Research graph
References from XL-MS and De Novo Protein Design Identified a Common Motif for TREM2 Binding. Local targets link to admitted publications; unresolved targets remain external evidence.
Spatial patterns of neuroimaging biomarker change in individuals from families with autosomal dominant Alzheimer’s disease: a longitudinal study
10.1016/s1474-4422(18)30028-0 · 2018 · External reference
The amyloid hypothesis of Alzheimer’s disease: progress and problems on the road to therapeutics
10.1126/science.1072994 · 2002 · External reference
Alzheimer’s disease: the amyloid cascade hypothesis
10.1126/science.1566067 · 1992 · External reference
The amyloid hypothesis of Alzheimer’s disease at 25 years
10.15252/emmm.201606210 · 2016 · External reference
Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer’s disease risk
10.1038/s41588-018-0311-9 · 2019 · External reference
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer’s disease
10.1038/ng.2802 · 2013 · External reference
Apolipoprotein E: Structural Insights and Links to Alzheimer Disease Pathogenesis
10.1016/j.neuron.2020.10.008 · 2021 · External reference
New insights into the role of TREM2 in Alzheimer’s disease
10.1186/s13024-018-0298-9 · 2018 · External reference
Microglia in Alzheimer’s disease
10.1083/jcb.201709069 · 2018 · External reference
Interplay between innate immunity and Alzheimer disease: APOE and TREM2 in the spotlight
10.1038/s41577-018-0051-1 · 2018 · External reference
TREM2 - a key player in microglial biology and Alzheimer disease
10.1038/s41582-018-0072-1 · 2018 · External reference
The Physiology, Pathology, and Potential Therapeutic Applications of the TREM2 Signaling Pathway
10.1016/j.cell.2020.05.003 · 2020 · External reference
TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy
10.1016/j.neuron.2016.05.003 · 2016 · External reference
TREM2 Maintains Microglial Metabolic Fitness in Alzheimer’s Disease
10.1016/j.cell.2017.07.023 · 2017 · External reference
Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2)
10.1074/jbc.m115.679043 · 2015 · External reference
The Triggering Receptor Expressed on Myeloid Cells 2 Binds Apolipoprotein E
10.1074/jbc.m115.677286 · 2015 · External reference
TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia
10.1016/j.neuron.2016.06.015 · 2016 · External reference
Functional insights from biophysical study of TREM2 interactions with apoE and Abeta1–42
10.1002/alz.12194 · 2021 · External reference
TREM2-apoE3 interactions and Alzheimer’s disease: Molecular and structural insights and effects of TREM2 R47H and apoE4 variants
10.1002/alz.70729 · 2025 · External reference
Biophysical mapping of TREM2-ligand interactions reveals shared surfaces for engagement of multiple Alzheimer’s disease ligands
10.1186/s13024-024-00795-9 · 2025 · External reference
Apolipoprotein E induces pathogenic senescent-like myeloid cells in prostate cancer
10.1016/j.ccell.2023.02.004 · 2023 · External reference
Helical structure, stability, and dynamics in human apolipoprotein E3 and E4 by hydrogen exchange and mass spectrometry
10.1073/pnas.1617523114 · 2017 · External reference
xiNET: cross-link network maps with residue resolution
10.1074/mcp.o114.042259 · 2015 · External reference
Topology of human apolipoprotein E3 uniquely regulates its diverse biological functions
10.1073/pnas.1106420108 · 2011 · External reference
Characterization of the N- and C-terminal domain interface of the three main apoE isoforms: A combined quantitative cross-linking mass spectrometry and molecular modeling study
10.1016/j.bbagen.2025.130768 · 2025 · External reference
AlphaFlex: Ensembles of the human proteome representing disordered regions
10.1101/2025.11.24.690279 · 2025 · External reference
Structural Biology in the Clouds: The WeNMR-EOSC Ecosystem
10.3389/fmolb.2021.729513 · 2021 · External reference
The HADDOCK2.4 web server for integrative modeling of biomolecular complexes
10.1038/s41596-024-01011-0 · 2024 · External reference
One-shot design of functional protein binders with BindCraft
10.1038/s41586-025-09429-6 · 2025 · External reference
TREM2-mediated regulation of myeloid cells in the tumor microenvironment: new insights and therapeutic prospects
10.1038/s41698-025-01152-9 · 2025 · External reference
Soluble TREM2 inhibits secondary nucleation of Abeta fibrillization and enhances cellular uptake of fibrillar Abeta
10.1073/pnas.2114486119 · 2022 · External reference
A high-speed search engine pLink 2 with systematic evaluation for proteome-scale identification of cross-linked peptides
10.1038/s41467-019-11337-z · 2019 · External reference
Xwalk: computing and visualizing distances in cross-linking experiments
10.1093/bioinformatics/btr348 · 2011 · External reference
PED in 2024: improving the community deposition of structural ensembles for intrinsically disordered proteins
10.1093/nar/gkad947 · 2024 · External reference
On the acquisition and analysis of microscale thermophoresis data
10.1016/j.ab.2015.12.013 · 2016 · External reference
BeStSel: webserver for secondary structure and fold prediction for protein CD spectroscopy
10.1093/nar/gkac345 · 2022 · External reference
Functional insights from biophysical study of TREM2 interactions with apoE and Abeta1–42
10.1002/alz.12194 · ExternalCitation · doi-reference
TREM2-apoE3 interactions and Alzheimer’s disease: Molecular and structural insights and effects of TREM2 R47H and apoE4 variants
10.1002/alz.70729 · ExternalCitation · doi-reference
On the acquisition and analysis of microscale thermophoresis data
10.1016/j.ab.2015.12.013 · ExternalCitation · doi-reference
Characterization of the N- and C-terminal domain interface of the three main apoE isoforms: A combined quantitative cross-linking mass spectrometry and molecular modeling study
10.1016/j.bbagen.2025.130768 · ExternalCitation · doi-reference
Apolipoprotein E induces pathogenic senescent-like myeloid cells in prostate cancer
10.1016/j.ccell.2023.02.004 · ExternalCitation · doi-reference
TREM2 Maintains Microglial Metabolic Fitness in Alzheimer’s Disease
10.1016/j.cell.2017.07.023 · ExternalCitation · doi-reference
The Physiology, Pathology, and Potential Therapeutic Applications of the TREM2 Signaling Pathway
10.1016/j.cell.2020.05.003 · ExternalCitation · doi-reference
TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy
10.1016/j.neuron.2016.05.003 · ExternalCitation · doi-reference
TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia
10.1016/j.neuron.2016.06.015 · ExternalCitation · doi-reference
Apolipoprotein E: Structural Insights and Links to Alzheimer Disease Pathogenesis
10.1016/j.neuron.2020.10.008 · ExternalCitation · doi-reference
Spatial patterns of neuroimaging biomarker change in individuals from families with autosomal dominant Alzheimer’s disease: a longitudinal study
10.1016/s1474-4422(18)30028-0 · ExternalCitation · doi-reference
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer’s disease
10.1038/ng.2802 · ExternalCitation · doi-reference
A high-speed search engine pLink 2 with systematic evaluation for proteome-scale identification of cross-linked peptides
10.1038/s41467-019-11337-z · ExternalCitation · doi-reference
Interplay between innate immunity and Alzheimer disease: APOE and TREM2 in the spotlight
10.1038/s41577-018-0051-1 · ExternalCitation · doi-reference
TREM2 - a key player in microglial biology and Alzheimer disease
10.1038/s41582-018-0072-1 · ExternalCitation · doi-reference
One-shot design of functional protein binders with BindCraft
10.1038/s41586-025-09429-6 · ExternalCitation · doi-reference
Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer’s disease risk
10.1038/s41588-018-0311-9 · ExternalCitation · doi-reference
The HADDOCK2.4 web server for integrative modeling of biomolecular complexes
10.1038/s41596-024-01011-0 · ExternalCitation · doi-reference
TREM2-mediated regulation of myeloid cells in the tumor microenvironment: new insights and therapeutic prospects
10.1038/s41698-025-01152-9 · ExternalCitation · doi-reference
Topology of human apolipoprotein E3 uniquely regulates its diverse biological functions
10.1073/pnas.1106420108 · ExternalCitation · doi-reference
Helical structure, stability, and dynamics in human apolipoprotein E3 and E4 by hydrogen exchange and mass spectrometry
10.1073/pnas.1617523114 · ExternalCitation · doi-reference
Soluble TREM2 inhibits secondary nucleation of Abeta fibrillization and enhances cellular uptake of fibrillar Abeta
10.1073/pnas.2114486119 · ExternalCitation · doi-reference
The Triggering Receptor Expressed on Myeloid Cells 2 Binds Apolipoprotein E
10.1074/jbc.m115.677286 · ExternalCitation · doi-reference
Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2)
10.1074/jbc.m115.679043 · ExternalCitation · doi-reference
xiNET: cross-link network maps with residue resolution
10.1074/mcp.o114.042259 · ExternalCitation · doi-reference
Microglia in Alzheimer’s disease
10.1083/jcb.201709069 · ExternalCitation · doi-reference
Xwalk: computing and visualizing distances in cross-linking experiments
10.1093/bioinformatics/btr348 · ExternalCitation · doi-reference
BeStSel: webserver for secondary structure and fold prediction for protein CD spectroscopy
10.1093/nar/gkac345 · ExternalCitation · doi-reference
PED in 2024: improving the community deposition of structural ensembles for intrinsically disordered proteins
10.1093/nar/gkad947 · ExternalCitation · doi-reference
AlphaFlex: Ensembles of the human proteome representing disordered regions
10.1101/2025.11.24.690279 · ExternalCitation · doi-reference
The amyloid hypothesis of Alzheimer’s disease: progress and problems on the road to therapeutics
10.1126/science.1072994 · ExternalCitation · doi-reference
Alzheimer’s disease: the amyloid cascade hypothesis
10.1126/science.1566067 · ExternalCitation · doi-reference
New insights into the role of TREM2 in Alzheimer’s disease
10.1186/s13024-018-0298-9 · ExternalCitation · doi-reference
Biophysical mapping of TREM2-ligand interactions reveals shared surfaces for engagement of multiple Alzheimer’s disease ligands
10.1186/s13024-024-00795-9 · ExternalCitation · doi-reference
The amyloid hypothesis of Alzheimer’s disease at 25 years
10.15252/emmm.201606210 · ExternalCitation · doi-reference
Structural Biology in the Clouds: The WeNMR-EOSC Ecosystem
10.3389/fmolb.2021.729513 · ExternalCitation · doi-reference
