Research graph
References from High-Throughput Screen in Cryptococcus neoformans Identifies a Novel Molecular Scaffold That Inhibits Cell Wall Integrity Pathway Signaling. Local targets link to admitted publications; unresolved targets remain external evidence.
Tackling human fungal infections
10.1126/science.1222236 · 2012 · External reference
Efficiently killing a sugar-coated yeast
10.1056/nejme1302038 · 2013 · External reference
Estimation of the current global burden of cryptococcal meningitis among persons living with HIV/AIDS
10.1097/qad.0b013e328322ffac · 2009 · External reference
Cryptococcus neoformans and Cryptococcus gattii, the etiologic agents of cryptococcosis
10.1101/cshperspect.a019760 · 2014 · External reference
Treatment of cryptococcal meningitis in resource-limited settings
10.1097/qco.0b013e32832fa214 · 2009 · External reference
Combination therapy for cryptococcal meningitis
10.1056/nejmoa1110404 · 2013 · External reference
Independent association of clearance of infection and clinical outcome of HIV-associated cryptococcal meningitis: analysis of combined cohort of 262 patients
10.1086/604716 · 2009 · External reference
Antifungal drug development: challenges, unmet clinical needs, and new approaches
10.1101/cshperspect.a019703 · 2014 · External reference
A high-throughput assay of yeast cell lysis for drug discovery and genetic analysis
10.1038/nprot.2010.47 · 2010 · External reference
A high-throughput screening assay for assessing the viability of Cryptococcus neoformans under nutrient starvation conditions
10.1007/s00216-013-7134-4 · 2013 · External reference
A high-throughput screening assay for fungicidal compounds against Cryptococcus neoformans
10.1177/1087057113496847 · 2014 · External reference
Antifungal drug discovery: something old and something new
10.1371/journal.ppat.1002870 · 2012 · External reference
Cryptococcus neoformans resistance to echinocandins: (1,3)β-glucan synthase activity is sensitive to echinocandins
10.1128/aac.49.7.2851-2856.2005 · 2005 · External reference
In vitro antifungal activity of nikkomycin Z in combination with fluconazole or itraconazole
10.1128/aac.43.6.1401 · 1999 · External reference
How sweet it is! Cell wall biogenesis and polysaccharide capsule formation in Cryptococcus neoformans
10.1146/annurev.micro.62.081307.162753 · 2009 · External reference
A re-purposing approach identifies off-patent drugs with fungicidal cryptococcal activity, a common structural chemotype, and pharmacological properties relevant to the treatment of cryptococcosis
10.1128/ec.00314-12 · 2013 · External reference
Genome evolution and innovation across the four major lineages of Cryptococcus gattii
10.1128/mbio.00868-15 · 2015 · External reference
Unraveling the biology of a fungal meningitis pathogen using chemical genetics
10.1016/j.cell.2014.10.044 · 2014 · External reference
Osmotic balance regulates cell fusion during mating in Saccharomyces cerevisiae
10.1083/jcb.138.5.961 · 1997 · External reference
Regulation of cell wall biogenesis in Saccharomyces cerevisiae: the cell wall integrity signaling pathway
10.1534/genetics.111.128264 · 2011 · External reference
Discovery and evaluation of fungicidal anti-cryptococcal molecules
2014 · External reference
A high-throughput screening assay for small molecules that disrupt yeast cell integrity
10.1177/1087057108320713 · 2008 · External reference
The Cryptococcus neoformans MAP kinase Mpk1 regulates cell integrity in response to antifungal drugs and loss of calcineurin function
10.1046/j.1365-2958.2003.03508.x · 2003 · External reference
Specialization of the HOG pathway and its impact on differentiation and virulence in Cryptococcus neoformans
10.1091/mbc.e04-11-0987 · 2005 · External reference
Identification, in vitro activity and mode of action of phosphoinositide-1 kinase inhibitors as antifungal molecules
10.1021/cb100399x · 2011 · External reference
Unresolved reference
2002 · External reference
SBF regulator as a target of yeast PKC-MAP kinase pathway
10.1126/science.275.5307.1781 · 1997 · External reference
Regulation of Rlm1 transcription factor by the Mpk1 cell wall integrity MAP kinase
10.1046/j.1365-2958.2002.03198.x · 2002 · External reference
Cryptococcus neoformans phosphoinositide-dependent kinase 1 (PDK1) ortholog is required for stress tolerance
10.1128/ec.00235-12 · 2013 · External reference
Genomic approach to identification of mutations affecting caspofungin susceptibility in Saccharomyces cerevisiae
10.1128/aac.48.10.3871-3876.2004 · 2004 · External reference
Cyanoguanidine-thiourea equivalence in the development of histamine H2-receptor antagonist, Cimetidine
10.1021/jm00217a007 · 1977 · External reference
Pkc1 is essential for protection against both oxidative and nitrosative stresses, cell integrity, and normal manifestation of virulence factors in the pathogenic fungus Cryptococcus neoformans
10.1128/ec.00146-08 · 2008 · External reference
