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References from Monoclonal Antibodies That Recognize the Alkylation Signature of Antimalarial Ozonides OZ277 (Arterolane) and OZ439 (Artefenomel). Local targets link to admitted publications; unresolved targets remain external evidence.
The discovery of artemisinin (qinghaosu) and gifts from Chinese medicine
10.1038/nm.2471 · 2011 · External reference
Qinghaosu (artemisinin): the price of success
10.1126/science.1155165 · 2008 · External reference
Synthetic peroxides as antimalarials
10.1002/med.10066 · 2004 · External reference
New developments in synthetic peroxidic drugs as artemisinin mimics
10.1016/j.drudis.2007.04.009 · 2007 · External reference
Progress in the development of peroxide-based anti-parasitic agents
10.1016/j.drudis.2009.05.008 · 2009 · External reference
Semisynthetic artemisinin and synthetic peroxide antimalarials
10.1039/9781849733496-00033 · 2011 · External reference
Identification of an antimalarial synthetic trioxolane drug development candidate
10.1038/nature02779 · 2004 · External reference
Antiparasitic agents: new drugs on the horizon
10.1016/j.coph.2012.05.001 · 2012 · External reference
The global pipeline of new medicines for the control and elimination of malaria
10.1186/1475-2875-11-316 · 2012 · External reference
Malaria medicines: a glass half full?
10.1038/nrd4573 · 2015 · External reference
Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria
10.1073/pnas.1015762108 · 2011 · External reference
First-in-man safety and pharmacokinetics of synthetic ozonide OZ439 demonstrates an improved exposure profile relative to other peroxide antimalarials
10.1111/j.1365-2125.2012.04368.x · 2013 · External reference
Peroxide bond-dependent antiplasmodial specificity of artemisinin and OZ277 (RBx11160)
10.1128/aac.00225-07 · 2007 · External reference
Reaction of antimalarial endoperoxides with specific parasite proteins
10.1128/aac.38.8.1854 · 1994 · External reference
Artemisinin and the antimalarial endoperoxides: from herbal remedy to targeted chemotherapy
10.1128/mr.60.2.301-315.1996 · 1996 · External reference
Artemisinin: mechanisms of action, resistance and toxicity
10.1016/s0020-7519(02)00194-7 · 2002 · External reference
Relationship between antimalarial activity and haem alkylation for spiro- and dispiro-1,2,4-trioxolane antimalarials
10.1128/aac.01033-07 · 2008 · External reference
Artemisinin activity against Plasmodium falciparum requires hemoglobin uptake and digestion
10.1073/pnas.1104063108 · 2011 · External reference
Iron and heme metabolism in Plasmodium falciparum and the mechanism of action of artemisinins
10.1016/j.mib.2013.07.005 · 2013 · External reference
Heme as trigger and target for trioxane-containing antimalarial drugs
10.1021/ar100070k · 2010 · External reference
Antimalarial peroxides: advances in drug discovery and design
10.1039/c2md00277a · 2012 · External reference
Probing the antimalarial mechanism of artemisinin and OZ277 (arterolane) with nonperoxidic isosteres and nitroxyl radicals
10.1128/aac.01305-09 · 2010 · External reference
In vitro interaction of artemisinin derivatives or the fully synthetic peroxidic anti-malarial OZ277 with thapsigargin in Plasmodium falciparum strains
10.1186/1475-2875-12-43 · 2013 · External reference
Correlation between Plasmodium yoelii nigeriensis susceptibility to artemisinin and alkylation of heme by the drug
10.1128/aac.01064-13 · 2013 · External reference
Artemisinin and a series of novel endoperoxide antimalarials exert early effects on digestive vacuole morphology
10.1128/aac.00609-07 · 2008 · External reference
Accumulation of artemisinin trioxane derivatives within neutral lipids of Plasmodium falciparum malaria parasites is endoperoxide-dependent
10.1016/j.bcp.2008.10.015 · 2009 · External reference
Investigating the antimalarial action of 1,2,4-trioxolanes with fluorescent chemical probes
10.1021/jm2012003 · 2011 · External reference
Qinghaosu (artemisinin): an antimalarial drug from China
10.1126/science.3887571 · 1985 · External reference
Artemisinins: their growing importance in medicine
10.1016/j.tips.2008.07.004 · 2008 · External reference
Dispiro-1,2,4-trioxane analogs of a prototype dispiro-1,2,4-trioxolane: mechanistic comparators for artemisinin in the context of reaction pathways with iron (II)
10.1021/jo050385+ · 2005 · External reference
A novel method for the synthesis of N-alkoxyamines starting from nitroxide radicals and ketones
10.1055/s-2008-1078526 · 2008 · External reference
Heme as an optical probe of a conformational transition of ovine recPrP
10.1110/ps.03409304 · 2004 · External reference
Mechanism of antimalarial action of the synthetic trioxolane RBX11160 (OZ277)
10.1128/aac.01064-06 · 2007 · External reference
Potent antihematozoan activity of novel bisthiazolium drug T16: evidence for inhibition of phosphatidylcholine metabolism in erythrocytes infected with Babesia and Plasmodium spp
10.1128/aac.00443-06 · 2006 · External reference
Alkylation of heme by the antimalarial drug artemisinin
10.1039/b110817b · 2002 · External reference
Interactions between artemisinins and other antimalarial drugs in relation to the cofactor model–a unifying proposal for drug action
10.1002/cmdc.201200383 · 2012 · External reference
Artemisinin directly targets malarial mitochondria through its specific mitochondrial activation
10.1371/journal.pone.0009582 · 2010 · External reference
Immunogenicity and effector functions of glutaraldehyde-treated rabbit and mouse immunoglobulins
10.1016/0161-5890(83)90048-2 · 1983 · External reference
CpG DNA is a potent enhancer of specific immunity in mice immunized with recombinant hepatitis B surface antigen
10.4049/jimmunol.160.2.870 · 1998 · External reference
Continuous cultures of fused cells secreting antibody of predefined specificity
10.1038/256495a0 · 1975 · External reference
Malarial haemozoin/beta-haematin supports haem polymerization in the absence of protein
10.1038/374269a0 · 1995 · External reference
Human malaria parasites in continuous culture
10.1126/science.781840 · 1976 · External reference
In vitro and in vivo interaction of synthetic peroxide RBx11160 (OZ277) with piperaquine in Plasmodium models
10.1016/j.exppara.2006.09.016 · 2007 · External reference
Inoculum effect with chloroquine and Plasmodium falciparum
10.1128/aac.31.1.32 · 1987 · External reference
Recrudescence in artesunate-treated patients with falciparum malaria is dependent on parasite burden not on parasite factors
10.4269/ajtmh.2003.68.147 · 2003 · External reference
In vitro assessment of the pharmacodynamic properties and the partitioning of OZ277/RBx-11160 in cultures of Plasmodium falciparum
10.1093/jac/dkl209 · 2006 · External reference
Synchronization of Plasmodium falciparum erythrocytic stages in culture
10.2307/3280287 · 1979 · External reference
