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References from The Combination of Two Bioactive Constituents, Lactoferrin and Linolenic Acid, Inhibits Mouse Xenograft Esophageal Tumor Growth by Downregulating Lithocholyltaurine and Inhibiting the JAK2/STAT3-Related Pathway. Local targets link to admitted publications; unresolved targets remain external evidence.
Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
10.3322/caac.21492 · 2018 · External reference
Human leukocyte elastase, cathepsin G, and lactoferrin: family of neutrophil granule glycoproteins that bind to an alveolar macrophage receptor
10.1073/pnas.79.22.6941 · 1982 · External reference
Lactoferrin - a multipotential protein
2007 · External reference
Investigation and comparison of the anti-tumor activities of lactoferrin, α-lactalbumin, and β-lactoglobulin in A549, HT29, HepG2, and MDA231-LM2 tumor models
10.3168/jds.2019-16429 · 2019 · External reference
The biological effects of bovine lactoferrin on inflammatory cytokine expression in the PMA stimulated cells
10.5851/kosfa.2012.32.3.364 · 2012 · External reference
Lactoferrin supresses neutrophil extracellular traps release in inflammation
10.1016/j.ebiom.2016.07.012 · 2016 · External reference
Significant antibacterial activity and synergistic effects of camel lactoferrin with antibiotics against methicillin-resistant staphylococcus aureus (mRSA)
10.1016/j.resmic.2016.04.006 · 2016 · External reference
Milk peptides and cardiovascular health: Effects on blood pressure and beyond
2009 · External reference
Olive oil intake is inversely related to cancer prevalence: a systematic review and a meta-analysis of 13,800 patients and 23,340 controls in 19 observational studies
10.1186/1476-511x-10-127 · 2011 · External reference
Potential anticancer effects of virgin olive oil phenols on colorectal carcinogenesis models in vitro
10.1002/ijc.21083 · 2005 · External reference
Pharmacokinetics and antitumor effects of vincristine carried by microemulsions composed of PEG-lipid, oleic acid, vitamin E and cholesterol
10.1016/s0378-5173(02)00580-x · 2003 · External reference
Antitumor effect of DHA compound in vitro and in vivo and its mechanism
2010 · External reference
Omega-3-polyunsaturated fatty acids suppress pancreatic cancer cell growth in vitro and in vivo via downregulation of WNT/beta-catenin signaling
10.1159/000334468 · 2011 · External reference
The effects of fish oil, olive oil, oleic acid and linoleic acid on colorectal neoplastic processes
10.1054/clnu.2002.0627 · 2003 · External reference
Colon cancer prevention with a small amount of dietary perilla oil high in alpha-linolenic acid in an animal model
10.1002/1097-0142(19940415)73:8<2069::aid-cncr2820730810>3.0.co;2-1 · 1994 · External reference
Low alpha-linolenic acid content of adipose breast tissue is associated with an increased risk of breast cancer
10.1016/s0959-8049(99)00254-3 · 2000 · External reference
Self-assembled β-lactoglobulin–oleic acid and β-lactoglobulin–linoleic acid complexes with antitumor activities
10.3168/jds.2014-8993 · 2015 · External reference
Cytotoxic aggregates of α-lactalbumin induced by unsaturated fatty acid induce apoptosis in tumor cells
10.1016/j.cbi.2009.03.019 · 2009 · External reference
HAMLET-like cell-growth-inhibitory effect of ovalbumin-oleic acid complex on colon cancer cell
2016 · External reference
Spectroscopic analysis of the interaction between ovalbumin and oleic acid
2016 · External reference
Lithocholyltaurine (LCT), a conjugated 3α-mono (hydroxy) bile acid, binds to M3 subtype muscarinic cholinergic receptors
10.1016/s0016-5085(98)84580-0 · 1998 · External reference
Interaction of taurine conjugates of lithocholic acid with M3 muscarinic receptors on a colon cancer cell line
10.1016/s0016-5085(00)84365-6 · 2000 · External reference
Muscarinic receptor M3 mediates cell proliferation induced by acetylcholine and contributes to apoptosis in gastric cancer
10.1007/s13277-015-4011-0 · 2016 · External reference
Fish oil blocks azoxymethane-induced rat colon tumorigenesis by increasing cell differentiation and apoptosis rather than decreasing cell proliferation
10.1093/jn/128.3.491 · 1998 · External reference
Cell proliferation, differentiation, and apoptosis are modified by n-3 polyunsaturated fatty acids in normal colonic mucosa
10.1007/s11745-999-0404-6 · 1999 · External reference
Combination of selenium and green tea improves the efficacy of chemoprevention in a rat colorectal cancer model by modulating genetic and epigenetic biomarkers
10.1371/journal.pone.0064362 · 2013 · External reference
Citrus limonoids and curcumin additively inhibit human colon cancer cells
10.1039/c3fo30325j · 2013 · External reference
Synergy between sulforaphane and selenium in protection against oxidative damage in colonic CCD841 cells
10.1016/j.nutres.2015.05.011 · 2015 · External reference
Anticancer effect of bovine lactoferrin on human esophagus cancer cell line
2016 · External reference
Protective effect of lactoferrin on acute acid reflux-induced esophageal mucosal damage
2014 · External reference
Comparison of medical and minimally invasive surgical therapy for primary esophageal motility disorders
10.1001/archsurg.1995.01430060047009 · 1995 · External reference
Alpha linolenic acid and oleic acid additively down-regulate malignant potential and positively cross-regulate AMPK/S6 axis in OE19 and OE33 esophageal cancer cells
10.1016/j.metabol.2014.07.009 · 2014 · External reference
Effects of a preoperative immune-modulating diet in patients with esophageal cancer: a prospective parallel group randomized study
10.1007/s00423-016-1538-5 · 2017 · External reference
Functional interaction of lithocholic acid conjugates with m3 muscarinic receptors on a human colon cancer cell line
10.1016/s0925-4439(02)00115-1 · 2002 · External reference
Lithocholylcholine, a bile acid/acetylcholine hybrid, is a muscarinic receptor antagonist
10.1124/jpet.102.036376 · 2002 · External reference
Targeting JAK1/STAT3 signaling suppresses tumor progression and metastasis in a peritoneal model of human ovarian cancer
10.1158/1535-7163.mct-14-0077 · 2014 · External reference
Targeted blockade of JAK/STAT3 signaling inhibits ovarian carcinoma growth
10.1158/1535-7163.mct-14-0800 · 2015 · External reference
6-bromoindirubin-3-oxime inhibits JAK/STAT3 signaling and induces apoptosis of human melanoma cells
10.1158/0008-5472.can-10-3852 · 2011 · External reference
Novel small molecular inhibitors disrupt the JAK/STAT3 and fak signaling pathways and exhibit a potent antitumor activity in glioma cells
10.4161/cbt.20083 · 2012 · External reference
Withaferin a inhibits JAK/STAT3 signaling and induces apoptosis of human renal carcinoma caki cells
10.1016/j.bbrc.2012.08.133 · 2012 · External reference
Metformin inhibits esophageal squamous cell carcinoma-induced angiogenesis by suppressing JAK/STAT3 signaling pathway
10.18632/oncotarget.20341 · 2017 · External reference
EGFR-induced cell migration is mediated predominantly by the jak-stat pathway in primary esophageal keratinocytes
10.1152/ajpgi.00253.2004 · 2004 · External reference
