Research graph
References from Synthesis, Biochemical Characterization, and Theoretical Studies of Novel β-Keto-enol Pyridine and Furan Derivatives as Potent Antifungal Agents. Local targets link to admitted publications; unresolved targets remain external evidence.
Emerging fungal threats to animal, plant and ecosystem health
10.1038/nature10947 · 2012 · External reference
Antifungal drugs: new insights in research & development
10.1016/j.pharmthera.2018.10.008 · 2019 · External reference
Hidden killers: human fungal infections
10.1126/scitranslmed.3004404 · 2012 · External reference
Impact of invasive fungal infection on outcomes of severe sepsis: a multicenter matched cohort study in critically ill surgical patients
10.1186/cc6766 · 2008 · External reference
Invasive fungal infections: a comprehensive review
10.12691/ajidm-1-4-2 · 2013 · External reference
Synthesis and fungicidal activity of novel pyrazole derivatives containing 5-Phenyl-2-Furan
10.1016/j.bmc.2019.115048 · 2019 · External reference
Design, synthesis and biological evaluation of amide-pyridine derivatives as novel dual-target (SE, CYP51) antifungal inhibitors
10.1016/j.bmc.2019.02.009 · 2019 · External reference
Synthesis and discovery of pyrazolo-pyridine analogs as inflammation medications through pro- and anti-inflammatory cytokine and COX-2 inhibition assessments
10.1016/j.bioorg.2019.103484 · 2020 · External reference
Synthesis, anti-inflammatory evaluation in vivo and docking studies of some new 5-(benzo[b]furan-2-ylmethyl)-6-methyl-pyridazin-3(2H)-one derivatives
10.1016/j.molstruc.2017.09.092 · 2018 · External reference
Small Molecules Targeting the Flavivirus E Protein with Broad-Spectrum Activity and Antiviral Efficacy in Vivo
10.1021/acsinfecdis.8b00322 · 2019 · External reference
Structure-activity relationship study of the pyridine moiety of isothiazolo[4,3-b]pyridines as antiviral agents targeting cyclin G-associated kinase
10.1016/j.bmc.2019.115188 · 2020 · External reference
Synthesis, Crystal Structure, and Agricultural Antimicrobial Evaluation of Novel Quinazoline Thioether Derivatives Incorporating the 1,2,4-Triazolo[4,3-a]pyridine Moiety
10.1021/acs.jafc.9b04733 · 2019 · External reference
Benzofuran derivatives and their anti-tubercular, anti-bacterial activities
10.1016/j.ejmech.2018.11.025 · 2019 · External reference
Discovery of a Potent Anticancer Agent PVHD303 with in Vivo Activity
10.1021/acsmedchemlett.0c00119 · 2020 · External reference
Tetra-2,3-pyrazinoporphyrazines with Peripherally Appended Pyridine Rings. 19. Pentanuclear Octa(2-pyridyl)tetrapyrazinoporphyrazines Carrying Externally Carboranthiolate Groups: Physicochemical Properties and Potentialities as Anticancer Drugs
10.1021/acs.inorgchem.8b02269 · 2019 · External reference
Crystal structure, anti-Trypanosoma cruzi and cytotoxic activities of Cu(II) complexes bearing β-diketone and α-diimine ligands
10.1016/j.ica.2019.119164 · 2020 · External reference
Prenylated β-diketones, two new additions to the family of biologically active Hypericum perforatum L. (Hypericaceae) secondary metabolites
10.1016/j.fct.2018.05.009 · 2018 · External reference
Pharmacokinetics, Pharmacodynamics, and PKPD Modeling of Curcumin in Regulating Antioxidant and Epigenetic Gene Expression in Healthy Human Volunteers
10.1021/acs.molpharmaceut.8b01246 · 2019 · External reference
Synthesis, docking and in vitro evaluation of l-proline derived 1,3-diketones possessing anti-cancer and anti-inflammatory activities
10.1016/j.molstruc.2020.127754 · 2020 · External reference
Biological studies and computational modeling of two new copper complexes derived from β-diketones and their nano-complexes
10.1080/00958972.2019.1606422 · 2019 · External reference
Novel β-keto-enol Pyrazolic Compounds as Potent Antifungal Agents. Design, Synthesis, Crystal Structure, DFT, Homology Modeling, and Docking Studies
10.1021/acs.jcim.8b00828 · 2019 · External reference
Polyphenols: Extraction Methods, Antioxidative Action, Bioavailability and Anticarcinogenic Effects
10.3390/molecules21070901 · 2016 · External reference
Structure-Activity Relationships of the Antitumor C5-Curcuminoid GO-Y030
10.3390/molecules200815374 · 2015 · External reference
Synthesis and Evaluation of Bisbenzylidenedioxotetrahydrothiopranones as Activators of Endoplasmic Reticulum (ER) Stress Signaling Pathways and Apoptotic Cell Death in Acute Promyelocytic Leukemic Cells
10.1021/jm401352a · 2014 · External reference
Structure of the HIV-1 integrase catalytic domain complexed with an inhibitor: A platform for antiviral drug design
10.1073/pnas.96.23.13040 · 1999 · External reference
Discovery of raltegravir, a potent, selective orally bioavailable HIV-integrase inhibitor for the treatment of HIV-AIDS infection
10.1021/jm800245z · 2008 · External reference
Tetrazole and Triazole as Bioisosteres of Carboxylic Acid: Discovery of Diketo Tetrazoles and Diketo Triazoles as Anti-HCV Agents
10.1016/j.bmcl.2013.06.045 · 2013 · External reference
Synthesis and Anti-Integrase Evaluation of Novel Calix[4]arene Derivatives Containing the Triazolyl 1,3-diketo Moiety
10.1016/j.cclet.2014.03.012 · 2014 · External reference
Synthesis of Some Coumarinyl Chalcones and Their Antiproliferative Activity Against Breast Cancer Cell Lines
10.2174/157018011794839475 · 2011 · External reference
Molecular Docking: Shifting Paradigms in Drug Discovery
10.3390/ijms20184331 · 2019 · External reference
Design, Synthesis, Toxicity Estimation and Molecular Docking Studies of N-(furan-2-yl)-1-(5-substituted) phenyl-1,3,4-oxadiazol-2-yl) methanimine as Antitubercular Agents
2014 · External reference
Comparison Study of Computational Prediction Tools for Drug-Target Binding Affinities
10.3389/fchem.2019.00782 · 2019 · External reference
Synthesis of Novel β-Keto-Enol Derivatives Tethered Pyrazole, Pyridine and Furan as New Potential Antifungal and Anti-Breast Cancer Agents
10.3390/molecules201119684 · 2015 · External reference
Selective chemical adsorption of Cd(II) on silica covalently decorated with a β-ketoenol-thiophene-furan receptor
10.1039/c9me00140a · 2020 · External reference
β-Keto-enol Tethered Pyridine and Thiophene: Synthesis, Crystal Structure Determination and Its Organic Immobilization on Silica for Efficient Solid-Liquid Extraction of Heavy Metals
10.3390/molecules21070888 · 2016 · External reference
Crystal Structure of (Z)-1-(1,5-dimethyl-1H-pyrazol-3-yl)-3-hydroxy-3-(4-methoxyphenyl)prop-2-en-1-one, C15H16N2O3
10.1515/ncrs-2016-0190 · 2017 · External reference
Crystal Structure of (Z)-1-(1,5-dimethyl-1H-pyrazol-3-yl)-3-hydroxy-3-phenylprop-2-en-1-one, C14H14N2O2
10.1515/ncrs-2016-0194 · 2017 · External reference
Crystal Structure of (Z)-1-(1,5-dimethyl-1H-pyrazol-3-yl)-3-(4-ethoxyphenyl)-3-hydroxyprop-2-en-1-one, C16H18N2O3
10.1515/ncrs-2016-0196 · 2017 · External reference
Crystal Structure of (Z)-1-(1,5-dimethyl-1H-pyrazol-3-yl)-3-hydroxy-3-(p-toly)prop-2-en-1-one, C15H16N2O2
10.1515/ncrs-2016-0199 · 2017 · External reference
Crystal Structure of (Z)-3-hydroxy-3-(4-methoxyphenyl)-1-(pyridin-2-yl)prop-2-en-1-one, C15H13NO3
10.1515/ncrs-2016-0219 · 2017 · External reference
Highly Selective Removal of Pb(II) by a Pyridylpyrazole-β-ketoenol Receptor Covalently Bonded onto the Silica Surface
10.1021/acsomega.8b03642 · 2019 · External reference
Cyclic Voltammetry of Ferrocene-containing B-diketones as a Tool to Obtain Group Electronegativities. The Structure of 3-ferrocenoyl-1,1,1-trifluoro-2- hydroxyprop-2-ene
10.1139/v99-015 · 1999 · External reference
Identification of antibacterial and antifungal pharmacophore sites for potent bacteria and fungi inhibition: Indolenyl sulfonamide derivatives
10.1016/j.ejmech.2009.11.029 · 2010 · External reference
Petra, Osiris and Molinspiration (POM) together as a successful support in drug design: antibacterial activity and biopharmaceutical characterization of some azo Schiff bases
10.1007/s00044-011-9723-0 · 2012 · External reference
Drug solubility: importance and enhancement techniques
10.5402/2012/195727 · 2012 · External reference
Molecular Docking and Dynamics Simulation of Protein β-Tubulin and Antifungal Cyclic Lipopeptides
10.3390/molecules24183387 · 2019 · External reference
Benomyl and Colchicine Synergistically Inhibit Cell Proliferation and Mitosis: Evidence of Distinct Binding Sites for These Agents in Tubulin
10.1021/bi801136q · 2008 · External reference
In vitro screening, homology modeling and molecular docking studies of some pyrazole and imidazole derivatives
10.1016/j.biopha.2018.04.061 · 2018 · External reference
Synthesis of New β-Lactams Bearing the Biologically Important Morpholine Ring and POM Analyses of Their Antimicrobial and Antimalarial Activities
2019 · External reference
Synthesis, antibacterial properties and bioinformatics computational analyses of novel 8-hydroxyquinoline derivatives
10.1016/j.heliyon.2019.e02689 · 2019 · External reference
CoMSIA and POM analyses of anti-malarial activity of synthetic prodiginines
10.1016/j.bmcl.2012.05.115 · 2012 · External reference
Synthesis, Bioactivity, Molecular Docking and POM Analyses of Novel Substituted Thieno[2,3-b]thiophenes and Related Congeners
10.3390/molecules20021824 · 2015 · External reference
AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading
10.1002/jcc.21334 · 2010 · External reference
SWISS-MODEL: homology modelling of protein structures and complexes
10.1093/nar/gky427 · 2018 · External reference
The Amber biomolecular simulation programs
10.1002/jcc.20290 · 2005 · External reference
A Smooth Particle Mesh Ewald Method
10.1063/1.470117 · 1995 · External reference
Settle: An analytical version of the SHAKE and RATTLE algorithm for rigid water models
10.1002/jcc.540130805 · 1992 · External reference
Application of Organized Microstructures to Study Keto-Enol Equilbrium of β-Dicarbonyl Compounds
10.2174/1385272043486124 · 2004 · External reference
Unresolved reference
1970 · External reference
