Research graph
References from Application of Bioorthogonal Chemistry in Targeted Antibacterial Therapy: Choosing the Right Chemistry. Local targets link to admitted publications; unresolved targets remain external evidence.
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Bioorthogonal chemistry for selective recognition, separation and killing bacteria over mammalian cells
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Bio-Orthogonal Chemistry and Reloadable Biomaterial Enable Local Activation of Antibiotic Prodrugs and Enhance Treatments against Staphylococcus aureus Infections
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D-amino acid mediated recruitment of endogenous antibodies to bacterial surfaces
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Visualization and In Situ Ablation of Intracellular Bacterial Pathogens through Metabolic Labeling
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Metabolic Labeling Strategy Boosted Antibacterial Efficiency for Photothermal and Photodynamic Synergistic Bacteria-Infected Wound Therapy
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In Situ Bioorthogonal Conjugation of Delivered Bacteria with Gut Inhabitants for Enhancing Probiotics Colonization
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A general strategy for high-efficiency live bacteria imaging and targeted phototherapy
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Harnessing Transition Metal Scaffolds for Targeted Antibacterial Therapy
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Light-Triggered Bioorthogonal Nanozyme Hydrogels for Prodrug Activation and Treatment of Bacterial Biofilms
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Bioorthogonal catalytic patch
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Bio-Inspired Bimetallic Enzyme Mimics as Bio-Orthogonal Catalysts for Enhanced Bacterial Capture and Inhibition
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Platelet Membrane-Enclosed Bioorthogonal Catalysis for Combating Dental Caries
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Erythrocyte-mediated delivery of bioorthogonal nanozymes for selective targeting of bacterial infections
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Antibody Mimics as Bio-orthogonal Catalysts for Highly Selective Bacterial Recognition and Antimicrobial Therapy
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AIE Bioconjugates for Accurate Identification and In Vivo Targeted Treatment of Bacterial Infection Based on Bioorthogonal Reaction
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The Staudinger Ligation
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Mechanistic investigation of the staudinger ligation
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Bioconjugation by copper(I)-catalyzed azide-alkyne [3 + 2] cycloaddition
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Cell surface labeling of Escherichia coli via copper(I)-catalyzed [3+2] cycloaddition
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Cellular consequences of copper complexes used to catalyze bioorthogonal click reactions
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Increasing the efficacy of bioorthogonal click reactions for bioconjugation: a comparative study
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Rapid Cu-free click chemistry with readily synthesized biarylazacyclooctynones
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Strain-Promoted 1,3-Dipolar Cycloaddition of Cycloalkynes and Organic Azides
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Visualizing metabolically labeled glycoconjugates of living cells by copper-free and fast huisgen cycloadditions
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Preventing thiol-yne addition improves the specificity of strain-promoted azide-alkyne cycloaddition
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Inverse electron demand Diels-Alder reactions in chemical biology
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Live-cell imaging of cyclopropene tags with fluorogenic tetrazine cycloadditions
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Development of a First-in-Class Click Chemistry-Based Cancer Therapeutic, from Preclinical Evaluation to a First-in-Human Dose Escalation Clinical Trial
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In vivo chemistry for pretargeted tumor imaging in live mice
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Strain-promoted cycloadditions involving nitrones and alkynes—rapid tunable reactions for bioorthogonal labeling
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Protein modification by strain-promoted alkyne-nitrone cycloaddition
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Bioorthogonal Reactions Utilizing Nitrones as Versatile Dipoles in Cycloaddition Reactions
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Strain-promoted cycloadditions of cyclic nitrones with cyclooctynes for labeling human cancer cells
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Aqueous synthesis of highly functional, hydrophobic, and chemically recyclable cellulose nanomaterials through oxime ligation
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Oxime ligation: a chemoselective click-type reaction for accessing multifunctional biomolecular constructs
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Recyclable thermoresponsive polymer-cellulase bioconjugates for biomass depolymerization
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1-Ethoxyethylidene, a new group for the stepwise SPPS of aminooxyacetic acid containing peptides
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Rapid oxime and hydrazone ligations with aromatic aldehydes for biomolecular labeling
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Engineering polymeric micelles for targeted drug delivery: “click” chemistry enabled bioconjugation strategies and emerging applications
10.1039/d5tb02193f · 2026 · External reference
Metabolic Implications of Using BioOrthogonal Non-Canonical Amino Acid Tagging (BONCAT) for Tracking Protein Synthesis
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In Situ Bioorthogonal Metabolic Labeling for Fluorescence Imaging of Virus Infection In Vivo
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Cyclopropenes as Chemical Reporters for Dual Bioorthogonal and Orthogonal Metabolic Labeling of DNA
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Rewiring Gram-Negative Bacteria Cell Surfaces with Bio-Orthogonal Chemistry via Liposome Fusion
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Bioorthogonal Noncanonical Amino Acid Tagging (BONCAT) Enables Time-Resolved Analysis of Protein Synthesis in Native Plant Tissue
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Labeling, detection and identification of newly synthesized proteomes with bioorthogonal non-canonical amino-acid tagging
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Selective Proteomic Analysis of Antibiotic-Tolerant Cellular Subpopulations in Pseudomonas aeruginosa Biofilms
10.1128/mbio.01593-17 · 2017 · External reference
Optimized Bioorthogonal Non-canonical Amino Acid Tagging to Identify Serotype-Specific Biomarkers in Verotoxigenic Escherichia coli
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Mechanisms and Minimization of False Discovery of Metabolic Bioorthogonal Noncanonical Amino Acid Proteomics
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Peptidoglycan-Targeted [18F]3,3,3-Trifluoro-d-alanine Tracer for Imaging Bacterial Infection
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Probing the Mycobacterial Trehalome with Bioorthogonal Chemistry
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Sensing Living Bacteria in Vivo Using d-Alanine-Derived 11C Radiotracers
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Quantitative aspects of septicemia
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Toward Rapid Detection of Viable Bacteria in Whole Blood for Early Sepsis Diagnostics and Susceptibility Testing
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Blood Culture Results Before and After Antimicrobial Administration in Patients With Severe Manifestations of Sepsis: A Diagnostic Study
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Point of care technologies for sepsis diagnosis and treatment
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Bacteria-Instructed Click Chemistry between Functionalized Gold Nanoparticles for Point-of-Care Microbial Detection
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Colorimetric sensor array allows fast detection and simultaneous identification of sepsis-causing bacteria in spiked blood culture
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Micro/nanomotors for biofilm remediation: Nanoarchitectonic breakthroughs with a focus on regulatory and clinical translation challenges
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Molecular mechanisms of antibiotic resistance revisited
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Escherichia coli mechanisms of copper homeostasis in a changing environment
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Target Enzyme-Triggered Click Chemistry and Hybridization Chain Reaction for Fluorescence Nonculture Homogeneous Analysis of E coli in Bloodstream Infections
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Illuminating vital surface molecules of symbionts in health and disease
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Bioorthogonal Radiolabeling of Azide-Modified Bacteria Using [18F]FB-sulfo-DBCO
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Sensitive NIR Fluorescence Identification of Bacteria in Whole Blood with Bioorthogonal Nanoprobes for Early Sepsis Diagnosis
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AIEgens for microbial detection and antimicrobial therapy
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Specific and quantitative detection of bacteria based on surface cell imprinted SERS mapping platform
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Liquid NanoBiosensors Enable One-Pot Electrochemical Detection of Bacteria in Complex Matrices
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Cluster-bomb type magnetic biosensor for ultrasensitive detection of Vibrio parahaemolyticus based on low field nuclear magnetic resonance
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Bacteria-induced aggregation of bioorthogonal gold nanoparticles for SERS imaging and enhanced photothermal ablation of Gram-positive bacteria
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Electrochemical sensor for single-cell determination of bacteria based on target-triggered click chemistry and fast scan voltammetry
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Specific pathogen detection using bioorthogonal chemistry and diagnostic magnetic resonance
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Ubiquitous Detection of Gram-Positive Bacteria with Bioorthogonal Magnetofluorescent Nanoparticles
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Charge-Switchable Nanozymes for Bioorthogonal Imaging of Biofilm-Associated Infections
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Imaging of Escherichia coli K5 and glycosaminoglycan precursors via targeted metabolic labeling of capsular polysaccharides in bacteria
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Ultrastructural Imaging of Salmonella–Host Interactions Using Super-resolution Correlative Light-Electron Microscopy of Bioorthogonal Pathogens
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Sensitive multicolor visual detection of telomerase activity based on catalytic hairpin assembly and etching of Au nanorods
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A colorimetric immunosensor for determination of foodborne bacteria using rotating immunomagnetic separation, gold nanorod indication, and click chemistry amplification
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High Enantiomeric Excess In-Loop Synthesis of d-[methyl-11C]Methionine for Use as a Diagnostic Positron Emission Tomography Radiotracer in Bacterial Infection
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Imaging Enterobacterales infections in patients using pathogen-specific positron emission tomography
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Zinc-doped Prussian blue enhances photothermal clearance of Staphylococcus aureus and promotes tissue repair in infected wounds
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NIR- and thermo-responsive semi-interpenetrated polypyrrole nanogels for imaging guided combinational photothermal and chemotherapy
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Emerging applications of porphyrins in photomedicine
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Beyond the Barriers of Light Penetration: Strategies, Perspectives and Possibilities for Photodynamic Therapy
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The role of the light source in antimicrobial photodynamic therapy
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Reaching new lights: a review on photo-controlled nanomedicines and their in vivo evaluation
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Nanomaterials enabling clinical translation of antimicrobial photodynamic therapy
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Arginine Accelerates Sulfur Fluoride Exchange and Phosphorus Fluoride Exchange Reactions between Proteins
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Thermoresponsive Hydrogel-Enabled Thermostatic Photothermal Therapy for Enhanced Healing of Bacteria-Infected Wounds
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Photoinducible bioorthogonal chemistry: a spatiotemporally controllable tool to visualize and perturb proteins in live cells
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Selective Functionalization of a Genetically Encoded Alkene-Containing Protein via “Photoclick Chemistry” in Bacterial Cells
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Increasing antibiotic activity by rapid bioorthogonal conjugation of drug to resistant bacteria using an upconverted light-activated photocatalyst
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Bio-Orthogonal AIEgen for Specific Discrimination and Elimination of Bacterial Pathogens via Metabolic Engineering
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Selective inactivation of Gram-positive bacteria in vitro and in vivo through metabolic labelling
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Metal-Organic-Framework-Assisted In Vivo Bacterial Metabolic Labeling and Precise Antibacterial Therapy
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Biomimetic Nanomedicine-Triggered in Situ Vaccination for Innate and Adaptive Immunity Activations for Bacterial Osteomyelitis Treatment
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pH Switchable Nanoplatform for In Vivo Persistent Luminescence Imaging and Precise Photothermal Therapy of Bacterial Infection
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Target-specific induced hyaluronic acid decorated silica fluorescent nanoparticles@polyaniline for bio-imaging guided near-infrared photothermal therapy
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Near-Infrared Light-Triggered Nitric-Oxide-Enhanced Photodynamic Therapy and Low-Temperature Photothermal Therapy for Biofilm Elimination
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A multifunctional platform with single-NIR-laser-triggered photothermal and NO release for synergistic therapy against multidrug-resistant Gram-negative bacteria and their biofilms
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Nanoparticle-modified microrobots for in vivo antibiotic delivery to treat acute bacterial pneumonia
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Green Algae as a Drug Delivery System for the Controlled Release of Antibiotics
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A pH-Responsive Cluster Metal-Organic Framework Nanoparticle for Enhanced Tumor Accumulation and Antitumor Effect
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Applications of microalga-powered microrobots in targeted drug delivery
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Microalgae-based oral microcarriers for gut microbiota homeostasis and intestinal protection in cancer radiotherapy
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Gastrointestinal tract drug delivery using algae motors embedded in a degradable capsule
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Engineered bioorthogonal cell delivery system for in situ antimicrobial peptide recruitment during systemic bacterial infection
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Exploring New Bioorthogonal Catalysts: Scaffold Diversity in Catalysis for Chemical Biology
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The transition metal-catalysed hydroboration reaction
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Transition-Metal-Catalyzed, Coordination-Assisted Functionalization of Nonactivated C(sp3)-H Bonds
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Copper-Triggered Bioorthogonal Cleavage Reactions for Reversible Protein and Cell Surface Modifications
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Mechanistic insights into transition metal-mediated bioorthogonal uncaging reactions
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Development and application of bond cleavage reactions in bioorthogonal chemistry
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Amino acid-protecting groups
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Synthesis of polystyrene microspheres and functionalization with Pd0 nanoparticles to perform bioorthogonal organometallic chemistry in living cells
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Bioorthogonal Catalytic Activation of Platinum and Ruthenium Anticancer Complexes by FAD and Flavoproteins
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Catalytic azide reduction in biological environments
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Selective treatment of intracellular bacterial infections using host cell-targeted bioorthogonal nanozymes
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Thermally Gated Bio-orthogonal Nanozymes with Supramolecularly Confined Porphyrin Catalysts for Antimicrobial Uses
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Defect-Rich Adhesive Nanozymes as Efficient Antibiotics for Enhanced Bacterial Inhibition
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Platelet Membrane-Coated Nanocarriers Targeting Plaques to Deliver Anti-CD47 Antibody for Atherosclerotic Therapy
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Role of Platelets in Detection and Regulation of Infection
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Platelet-derived biomimetic nanoplatforms: a promising drug delivery strategy for cardiovascular disease
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Monolayer-protected cluster molecules
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Biofilms: an emergent form of bacterial life
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The good and the bad of antibiotics
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Polymer-Based Bioorthogonal Nanocatalysts for the Treatment of Bacterial Biofilms
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A Motor-Based Carbonaceous Nanocalabash Catalyst for Deep-Layered Bioorthogonal Chemistry
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Clicking 1,2,4,5-tetrazine and cyclooctynes with tunable reaction rates
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Doubly orthogonal” labeling of peptides and proteins
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Thiol-Ene Click Reaction Modified Triazinyl-Based Covalent Organic Framework for Pb(II) Ion Effective Removal
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Machine Learning-Guided Computational Screening of New Candidate Reactions with High Bioorthogonal Click Potential
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