkene Carboimination for the Synthesis of Pyrrolines
10.1002/anie.201706270 · 2017 · External reference
New mode of asymmetric induction for enantioselective radical N-heterobicyclization via kinetically stable chiral radical center
10.1016/j.chempr.2023.09.010 · 2024 · External reference
Photodriven Enantioselective 6-endo Hydroaminative Cyclization to Chiral 4-Substituted 3,4-Dihydroisoquinolones
10.1021/jacs.5c16930 · 2026 · External reference
Asymmetric Hydroamination Using Oxidative Radical Initiation in Flavin Enzymes
10.1021/jacs.6c04368 · 2026 · External reference
Enantioselective Functionalization of Radical Intermediates in Redox Catalysis: Copper-Catalyzed Asymmetric Oxytrifluoromethylation of Alkenes
10.1002/anie.201307790 · 2013 · External reference
Highly Regio- and Diastereoselective Synthesis of CF3-Substituted Lactones via Photoredox-Catalyzed Carbolactonization of Alkenoic Acids
10.1021/ol403500y · 2014 · External reference
Visible-light-mediated difluoromethylphosphonation of alkenes for the synthesis of CF2P-containing heterocycles
10.1039/c9qo01030k · 2019 · External reference
De Novo Synthesis of γ,γ-Disubstituted Butyrolactones through a Visible Light Photocatalytic Arylation–Lactonization Sequence
10.1002/adsc.201400041 · 2014 · External reference
Versatile Enantioselective Synthesis of Functionalized Lactones via Copper-Catalyzed Radical Oxyfunctionalization of Alkenes
10.1021/jacs.5b04821 · 2015 · External reference
Copper-Catalyzed Amino Lactonization and Amino Oxygenation of Alkenes Using O-Benzoylhydroxylamines
10.1021/jacs.6b02840 · 2016 · External reference
Access to Alkyl-Substituted Lactone via Photoredox-Catalyzed Alkylation/Lactonization of Unsaturated Carboxylic Acids
10.1021/acs.orglett.7b02899 · 2017 · External reference
Access to Aminated Saturated Oxygen Heterocycles via Copper-Catalyzed Aminooxygenation of Alkenes
10.1021/acs.orglett.7b00182 · 2017 · External reference
Copper(I)-Catalyzed Oxydifluoroalkylation of Alkenes: A Route to Functionalization of Lactones
10.1021/acs.orglett.8b02069 · 2018 · External reference
Di-tert-butyl Peroxide (DTBP)-Mediated Oxysilylation of Unsaturated Carboxylic Acids for the Synthesis of Silyl Lactones
10.1021/acs.orglett.0c03640 · 2020 · External reference
Atom Transfer Radical Coupling Enables Highly Enantioselective Carbo-Oxygenation of Alkenes with Hydrocarbons
10.1021/jacs.3c07008 · 2023 · External reference
Synthesis of CHF2-Containing Heterocycles through Oxy-difluoromethylation Using Low-Cost 3D Printed PhotoFlow Reactors
10.1021/acs.orglett.3c03997 · 2024 · External reference
Persistent Radical Cation Catalysis Enables Radical-Polar Crossover Cycloisomerization of Unactivated Alkenes to CF3- Heterocycles
10.1021/acs.orglett.5c03659 · 2025 · External reference
Directed Evolution of Copper-Substituted Nonheme Enzymes for Enantioselective Alkene Oxytrifluoromethylation
10.1021/jacs.4c18532 · 2025 · External reference
Copper-Catalyzed Asymmetric Amino Lactonization of Alkenes: Direct Access to Enantioenriched 1,2-Alkylamino Alcohol Derivatives
10.1021/jacs.5c23103 · 2026 · External reference
Reactions between Diazo Compounds and Hypervalent Iodine(III) Reagents
10.1002/anie.202003081 · 2020 · External reference
Synthesis of Hypervalent Iodine Diazo Compounds and Their Application in Organic Synthesis
10.1002/chem.202302718 · 2024 · External reference
Visible Light-Induced Reactions of Diazo Compounds and Their Precursors
10.1021/acs.chemrev.3c00869 · 2024 · External reference
Chemo- and diastereoselective four-component reactions with Rh carbynoids
10.1016/j.gresc.2024.10.006 · 2025 · External reference
Room Temperature Ruthenium-Catalyzed Coupling of Cyclopropanols and α-Diazo-β-ketoesters to α-Ester-δ-diketones
10.1021/acs.joc.5c01259 · 2025 · External reference
Convergent Synthesis of Functionalized Indolines from Alkyl Aryl Tertiary Amines and Diazoesters via Visible Light-Driven [4 + 1] Annulation Approach
10.1021/acs.orglett.5c02530 · 2025 · External reference
Photocatalytic free radical geminal carboamination of α-diazo esters toward chromone-derived α-amino acids
10.1016/j.cclet.2025.112202 · 2026 · External reference
Generating carbyne equivalents with photoredox catalysis
10.1038/nature25185 · 2018 · External reference
Photoredox-Catalyzed Cascade sp2 C–H Bond Functionalization to Construct Substituted Acridine with Diarylamine and Hypervalent Iodine(III) Reagents
10.1021/acs.orglett.2c04114 · 2023 · External reference
Trifluoromethylcarbinolation of (hetero)arenes enabled by trifluoromethyl carbyne
10.1007/s11426-025-2728-6 · 2025 · External reference
Csp3–H Bond Carbynoid Functionalization by Photoredox Catalysis
10.1021/acs.orglett.6c01646 · 2026 · External reference
Photoredox Catalysis Enables Decarboxylative Cyclization with Hypervalent Iodine(III) Reagents: Access to 2,5-Disubstituted 1,3,4-Oxadiazoles
10.1021/acs.orglett.0c03663 · 2020 · External reference
Diazotrifluoroethyl Radical: A CF3-Containing Building Block in [3 + 2] Cycloaddition
10.1021/acs.orglett.1c03603 · 2021 · External reference
Catalyst-Free Visible-Light-Promoted Cyclization of Aldehydes: Access to 2,5-Disubstituted 1,3,4-Oxadiazole Derivatives
10.1021/acsomega.1c04098 · 2021 · External reference
Synthesis of [1,2,3]Triazolo-[1,5-a]quinoxalin-4(5H)-ones through Photoredox-Catalyzed [3 + 2] Cyclization Reactions with Hypervalent Iodine(III) Reagents
10.1021/acs.joc.2c00135 · 2022 · External reference
Diazotrifluoroethyl Radical in Photoinduced [3 + 2] Cycloadditions
10.1021/acs.orglett.5c05142 · 2026 · External reference
Ring expansion of indene by photoredox-enabled functionalized carbon-atom insertion
10.1038/s41929-023-01089-x · 2024 · External reference
Photoredox-Catalyzed [2 + 1 + 2] Cyclization of Alkenes, Carbyne Equivalents, and Nitriles
10.1021/acscatal.5c02051 · 2025 · External reference
Photochemical Skeletal Editing of α,β-Unsaturated Ketones to Furans via Single-Carbon-Atom Insertion
10.1021/acs.orglett.6c02029 · 2026 · External reference
Oxydiazomethylation of Alkenes via Photoredox Catalysis
10.1002/chem.202403509 · 2025 · External reference
Alkoxy Diazomethylation of Alkenes by Photoredox-Catalyzed Oxidative Radical-Polar Crossover
10.1021/jacs.4c00867 · 2024 · External reference
Recent advances in copper-catalysed radical-involved asymmetric 1,2-difunctionalization of alkenes
10.1039/c9cs00681h · 2020 · External reference
Copper-catalyzed radical relay in C(sp3)–H functionalization
10.1039/d1cs00727k · 2022 · External reference
Copper-Catalyzed Benzylic C–H Cross-Coupling Enabled by Redox Buffers: Expanding Synthetic Access to Three-Dimensional Chemical Space
10.1021/acs.accounts.3c00580 · 2023 · External reference
Metal-Bound Heteroatom Radicals: Advancing Site-Selective C–H Functionalization
10.1021/jacs.5c07456 · 2025 · External reference
Enantioselective Three-Component Radical Alkene Diazomethyl-Cyanation Enabled by Copper/Photoredox Dual Catalysis
10.1021/acscatal.5c08757 · 2026 · External reference
Diazo-Preserving Radical Cascades for the Modular Photoinduced Synthesis of Oxindoles and Pyrazolones
10.1021/acs.orglett.6c01312 · 2026 · External reference
Photocatalytic Trifluoromethyl Carbyne Equivalent Generation: A Modular Platform for Cascade Cycloannulation
10.1021/acs.orglett.6c02053 · 2026 · External reference
Structurally Constrained Cyclic (Diacyloxyiodo)Arenes as an Enabling Platform for Hypervalent Iodine(III) Chemistry
10.1002/advs.202506041 · 2025 · External reference
Phthalides and Phthalans: Synthetic Methodologies and Their Applications in the Total Synthesis
10.1021/cr400524q · 2014 · External reference
De Novo Synthesis of γ,γ-Disubstituted Butyrolactones through a Visible Light Photocatalytic Arylation–Lactonization Sequence
10.1002/adsc.201400041 · ExternalCitation · doi-reference
Electrophotocatalytic Radical Cyclizations
10.1002/adsc.70313 · ExternalCitation · doi-reference
Structurally Constrained Cyclic (Diacyloxyiodo)Arenes as an Enabling Platform for Hypervalent Iodine(III) Chemistry
10.1002/advs.202506041 · ExternalCitation · doi-reference
Radical Cascade Cyclization of Alkene-Tethered Compounds: Versatile Approach towards Ring-Fused Polycyclic Structures
10.1002/ajoc.202300101 · ExternalCitation · doi-reference
Enantioselective Functionalization of Radical Intermediates in Redox Catalysis: Copper-Catalyzed Asymmetric Oxytrifluoromethylation of Alkenes
10.1002/anie.201307790 · ExternalCitation · doi-reference
Iminyl-Radicals by Oxidation of α-Imino-oxy Acids: Photoredox-Neutral Alkene Carboimination for the Synthesis of Pyrrolines
10.1002/anie.201706270 · ExternalCitation · doi-reference
Reactions between Diazo Compounds and Hypervalent Iodine(III) Reagents
10.1002/anie.202003081 · ExternalCitation · doi-reference
Synthesis of Hypervalent Iodine Diazo Compounds and Their Application in Organic Synthesis
10.1002/chem.202302718 · ExternalCitation · doi-reference
Oxydiazomethylation of Alkenes via Photoredox Catalysis
10.1002/chem.202403509 · ExternalCitation · doi-reference
Trifluoromethylcarbinolation of (hetero)arenes enabled by trifluoromethyl carbyne
10.1007/s11426-025-2728-6 · ExternalCitation · doi-reference
Photocatalytic free radical geminal carboamination of α-diazo esters toward chromone-derived α-amino acids
10.1016/j.cclet.2025.112202 · ExternalCitation · doi-reference
New mode of asymmetric induction for enantioselective radical N-heterobicyclization via kinetically stable chiral radical center
10.1016/j.chempr.2023.09.010 · ExternalCitation · doi-reference
Chemo- and diastereoselective four-component reactions with Rh carbynoids
10.1016/j.gresc.2024.10.006 · ExternalCitation · doi-reference
Lactones: Classification, synthesis, biological activities, and industrial applications
10.1016/j.tet.2021.132001 · ExternalCitation · doi-reference
Copper-Catalyzed Benzylic C–H Cross-Coupling Enabled by Redox Buffers: Expanding Synthetic Access to Three-Dimensional Chemical Space
10.1021/acs.accounts.3c00580 · ExternalCitation · doi-reference
Visible Light-Induced Reactions of Diazo Compounds and Their Precursors
10.1021/acs.chemrev.3c00869 · ExternalCitation · doi-reference
An Update on the Nitrogen Heterocycle Compositions and Properties of U.S. FDA-Approved Pharmaceuticals (2013–2023)
10.1021/acs.jmedchem.4c01122 · ExternalCitation · doi-reference
Synthesis of [1,2,3]Triazolo-[1,5-a]quinoxalin-4(5H)-ones through Photoredox-Catalyzed [3 + 2] Cyclization Reactions with Hypervalent Iodine(III) Reagents
10.1021/acs.joc.2c00135 · ExternalCitation · doi-reference
Room Temperature Ruthenium-Catalyzed Coupling of Cyclopropanols and α-Diazo-β-ketoesters to α-Ester-δ-diketones
10.1021/acs.joc.5c01259 · ExternalCitation · doi-reference
Diastereoselective Synthesis of CF3- and CF2H- Substituted Spiroethers from Aryl-Fused Cycloalkenylalkanols by Photoredox Catalysis
10.1021/acs.joc.6b00953 · ExternalCitation · doi-reference
Di-tert-butyl Peroxide (DTBP)-Mediated Oxysilylation of Unsaturated Carboxylic Acids for the Synthesis of Silyl Lactones
10.1021/acs.orglett.0c03640 · ExternalCitation · doi-reference
Photoredox Catalysis Enables Decarboxylative Cyclization with Hypervalent Iodine(III) Reagents: Access to 2,5-Disubstituted 1,3,4-Oxadiazoles
10.1021/acs.orglett.0c03663 · ExternalCitation · doi-reference
Diazotrifluoroethyl Radical: A CF3-Containing Building Block in [3 + 2] Cycloaddition
10.1021/acs.orglett.1c03603 · ExternalCitation · doi-reference
Photoredox-Catalyzed Cascade sp2 C–H Bond Functionalization to Construct Substituted Acridine with Diarylamine and Hypervalent Iodine(III) Reagents
10.1021/acs.orglett.2c04114 · ExternalCitation · doi-reference
Photocatalytic Tandem Radical Cyclization Enables Expeditious Total Synthesis of Epoxyhinokiol Analogues for Anticancer Activity Evaluation
10.1021/acs.orglett.3c03811 · ExternalCitation · doi-reference
Synthesis of CHF2-Containing Heterocycles through Oxy-difluoromethylation Using Low-Cost 3D Printed PhotoFlow Reactors
10.1021/acs.orglett.3c03997 · ExternalCitation · doi-reference
Convergent Synthesis of Functionalized Indolines from Alkyl Aryl Tertiary Amines and Diazoesters via Visible Light-Driven [4 + 1] Annulation Approach
10.1021/acs.orglett.5c02530 · ExternalCitation · doi-reference
Persistent Radical Cation Catalysis Enables Radical-Polar Crossover Cycloisomerization of Unactivated Alkenes to CF3- Heterocycles
10.1021/acs.orglett.5c03659 · ExternalCitation · doi-reference
Diazotrifluoroethyl Radical in Photoinduced [3 + 2] Cycloadditions
10.1021/acs.orglett.5c05142 · ExternalCitation · doi-reference
Diazo-Preserving Radical Cascades for the Modular Photoinduced Synthesis of Oxindoles and Pyrazolones
10.1021/acs.orglett.6c01312 · ExternalCitation · doi-reference
Csp3–H Bond Carbynoid Functionalization by Photoredox Catalysis
10.1021/acs.orglett.6c01646 · ExternalCitation · doi-reference
Photochemical Skeletal Editing of α,β-Unsaturated Ketones to Furans via Single-Carbon-Atom Insertion
10.1021/acs.orglett.6c02029 · ExternalCitation · doi-reference
Photocatalytic Trifluoromethyl Carbyne Equivalent Generation: A Modular Platform for Cascade Cycloannulation
10.1021/acs.orglett.6c02053 · ExternalCitation · doi-reference
Access to Aminated Saturated Oxygen Heterocycles via Copper-Catalyzed Aminooxygenation of Alkenes
10.1021/acs.orglett.7b00182 · ExternalCitation · doi-reference
Access to Alkyl-Substituted Lactone via Photoredox-Catalyzed Alkylation/Lactonization of Unsaturated Carboxylic Acids
10.1021/acs.orglett.7b02899 · ExternalCitation · doi-reference
Copper(I)-Catalyzed Oxydifluoroalkylation of Alkenes: A Route to Functionalization of Lactones
10.1021/acs.orglett.8b02069 · ExternalCitation · doi-reference
Photoredox-Catalyzed [2 + 1 + 2] Cyclization of Alkenes, Carbyne Equivalents, and Nitriles
10.1021/acscatal.5c02051 · ExternalCitation · doi-reference
Enantioselective Three-Component Radical Alkene Diazomethyl-Cyanation Enabled by Copper/Photoredox Dual Catalysis
10.1021/acscatal.5c08757 · ExternalCitation · doi-reference
Catalyst-Free Visible-Light-Promoted Cyclization of Aldehydes: Access to 2,5-Disubstituted 1,3,4-Oxadiazole Derivatives
10.1021/acsomega.1c04098 · ExternalCitation · doi-reference
Phthalides and Phthalans: Synthetic Methodologies and Their Applications in the Total Synthesis
10.1021/cr400524q · ExternalCitation · doi-reference
Catalytic Olefin Hydroamination with Aminium Radical Cations: A Photoredox Method for Direct C–N Bond Formation
10.1021/ja5056774 · ExternalCitation · doi-reference
Organoelectrocatalysis Enables Direct Cyclopropanation of Methylene Compounds
10.1021/jacs.1c12762 · ExternalCitation · doi-reference
Ketone–Olefin Coupling of Aliphatic and Aromatic Carbonyls Catalyzed by Excited-State Acridine Radicals
10.1021/jacs.2c04822 · ExternalCitation · doi-reference
Atom Transfer Radical Coupling Enables Highly Enantioselective Carbo-Oxygenation of Alkenes with Hydrocarbons
10.1021/jacs.3c07008 · ExternalCitation · doi-reference
Methyl Ketones as Alkyl Halide Surrogates: A Deacylative Halogenation Approach for Strategic Functional Group Conversions
10.1021/jacs.3c08176 · ExternalCitation · doi-reference
Alkoxy Diazomethylation of Alkenes by Photoredox-Catalyzed Oxidative Radical-Polar Crossover
10.1021/jacs.4c00867 · ExternalCitation · doi-reference
Directed Evolution of Copper-Substituted Nonheme Enzymes for Enantioselective Alkene Oxytrifluoromethylation
10.1021/jacs.4c18532 · ExternalCitation · doi-reference
Versatile Enantioselective Synthesis of Functionalized Lactones via Copper-Catalyzed Radical Oxyfunctionalization of Alkenes
10.1021/jacs.5b04821 · ExternalCitation · doi-reference
Metal-Bound Heteroatom Radicals: Advancing Site-Selective C–H Functionalization
10.1021/jacs.5c07456 · ExternalCitation · doi-reference
Photodriven Enantioselective 6-endo Hydroaminative Cyclization to Chiral 4-Substituted 3,4-Dihydroisoquinolones
10.1021/jacs.5c16930 · ExternalCitation · doi-reference
Copper-Catalyzed Asymmetric Amino Lactonization of Alkenes: Direct Access to Enantioenriched 1,2-Alkylamino Alcohol Derivatives
10.1021/jacs.5c23103 · ExternalCitation · doi-reference
Copper-Catalyzed Amino Lactonization and Amino Oxygenation of Alkenes Using O-Benzoylhydroxylamines
10.1021/jacs.6b02840 · ExternalCitation · doi-reference
Radical–Radical Cyclization Cascades of Barbiturates Triggered by Electron-Transfer Reduction of Amide-Type Carbonyls
10.1021/jacs.6b04086 · ExternalCitation · doi-reference
Biocatalytic Metal Hydrogen Atom Transfer for Asymmetric Olefin–Olefin Coupling
10.1021/jacs.6c01998 · ExternalCitation · doi-reference
Asymmetric Hydroamination Using Oxidative Radical Initiation in Flavin Enzymes
10.1021/jacs.6c04368 · ExternalCitation · doi-reference
Analysis of the Structural Diversity, Substitution Patterns, and Frequency of Nitrogen Heterocycles among U.S. FDA Approved Pharmaceuticals
10.1021/jm501100b · ExternalCitation · doi-reference
Highly Regio- and Diastereoselective Synthesis of CF3-Substituted Lactones via Photoredox-Catalyzed Carbolactonization of Alkenoic Acids
10.1021/ol403500y · ExternalCitation · doi-reference
Generating carbyne equivalents with photoredox catalysis
10.1038/nature25185 · ExternalCitation · doi-reference
Ring expansion of indene by photoredox-enabled functionalized carbon-atom insertion
10.1038/s41929-023-01089-x · ExternalCitation · doi-reference
Recent advances in copper-catalysed radical-involved asymmetric 1,2-difunctionalization of alkenes
10.1039/c9cs00681h · ExternalCitation · doi-reference
Visible-light-mediated difluoromethylphosphonation of alkenes for the synthesis of CF2P-containing heterocycles
10.1039/c9qo01030k · ExternalCitation · doi-reference
Recent advances in cascade radical cyclization of radical acceptors for the synthesis of carbo- and heterocycles
10.1039/d0qo01453b · ExternalCitation · doi-reference
Copper-catalyzed radical relay in C(sp3)–H functionalization
10.1039/d1cs00727k · ExternalCitation · doi-reference
Radical Strategy for the Transition-Metal-Catalyzed Synthesis of γ-Lactones: A Review
10.1055/s-0040-1707835 · ExternalCitation · doi-reference
A Review of the Pharmacological Activities and Recent Synthetic Advances of γ-Butyrolactones
10.3390/ijms22052769 · ExternalCitation · doi-reference
