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References from Description of Druglike Properties of Safranal and Its Chemistry behind Low Oral Exposure. Local targets link to admitted publications; unresolved targets remain external evidence.
Natural products as sources of new drugs from 1981 to 2014
10.1021/acs.jnatprod.5b01055 · 2016 · External reference
A historical overview of natural products in drug discovery
10.3390/metabo2020303 · 2012 · External reference
Safranal: from an aromatic natural product to a rewarding pharmacological agent
10.22038/ijbms.2013.244 · 2013 · External reference
Chemical and biological properties of the world’s most expensive spice: saffron
10.1016/j.foodres.2010.07.033 · 2010 · External reference
Neuroprotective effect of safranal, an active ingredient of Crocus sativus, in a rat model of transient cerebral ischemia
10.5114/fn.2017.70485 · 2017 · External reference
Neuroprotective effects of safranal in a rat model of traumatic injury to the spinal cord by anti-apoptotic, anti-inflammatory and edema-attenuating
10.1016/j.tice.2015.03.007 · 2015 · External reference
Experimental and computational investigation on the molecular interactions of safranal with bovine serum albumin: binding and anti-amyloidogenic efficacy of ligand
10.1016/j.molliq.2019.01.034 · 2019 · External reference
Akt/GSK-3β/eNOS phosphorylation arbitrates safranal-induced myocardial protection against ischemia–reperfusion injury in rats
10.1007/s00394-011-0251-y · 2012 · External reference
Safranal, a constituent of Crocus sativus (saffron), attenuated cerebral ischemia induced oxidative damage in rat hippocampus
2005 · External reference
Protective effect of safranal, a constituent of Crocus sativus, on quinolinic acid-induced oxidative damage in rat hippocampus
2013 · External reference
Preventive effect of safranal against oxidative damage in aged male rat brain
10.1538/expanim.14-0027 · 2015 · External reference
Anti-allodynia effect of safranal on neuropathic pain induced by spinal nerve transection in rat
2014 · External reference
Psychological and neuroendocrinological effects of odor of saffron (Crocus sativus)
10.1016/j.phymed.2010.11.013 · 2011 · External reference
Antinociceptive and anti-inflammatory effects of Crocus sativus L. stigma and petal extracts in mice
10.1186/1471-2210-2-7 · 2002 · External reference
High throughput physicochemical profiling for drug discovery
10.1002/jps.1134 · 2001 · External reference
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
10.1016/s0169-409x(00)00129-0 · 2001 · External reference
Unresolved reference
2019 · External reference
Lipophilicity of Selected Steroid Compounds. I. Investigations on RP18W Stationary Phase by RP-HPTLC
10.1080/10826070600757748 · 2006 · External reference
Use of P-glycoprotein and BCRP inhibitors to improve oral bioavailability and CNS penetration of anticancer drugs
10.1016/j.tips.2005.11.009 · 2006 · External reference
Measuring in vitro ATPase activity for enzymatic characterization
10.3791/54305 · 2016 · External reference
Transporter-mediated natural product-drug interactions for the treatment of cardiovascular diseases
10.1016/j.jfda.2017.11.008 · 2018 · External reference
High-Throughput permeability pH profile and high throughput alkane/water Log P with artificial membranes
10.1021/jm001020e · 2001 · External reference
Unresolved reference
2003 · External reference
Predicting a drug’s membrane permeability: a computational model validated with in vitro permeability assay data
10.1021/acs.jpcb.7b02914 · 2017 · External reference
Binding of rifampicin by human plasma proteins
10.1007/bf00558209 · 1974 · External reference
Protein binding of rifampicin is not saturated when using high-dose rifampicin
10.1093/jac/dky527 · 2019 · External reference
Bioanalysis for plasma protein binding studies in drug discovery and drug development: views and recommendations of the European Bioanalysis Forum
10.4155/bio.13.338 · 2014 · External reference
The effect of plasma protein binding on in vivo efficacy: misconceptions in drug discovery
10.1038/nrd3287 · 2010 · External reference
A novel liquid chromatography/tandem mass spectrometry based depletion method for measuring red blood cell partitioning of pharmaceutical compounds in drug discovery
10.1002/rcm.1777 · 2005 · External reference
Unresolved reference
External reference
Determination of drug like properties of a novel antileishmanial compound: in vitro absorption, distribution, metabolism, and excretion studies
10.4103/0253-7613.56075 · 2009 · External reference
Curcumin uptake and metabolism
10.1002/biof.1042 · 2013 · External reference
Physicochemical, pharmacokinetic, eficacy and toxicity profiling of a potential nitrofuranyl methyl piperazine derivative IIIM-MCD-211 for oral tuberculosis therapy via in-silico–in-vitro–in-vivo approach
10.1016/j.pupt.2017.11.006 · 2018 · External reference
Pharmacokinetic evaluation of medicinally important synthetic N, N′ diindolylmethaneglucoside: improved synthesis and metabolic stability
10.1016/j.bmcl.2019.02.010 · 2019 · External reference
Effect of IS01957, a para-coumaric acid derivative on pharmacokinetic modulation of diclofenac through oral route for augmented efficacy
10.1002/ddr.21574 · 2019 · External reference
Pharmacokinetics, pharmacodynamics and safety profiling of IS01957, a preclinical candidate possessing dual activity against inflammation and nociception
10.1016/j.yrtph.2017.10.033 · 2017 · External reference
Synthesis, pH dependent, plasma and enzymatic stability of bergenin prodrugs for potential use against rheumatoid arthritis
10.1016/j.bmc.2017.08.011 · 2017 · External reference
