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References from Omics-Scale Capture of Electrophilic Metabolites. Local targets link to admitted publications; unresolved targets remain external evidence.
Metabolomic “Dark Matter” Dependent on Peroxisomal β-Oxidation in Caenorhabditis elegans
10.1021/jacs.7b11811 · 2018 · External reference
Eight Kinetically Stable but Thermodynamically Activated Molecules that Power Cell Metabolism
10.1021/acs.chemrev.7b00510 · 2018 · External reference
Role of long-chain fatty acyl-CoA esters in the regulation of metabolism and in cell signalling
10.1042/bj3230001 · 1997 · External reference
Long-chain fatty acyl-CoA esters regulate metabolism via allosteric control of AMPK β1 isoforms
10.1038/s42255-020-0245-2 · 2020 · External reference
Type III polyketide synthases in natural product biosynthesis
10.1002/iub.1005 · 2012 · External reference
Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes
10.1016/0891-5849(91)90192-6 · 1991 · External reference
Guidelines for measuring reactive oxygen species and oxidative damage in cells and in vivo
10.1038/s42255-022-00591-z · 2022 · External reference
Aldehyde-Associated Mutagenesis─Current State of Knowledge
10.1021/acs.chemrestox.3c00045 · 2023 · External reference
Endogenous aldehyde-induced DNA–protein crosslinks are resolved by transcription-coupled repair
10.1038/s41556-024-01401-2 · 2024 · External reference
Detection of COVID-19 by quantitative analysis of carbonyl compounds in exhaled breath
10.1038/s41598-024-61735-7 · 2024 · External reference
Endogenous aldehyde accumulation generates genotoxicity and exhaled biomarkers in esophageal adenocarcinoma
10.1038/s41467-021-21800-5 · 2021 · External reference
Discovery of Electrophiles and Profiling of Enzyme Cofactors
10.1002/cpch.86 · 2020 · External reference
The Relative Rates of Thiol–Thioester Exchange and Hydrolysis for Alkyl and Aryl Thioalkanoates in Water
10.1007/s11084-011-9243-4 · 2011 · External reference
Profiling Reactive Metabolites via Chemical Trapping and Targeted Mass Spectrometry
10.1021/acs.analchem.6b02009 · 2016 · External reference
A hydroxylamine probe for profiling S-acylated fatty acids on proteins
10.1039/c9cc05989j · 2019 · External reference
Amino acid and protein specificity of protein fatty acylation in Caenorhabditis elegans
10.1073/pnas.2307515121 · 2024 · External reference
An Untargeted Approach for Revealing Electrophilic Metabolites
10.1021/acschembio.0c00706 · 2020 · External reference
An acyl-CoA thioesterase is essential for the biosynthesis of a key dauer pheromone in C. elegans
10.1016/j.chembiol.2023.12.006 · 2024 · External reference
Rapid Kinetic Characterization of Glycosyl Hydrolases Based on Oxime Derivatization and Nanostructure-Initiator Mass Spectrometry (NIMS)
10.1021/cb5000289 · 2014 · External reference
Quantitative-Profiling Method of Serum Steroid Hormones by Hydroxylamine-Derivatization HPLC-MS
10.1007/s13659-019-0204-3 · 2019 · External reference
Analysis of DNA by ‘Charge Tagging’ and Matrix-assisted Laser Desorption/Ionization Mass Spectrometry
10.1002/(sici)1097-0231(19970115)11:1<43::aid-rcm817>3.0.co;2-h · 1997 · External reference
Trimethylation Enhancement Using Diazomethane (TrEnDi) II: Rapid In-Solution Concomitant Quaternization of Glycerophospholipid Amino Groups and Methylation of Phosphate Groups via Reaction with Diazomethane Significantly Enhances Sensitivity in Mass Spectrometry Analyses via a Fixed, Permanent Positive Charge
10.1021/ac501588y · 2014 · External reference
Development of a novel imidazolium-based aromatic quaternary ammonium tag: Synthesis and application to the efficient analysis of cysteinyl-peptides by mass spectrometry
10.1002/rcm.6785 · 2014 · External reference
Comparative metabolomics with Metaboseek reveals functions of a conserved fat metabolism pathway in C elegans
10.1038/s41467-022-28391-9 · 2022 · External reference
XCMS: Processing Mass Spectrometry Data for Metabolite Profiling Using Nonlinear Peak Alignment, Matching, and Identification
10.1021/ac051437y · 2006 · External reference
MZmine: toolbox for processing and visualization of mass spectrometry based molecular profile data
10.1093/bioinformatics/btk039 · 2006 · External reference
Click Chemistry: Diverse Chemical Function from a Few Good Reactions
10.1002/1521-3773(20010601)40:11<2004::aid-anie2004>3.0.co;2-5 · 2001 · External reference
Cell surface engineering by a modified Staudinger reaction
10.1126/science.287.5460.2007 · 2000 · External reference
A Stepwise Huisgen Cycloaddition Process: Copper(I)-Catalyzed Regioselective “Ligation” of Azides and Terminal Alkynes
10.1002/1521-3773(20020715)41:14<2596::aid-anie2596>3.0.co;2-4 · 2002 · External reference
Solid-Phase Enrichment and Analysis of Azide-Labeled Natural Products: Fishing Downstream of Biochemical Pathways
10.1002/chem.201503781 · 2016 · External reference
Selective enrichment of azide-containing peptides from complex mixtures
10.1021/pr900257z · 2009 · External reference
Deep Interrogation of Metabolism Using a Pathway-Targeted Click-Chemistry Approach
10.1021/jacs.0c06877 · 2020 · External reference
How the Nature of an Alpha-Nucleophile Determines a Brønsted Type-Plot and Its Reaction Pathways An Experimental Study
10.3389/fchem.2021.740161 · 2021 · External reference
A simple oxime–nitrone isomerisation and intramolecular nitrone-cycloaddition reaction of 3-(alk-2-enylamino)propionaldehyde oximes
10.1039/a807542e · 1999 · External reference
Stable isotope labeling by amino acids in cell culture, SILAC, as a simple and accurate approach to expression proteomics
10.1074/mcp.m200025-mcp200 · 2002 · External reference
Determination of aldehydes in drinking water using pentafluorobenzylhydroxylamine derivatization and solid-phase microextraction
10.1016/s0021-9673(01)01437-6 · 2002 · External reference
Detection Limits of Electron and Electron Capture Negative Ionization-Mass Spectrometry for Aldehydes Derivatized with o-(2,3,4,5,6-Pentafluorobenzyl)-Hydroxylamine Hydrochloride
10.1016/j.jasms.2009.12.009 · 2010 · External reference
One Carbon to Rule Them All: Formaldehyde is a One-Carbon Signal Connecting One-Carbon Metabolism and Epigenetic Methylation
10.1021/acschembio.4c00106 · 2024 · External reference
Emerging mechanisms underlying formaldehyde toxicity and response
10.1016/j.molcel.2025.04.018 · 2025 · External reference
Formaldehyde as a probe of DNA structure. I Reaction with exocyclic amino groups of DNA bases
10.1021/bi00677a029 · 1975 · External reference
Formaldehyde as a probe of DNA structure. II Reaction with endocyclic imino groups of DNA bases
10.1021/bi00677a030 · 1975 · External reference
Identification of Formaldehyde-induced Modifications in Proteins: Reactions with Model Peptides
10.1074/jbc.m310752200 · 2004 · External reference
Exogenous and endogenous formaldehyde-induced DNA damage in the aging brain: mechanisms and implications for brain diseases
10.1007/s10565-024-09926-w · 2024 · External reference
Formaldehyde Carcinogenicity Research: 30 Years and Counting for Mode of Action, Epidemiology, and Cancer Risk Assessment
10.1177/0192623312466459 · 2013 · External reference
The cellular function and molecular mechanism of formaldehyde in cardiovascular disease and heart development
10.1111/jcmm.16602 · 2021 · External reference
Genotoxic aldehydes in the hematopoietic system
10.1182/blood.2019004316 · 2022 · External reference
Breath Analysis for the In Vivo Detection of Diabetic Ketoacidosis
10.1021/acsomega.1c05948 · 2022 · External reference
Two Aldehyde Clearance Systems Are Essential to Prevent Lethal Formaldehyde Accumulation in Mice and Humans
10.1016/j.molcel.2020.10.012 · 2020 · External reference
Metabolite-induced DNA damage drives stochastic stem cell loss and clonal hematopoiesis
10.1016/j.stem.2026.02.011 · 2026 · External reference
Rat liver microsomal and nuclear activation of methanol to hydroxymethyl free radicals
10.1016/s0378-4274(02)00021-8 · 2002 · External reference
Role of catalase and hydroxyl radicals in the oxidation of methanol by rat liver microsomes
10.1016/0006-2952(82)90179-4 · 1982 · External reference
Developmental toxicity of methanol in whole embryo culture: a comparative study with mouse and rat embryos
10.1016/0300-483x(93)90013-i · 1993 · External reference
Review of the genotoxicity of formaldehyde
10.1016/0165-1110(88)90027-9 · 1988 · External reference
S1P and plasmalogen derived fatty aldehydes in cellular signaling and functions
10.1016/j.bbalip.2020.158681 · 2020 · External reference
Emerging Roles of Aldehyde Dehydrogenase Isoforms in Anti-cancer Therapy Resistance
10.3389/fmed.2022.795762 · 2022 · External reference
Reactive Chlorinating Species Produced by Myeloperoxidase Target the Vinyl Ether Bond of Plasmalogens: IDENTIFICATION OF 2-CHLOROHEXADECANAL*
10.1074/jbc.m101447200 · 2001 · External reference
Identification of glutathione adducts of α-chlorofatty aldehydes produced in activated neutrophils
10.1194/jlr.m058636 · 2015 · External reference
Strategies for the analysis of chlorinated lipids in biological systems
10.1016/j.freeradbiomed.2012.06.013 · 2013 · External reference
Novel keto-phospholipids are generated by monocytes and macrophages, detected in cystic fibrosis, and activate peroxisome proliferator-activated receptor-γ
10.1074/jbc.m112.405407 · 2012 · External reference
Half is enough: Oxidized lysophospholipids as novel bioactive molecules
10.1016/j.freeradbiomed.2022.06.228 · 2022 · External reference
Comparative Metabolomics Reveals Endogenous Ligands of DAF-12, a Nuclear Hormone Receptor, Regulating C elegans Development and Lifespan
10.1016/j.cmet.2013.11.024 · 2014 · External reference
Identification of ligands for DAF-12 that govern dauer formation and reproduction in C. elegans
10.1016/j.cell.2006.01.037 · 2006 · External reference
Small-molecule pheromones and hormones controlling nematode development
10.1038/nchembio.2356 · 2017 · External reference
Repurposing degradation pathways for modular metabolite biosynthesis in nematodes
10.1038/s41589-023-01301-w · 2023 · External reference
A blend of small molecules regulates both mating and development in Caenorhabditis elegans
10.1038/nature07168 · 2008 · External reference
Comparative Metabolomics Reveals Biogenesis of Ascarosides, a Modular Library of Small-Molecule Signals in C. elegans
10.1021/ja210202y · 2012 · External reference
Engineering Escherichia coli for odd straight medium chain free fatty acid production
10.1007/s00253-014-5882-5 · 2014 · External reference
Identification and relative quantification of fatty acids in Escherichia coli membranes by gas chromatography/mass spectrometry
10.1002/rcm.3177 · 2007 · External reference
Physiological role of Acyl coenzyme A synthetase homologs in lipid metabolism in Neurospora crassa
10.1128/ec.00079-13 · 2013 · External reference
Acyl-coenzyme A synthetases in metabolic control
10.1097/mol.0b013e32833884bb · 2010 · External reference
The Escherichia coli fadK (ydiD) Gene Encodes an Anerobically Regulated Short Chain Acyl-CoA Synthetase*
10.1074/jbc.m405233200 · 2004 · External reference
Regulation of C elegans fat uptake and storage by acyl-CoA synthase-3 is dependent on NR5A family nuclear hormone receptor nhr-25
10.1016/j.cmet.2010.08.013 · 2010 · External reference
Fatty acid degradation in Escherichia coli. An inducible acyl-CoA synthetase, the mapping of old-mutations, and the isolation of regulatory mutants
10.1111/j.1432-1033.1969.tb19644.x · 1969 · External reference
Cloning, sequencing, and expression of the fadD gene of Escherichia coli encoding acyl coenzyme A synthetase
10.1016/s0021-9258(19)74070-8 · 1992 · External reference
Molecular effect of FadD on the regulation and metabolism of fatty acid in Escherichia coli
10.1111/j.1574-6968.2006.00277.x · 2006 · External reference
Identification of Cyclopropane Fatty Acids in Human Plasma after Controlled Dietary Intake of Specific Foods
10.3390/nu12113347 · 2020 · External reference
Identification of Cyclopropaneoctanoic Acid 2-Hexyl in Human Adipose Tissue and Serum
10.1007/s11745-013-3806-2 · 2013 · External reference
Determination of Cyclopropane Fatty Acids in Food of Animal Origin by 1H NMR
10.1155/2018/8034042 · 2018 · External reference
An Overview on the Presence of Cyclopropane Fatty Acids in Milk and Dairy Products
10.1021/jf4057204 · 2014 · External reference
Evolutionarily related host and microbial pathways regulate fat desaturation in C. elegans
10.1038/s41467-024-45782-2 · 2024 · External reference
Acyl-CoA Dehydrogenase Drives Heat Adaptation by Sequestering Fatty Acids
10.1016/j.cell.2015.04.026 · 2015 · External reference
Cytochrome P450 omega hydroxylase (CYP4) function in fatty acid metabolism and metabolic diseases
10.1016/j.bcp.2008.03.004 · 2008 · External reference
Biosynthesis of Modular Ascarosides in C. elegans
10.1002/anie.201700103 · 2017 · External reference
Biosynthetic tailoring of existing ascaroside pheromones alters their biological function in C elegans
10.7554/elife.33286 · 2018 · External reference
A Large Family of Enzymes Responsible for the Modular Architecture of Nematode Pheromones
10.1021/jacs.0c04223 · 2020 · External reference
Modular metabolite assembly in Caenorhabditis elegans depends on carboxylesterases and formation of lysosome-related organelles
10.7554/elife.61886 · 2020 · External reference
Lysine iminylation derived from ω 3 polyunsaturated fatty acids
2025 · External reference
Mechanisms of metabolism-coupled protein modifications
10.1038/s41589-024-01805-z · 2025 · External reference
Complex peptide natural products: Biosynthetic principles, challenges and opportunities for pathway engineering
10.1016/j.synbio.2022.01.007 · 2022 · External reference
Aminoacyl chain translocation catalysed by a type II thioesterase domain in an unusual non-ribosomal peptide synthetase
10.1038/s41467-021-27512-0 · 2022 · External reference