Research graph
References from Second-Generation Acyl Modifications Stabilize RNA, Support Translation, and Suppress Cytokine Responses. Local targets link to admitted publications; unresolved targets remain external evidence.
Challenges and Opportunities for Nucleic Acid Therapeutics
10.1089/nat.2021.0085 · 2022 · External reference
Transcribed mRNA Therapeutics: Out of the Shadows and Into the Spotlight
10.1016/j.ymthe.2019.03.009 · 2019 · External reference
CRISPR Technology: A Decade of Genome Editing Is Only the Beginning
10.1126/science.add8643 · 2023 · External reference
RNAi-Based Drug Design: Considerations and Future Directions
10.1038/s41573-024-00912-9 · 2024 · External reference
Unlocking the Promise of mRNA Therapeutics
10.1038/s41587-022-01491-z · 2022 · External reference
Using Synthetically Engineered Guide RNAs to Enhance CRISPR Genome Editing Systems in Mammalian Cells
10.3389/fgeed.2020.617910 · 2021 · External reference
mRNA Stability: An Unresolved Challenge for Broad Therapeutic Applications
10.1002/biot.70146 · 2025 · External reference
Factors Affecting Stability of RNA: Temperature, Length, Concentration, pH, and Buffering Species
10.1016/j.xphs.2023.11.023 · 2024 · External reference
Combinatorial Optimization of mRNA Structure, Stability, and Translation for RNA-Based Therapeutics
10.1038/s41467-022-28776-w · 2022 · External reference
Kinetics and Mechanisms for the Cleavage and Isomerization of the Phosphodiester Bonds of RNA by Brønsted Acids and Bases
10.1021/cr960425x · 1998 · External reference
The Mechanism of Action of Ribonuclease
10.1073/pnas.62.4.1151 · 1969 · External reference
Bovine Pancreatic Ribonuclease: Fifty Years of the First Enzymatic Reaction Mechanism
10.1021/bi201075b · 2011 · External reference
RNA Circularization Diminishes Immunogenicity and Can Extend Translation Duration In Vivo
10.1016/j.molcel.2019.02.015 · 2019 · External reference
Engineering Highly Efficient Backsplicing and Translation of Synthetic circRNAs
10.1016/j.omtn.2021.01.003 · 2021 · External reference
Internal Cap-Initiated Translation for Efficient Protein Production from Circular mRNA
10.1038/s41587-025-02561-8 · 2026 · External reference
The Storage and In-Use Stability of mRNA Vaccines and Therapeutics: Not a Cold Case
10.1016/j.xphs.2022.11.001 · 2023 · External reference
Replacing Helper Lipids with Cationic Lipids Enhances mRNA Lipid Nanoparticle Stability in Solution
10.1002/advs.202511637 · 2026 · External reference
Multiple Covalent Fluorescence Labeling of Eukaryotic mRNA at the Poly(A) Tail Enhances Translation and Can Be Performed in Living Cells
10.1093/nar/gkz084 · 2019 · External reference
Branched Chemically Modified Poly(A) Tails Enhance the Translation Capacity of mRNA
10.1038/s41587-024-02174-7 · 2025 · External reference
Localized 2′-OH Acylation at Poly(A) Extends RNA Translation
10.1021/jacs.5c11900 · 2025 · External reference
RNA Interference in Mammalian Cells by Chemically Modified RNA
10.1021/bi0343774 · 2003 · External reference
siRNA Function in RNAi: A Chemical Modification Analysis
10.1261/rna.5103703 · 2003 · External reference
Identification of a T7 RNA Polymerase Variant That Permits the Enzymatic Synthesis of Fully 2′-O-Methyl-Modified RNA
10.1016/j.jbiotec.2013.07.005 · 2013 · External reference
Translation of 2′-Modified mRNA In Vitro and In Vivo
10.1093/nar/22.23.4963 · 1994 · External reference
Translation of Non-Standard Codon Nucleotides Reveals Minimal Requirements for Codon–Anticodon Interactions
10.1038/s41467-018-07321-8 · 2018 · External reference
One-Pot Ligation of Multiple mRNA Fragments on dsDNA Splint Advancing Regional Modification and Translation
10.1093/nar/gkae1280 · 2025 · External reference
RNA Cloaking by Reversible Acylation
10.1002/anie.201708696 · 2018 · External reference
RNA Control by Photoreversible Acylation
10.1021/jacs.7b12408 · 2018 · External reference
Control of RNA with Quinone Methide Reversible Acylating Reagents
10.1039/d1ob01713f · 2021 · External reference
Universal crRNA Acylation Strategy for Robust Photo-Initiated One-Pot CRISPR–Cas12a Nucleic Acid Diagnostics
10.1002/anie.202401486 · 2024 · External reference
RNA Functionalization via Acylation Chemistry: Recent Advances and Biomedical Applications
10.1016/j.bmc.2024.117878 · 2024 · External reference
RNA Control via Redox-Responsive Acylation
10.1002/anie.202402178 · 2024 · External reference
Reversible RNA Acylation Using Bio-Orthogonal Chemistry Enables Temporal Control of CRISPR-Cas9 Nuclease Activity
10.1021/acschembio.4c00117 · 2024 · External reference
Reversible 2′-OH Acylation Enhances RNA Stability
10.1038/s41557-023-01246-6 · 2023 · External reference
DNA Tiling Enables Precise Acylation-Based Labeling and Control of mRNA
10.1002/anie.202112106 · 2021 · External reference
Toll-Like Receptor 8 Senses Degradation Products of Single-Stranded RNA
10.1038/nsmb.2943 · 2015 · External reference
Structural Analysis Reveals That Toll-Like Receptor 7 Is a Dual Receptor for Guanosine and Single-Stranded RNA
10.1016/j.immuni.2016.09.011 · 2016 · External reference
Generating the Optimal mRNA for Therapy: HPLC Purification Eliminates Immune Activation and Improves Translation of Nucleoside-Modified, Protein-Encoding mRNA
10.1093/nar/gkr695 · 2011 · External reference
Corticosteroids and Cellulose Purification Improve, Respectively, the In Vivo Translation and Vaccination Efficacy of sa-mRNAs
10.1016/j.ymthe.2021.01.023 · 2021 · External reference
Isolation of Two Interferon-Induced Translational Inhibitors: A Protein Kinase and an Oligo-Isoadenylate Synthetase
10.1073/pnas.75.10.4734 · 1978 · External reference
Interferons at Age 50: Past, Current and Future Impact on Biomedicine
10.1038/nrd2422 · 2007 · External reference
The OAS-RNase L Pathway: Insights from Experiments of Nature
10.1126/sciimmunol.ads9407 · 2026 · External reference
Incorporation of Pseudouridine into mRNA Enhances Translation by Diminishing PKR Activation
10.1093/nar/gkq347 · 2010 · External reference
Suppression of RNA Recognition by Toll-Like Receptors: The Impact of Nucleoside Modification and the Evolutionary Origin of RNA
10.1016/j.immuni.2005.06.008 · 2005 · External reference
Incorporation of Pseudouridine into mRNA Yields Superior Nonimmunogenic Vector with Increased Translational Capacity and Biological Stability
10.1038/mt.2008.200 · 2008 · External reference
Conjugation of RNA via 2′-OH Acylation: Mechanisms Determining Nucleotide Reactivity
10.1039/d2cc00660j · 2022 · External reference
The Many Pathways of RNA Degradation
10.1016/j.cell.2009.01.019 · 2009 · External reference
Generation of Destabilized Green Fluorescent Protein as a Transcription Reporter
10.1074/jbc.273.52.34970 · 1998 · External reference
Incorporation of Pseudouridine into mRNA Yields Superior Nonimmunogenic Vector with Increased Translational Capacity and Biological Stability
10.1038/mt.2008.200 · 2008 · External reference
Conditional Control of RNA-Guided Nucleic Acid Cleavage and Gene Editing
10.1038/s41467-019-13765-3 · 2020 · External reference
Reversible RNA Acylation for Control of CRISPR-Cas9 Gene Editing
10.1039/c9sc03639c · 2020 · External reference
Design of Noninflammatory Synthetic siRNA Mediating Potent Gene Silencing In Vivo
10.1016/j.ymthe.2005.11.002 · 2006 · External reference
