Research graph
References from Toward Rational Design of Orally Bioavailable PROTACs: Development of a Fully Computational Oral Absorption Score. Local targets link to admitted publications; unresolved targets remain external evidence.
Targeted Protein Degradation: Advances in Drug Discovery and Clinical Practice
10.1038/s41392-024-02004-x · 2024 · External reference
PROTAC Targeted Protein Degraders: The Past Is Prologue
10.1038/s41573-021-00371-6 · 2022 · External reference
Proteolysis-Targeting Chimeras as Therapeutics and Tools for Biological Discovery
10.1016/j.cell.2019.11.031 · 2020 · External reference
Unresolved reference
External reference
Cell Permeability beyond the Rule of 5
10.1016/j.addr.2016.03.013 · 2016 · External reference
Proteolysis-Targeting Chimeras (PROTACs) in beyond Rule-of-Five Chemical Space: Recent Progress and Future Challenges
10.1016/j.bmcl.2019.04.030 · 2019 · External reference
Optimizing Proteolysis-Targeting Chimeras (PROTACs) for Oral Drug Delivery: A Drug Metabolism and Pharmacokinetics Perspective
10.1016/j.drudis.2020.07.013 · 2020 · External reference
Closing the Design-Make-Test-Analyze Loop: Interplay between Experiments and Prediction Drives PROTACs Bioavailability
10.1021/acs.jmedchem.4c01642 · 2024 · External reference
Structural and Physicochemical Features of Oral PROTACs
10.1021/acs.jmedchem.4c01017 · 2024 · External reference
Physicochemical Property Determinants of Oral Absorption for PROTAC Protein Degraders
10.1021/acs.jmedchem.3c00740 · 2023 · External reference
Exploring the Chemical Space of Orally Bioavailable PROTACs
10.1016/j.drudis.2024.103917 · 2024 · External reference
Solution Conformations Shed Light on PROTAC Cell Permeability
10.1021/acsmedchemlett.0c00556 · 2021 · External reference
Chamelogk: A Chromatographic Chameleonicity Quantifier To Design Orally Bioavailable beyond-Rule-of-5 Drugs
10.1021/acs.jmedchem.3c00823 · 2023 · External reference
IMHB-Mediated Chameleonicity in Drug Design: A Focus on Structurally Related PROTACs
10.1021/acs.jmedchem.4c01200 · 2024 · External reference
Intramolecular Hydrogen Bonding: An Opportunity for Improved Design in Medicinal Chemistry
10.1002/med.21562 · 2019 · External reference
A New Multiparameter Index Is a Strong Predictor of Oral Bioavailability for Heterobifunctional Degraders
10.1021/acsmedchemlett.5c00156 · 2025 · External reference
Evaluation of Oral PROTAC Guidelines: Efflux Ratio Outweighs Chameleonicity Descriptors
10.1021/acsmedchemlett.6c00043 · 2026 · External reference
First-Pass Elimination: Basic Concepts and Clinical Consequences
10.2165/00003088-198409010-00001 · 1984 · External reference
Using Physicochemical Measurements to Influence Better Compound Design
10.1177/2472555219859845 · 2019 · External reference
Beyond Rule of Five and PROTACs in Modern Drug Discovery: Polarity Reducers, Chameleonicity, and the Evolving Physicochemical Landscape
10.1021/acs.jmedchem.3c02332 · 2024 · External reference
Intramolecular Hydrogen Bonding: An Opportunity for Improved Design in Medicinal Chemistry
10.1002/med.21562 · ExternalCitation · doi-reference
Cell Permeability beyond the Rule of 5
10.1016/j.addr.2016.03.013 · ExternalCitation · doi-reference
Proteolysis-Targeting Chimeras (PROTACs) in beyond Rule-of-Five Chemical Space: Recent Progress and Future Challenges
10.1016/j.bmcl.2019.04.030 · ExternalCitation · doi-reference
Proteolysis-Targeting Chimeras as Therapeutics and Tools for Biological Discovery
10.1016/j.cell.2019.11.031 · ExternalCitation · doi-reference
Optimizing Proteolysis-Targeting Chimeras (PROTACs) for Oral Drug Delivery: A Drug Metabolism and Pharmacokinetics Perspective
10.1016/j.drudis.2020.07.013 · ExternalCitation · doi-reference
Exploring the Chemical Space of Orally Bioavailable PROTACs
10.1016/j.drudis.2024.103917 · ExternalCitation · doi-reference
Physicochemical Property Determinants of Oral Absorption for PROTAC Protein Degraders
10.1021/acs.jmedchem.3c00740 · ExternalCitation · doi-reference
Chamelogk: A Chromatographic Chameleonicity Quantifier To Design Orally Bioavailable beyond-Rule-of-5 Drugs
10.1021/acs.jmedchem.3c00823 · ExternalCitation · doi-reference
Beyond Rule of Five and PROTACs in Modern Drug Discovery: Polarity Reducers, Chameleonicity, and the Evolving Physicochemical Landscape
10.1021/acs.jmedchem.3c02332 · ExternalCitation · doi-reference
Structural and Physicochemical Features of Oral PROTACs
10.1021/acs.jmedchem.4c01017 · ExternalCitation · doi-reference
IMHB-Mediated Chameleonicity in Drug Design: A Focus on Structurally Related PROTACs
10.1021/acs.jmedchem.4c01200 · ExternalCitation · doi-reference
Closing the Design-Make-Test-Analyze Loop: Interplay between Experiments and Prediction Drives PROTACs Bioavailability
10.1021/acs.jmedchem.4c01642 · ExternalCitation · doi-reference
Solution Conformations Shed Light on PROTAC Cell Permeability
10.1021/acsmedchemlett.0c00556 · ExternalCitation · doi-reference
A New Multiparameter Index Is a Strong Predictor of Oral Bioavailability for Heterobifunctional Degraders
10.1021/acsmedchemlett.5c00156 · ExternalCitation · doi-reference
Evaluation of Oral PROTAC Guidelines: Efflux Ratio Outweighs Chameleonicity Descriptors
10.1021/acsmedchemlett.6c00043 · ExternalCitation · doi-reference
Targeted Protein Degradation: Advances in Drug Discovery and Clinical Practice
10.1038/s41392-024-02004-x · ExternalCitation · doi-reference
PROTAC Targeted Protein Degraders: The Past Is Prologue
10.1038/s41573-021-00371-6 · ExternalCitation · doi-reference
Using Physicochemical Measurements to Influence Better Compound Design
10.1177/2472555219859845 · ExternalCitation · doi-reference
First-Pass Elimination: Basic Concepts and Clinical Consequences
10.2165/00003088-198409010-00001 · ExternalCitation · doi-reference
