Research graph
References from Intestinal Macrophage-Mediated Exosomal Repackaging Establishes Bioactive Reservoirs for Long-Acting Oral Peptide Therapy. Local targets link to admitted publications; unresolved targets remain external evidence.
Glucagon-Like Peptide-1 Receptor: Mechanisms and Advances in Therapy
10.1038/s41392-024-01931-z · 2024 · External reference
Glucagon-Like Peptide 1 in Health and Disease
10.1038/s41574-018-0016-2 · 2018 · External reference
Oral Delivery of Exenatide-Loaded Hybrid Zein Nanoparticles for Stable Blood Glucose Control and Beta-Cell Repair of Type 2 Diabetes Mice
10.1186/s12951-020-00619-0 · 2020 · External reference
Metabolic and Immunomodulatory Control of Type 1 Diabetes Via Orally Delivered Bile-Acid-Polymer Nanocarriers of Insulin or Rapamycin
10.1038/s41551-021-00791-0 · 2021 · External reference
Pancreatic Beta-Cells in Type 1 and Type 2 Diabetes Mellitus: Different Pathways to Failure
10.1038/s41574-020-0355-7 · 2020 · External reference
Inter-Organ Crosstalk during Development and Progression of Type 2 Diabetes Mellitus
10.1038/s41574-023-00898-1 · 2024 · External reference
Inflammation in Obesity, Diabetes, and Related Disorders
10.1016/j.immuni.2021.12.013 · 2022 · External reference
Insights into the Role of the Microbiome in Obesity and Type 2 Diabetes
10.2337/dc14-0769 · 2015 · External reference
Macrophages in Intestinal Homeostasis and Inflammatory Bowel Disease
10.1038/s41575-023-00769-0 · 2023 · External reference
Macrophages in the Gut: Masters in Multitasking
10.1016/j.immuni.2022.08.005 · 2022 · External reference
Type 2 Diabetes Mellitus in Adults: Pathogenesis, Prevention and Therapy
10.1038/s41392-024-01951-9 · 2024 · External reference
The Roles of Cell-Cell and Organ-Organ Crosstalk in the Type 2 Diabetes Mellitus Associated Inflammatory Microenvironment
10.1016/j.cytogfr.2022.04.002 · 2022 · External reference
Diversity, Mechanisms, and Significance of Macrophage Plasticity
10.1146/annurev-pathmechdis-012418-012718 · 2020 · External reference
Adipose Tissue Macrophage-Derived Exosomal Mirnas Can Modulate in Vivo and in Vitro Insulin Sensitivity
10.1016/j.cell.2017.08.035 · 2017 · External reference
The Glucose-Lowering Potential of Exendin-4 Orally Delivered Via a Ph-Sensitive Nanoparticle Vehicle and Effects on Subsequent Insulin Secretion in Vivo
10.1016/j.biomaterials.2010.12.044 · 2011 · External reference
The Negative Electrostatic Potential of the Coordination between Calcium and Carboxyl/Oxygen Group in Calcium-Peptide Complexes Contributes to Calcium Utilization
10.1016/j.foodchem.2024.141909 · 2025 · External reference
Synthesis of Silica/Polypeptide Hybrid Nanomaterials and Mesoporous Silica by Molecular Replication of Sheet-Like Polypeptide Complexes through Biomimetic Mineralization
10.1016/j.jcis.2019.02.014 · 2019 · External reference
Gelation Behavior and Mechanism of Alginate with Calcium: Dependence on Monovalent Counterions
10.1016/j.carbpol.2022.119788 · 2022 · External reference
Designing Hydrogels for Controlled Drug Delivery
10.1038/natrevmats.2016.71 · 2016 · External reference
Intestinal Ph: A Major Driver of Human Gut Microbiota Composition and Metabolism
10.1038/s41575-025-01092-6 · 2025 · External reference
Milk Exosome-Liposome Hybrid Vesicles with Self-Adapting Surface Properties Overcome the Sequential Absorption Barriers for Oral Delivery of Peptides
10.1021/acsnano.4c02560 · 2024 · External reference
The Intestinal Microbiota Fuelling Metabolic Inflammation
10.1038/s41577-019-0198-4 · 2020 · External reference
Surface Wettability-Directed Propulsion of Glucose-Powered Nanoflask Motors
10.1021/acsnano.9b04708 · 2019 · External reference
Cell Membranes Open “Doors” for Cationic Nanoparticles/Biomolecules: Insights into Uptake Kinetics
10.1021/nn4040553 · 2013 · External reference
Interaction between O-Carboxymethylchitosan and Dipalmitoyl-Sn-Glycero-3-Phosphocholine Bilayer
10.1016/j.biomaterials.2005.05.021 · 2005 · External reference
Mechanism and Consequence of Chitosan-Mediated Reversible Epithelial Tight Junction Opening
10.1016/j.biomaterials.2011.03.056 · 2011 · External reference
Mucoadhesive and Corneal Permeable Nano Eye Drops for Improved Anti-Glaucoma Therapy
10.1186/s12951-026-04141-7 · 2026 · External reference
Wnt/Beta-Catenin Signaling in Liver Development, Homeostasis, and Pathobiology
10.1146/annurev-pathol-020117-044010 · 2018 · External reference
Protein Moiety in Oligochitosan Modified Vector Regulates Internalization Mechanism and Gene Delivery: Polyplex Characterization, Intracellular Trafficking and Transfection
10.1016/j.carbpol.2018.08.131 · 2018 · External reference
Mucoadhesive and Self-Assembled Chitosan Oligosaccharide-Glycyrrhizin Nanoparticle for Oral Nanotherapeutic in Inflammatory Bowel Disease
10.1021/acsnano.5c09985 · 2025 · External reference
Plasmablasts Induced by Chitosan Oligosaccharide Secrete Natural Igm to Enhance the Humoral Immunity in Grass Carp
10.1016/j.carbpol.2021.119073 · 2022 · External reference
Somatostatin and Mannooligosaccharide Modified Selenium Nanoparticles with Dual-Targeting for Ulcerative Colitis Treatment
10.1021/acsnano.5c00355 · 2025 · External reference
Colonic Pro-Inflammatory Macrophages Cause Insulin Resistance in an Intestinal Ccl2/Ccr2-Dependent Manner
10.1016/j.cmet.2016.07.009 · 2016 · External reference
Changes in Gut Microbiota Control Metabolic Endotoxemia-Induced Inflammation in High-Fat Diet–Induced Obesity and Diabetes in Mice
10.2337/db07-1403 · 2008 · External reference
Reprogramming Macrophage Polarization, Depleting Ros by Astaxanthin and Thioketal-Containing Polymers Delivering Rapamycin for Osteoarthritis Treatment
10.1002/advs.202305363 · 2024 · External reference
Mir-690, an Exosomal-Derived Mirna from M2-Polarized Macrophages, Improves Insulin Sensitivity in Obese Mice
10.1016/j.cmet.2020.12.019 · 2021 · External reference
Fourteen Composite Probiotics Alleviate Type 2 Diabetes through Modulating Gut Microbiota and Modifying M1/M2 Phenotype Macrophage in Db/Db Mice
10.1016/j.phrs.2020.105150 · 2020 · External reference
M2Macrophages-Derived Exosomes for Osteonecrosis of Femoral Head Treatment: Modulating Neutrophil Extracellular Traps Formation and Endothelial Phenotype Transition
10.1038/s41413-025-00412-5 · 2025 · External reference
Melatonin Engineering M2Macrophage-Derived Exosomes Mediate Endoplasmic Reticulum Stress and Immune Reprogramming for Periodontitis Therapy
10.1002/advs.202302029 · 2023 · External reference
Elevation of P53 Sensitizes Obese Kidney to Adriamycin-Induced Aberrant Lipid Homeostasis Via Repressing Hnf4alpha-Mediated Fgf21 Sensitivity
10.1016/j.jare.2024.07.014 · 2025 · External reference
Extracellular Vesicles for Improved Tumor Accumulation and Penetration
10.1016/j.addr.2022.114450 · 2022 · External reference
Precise Nanoscale Fabrication Technologies, the ″Last Mile″ of Medicinal Development
10.1016/j.apsb.2025.03.040 · 2025 · External reference
The Role of Macrophages in Obesity-Associated Islet Inflammation and Beta-Cell Abnormalities
10.1038/s41574-019-0286-3 · 2020 · External reference
Mitophagy-Mediated Adipose Inflammation Contributes to Type 2 Diabetes with Hepatic Insulin Resistance
10.1084/jem.20201416 · 2021 · External reference
Type 2 Diabetes: Principles of Pathogenesis and Therapy
10.1016/s0140-6736(05)61032-x · 2005 · External reference
Small Molecule Activators of Sirt1 as Therapeutics for the Treatment of Type 2 Diabetes
10.1038/nature06261 · 2007 · External reference
Polysulfide-Mediated Sulfhydration of Sirt1 Prevents Diabetic Nephropathy by Suppressing Phosphorylation and Acetylation of P65 Nf-Kappab and Stat3
10.1016/j.redox.2020.101813 · 2021 · External reference
Melatonin Engineering M2Macrophage-Derived Exosomes Mediate Endoplasmic Reticulum Stress and Immune Reprogramming for Periodontitis Therapy
10.1002/advs.202302029 · ExternalCitation · doi-reference
Reprogramming Macrophage Polarization, Depleting Ros by Astaxanthin and Thioketal-Containing Polymers Delivering Rapamycin for Osteoarthritis Treatment
10.1002/advs.202305363 · ExternalCitation · doi-reference
Extracellular Vesicles for Improved Tumor Accumulation and Penetration
10.1016/j.addr.2022.114450 · ExternalCitation · doi-reference
Precise Nanoscale Fabrication Technologies, the ″Last Mile″ of Medicinal Development
10.1016/j.apsb.2025.03.040 · ExternalCitation · doi-reference
Interaction between O-Carboxymethylchitosan and Dipalmitoyl-Sn-Glycero-3-Phosphocholine Bilayer
10.1016/j.biomaterials.2005.05.021 · ExternalCitation · doi-reference
The Glucose-Lowering Potential of Exendin-4 Orally Delivered Via a Ph-Sensitive Nanoparticle Vehicle and Effects on Subsequent Insulin Secretion in Vivo
10.1016/j.biomaterials.2010.12.044 · ExternalCitation · doi-reference
Mechanism and Consequence of Chitosan-Mediated Reversible Epithelial Tight Junction Opening
10.1016/j.biomaterials.2011.03.056 · ExternalCitation · doi-reference
Protein Moiety in Oligochitosan Modified Vector Regulates Internalization Mechanism and Gene Delivery: Polyplex Characterization, Intracellular Trafficking and Transfection
10.1016/j.carbpol.2018.08.131 · ExternalCitation · doi-reference
Plasmablasts Induced by Chitosan Oligosaccharide Secrete Natural Igm to Enhance the Humoral Immunity in Grass Carp
10.1016/j.carbpol.2021.119073 · ExternalCitation · doi-reference
Gelation Behavior and Mechanism of Alginate with Calcium: Dependence on Monovalent Counterions
10.1016/j.carbpol.2022.119788 · ExternalCitation · doi-reference
Adipose Tissue Macrophage-Derived Exosomal Mirnas Can Modulate in Vivo and in Vitro Insulin Sensitivity
10.1016/j.cell.2017.08.035 · ExternalCitation · doi-reference
Colonic Pro-Inflammatory Macrophages Cause Insulin Resistance in an Intestinal Ccl2/Ccr2-Dependent Manner
10.1016/j.cmet.2016.07.009 · ExternalCitation · doi-reference
Mir-690, an Exosomal-Derived Mirna from M2-Polarized Macrophages, Improves Insulin Sensitivity in Obese Mice
10.1016/j.cmet.2020.12.019 · ExternalCitation · doi-reference
The Roles of Cell-Cell and Organ-Organ Crosstalk in the Type 2 Diabetes Mellitus Associated Inflammatory Microenvironment
10.1016/j.cytogfr.2022.04.002 · ExternalCitation · doi-reference
The Negative Electrostatic Potential of the Coordination between Calcium and Carboxyl/Oxygen Group in Calcium-Peptide Complexes Contributes to Calcium Utilization
10.1016/j.foodchem.2024.141909 · ExternalCitation · doi-reference
Inflammation in Obesity, Diabetes, and Related Disorders
10.1016/j.immuni.2021.12.013 · ExternalCitation · doi-reference
Macrophages in the Gut: Masters in Multitasking
10.1016/j.immuni.2022.08.005 · ExternalCitation · doi-reference
Elevation of P53 Sensitizes Obese Kidney to Adriamycin-Induced Aberrant Lipid Homeostasis Via Repressing Hnf4alpha-Mediated Fgf21 Sensitivity
10.1016/j.jare.2024.07.014 · ExternalCitation · doi-reference
Synthesis of Silica/Polypeptide Hybrid Nanomaterials and Mesoporous Silica by Molecular Replication of Sheet-Like Polypeptide Complexes through Biomimetic Mineralization
10.1016/j.jcis.2019.02.014 · ExternalCitation · doi-reference
Fourteen Composite Probiotics Alleviate Type 2 Diabetes through Modulating Gut Microbiota and Modifying M1/M2 Phenotype Macrophage in Db/Db Mice
10.1016/j.phrs.2020.105150 · ExternalCitation · doi-reference
Polysulfide-Mediated Sulfhydration of Sirt1 Prevents Diabetic Nephropathy by Suppressing Phosphorylation and Acetylation of P65 Nf-Kappab and Stat3
10.1016/j.redox.2020.101813 · ExternalCitation · doi-reference
Type 2 Diabetes: Principles of Pathogenesis and Therapy
10.1016/s0140-6736(05)61032-x · ExternalCitation · doi-reference
Milk Exosome-Liposome Hybrid Vesicles with Self-Adapting Surface Properties Overcome the Sequential Absorption Barriers for Oral Delivery of Peptides
10.1021/acsnano.4c02560 · ExternalCitation · doi-reference
Somatostatin and Mannooligosaccharide Modified Selenium Nanoparticles with Dual-Targeting for Ulcerative Colitis Treatment
10.1021/acsnano.5c00355 · ExternalCitation · doi-reference
Mucoadhesive and Self-Assembled Chitosan Oligosaccharide-Glycyrrhizin Nanoparticle for Oral Nanotherapeutic in Inflammatory Bowel Disease
10.1021/acsnano.5c09985 · ExternalCitation · doi-reference
Surface Wettability-Directed Propulsion of Glucose-Powered Nanoflask Motors
10.1021/acsnano.9b04708 · ExternalCitation · doi-reference
Cell Membranes Open “Doors” for Cationic Nanoparticles/Biomolecules: Insights into Uptake Kinetics
10.1021/nn4040553 · ExternalCitation · doi-reference
Designing Hydrogels for Controlled Drug Delivery
10.1038/natrevmats.2016.71 · ExternalCitation · doi-reference
Small Molecule Activators of Sirt1 as Therapeutics for the Treatment of Type 2 Diabetes
10.1038/nature06261 · ExternalCitation · doi-reference
Glucagon-Like Peptide-1 Receptor: Mechanisms and Advances in Therapy
10.1038/s41392-024-01931-z · ExternalCitation · doi-reference
Type 2 Diabetes Mellitus in Adults: Pathogenesis, Prevention and Therapy
10.1038/s41392-024-01951-9 · ExternalCitation · doi-reference
M2Macrophages-Derived Exosomes for Osteonecrosis of Femoral Head Treatment: Modulating Neutrophil Extracellular Traps Formation and Endothelial Phenotype Transition
10.1038/s41413-025-00412-5 · ExternalCitation · doi-reference
Metabolic and Immunomodulatory Control of Type 1 Diabetes Via Orally Delivered Bile-Acid-Polymer Nanocarriers of Insulin or Rapamycin
10.1038/s41551-021-00791-0 · ExternalCitation · doi-reference
Glucagon-Like Peptide 1 in Health and Disease
10.1038/s41574-018-0016-2 · ExternalCitation · doi-reference
The Role of Macrophages in Obesity-Associated Islet Inflammation and Beta-Cell Abnormalities
10.1038/s41574-019-0286-3 · ExternalCitation · doi-reference
Pancreatic Beta-Cells in Type 1 and Type 2 Diabetes Mellitus: Different Pathways to Failure
10.1038/s41574-020-0355-7 · ExternalCitation · doi-reference
Inter-Organ Crosstalk during Development and Progression of Type 2 Diabetes Mellitus
10.1038/s41574-023-00898-1 · ExternalCitation · doi-reference
Macrophages in Intestinal Homeostasis and Inflammatory Bowel Disease
10.1038/s41575-023-00769-0 · ExternalCitation · doi-reference
Intestinal Ph: A Major Driver of Human Gut Microbiota Composition and Metabolism
10.1038/s41575-025-01092-6 · ExternalCitation · doi-reference
The Intestinal Microbiota Fuelling Metabolic Inflammation
10.1038/s41577-019-0198-4 · ExternalCitation · doi-reference
Mitophagy-Mediated Adipose Inflammation Contributes to Type 2 Diabetes with Hepatic Insulin Resistance
10.1084/jem.20201416 · ExternalCitation · doi-reference
Diversity, Mechanisms, and Significance of Macrophage Plasticity
10.1146/annurev-pathmechdis-012418-012718 · ExternalCitation · doi-reference
Wnt/Beta-Catenin Signaling in Liver Development, Homeostasis, and Pathobiology
10.1146/annurev-pathol-020117-044010 · ExternalCitation · doi-reference
Oral Delivery of Exenatide-Loaded Hybrid Zein Nanoparticles for Stable Blood Glucose Control and Beta-Cell Repair of Type 2 Diabetes Mice
10.1186/s12951-020-00619-0 · ExternalCitation · doi-reference
Mucoadhesive and Corneal Permeable Nano Eye Drops for Improved Anti-Glaucoma Therapy
10.1186/s12951-026-04141-7 · ExternalCitation · doi-reference
Changes in Gut Microbiota Control Metabolic Endotoxemia-Induced Inflammation in High-Fat Diet–Induced Obesity and Diabetes in Mice
10.2337/db07-1403 · ExternalCitation · doi-reference
Insights into the Role of the Microbiome in Obesity and Type 2 Diabetes
10.2337/dc14-0769 · ExternalCitation · doi-reference
