Research graph
References from Development of GuaB Inhibitors to Treat <i>Mycobacterium tuberculosis</i> Infection. Local targets link to admitted publications; unresolved targets remain external evidence.
Unresolved reference
External reference
Unresolved reference
External reference
The WHO Global Tuberculosis 2021 Report – Not so Good News and Turning the Tide Back to End TB
10.1016/j.ijid.2022.03.011 · 2022 · External reference
Drug-Resistant Tuberculosis: A Persistent Global Health Concern
10.1038/s41579-024-01025-1 · 2024 · External reference
Treatment of Drug-Resistant Tuberculosis. An Official ATS/CDC/ERS/IDSA Clinical Practice Guideline
10.1164/rccm.201909-1874st · 2019 · External reference
Immune Evasion and Provocation by Mycobacterium Tuberculosis
10.1038/s41579-022-00763-4 · 2022 · External reference
Alveolar Macrophages Provide an Early Mycobacterium Tuberculosis Niche and Initiate Dissemination
10.1016/j.chom.2018.08.001 · 2018 · External reference
Growth of Mycobacterium Tuberculosis in Vivo Segregates with Host Macrophage Metabolism and Ontogeny
10.1084/jem.20172020 · 2018 · External reference
Caseation of Human Tuberculosis Granulomas Correlates with Elevated Host Lipid Metabolism
10.1002/emmm.201000079 · 2010 · External reference
The Tuberculous Granuloma: An Unsuccessful Host Defence Mechanism Providing a Safety Shelter for the Bacteria?
10.1155/2012/139127 · 2012 · External reference
Extreme Drug Tolerance of Mycobacterium Tuberculosis in Caseum
10.1128/aac.02266-17 · 2018 · External reference
Evaluation of a Mouse Model of Necrotic Granuloma Formation Using C3HeB/FeJ Mice for Testing of Drugs against Mycobacterium Tuberculosis
10.1128/aac.00217-12 · 2012 · External reference
Official American Thoracic Society/Centers for Disease Control and Prevention/Infectious Diseases Society of America Clinical Practice Guidelines: Treatment of Drug-Susceptible Tuberculosis
10.1093/cid/ciw376 · 2016 · External reference
Prediction of Drug Penetration in Tuberculosis Lesions
10.1021/acsinfecdis.6b00051 · 2016 · External reference
Design Principles to Assemble Drug Combinations for Effective Tuberculosis Therapy Using Interpretable Pairwise Drug Response Measurements
10.1016/j.xcrm.2022.100737 · 2022 · External reference
Targeting de Novo Purine Biosynthesis for Tuberculosis Treatment
10.1038/s41586-025-09177-7 · 2025 · External reference
Mycobacterium Tuberculosis IMPDH in Complexes with Substrates, Products and Antitubercular Compounds
10.1371/journal.pone.0138976 · 2015 · External reference
The Bare Essentials of Antibiotic Target Validation
10.1021/acsinfecdis.6b00185 · 2017 · External reference
The Antibiotic Potential of Prokaryotic IMP Dehydrogenase Inhibitors
10.2174/092986711795590129 · 2011 · External reference
Discovery of GuaB Inhibitors with Efficacy against Acinetobacter Baumannii Infection
10.1128/mbio.00897-24 · 2024 · External reference
Mechanism of Activation of Elongation Factor Tu by Ribosome: Catalytic Histidine Activates GTP by Protonation
10.1261/rna.040097.113 · 2013 · External reference
The Essential Bacterial Cell-Division Protein FtsZ Is a GTPase
10.1038/359254a0 · 1992 · External reference
IMP Dehydrogenase: Structure, Mechanism, and Inhibition
10.1021/cr900021w · 2009 · External reference
The Mycobacterial guaB1 Gene Encodes a Guanosine 5′-monophosphate Reductase with a Cystathionine-β-synthase Domain
10.1111/febs.16448 · 2022 · External reference
Identification of Novel Mt-Guab2 Inhibitor Series Active against M. Tuberculosis
10.1371/journal.pone.0033886 · 2012 · External reference
Genome-Wide Gene Expression Tuning Reveals Diverse Vulnerabilities of M. Tuberculosis
10.1016/j.cell.2021.06.033 · 2021 · External reference
The Inosine Monophosphate Dehydrogenase, GuaB2, Is a Vulnerable New Bactericidal Drug Target for Tuberculosis
10.1021/acsinfecdis.6b00102 · 2017 · External reference
GuaB3, an Overlooked Enzyme in Cyanobacteria’s Toolbox That Sheds Light on IMP Dehydrogenase Evolution
10.1016/j.str.2023.09.014 · 2023 · External reference
TnSeq of Mycobacterium Tuberculosis Clinical Isolates Reveals Strain-Specific Antibiotic Liabilities
10.1371/journal.ppat.1006939 · 2018 · External reference
Essential but Not Vulnerable: Indazole Sulfonamides Targeting Inosine Monophosphate Dehydrogenase as Potential Leads against Mycobacterium Tuberculosis
10.1021/acsinfecdis.6b00103 · 2017 · External reference
Novel Inhibitors of Mycobacterium Tuberculosis GuaB2 Identified by a Target Based High-Throughput Phenotypic Screen
10.1038/srep38986 · 2016 · External reference
Inhibitors of Inosine 5′-Monophosphate Dehydrogenase as Emerging New Generation Antimicrobial Agents
10.1039/c9md00179d · 2019 · External reference
Expanding Benzoxazole-Based Inosine 5′-Monophosphate Dehydrogenase (IMPDH) Inhibitor Structure–Activity As Potential Antituberculosis Agents
10.1021/acs.jmedchem.7b01839 · 2018 · External reference
Synthesis and Structure–Activity Relationship of 1-(5-Isoquinolinesulfonyl)Piperazine Analogues as Inhibitors of Mycobacterium Tuberculosis IMPDH
10.1016/j.ejmech.2019.04.027 · 2019 · External reference
Discovery of Potent Dihydro-Oxazinoquinolinone Inhibitors of GuaB for the Treatment of Tuberculosis
10.1016/j.bmcl.2024.130026 · 2025 · External reference
The Impact of Bacterial Purine Metabolism on Antibiotic Efficacy
10.1038/s44259-025-00139-7 · 2025 · External reference
Hypoxanthine–Guanine Phosphoribosyltransferase from Mycobacteriumtuberculosis H37Rv: Cloning, Expression, and Biochemical Characterization
10.1016/j.pep.2009.04.001 · 2009 · External reference
Development of an Intracellular Screen for New Compounds Able To Inhibit Mycobacterium Tuberculosis Growth in Human Macrophages
10.1128/aac.01920-15 · 2016 · External reference
Foamy Macrophages and the Progression of the Human Tuberculosis Granuloma
10.1038/ni.1781 · 2009 · External reference
Heterogeneous Disease Progression and Treatment Response in a C3HeB/FeJ Mouse Model of Tuberculosis
10.1242/dmm.019513 · 2015 · External reference
When Does 2 Plus 2 Equal 5? A Review of Antimicrobial Synergy Testing
10.1128/jcm.01121-14 · 2014 · External reference
Efficient Measurement and Factorization of High-Order Drug Interactions in Mycobacterium Tuberculosis
10.1126/sciadv.1701881 · 2017 · External reference
Differential Effects of Inosine Monophosphate Dehydrogenase (IMPDH/GuaB) Inhibition in Acinetobacter Baumannii and Escherichia Coli
10.1128/jb.00102-24 · 2024 · External reference
Structural Determinants of Inhibitor Selectivity in Prokaryotic IMP Dehydrogenases
10.1016/j.chembiol.2010.07.014 · 2010 · External reference
Probability Distribution of Drug-Resistant Mutants in Unselected Populations of Mycobacterium Tuberculosis
10.1128/am.20.5.810-814.1970 · 1970 · External reference
Genetic Mutations Associated with Isoniazid Resistance in Mycobacterium Tuberculosis: A Systematic Review
10.1371/journal.pone.0119628 · 2015 · External reference
PurFect Timing: Revisiting Purine Metabolism for Tuberculosis Treatment
10.1016/j.tim.2025.10.010 · 2026 · External reference
Features and Development of Coot
10.1107/s0907444910007493 · 2010 · External reference
PHENIX: A Comprehensive Python-based System for Macromolecular Structure Solution
10.1107/s0907444909052925 · 2010 · External reference
Macromolecular Structure Determination Using X-Rays, Neutrons and Electrons: Recent Developments in Phenix
10.1107/s2059798319011471 · 2019 · External reference
Exploiting Structure Similarity in Refinement: Automated NCS and Target-structure Restraints in BUSTER
10.1107/s0907444911056058 · 2012 · External reference
Caseation of Human Tuberculosis Granulomas Correlates with Elevated Host Lipid Metabolism
10.1002/emmm.201000079 · ExternalCitation · doi-reference
Discovery of Potent Dihydro-Oxazinoquinolinone Inhibitors of GuaB for the Treatment of Tuberculosis
10.1016/j.bmcl.2024.130026 · ExternalCitation · doi-reference
Genome-Wide Gene Expression Tuning Reveals Diverse Vulnerabilities of M. Tuberculosis
10.1016/j.cell.2021.06.033 · ExternalCitation · doi-reference
Structural Determinants of Inhibitor Selectivity in Prokaryotic IMP Dehydrogenases
10.1016/j.chembiol.2010.07.014 · ExternalCitation · doi-reference
Alveolar Macrophages Provide an Early Mycobacterium Tuberculosis Niche and Initiate Dissemination
10.1016/j.chom.2018.08.001 · ExternalCitation · doi-reference
Synthesis and Structure–Activity Relationship of 1-(5-Isoquinolinesulfonyl)Piperazine Analogues as Inhibitors of Mycobacterium Tuberculosis IMPDH
10.1016/j.ejmech.2019.04.027 · ExternalCitation · doi-reference
The WHO Global Tuberculosis 2021 Report – Not so Good News and Turning the Tide Back to End TB
10.1016/j.ijid.2022.03.011 · ExternalCitation · doi-reference
Hypoxanthine–Guanine Phosphoribosyltransferase from Mycobacteriumtuberculosis H37Rv: Cloning, Expression, and Biochemical Characterization
10.1016/j.pep.2009.04.001 · ExternalCitation · doi-reference
GuaB3, an Overlooked Enzyme in Cyanobacteria’s Toolbox That Sheds Light on IMP Dehydrogenase Evolution
10.1016/j.str.2023.09.014 · ExternalCitation · doi-reference
PurFect Timing: Revisiting Purine Metabolism for Tuberculosis Treatment
10.1016/j.tim.2025.10.010 · ExternalCitation · doi-reference
Design Principles to Assemble Drug Combinations for Effective Tuberculosis Therapy Using Interpretable Pairwise Drug Response Measurements
10.1016/j.xcrm.2022.100737 · ExternalCitation · doi-reference
Expanding Benzoxazole-Based Inosine 5′-Monophosphate Dehydrogenase (IMPDH) Inhibitor Structure–Activity As Potential Antituberculosis Agents
10.1021/acs.jmedchem.7b01839 · ExternalCitation · doi-reference
Prediction of Drug Penetration in Tuberculosis Lesions
10.1021/acsinfecdis.6b00051 · ExternalCitation · doi-reference
The Inosine Monophosphate Dehydrogenase, GuaB2, Is a Vulnerable New Bactericidal Drug Target for Tuberculosis
10.1021/acsinfecdis.6b00102 · ExternalCitation · doi-reference
Essential but Not Vulnerable: Indazole Sulfonamides Targeting Inosine Monophosphate Dehydrogenase as Potential Leads against Mycobacterium Tuberculosis
10.1021/acsinfecdis.6b00103 · ExternalCitation · doi-reference
The Bare Essentials of Antibiotic Target Validation
10.1021/acsinfecdis.6b00185 · ExternalCitation · doi-reference
IMP Dehydrogenase: Structure, Mechanism, and Inhibition
10.1021/cr900021w · ExternalCitation · doi-reference
The Essential Bacterial Cell-Division Protein FtsZ Is a GTPase
10.1038/359254a0 · ExternalCitation · doi-reference
Foamy Macrophages and the Progression of the Human Tuberculosis Granuloma
10.1038/ni.1781 · ExternalCitation · doi-reference
Immune Evasion and Provocation by Mycobacterium Tuberculosis
10.1038/s41579-022-00763-4 · ExternalCitation · doi-reference
Drug-Resistant Tuberculosis: A Persistent Global Health Concern
10.1038/s41579-024-01025-1 · ExternalCitation · doi-reference
Targeting de Novo Purine Biosynthesis for Tuberculosis Treatment
10.1038/s41586-025-09177-7 · ExternalCitation · doi-reference
The Impact of Bacterial Purine Metabolism on Antibiotic Efficacy
10.1038/s44259-025-00139-7 · ExternalCitation · doi-reference
Novel Inhibitors of Mycobacterium Tuberculosis GuaB2 Identified by a Target Based High-Throughput Phenotypic Screen
10.1038/srep38986 · ExternalCitation · doi-reference
Inhibitors of Inosine 5′-Monophosphate Dehydrogenase as Emerging New Generation Antimicrobial Agents
10.1039/c9md00179d · ExternalCitation · doi-reference
Growth of Mycobacterium Tuberculosis in Vivo Segregates with Host Macrophage Metabolism and Ontogeny
10.1084/jem.20172020 · ExternalCitation · doi-reference
Official American Thoracic Society/Centers for Disease Control and Prevention/Infectious Diseases Society of America Clinical Practice Guidelines: Treatment of Drug-Susceptible Tuberculosis
10.1093/cid/ciw376 · ExternalCitation · doi-reference
PHENIX: A Comprehensive Python-based System for Macromolecular Structure Solution
10.1107/s0907444909052925 · ExternalCitation · doi-reference
Features and Development of Coot
10.1107/s0907444910007493 · ExternalCitation · doi-reference
Exploiting Structure Similarity in Refinement: Automated NCS and Target-structure Restraints in BUSTER
10.1107/s0907444911056058 · ExternalCitation · doi-reference
Macromolecular Structure Determination Using X-Rays, Neutrons and Electrons: Recent Developments in Phenix
10.1107/s2059798319011471 · ExternalCitation · doi-reference
The Mycobacterial guaB1 Gene Encodes a Guanosine 5′-monophosphate Reductase with a Cystathionine-β-synthase Domain
10.1111/febs.16448 · ExternalCitation · doi-reference
Efficient Measurement and Factorization of High-Order Drug Interactions in Mycobacterium Tuberculosis
10.1126/sciadv.1701881 · ExternalCitation · doi-reference
Evaluation of a Mouse Model of Necrotic Granuloma Formation Using C3HeB/FeJ Mice for Testing of Drugs against Mycobacterium Tuberculosis
10.1128/aac.00217-12 · ExternalCitation · doi-reference
Development of an Intracellular Screen for New Compounds Able To Inhibit Mycobacterium Tuberculosis Growth in Human Macrophages
10.1128/aac.01920-15 · ExternalCitation · doi-reference
Extreme Drug Tolerance of Mycobacterium Tuberculosis in Caseum
10.1128/aac.02266-17 · ExternalCitation · doi-reference
Probability Distribution of Drug-Resistant Mutants in Unselected Populations of Mycobacterium Tuberculosis
10.1128/am.20.5.810-814.1970 · ExternalCitation · doi-reference
Differential Effects of Inosine Monophosphate Dehydrogenase (IMPDH/GuaB) Inhibition in Acinetobacter Baumannii and Escherichia Coli
10.1128/jb.00102-24 · ExternalCitation · doi-reference
When Does 2 Plus 2 Equal 5? A Review of Antimicrobial Synergy Testing
10.1128/jcm.01121-14 · ExternalCitation · doi-reference
Discovery of GuaB Inhibitors with Efficacy against Acinetobacter Baumannii Infection
10.1128/mbio.00897-24 · ExternalCitation · doi-reference
The Tuberculous Granuloma: An Unsuccessful Host Defence Mechanism Providing a Safety Shelter for the Bacteria?
10.1155/2012/139127 · ExternalCitation · doi-reference
Treatment of Drug-Resistant Tuberculosis. An Official ATS/CDC/ERS/IDSA Clinical Practice Guideline
10.1164/rccm.201909-1874st · ExternalCitation · doi-reference
Heterogeneous Disease Progression and Treatment Response in a C3HeB/FeJ Mouse Model of Tuberculosis
10.1242/dmm.019513 · ExternalCitation · doi-reference
Mechanism of Activation of Elongation Factor Tu by Ribosome: Catalytic Histidine Activates GTP by Protonation
10.1261/rna.040097.113 · ExternalCitation · doi-reference
Identification of Novel Mt-Guab2 Inhibitor Series Active against M. Tuberculosis
10.1371/journal.pone.0033886 · ExternalCitation · doi-reference
Genetic Mutations Associated with Isoniazid Resistance in Mycobacterium Tuberculosis: A Systematic Review
10.1371/journal.pone.0119628 · ExternalCitation · doi-reference
Mycobacterium Tuberculosis IMPDH in Complexes with Substrates, Products and Antitubercular Compounds
10.1371/journal.pone.0138976 · ExternalCitation · doi-reference
TnSeq of Mycobacterium Tuberculosis Clinical Isolates Reveals Strain-Specific Antibiotic Liabilities
10.1371/journal.ppat.1006939 · ExternalCitation · doi-reference
The Antibiotic Potential of Prokaryotic IMP Dehydrogenase Inhibitors
10.2174/092986711795590129 · ExternalCitation · doi-reference
