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References from Minimal Functional Scaffolds of the <i>Streptococcus sinensis</i> Competence-Stimulating Peptide Define the Balance between Receptor Promiscuity and Signaling Specificity. Local targets link to admitted publications; unresolved targets remain external evidence.
Microbial Quorum Sensing: Mechanisms, Applications, and Challenges
10.1016/j.biotechadv.2025.108733 · 2026 · External reference
Quorum Sensing: Not Just a Bridge between Bacteria
10.1002/mbo3.70016 · 2025 · External reference
A Review of Quorum-Sensing and Its Role in Mediating Interkingdom Interactions in the Ocean
10.1038/s42003-025-07608-9 · 2025 · External reference
Bacterial Quorum Sensing and Microbial Community Interactions
10.1128/mbio.02331-17 · 2018 · External reference
Quorum Sensing: Cell-to-Cell Communication in Bacteria
10.1146/annurev.cellbio.21.012704.131001 · 2005 · External reference
Quorum Sensing in Bacteria
10.1146/annurev.micro.55.1.165 · 2001 · External reference
Expression of Pseudomonas aeruginosa Virulence Genes Requires Cell-to-Cell Communication
10.1126/science.8493556 · 1993 · External reference
The Multiple Signaling Systems Regulating Virulence in Pseudomonas aeruginosa
10.1128/mmbr.05007-11 · 2012 · External reference
Revisiting the Virulence Hallmarks of Pseudomonas aeruginosa: A Chronicle through the Perspective of Quorum Sensing
10.1111/1462-2920.15784 · 2022 · External reference
Quorum Sensing Negatively Regulates Hemolysin Transcriptionally and Posttranslationally in Vibrio cholerae
10.1128/iai.00590-09 · 2010 · External reference
Quorum Sensing Regulates Type III Secretion in Vibrio harveyi and Vibrio parahaemolyticus
10.1128/jb.186.12.3794-3805.2004 · 2004 · External reference
Quorum-Sensing Regulators Control Virulence Gene Expression in Vibrio cholerae
10.1073/pnas.052694299 · 2002 · External reference
Regulation of Virulence in Staphylococcus aureus: Molecular Mechanisms and Remaining Puzzles
10.1016/j.chembiol.2016.01.004 · 2016 · External reference
The Staphylococcal Biofilm: Adhesins, Regulation, and Host Response
10.1128/microbiolspec.vmbf-0022-2015 · 2016 · External reference
Molecular Mechanisms of agr Quorum Sensing in Virulent Staphylococci
10.1002/cbic.200700023 · 2007 · External reference
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis Presenting with Disseminated Streptococcus constellatus Pyogenic Infection
10.7759/cureus.87317 · 2025 · External reference
Quorum Sensing and Biofilm Formation in Streptococcal Infections
10.1172/jci20430 · 2003 · External reference
Streptococcus sinensis sp. nov., a Novel Species Isolated from a Patient with Infective Endocarditis
10.1128/jcm.40.3.805-810.2002 · 2002 · External reference
A Quorum-Sensing Signaling System Essential for Genetic Competence in Streptococcus mutans Is Involved in Biofilm Formation
10.1128/jb.184.10.2699-2708.2002 · 2002 · External reference
Effects of Mutating Putative Two-Component Systems on Biofilm Formation by Streptococcus mutans UA159
10.1111/j.1574-6968.2001.tb10952.x · 2001 · External reference
The MutRS Quorum-Sensing System Controls Lantibiotic Mutacin Production in the Human Pathogen Streptococcus mutans
10.1073/pnas.2421164122 · 2025 · External reference
RRNPP Quorum-Sensing Repertoires in the salivarius Group Genomes: Overrepresentation and Synchronous Activation of SHP/Rgg Systems in Streptococcus thermophilus
10.1128/jb.00231-25 · 2025 · External reference
Transcriptome Analysis of Streptococcus mutans Quorum Sensing-Mediated Persisters Reveals an Enrichment in Genes Related to Stress Defense Mechanisms
10.3390/genes14101887 · 2023 · External reference
Streptococcus mutans sigX-Inducing Peptide Inhibits the Virulence of Candida albicans and Oral Candidiasis through the Ras1-cAMP-Efg1 Pathway
10.1016/j.ijantimicag.2023.106855 · 2023 · External reference
Crosstalk between paralogous ComRS quorum-sensing systems diversifies the competence/bacteriocin networks of oral streptococci
10.1101/2022.10.14.512260 · 2022 · External reference
Distribution of Two-Component Signal Transduction Systems BlpRH and ComDE Across Streptococcal Species
10.3389/fmicb.2022.960994 · 2022 · External reference
Export of Rgg Quorum Sensing Peptides Is Mediated by the PptAB ABC Transporter in Streptococcus thermophilus Strain LMD-9
10.3390/genes11091096 · 2020 · External reference
Competence in Streptococcus pneumoniae and Close Commensal Relatives: Mechanisms and Implications
10.3389/fcimb.2019.00094 · 2019 · External reference
Rgg-Shp Regulators Are Important for Pneumococcal Colonization and Invasion through Their Effect on Mannose Utilization and Capsule Synthesis
10.1038/s41598-018-24910-1 · 2018 · External reference
A Quorum-Sensing System That Regulates Streptococcus pneumoniae Biofilm Formation and Surface Polysaccharide Production
10.1128/msphere.00324-17 · 2017 · External reference
Quorum Sensing Regulation of Competence and Bacteriocins in Streptococcus pneumoniae and mutans
10.3390/genes8010015 · 2017 · External reference
Genetic and Structural Analyses of RRNPP Intercellular Peptide Signaling of Gram-Positive Bacteria
10.1146/annurev-genet-120116-023507 · 2017 · External reference
Quorum-Sensing Regulators in Gram-Positive Bacteria: ‘Cherchez le Peptide’
10.1111/mmi.13060 · 2015 · External reference
Death and Survival in Streptococcus mutans: Differing Outcomes of a Quorum-Sensing Signaling Peptide
10.3389/fmicb.2015.01176 · 2015 · External reference
Cell Death of Streptococcus mutans Induced by a Quorum-Sensing Peptide Occurs via a Conserved Streptococcal Autolysin
10.1128/jb.00926-12 · 2013 · External reference
Two Group A Streptococcal Peptide Pheromones Act through Opposing Rgg Regulators to Control Biofilm Development
10.1371/journal.ppat.1002190 · 2011 · External reference
Regulation of Competence for Genetic Transformation in Streptococcus pneumoniae: A Link between Quorum Sensing and DNA Processing Genes
10.1016/s0923-2508(00)00171-6 · 2000 · External reference
Development of Competence in Streptococcus pneumoniae: Pheromone Autoinduction and Control of Quorum Sensing by the Oligopeptide Permease
10.1046/j.1365-2958.1998.00904.x · 1998 · External reference
Mapping the Structural Determinants of Quorum Sensing Activity in Streptococcus sinensis via Mutational Analysis of Its Competence Stimulating Peptide
10.1021/acs.biochem.6c00057 · 2026 · External reference
Deciphering the Regulatory Role and Molecular Interactions That Drive the Competence Regulon Quorum Sensing Circuitry in Streptococcus constellatus
10.1021/acs.biochem.5c00195 · 2025 · External reference
Elucidating the Role of the Competence Regulon Quorum Sensing Circuitry in Streptococcus cristatus
10.1021/acschembio.5c00180 · 2025 · External reference
The Quorum Sensing-Controlled Competence Regulon Drives H2O2 Production in Streptococcus gordonii
10.1021/acsinfecdis.5c00926 · 2025 · External reference
Noncanonical Streptococcus sanguinis ComCDE Circuitry Integrates Environmental Cues in Transformation Outcome Decision
10.1016/j.chembiol.2023.09.007 · 2024 · External reference
Investigating the Streptococcus sinensis Competence Regulon through a Combination of Transcriptome Analysis and Phenotypic Evaluation
10.1099/mic.0.001256 · 2022 · External reference
Elucidating the Role and Structure-Activity Relationships of the Streptococcus oligofermentans Competence-Stimulating Peptide
10.1021/acschembio.1c00746 · 2021 · External reference
Secretion, Maturation, and Activity of a Quorum Sensing Peptide (GSP) Inducing Bacteriocin Transcription in Streptococcus gallolyticus
10.1128/mbio.03189-20 · 2021 · External reference
Biological Evaluation of Native Streptococcal Competence Stimulating Peptides Reveals Potential Crosstalk between Streptococcus mitis and Streptococcus pneumoniae and a New Scaffold for the Development of S. pneumoniae Quorum Sensing Modulators
10.1039/d0cb00012d · 2020 · External reference
Structure Activity Relationship Study of the XIP Quorum Sensing Pheromone in Streptococcus mutans Reveal Inhibitors of the Competence Regulon
10.1021/acschembio.0c00650 · 2020 · External reference
Exploring the Competence Stimulating Peptide (CSP) N-Terminal Requirements for Effective ComD Receptor Activation in Group1 Streptococcus pneumoniae
10.1016/j.bioorg.2019.102987 · 2019 · External reference
Identification of Highly Potent Competence Stimulating Peptide-Based Quorum Sensing Activators in Streptococcus mutans through the Utilization of N-Methyl and Reverse Alanine Scanning
10.1016/j.bmcl.2019.01.029 · 2019 · External reference
Defining the Hydrophobic Interactions That Drive Competence Stimulating Peptide (CSP)-ComD Binding in Streptococcus pneumoniae
10.3762/bjoc.14.151 · 2018 · External reference
Structure-Activity Relationships of the Competence Stimulating Peptide in Streptococcus mutans Reveal Motifs Critical for Membrane Protease SepM Recognition and ComD Receptor Activation
10.1021/acsinfecdis.8b00115 · 2018 · External reference
Structure-Activity Relationships of the Competence Stimulating Peptides (CSPs) in Streptococcus pneumoniae Reveal Motifs Critical for Intra-Group and Cross-Group ComD Receptor Activation
10.1021/acschembio.7b00007 · 2017 · External reference
Quorum Sensing in Streptococci and Its Peptide-Mediated Modulation
10.1042/bsr20260162 · 2026 · External reference
Pharmacological Evaluation of Synthetic Dominant-Negative Peptides Derived from the Competence-Stimulating Peptide of Streptococcus pneumoniae
10.1021/acsptsci.2c00037 · 2022 · External reference
Development of a Dominant Negative Competence-Stimulating Peptide (dnCSP) That Attenuates Streptococcus pneumoniae Infectivity in a Mouse Model of Acute Pneumonia
10.1002/cbic.201800505 · 2018 · External reference
Inhibition of Competence Development, Horizontal Gene Transfer and Virulence in Streptococcus pneumoniae by a Modified Competence Stimulating Peptide
10.1371/journal.ppat.1002241 · 2011 · External reference
Accurate Structure Prediction of Biomolecular Interactions with AlphaFold 3
10.1038/s41586-024-07487-w · 2024 · External reference
Quantitative Analysis of Autoinducing Peptide I (AIP-I) from Staphylococcus aureus Cultures Using Ultrahigh Performance Liquid Chromatography–High Resolving Power Mass Spectrometry
10.1016/j.jchromb.2013.04.019 · 2013 · External reference
UCSF ChimeraX: Tools for Structure Building and Analysis
10.1002/pro.4792 · 2023 · External reference
