Research graph
References from Targeting Achilles’ Heel: Copper-Based Nanoantibiotics Synergistically Disrupt the TCA Cycle to Induce Bacterial Metabolic Cell Death. Local targets link to admitted publications; unresolved targets remain external evidence.
Molecular Mechanisms of Antibiotic Resistance Revisited
10.1038/s41579-022-00820-y · 2023 · External reference
Ecological and Evolutionary Mechanisms Driving within-Patient Emergence of Antimicrobial Resistance
10.1038/s41579-024-01041-1 · 2024 · External reference
Novel Targets for Antimicrobials
10.4274/tjps.galenos.2020.90197 · 2020 · External reference
Food for Thought: Opportunities to Target Carbon Metabolism in Antibacterial Drug Discovery
10.1111/nyas.14991 · 2023 · External reference
Targeting Bacterial Central Metabolism for Drug Development
10.1016/j.chembiol.2014.08.020 · 2014 · External reference
Bedaquiline Reprograms Central Metabolism to Reveal Glycolytic Vulnerability in Mycobacterium Tuberculosis
10.1038/s41467-020-19959-4 · 2020 · External reference
Beyond Metabolic Dormancy: Metabolic Rewiring in Bacterial Persistence
10.1038/s41467-026-71427-7 · 2026 · External reference
Mitochondrial Tca Cycle Metabolites Control Physiology and Disease
10.1038/s41467-019-13668-3 · 2020 · External reference
Exploiting Metabolic Cell Death for Cancer Therapy
10.1038/s41568-025-00879-8 · 2026 · External reference
Copper Induces Cell Death by Targeting Lipoylated Tca Cycle Proteins
10.1126/science.abf0529 · 2022 · External reference
Cuproptosis to Cuproptosis-Like: Therapeutic Strategies for Bacterial Infection
10.1002/adma.202506119 · 2025 · External reference
CeO2@Cuxos Photocatalyst for Diabetic Wound Healing Via Programmable Ros Regulation
10.1021/acsami.6c01209 · 2026 · External reference
Spindle-Shaped Multifunctional Nanozymes with Nir-Enhanced Catalytic Activity for Treating Methicillin-Resistant Staphylococcus Aureus (Mrsa)-Infected Wounds through Bacterial Cuproptosis-Like Death
10.1021/acsami.5c05553 · 2025 · External reference
Piezoelectric-Enhanced Nanocatalysts Trigger Neutrophil N1 Polarization against Bacterial Biofilm by Disrupting Redox Homeostasis
10.1002/adma.202409633 · 2025 · External reference
CuCo2O4 Nanoflowers with Multiple Enzyme Activities for Treating Bacterium-Infected Wounds Via Cuproptosis-Like Death
10.1021/acsnano.4c02825 · 2024 · External reference
Biofilm Microenvironment-Responsive Self-Assembly Nanoreactors for All-Stage Biofilm Associated Infection through Bacterial Cuproptosis-Like Death and Macrophage Re-Rousing
10.1002/adma.202303432 · 2023 · External reference
A Mucous Permeable Local Delivery Strategy Based on Manganese-Enhanced Bacterial Cuproptosis-Like Death for Bacterial Pneumonia Treatment
10.1021/acsnano.4c09695 · 2024 · External reference
Copper-Induced Cell Death and the Protective Role of Glutathione: The Implication of Impaired Protein Folding Rather Than Oxidative Stress
10.1039/c8mt00182k · 2018 · External reference
Reactive Oxygen Species (Ros) as Pleiotropic Physiological Signalling Agents
10.1038/s41580-020-0230-3 · 2020 · External reference
Cellular Responses to Reactive Oxygen Species Are Predicted from Molecular Mechanisms
10.1073/pnas.1905039116 · 2019 · External reference
The Molecular Mechanisms and Physiological Consequences of Oxidative Stress: Lessons from a Model Bacterium
10.1038/nrmicro3032 · 2013 · External reference
Directional Freeze-Casting Cryogel Loaded with Quaternized Chitosan Modified Gallium Metal-Organic Frameworks to Capture and Eradicate the Resistant Bacteria for Guided Regeneration in Infected Bone Defects
10.1002/adma.202414437 · 2025 · External reference
Antibacterial Nanomaterials: Mechanisms, Impacts on Antimicrobial Resistance and Design Principles
10.1002/anie.202217345 · 2023 · External reference
Hydrophilic Nanoparticles That Kill Bacteria While Sparing Mammalian Cells Reveal the Antibiotic Role of Nanostructures
10.1038/s41467-021-27193-9 · 2022 · External reference
Lethal Interactions of Atomically Precise Gold Nanoclusters and Pseudomonas Aeruginosa and Staphylococcus Aureus Bacterial Cells
10.1021/acsami.2c04410 · 2022 · External reference
Overcoming Bacterial Physical Defenses with Molecule-Like Ultrasmall Antimicrobial Gold Nanoclusters
10.1016/j.bioactmat.2020.09.026 · 2021 · External reference
Tailoring the Photoluminescence of Atomically Precise Nanoclusters
10.1039/c8cs00800k · 2019 · External reference
Ultrasmall Coinage Metal Nanoclusters as Promising Theranostic Probes for Biomedical Applications
10.1021/jacs.3c02880 · 2023 · External reference
Synthesis of Small Atomic Copper Clusters in Microemulsions
10.1021/la900100w · 2009 · External reference
Enzyme-Mimetic Hydrogel Balancing Antibacterial Activity and Cytoprotection for Corneal Regeneration in Bacterial Keratitis
10.1021/acsnano.5c22118 · 2026 · External reference
Copper Clusters: An Effective Antibacterial for Eradicating Multidrug-Resistant Bacterial Infection in Vitro and in Vivo
10.1002/adfm.202008720 · 2021 · External reference
Design of Flexible Copper Clad Laminate with Outstanding Adhesion Strength Induced by Chemical Bonding
10.1007/s10854-014-2327-y · 2014 · External reference
Molecule-Like Synthesis of Ligand-Protected Metal Nanoclusters
10.1038/s41578-024-00741-7 · 2025 · External reference
Copper Nanoclusters as Peroxidase Mimetics and Their Applications to H2O2 and Glucose Detection
10.1016/j.aca.2012.11.056 · 2013 · External reference
Gemini Surfactant-Induced Cysteine-Capped Copper Nanoclusters Self-Assembly with Enhanced Peroxidase-Like Activity and Colorimetric Glutathione Sensing
10.1021/acs.langmuir.4c01620 · 2024 · External reference
Cu Nanoparticles Have Different Impacts in Escherichia Coli and Lactobacillus Brevis Than Their Microsized and Ionic Analogues
10.1021/acsnano.5b02021 · 2015 · External reference
Understanding the Antibacterial Mechanism of Cuo Nanoparticles: Revealing the Route of Induced Oxidative Stress
10.1002/smll.201200772 · 2012 · External reference
Antimicrobial Gold Nanoclusters
10.1021/acsnano.7b02035 · 2017 · External reference
Nanozyme-Based Supramolecular Self-Assembly as an Artificial Host Defense System for Treatment of Bacterial Infections
10.1002/smll.202301096 · 2023 · External reference
Comparative Determination of Cytotoxicity of Sub-10 Nm Copper Nanoparticles to Prokaryotic and Eukaryotic Systems
10.1021/acsami.0c11052 · 2020 · External reference
Mitochondrial Copper Overload Promotes Renal Fibrosis Via Inhibiting Pyruvate Dehydrogenase Activity
10.1007/s00018-024-05358-1 · 2024 · External reference
Piezoelectric-Driven Cu2+/Cu+ Conversion Strategy for Amplifying Cuproptosis and Oxidative Stress
10.1021/acsami.5c17223 · 2025 · External reference
The Crosstalk between Copper-Induced Oxidative Stress and Cuproptosis: A Novel Potential Anticancer Paradigm
10.1186/s12964-024-01726-3 · 2024 · External reference
Growth of Mycobacterium Tuberculosis at Acidic Ph Depends on Lipid Assimilation and Is Accompanied by Reduced Gapdh Activity
10.1073/pnas.2024571118 · 2021 · External reference
Metabolomics of Escherichia Coli Treated with the Antimicrobial Carbon Monoxide-Releasing Molecule Corm-3 Reveals Tricarboxylic Acid Cycle as Major Target
10.1128/aac.00643-19 · 2019 · External reference
Combatting Antimicrobial Resistance Via the Cysteine Biosynthesis Pathway in Bacterial Pathogens
10.1042/bsr20220368 · 2022 · External reference
Two-Component Signal Transduction as Potential Drug Targets in Pathogenic Bacteria
10.1016/j.mib.2010.01.008 · 2010 · External reference
Phages against Pathogenic Bacterial Biofilms and Biofilm-Based Infections: A Review
10.3390/pharmaceutics14020427 · 2022 · External reference
In Situ Neutralization and Detoxification of Lps to Attenuate Hyperinflammation
10.1002/advs.202302950 · 2023 · External reference
Interplay between Interleukin-6 Signaling and the Vascular Endothelium in Cytokine Storms
10.1038/s12276-021-00649-0 · 2021 · External reference
A Pairwise Cytokine Code Explains the Organism-Wide Response to Sepsis
10.1038/s41590-023-01722-8 · 2024 · External reference
Self-Healing, Antibacterial and Anti-Inflammatory Chitosan-Peg Hydrogels for Ulcerated Skin Wound Healing and Drug Delivery
10.1016/j.bioadv.2022.212992 · 2022 · External reference