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References from Amoebae-Based Screening Reveals a Novel Family of Compounds Restricting Intracellular Legionella pneumophila. Local targets link to admitted publications; unresolved targets remain external evidence.
Legionella spp. outdoors: colonization, communication and persistence
10.1111/j.1758-2229.2011.00247.x · 2011 · External reference
Molecular pathogenesis of infections caused by Legionella pneumophila
10.1128/cmr.00052-09 · 2010 · External reference
The Legionella pneumophila replication vacuole: making a cosy niche inside host cells
10.1038/nrmicro1967 · 2009 · External reference
Modulation of host cell function by Legionella pneumophila type IV effectors
10.1146/annurev-cellbio-100109-104034 · 2010 · External reference
Secretive bacterial pathogens and the secretory pathway
10.1111/j.1600-0854.2012.01344.x · 2012 · External reference
The natural alternative: protozoa as cellular models for Legionella infection
10.1111/cmi.12235 · 2014 · External reference
Legionella: macrolides or quinolones?
10.1111/j.1469-0691.2006.01394.x · 2006 · External reference
Subversion of membrane transport pathways by vacuolar pathogens
10.1083/jcb.201105019 · 2011 · External reference
Unresolved reference
2013 · External reference
Inhibition of Legionella pneumophila multiplication within human macrophages by antimicrobial agents
10.1128/aac.30.5.743 · 1986 · External reference
Intraphagocytic growth induces an antibiotic-resistant phenotype of Legionella pneumophila
10.1128/aac.39.12.2684 · 1995 · External reference
Acanthamoeba polyphaga resuscitates viable non-culturable Legionella pneumophila after disinfection
10.1111/j.1462-2920.2007.01245.x · 2007 · External reference
Legionella, protozoa, and biofilms: interactions within complex microbial systems
10.1007/s00248-009-9514-z · 2009 · External reference
Drugs for bad bugs: confronting the challenges of antibacterial discovery
10.1038/nrd2201 · 2007 · External reference
Effect of antibiotic prescribing in primary care on antimicrobial resistance in individual patients: systematic review and meta-analysis
10.1136/bmj.c2096 · 2010 · External reference
Targeting virulence: a new paradigm for antimicrobial therapy
10.1038/nchembio.2007.24 · 2007 · External reference
The biology and future prospects of antivirulence therapies
10.1038/nrmicro1818 · 2008 · External reference
Exploiting quorum sensing to confuse bacterial pathogens
10.1128/mmbr.00046-12 · 2013 · External reference
Safety and pharmacokinetics of urtoxazumab, a humanized monoclonal antibody, against Shiga-like toxin 2 in healthy adults and in pediatric patients infected with Shiga-like toxin-producing Escherichia coli
10.1128/aac.00343-09 · 2010 · External reference
Salicylidene acylhydrazides that affect type III protein secretion in Salmonella enterica serovar typhimurium
10.1128/aac.00223-07 · 2007 · External reference
Small-molecule inhibitor of Vibrio cholerae virulence and intestinal colonization
10.1126/science.1116739 · 2005 · External reference
Identification of anti-virulence compounds that disrupt quorum-sensing regulated acute and persistent pathogenicity
10.1371/journal.ppat.1004321 · 2014 · External reference
Exploring anti-bacterial compounds against intracellular Legionella
10.1371/journal.pone.0074813 · 2013 · External reference
Comparison of shape-matching and docking as virtual screening tools
10.1021/jm0603365 · 2006 · External reference
Novel inhibitors of the calcineurin/NFATc hub - alternatives to CsA and FK506?
10.1186/1478-811x-7-25 · 2009 · External reference
The novel calcineurin inhibitor CN585 has potent immunosuppressive properties in stimulated human T cells
10.1074/jbc.m109.024844 · 2010 · External reference
Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes
10.1016/0092-8674(91)90124-h · 1991 · External reference
Inhibition of calcineurin by quercetin in vitro and in Jurkat cells
10.1093/jb/mvp163 · 2010 · External reference
Effects of chlorogenic acid, an active compound activating calcineurin, purified from Flos lonicerae on macrophage
2004 · External reference
Legionella phagosomes intercept vesicular traffic from endoplasmic reticulum exit sites
10.1038/ncb883 · 2002 · External reference
Calnexin, calreticulin and cytoskeleton-associated proteins modulate uptake and growth of Legionella pneumophila in Dictyostelium discoideum
10.1099/mic.0.27111-0 · 2004 · External reference
Intracellular growth of Legionella pneumophila in Dictyostelium discoideum, a system for genetic analysis of host-pathogen interactions
10.1128/iai.68.5.2939-2947.2000 · 2000 · External reference
The mechanism of action of FK-506 and cyclosporin A
10.1111/j.1749-6632.1993.tb17137.x · 1993 · External reference
From Norway to Novartis: cyclosporin from Tolypocladium inflatum in an open access bioprospecting regime
10.1023/a:1008990919682 · 2000 · External reference
Cyclophilin: a specific cytosolic binding protein for cyclosporin A
10.1126/science.6238408 · 1984 · External reference
A role for calcineurin in Dictyostelium discoideum development
10.1046/j.1432-0436.1996.6050269.x · 1996 · External reference
On the action of cyclosporine A, rapamycin and tacrolimus on M. avium including subspecies paratuberculosis
10.1371/journal.pone.0002496 · 2008 · External reference
Calmodulin-dependent activation of calcineurin by chlorogenic acid
10.1080/15216540701411244 · 2007 · External reference
Stress and development in Dictyostelium discoideum: the involvement of the catalytic calcineurin A subunit
10.1002/jobm.201200574 · 2014 · External reference
Aberrant stalk development and breakdown of tip dominance in Dictyostelium cell lines with RNAi-silenced expression of calcineurin B
10.1186/1471-213x-6-12 · 2006 · External reference
Chlamydia trachomatis Mip-like protein has peptidyl-prolyl cis/trans isomerase activity that is inhibited by FK506 and rapamycin and is implicated in initiation of chlamydial infection
10.1111/j.1365-2958.1993.tb01168.x · 1993 · External reference
Legionella pneumophila mip gene potentiates intracellular infection of protozoa and human macrophages
10.1073/pnas.89.11.5188 · 1992 · External reference
Characterization of a Legionella micdadei mip mutant
10.1128/iai.63.8.2840-2845.1995 · 1995 · External reference
Cytosolic free Ca(2+) changes and calpain activation are required for beta integrin-accelerated phagocytosis by human neutrophils
10.1083/jcb.200206089 · 2002 · External reference
Dictyostelium discoideum as a model system for identification of Burkholderia pseudomallei virulence factors
10.1128/iai.01233-10 · 2011 · External reference
Establishment and validation of whole-cell based fluorescence assays to identify anti-mycobacterial compounds using the Acanthamoeba castellanii-Mycobacterium marinum host-pathogen system
10.1371/journal.pone.0087834 · 2014 · External reference
Chemical genetics reveals bacterial and host cell functions critical for type IV effector translocation by Legionella pneumophila
10.1371/journal.ppat.1000501 · 2009 · External reference
Fusaric acid modulates type three secretion system of Salmonella enterica serovar typhimurium
10.1016/j.bbrc.2014.05.044 · 2014 · External reference
High-throughput identification of chemical inhibitors of E. coli group 2 capsule biogenesis as anti-virulence agents
10.1371/journal.pone.0011642 · 2010 · External reference
Host-directed antimicrobial drugs with broad-spectrum efficacy against intracellular bacterial pathogens
10.1128/mbio.01534-14 · 2014 · External reference
Identification of Legionella pneumophila genes required for growth within and killing of human macrophages
10.1128/iai.61.12.5361-5373.1993 · 1993 · External reference
Intracellular multiplication and human macrophage killing by Legionella pneumophila are inhibited by conjugal components of IncQ plasmid RSF1010
10.1046/j.1365-2958.1998.01054.x · 1998 · External reference
The Legionella pneumophila response regulator LqsR promotes host cell interactions as an element of the virulence regulatory network controlled by RpoS and LetA
10.1111/j.1462-5822.2007.01005.x · 2007 · External reference
Charcoal-yeast extract agar: primary isolation medium for Legionella pneumophila
10.1128/jcm.10.4.437-441.1979 · 1979 · External reference
Initiation of multicellular differentiation in Dictyostelium discoideum is regulated by coronin A
10.1091/mbc.e13-04-0219 · 2014 · External reference
Legionella pneumophila exploits PI(4)P to anchor secreted effector proteins to the replicative vacuole
10.1371/journal.ppat.0020046 · 2006 · External reference
The inositol polyphosphate 5-phosphatase OCRL1 restricts intracellular growth of Legionella, localizes to the replicative vacuole and binds to the bacterial effector LpnE
10.1111/j.1462-5822.2008.01266.x · 2009 · External reference
The Legionella effector RidL inhibits retrograde trafficking to promote intracellular replication
10.1016/j.chom.2013.06.001 · 2013 · External reference
Functional analysis of novel Rab GTPases identified in the proteome of purified Legionella-containing vacuoles from macrophages
2014 · External reference
Activation of Ran GTPase by a Legionella effector promotes microtubule polymerization, pathogen vacuole motility and infection
10.1371/journal.ppat.1003598 · 2013 · External reference
ZINC: a free tool to discover chemistry for biology
10.1021/ci3001277 · 2012 · External reference
