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References from Comprehensive Biophysical and Biochemical Characterization of Multi-Arm Maleimide-Poly(ethylene glycol) Conjugated Bovine and Human Hemoglobin as Potential Red Blood Cell Substitutes. Local targets link to admitted publications; unresolved targets remain external evidence.
Blood substitutes: evolution and future applications
10.1093/clinchem/43.9.1724 · 1997 · External reference
Blood substitutes based on nanobiotechnology
10.1016/j.tibtech.2006.06.005 · 2006 · External reference
Crisis in the Sustainability of the U.S Blood System
10.1056/nejmsb1706496 · 2017 · External reference
Red cell alloimmunization is associated with development of autoantibodies and increased red cell transfusion requirements in myelodysplastic syndrome
10.3324/haematol.2017.175752 · 2017 · External reference
Engineering Therapeutics to Detoxify Hemoglobin, Heme, and Iron
10.1146/annurev-bioeng-081622-031203 · 2023 · External reference
A clinical safety trial of stroma-free hemoglobin
10.1002/cpt197823173 · 1978 · External reference
Acellular Hemoglobin Impairs Cardiomyocyte Excitation-Contraction Coupling
10.1097/mat.0000000000002668 · 2026 · External reference
Toxic side-effects of diaspirin cross-linked human hemoglobin are attenuated by the apohemoglobin-haptoglobin complex
10.1016/j.biopha.2024.116569 · 2024 · External reference
Blood substitutes: why haven't we been more successful?
10.1016/j.tibtech.2014.02.006 · 2014 · External reference
Hemoglobin-based oxygen carriers: current status and future directions
10.1111/j.1537-2995.2009.02356.x · 2009 · External reference
Oxygen therapeutics: pursuit of an alternative to the donor red blood cell
10.5858/2007-131-734-otpoaa · 2007 · External reference
Hemoglobin-vesicles as an artificial oxygen carrier
10.1016/s0076-6879(09)65019-9 · 2009 · External reference
Development of recombinant hemoglobin-based oxygen carriers
10.1089/ars.2012.4917 · 2013 · External reference
Synthesis, biophysical properties and pharmacokinetics of ultrahigh molecular weight tense and relaxed state polymerized bovine hemoglobins
10.1016/j.biomaterials.2010.01.072 · 2010 · External reference
The life-sustaining capacity of human polymerized hemoglobin when red cells might be unavailable
10.1016/s1072-7515(02)01335-2 · 2002 · External reference
A prospective, randomized comparison of Oxyglobin (HB-200) and packed red blood cell transfusion for canine babesiosis
10.1111/j.1476-4431.2009.00386.x · 2009 · External reference
Diaspirin cross-linked hemoglobin infusion did not influence base deficit and lactic acid levels in two clinical trials of traumatic hemorrhagic shock patient resuscitation
10.1097/ta.0b013e3181bbfaac · 2010 · External reference
Emergency Resuscitation of Patients Enrolled in the US Diaspirin Cross-linked Hemoglobin (DCLHb) Clinical Efficacy Trial
10.1017/s1049023x14001174 · 2015 · External reference
O-raffinose crosslinked hemoglobin lacks site-specific chemistry in the central cavity: structural and functional consequences of beta93Cys modification
10.1002/prot.20453 · 2005 · External reference
A phase I study of oxidized raffinose cross-linked human hemoglobin
10.1097/00003246-200007000-00017 · 2000 · External reference
Endothelial dysfunction enhances vasoconstriction due to scavenging of nitric oxide by a hemoglobin-based oxygen carrier
10.1097/aln.0b013e3181cd7838 · 2010 · External reference
Scalable Production and Biophysical Characterization of High-Molecular-Weight Relaxed and Tense Quaternary State Polymerized Human Hemoglobin as Potential Red Blood Cell Substitutes
10.1021/acs.biomac.4c01024 · 2024 · External reference
Biophysical Analysis and Preclinical Pharmacokinetics-Pharmacodynamics of Tangential Flow Filtration Fractionated Polymerized Human Hemoglobin as a Red Blood Cell Substitute
10.1021/acs.biomac.3c00051 · 2023 · External reference
The Molecular Size of Bioengineered Oxygen Carriers Determines Tissue Oxygenation in a Hypercholesterolemia Guinea Pig Model of Hemorrhagic Shock and Resuscitation
10.1021/acs.molpharmaceut.3c00611 · 2023 · External reference
Effect of pegylation on pharmaceuticals
10.1038/nrd1033 · 2003 · External reference
Arterial blood pressure responses to cell-free hemoglobin solutions and the reaction with nitric oxide
10.1074/jbc.273.20.12128 · 1998 · External reference
Accelerated clearance by antibodies against methoxy PEG depends on pegylation architecture
10.1016/j.jconrel.2023.01.021 · 2023 · External reference
Evaluation of MP4OX for prevention of perioperative hypotension in patients undergoing primary hip arthroplasty with spinal anesthesia: a randomized, double-blind, multicenter study
10.1097/aln.0b013e318215e198 · 2011 · External reference
Hemoglobin-Based Oxygen Carrier (HBOC) Development in Trauma: Previous Regulatory Challenges, Lessons Learned, and a Path Forward
10.1007/978-3-319-55231-6_45 · 2017 · External reference
Transfusion of hemoglobin-based oxygen carriers in the carboxy state is beneficial during transient focal cerebral ischemia
10.1152/japplphysiol.01079.2012 · 2012 · External reference
MP4, a new nonvasoactive PEG-Hb conjugate
10.1046/j.1537-2995.2003.00341.x · 2003 · External reference
Site-specific PEGylation of hemoglobin at Cys-93(beta): correlation between the colligative properties of the PEGylated protein and the length of the conjugated PEG chain
10.1021/bc0200733 · 2003 · External reference
Towards a novel haemoglobin-based oxygen carrier: Euro-PEG-Hb, physico-chemical properties, vasoactivity and renal filtration
10.1016/j.bbapap.2008.03.005 · 2008 · External reference
“Inside-Out” PEGylation of Bovine β-Cross-Linked Hemoglobin
10.1111/aor.12928 · 2017 · External reference
Tangential flow filtration of hemoglobin
10.1002/btpr.119 · 2009 · External reference
Comprehensive biophysical and biochemical characterization of polymerized dopamine coated hemoglobin based oxygen carrier
10.1016/j.ijbiomac.2025.146658 · 2025 · External reference
Spectrophotometric Studies: II. Preparations from Washed Blood Cells; Nitric Oxide Hemoglobin and Sulfhemoglobin
10.1016/s0021-9258(18)74965-x · 1935 · External reference
Preparation and in vitro characteristics of polymerized pyridoxylated hemoglobin
10.1046/j.1537-2995.1983.23283172857.x · 1983 · External reference
Biophysical and Biochemical Characterization of High Molecular Weight Co-Polymerized Human Hemoglobin and Albumin as a Potential Hemoglobin-Based Oxygen Carrier
10.1021/acsbiomaterials.5c01253 · 2026 · External reference
Scalable production and biophysical characterization of an enzyme cocktail derived from human red blood cells
10.1002/btpr.70072 · 2026 · External reference
10.1007/978-1-4757-6203-7_1
10.1007/978-1-4757-6203-7_1 · 1992 · External reference
Biophysical and Biochemical Characterization of PEGylated High-Molecular-Weight Relaxed and Tense Quaternary State Polymerized Human Hemoglobin
10.1021/acs.bioconjchem.5c00311 · 2025 · External reference
The safety profile of Hemospan®: a new oxygen therapeutic designed using maleimide poly(ethylene) glycol conjugation to human hemoglobin
10.1111/j.1778-428x.2007.00083.x · 2007 · External reference
Ligand binding properties and structural studies of recombinant and chemically modified hemoglobins altered at beta 93 cysteine
10.1021/bi0202880 · 2002 · External reference
βCysteine 93 in human hemoglobin: a gateway to oxidative stability in health and disease
10.1038/s41374-020-00492-3 · 2021 · External reference
Stereochemistry of cooperative effects in haemoglobin
10.1038/228726a0 · 1970 · External reference
Hemoglobin based oxygen carriers: how much methemoglobin is too much?
10.3109/10731199809119772 · 1998 · External reference
Optimizing the Hemoglobin-Based Oxygen Carrier Molecular Size to Balance Vascular Function and Hemodynamic Responses after Transfusion
10.1021/acsabm.6c00900 · 2026 · External reference
Tonicity and colloid osmotic pressure drive microvascular recovery from low volume hypotensive resuscitation from hemorrhagic shock
10.1016/j.resplu.2026.101216 · 2026 · External reference
Nonlinear cardiovascular regulation consequent to changes in blood viscosity
10.3233/ch-2011-1454 · 2011 · External reference
Plasma expander viscosity effects on red cell-free layer thickness after moderate hemodilution
10.3233/bir-2012-0598 · 2011 · External reference
Endothelium dependent control of arterial diameter by blood viscosity
10.1093/cvr/23.9.741 · 1989 · External reference
Biophysical and Biochemical Roles of Shear Stress on Endothelium: A Revisit and New Insights
10.1161/circresaha.124.325685 · 2025 · External reference
Recent advances in blood rheology: a review
10.1039/d1sm01212f · 2021 · External reference
Microvascular fluid exchange and the revised Starling principle
10.1093/cvr/cvq062 · 2010 · External reference
Resuscitation from Hemorrhagic Shock with a Novel Protein Cocktail Restores Microvascular Perfusion and Protects Vital Organs
10.1097/shk.0000000000002636 · 2026 · External reference
Resuscitation After Hemorrhagic Shock in the Microcirculation: Targeting Optimal Oxygen Delivery in the Design of Artificial Blood Substitutes
10.3389/fmed.2020.585638 · 2020 · External reference
The role of facilitated diffusion in oxygen transport by cell-free hemoglobins: implications for the design of hemoglobin-based oxygen carriers
10.1016/s0301-4622(01)00194-6 · 2001 · External reference
Preparation and properties of hemoglobin modified with derivatives of pyridoxal
10.1016/0076-6879(81)76123-8 · 1981 · External reference
Microvascular and tissue oxygen distribution
10.1016/s0008-6363(96)00110-1 · 1996 · External reference
Influence of oxygen on perfused capillary density and capillary red cell velocity in rabbit skeletal muscle
10.1016/0026-2862(80)90040-0 · 1980 · External reference
Kinetics of NO and O2 binding to a maleimide poly(ethylene glycol)-conjugated human haemoglobin
10.1042/bj20040156 · 2004 · External reference
Cys-93-betabeta-succinimidophenyl polyethylene glycol 2000 hemoglobin A. Intramolecular cross-bridging of hemoglobin outside the central cavity
10.1074/jbc.275.8.5527 · 2000 · External reference
A PEGylated bovine hemoglobin as a potent hemoglobin-based oxygen carrier
10.1002/btpr.2380 · 2017 · External reference
Hemolysis and free hemoglobin revisited: exploring hemoglobin and hemin scavengers as a novel class of therapeutic proteins
10.1182/blood-2012-11-451229 · 2013 · External reference
Oxidation and haem loss kinetics of poly(ethylene glycol)-conjugated haemoglobin (MP4): dissociation between in vitro and in vivo oxidation rates
10.1042/bj20060809 · 2006 · External reference
Superoxide produced in the heme pocket of the beta-chain of hemoglobin reacts with the beta-93 cysteine to produce a thiyl radical
10.1021/bi980941 · 1998 · External reference
Molecular controls of the oxygenation and redox reactions of hemoglobin
10.1089/ars.2012.4947 · 2013 · External reference
Structural basis of peroxide-mediated changes in human hemoglobin: a novel oxidative pathway
10.1074/jbc.m609955200 · 2007 · External reference
