Research graph
References from Ni-Catalyzed Reductive and Merged Photocatalytic Cross-Coupling Reactions toward sp3/sp2-Functionalized Isoquinolones: Creating Diversity at C-6 and C-7 to Address Bioactive Analogues. Local targets link to admitted publications; unresolved targets remain external evidence.
Synthesis of 1(2H)-Isoquinolones. (Review)
10.1023/a:1011958810129 · 2001 · External reference
Cheritamine, A New N-Fatty Acyl Tryptamine and Other Constituents from the Stems of Annona cherimola
10.1002/jccs.199900010 · 1999 · External reference
Siamin, ein Neues Isochinolon-Derivat aus Cassia Siamea
10.1016/s0040-4039(00)92893-4 · 1976 · External reference
The Isoquinolones
10.1007/978-1-4615-8819-1_3 · 1978 · External reference
A Revision of the Structure of Isoquinolone Alkaloid Thalflavine
10.1016/s0031-9422(00)97896-8 · 1989 · External reference
Isolation and Structure of Ruprechstyril from Ruprechtia tangarana
10.1021/np0300986 · 2003 · External reference
Lycoricidinol and Lycoricidine, New Plant-growth Regulators in the Bulbs of Lycoris radiata Herb
10.1248/cpb.16.1860 · 1968 · External reference
A Short Chemoenzymatic Synthesis of (+)-Narciclasine
10.1016/s0040-4039(99)00433-5 · 1999 · External reference
Non-Peptide RGD Surrogates Which Mimic a Gly-Asp β-turn: Potent Antagonists of Platelet Glycoprotein IIb-IIIa
10.1021/jm9701076 · 1997 · External reference
Discovery of Potent Poly(ADP-ribose) Polymerase-1 Inhibitors from the Modification of Indeno[1,2-c]isoquinolone
10.1021/jm0502891 · 2005 · External reference
Potent Antifungal Synergy of Phtalazinone and Isoquinolones with Azoles Against Candida albicans
10.1021/acsmedchemlett.6b00355 · 2017 · External reference
1(2H)-Isoquinolones as Potential Antiallergic Agents
10.1248/cpb.31.1277 · 1983 · External reference
New positive allosteric modulators of the metabotropic glutamate receptor 2 (mGluR2): Identification and synthesis of N-propyl-8-chloro-6-substituted isoquinolones
10.1016/j.bmcl.2010.12.048 · 2011 · External reference
Synthesis and Structure-Activity Relationship Studies of Substituted Isoquinoline Analogs as Antitumor Agent
10.1007/bf02974027 · 1998 · External reference
10.1002/9783527619535
10.1002/9783527619535 · 2004 · External reference
Introduction to Frontiers in Transition Metal Catalyzed Reactions (and a Brief Adieu)
10.1021/cr2000515 · 2011 · External reference
Iridium(III)-Catalyzed Regiocontrolled Direct Amidation of Isoquinolones and Pyridones
10.1002/adsc.201701244 · 2018 · External reference
Rhodium(III)-Catalyzed Site-Selective C-H Alkylation and Arylation of Pyridones Using Organoboron Reagents
10.1021/acs.orglett.6b02755 · 2016 · External reference
Rhodium(III)-Catalyzed C6-Selective Arylation of 2-Pyridones and Related Heterocycles Using Quinone Diazides: Syntheses of Heteroarylated Phenols
10.1021/acs.joc.7b00135 · 2017 · External reference
Manganese(I)-Catalyzed C-H 3,3-Difluoroallylation of Pyridines and Indoles
10.1021/acs.orglett.7b01282 · 2017 · External reference
Ruthenium-catalyzed site-selective C-H arylation of 2-pyridones and 1-isoquinolinones
10.1039/c7ob01277b · 2017 · External reference
Cobalt(III)-catalyzed site-selective C-H amidation of pyridines and isoquinolones
10.1039/c8ra06716c · 2018 · External reference
Access to Substituted Propenoic Acids via Rh(III)-Catalyzed C-H Allylation of (Hetero)Arenes with Methyleneoxetanones
10.1021/acs.orglett.7b02983 · 2017 · External reference
Rh(III)-Catalyzed C-C Coupling of Diverse Arenes and 4-Acyl-1-sulfonyltriazoles via C-H activation
10.1021/acs.orglett.8b02078 · 2018 · External reference
Ru(II)-Catalyzed C6-selective C-H amidation of 2-pyridones
10.1039/c8qo00795k · 2018 · External reference
Reaction of Isoquinolin-1(2H)-Ones with Methylenecyclopropanes via Rhodium(III)-Catalyzed C-H Activation
10.1002/adsc.201900176 · 2019 · External reference
Ru(II)-catalyzed C6-selective C-H acylmethylation of pyridones using sulfoxonium ylides as carbene precursors
10.1039/c9ra10749e · 2020 · External reference
RhI-Catalyzed Site-Selective Decarbonylative Alkenylation and Arylation of Quinolones under Chelation Assistance
10.1002/ejoc.201500187 · 2015 · External reference
Rh(III) and Ru(II)-Catalyzed Site-Selective C-H Alkynylation of Quinolones
10.1021/acs.orglett.5b00641 · 2015 · External reference
Catalyst Controlled Divergent C4/C8 Site-Selective C-H Arylation of Isoquinolones
10.1021/acs.orglett.5b01840 · 2015 · External reference
Gold vs Rhodium Catalysis: Tuning Reactivity through Catalyst Control in the C-H Alkynylation of Isoquinolones
10.1021/acs.orglett.6b00175 · 2016 · External reference
AgSbF6-Mediated Selective Thiolation and Selenylation at C-4 Position of Isoquinolin-1(2H)-ones
10.1021/acs.joc.8b01361 · 2018 · External reference
Simple Synthesis of 4-Substituted 1(2H)-Isoquinolinones via Electrophilic Trapping of Lithiated Mono- and Dianion Precursors
10.1080/00397910701575343 · 2007 · External reference
Photocycloaddition and Rearrangement Reactions in a Putative Route to the Skeleton of Plicamine-Type Alkaloids
10.1055/s-0034-1380756 · 2015 · External reference
Discovery of Isoquinolone Indole Acetic Acids as Antagonists of Chemoattractant Receptor Homologous Molecule Expressed on Th2 Cells (CRTH2) for the Treatment of Allergic Inflammatory Diseases
10.1021/jm401509e · 2014 · External reference
Selective Urokinase-Type Plasminogen Activator Inhibitors. 4.1-(7-Sulfonamidoisoquinolinyl)guanidines
10.1021/jm061066t · 2007 · External reference
Selective fluorination of 1-hydroxyisoquinolines using SelectFluor
10.1016/j.tetlet.2007.08.024 · 2007 · External reference
Rhodium(III)- and Ruthenium(II)-Catalyzed Olefination of Isoquinolones
10.1021/ol3018352 · 2012 · External reference
Design, synthesis and biological evaluation of novel 4-phenylisoquinolinone BET bromodomain inhibitors
10.1016/j.bmcl.2018.04.016 · 2018 · External reference
Synthesis and Application of Heterocyclic Germatranes via Rhodium-Catalyzed Directed C-H Activation/Annulation with Alkynyl Germatranes and Palladium-Catalyzed Cross-Coupling
10.1002/adsc.201901633 · 2020 · External reference
Optimisation of 6-substituted isoquinolin-1-amine based ROCK-I inhibitors
10.1016/j.bmcl.2010.12.104 · 2011 · External reference
The impact of aromatic ring count on compound developability: further insights by examining carbo- and hetero-aromatic and −aliphatic ring types
10.1016/j.drudis.2010.11.014 · 2011 · External reference
Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success
10.1021/jm901241e · 2009 · External reference
Escape from Flatland 2: complexity and promiscuity
10.1039/c2md20347b · 2013 · External reference
Unresolved reference
External reference
Discovery of a Covalent Inhibitor of KRASG12C (AMG 510) for the Treatment of Solid Tumors
10.1021/acs.jmedchem.9b01180 · 2020 · External reference
Nickel-Catalyzed Reductive Cross-Coupling of Aryl Halides with Alkyl Halides
10.1021/ja9093956 · 2010 · External reference
Replacing Conventional Carbon Nucleophiles with Electrophiles: Nickel-Catalyzed Reductive Alkylation of Aryl Bromides and Chlorides
10.1021/ja301769r · 2012 · External reference
Nickel-Catalyzed Cross-Electrophile Coupling of 2-Chloropyridines with Alkyl Bromides
10.1055/s-0033-1340151 · 2014 · External reference
Nickel-Catalyzed Reductive Coupling of Aryl Halides with Secondary Alkyl Bromides and Allylic Acetate
10.1021/ol3013342 · 2012 · External reference
Nickel-catalyzed methylation of aryl halides/tosylates with methyl tosylate
10.1039/c7cc06106d · 2017 · External reference
Nickel-Catalyzed Reductive Coupling of Aryl Bromides with Tertiary Alkyl Halides
10.1021/jacs.5b06255 · 2015 · External reference
Reductive Cross-Coupling of Nonaromatic, Heterocyclic Bromides with Aryl and Heteroaryl Bromides
10.1021/jo500905m · 2014 · External reference
Engaging Nonaromatic, Heterocyclic Tosylates in Reductive Cross-Coupling with Aryl and Heteroaryl Bromides
10.1021/acs.joc.5b00135 · 2015 · External reference
Recent Advances in Nickel Catalysis Enabled by Stoichiometric Metallic Reducing Agents
2018 · External reference
Methods and Mechanisms for Cross-Electrophile Coupling of Csp2 Halides with Alkyl Electrophiles
10.1021/acs.accounts.5b00057 · 2015 · External reference
Nickel-catalyzed reductive coupling of alkyl halides with other electrophiles: concept and mechanistic considerations
10.1039/c5qo00224a · 2015 · External reference
Nickel-Catalyzed Reductive Couplings
10.1007/s41061-016-0042-2 · 2016 · External reference
Cross-Electrophile Coupling: Principles and New reactions
2019 · External reference
The merger of transition metal and photocatalysis
10.1038/s41570-017-0052 · 2017 · External reference
Shining Light on Photoredox Catalysis: Theory and Synthetic Applications
10.1021/jo202538x · 2012 · External reference
Visible Light Photoredox Catalysis with Transition Metal Complexes: Applications in Organic Synthesis
10.1021/cr300503r · 2013 · External reference
When C-H bond functionalization meets visible-light photoredox catalysis
10.1016/j.tetlet.2013.10.090 · 2014 · External reference
Solar Synthesis: Prospects in Visible Light Photocatalysis
10.1126/science.1239176 · 2014 · External reference
Recent Progress in Visible-Light Photoredox-Catalyzed Intermolecular 1,2-Difunctionalization of Double Bonds via an ATRA-Type Mechanism
10.1021/acs.joc.6b01058 · 2016 · External reference
Dual Catalysis Strategies in Photochemical Synthesis
10.1021/acs.chemrev.6b00018 · 2016 · External reference
Enhancing the potential of enantioselective organocatalysis with light
10.1038/nature25175 · 2018 · External reference
Energy transfer catalysis mediated by visible light: principles, applications, directions
10.1039/c8cs00054a · 2018 · External reference
Iminium and enamine catalysis in enantioselective photochemical reactions
10.1039/c7cs00509a · 2018 · External reference
Mechanistic Studies in Photocatalysis
10.1002/anie.201809984 · 2019 · External reference
A Retrosynthetic Approach for Photocatalysis
10.1002/ejoc.201901421 · 2019 · External reference
10.1002/9783527674145
10.1002/9783527674145 · 2018 · External reference
The Methylation Effect in Medicinal Chemistry
10.1021/cr200060g · 2011 · External reference
Mechanism and Selectivity in Nickel-Catalyzed Cross-Electrophile Coupling of Aryl Halides with Alkyl Halides
10.1021/ja407589e · 2013 · External reference
Design and Reactivity of Organic Functional Groups – 2-pyridylsulfonates as Nucleofugal Esters: Remarkably Mild Transformations into Halides and Olefins
10.3987/com-88-s134 · 1989 · External reference
DFT study of the single electron transfer mechanisms in Ni-Catalyzed reductive cross-coupling of aryl bromide and alkyl bromide
10.1016/j.jorganchem.2014.08.015 · 2014 · External reference
Mechanism of Ni-Catalyzed Reductive 1,2-Dicarbofunctionalization of Alkenes
10.1021/jacs.9b10026 · 2019 · External reference
Ni-Catalyzed Reductive Coupling of Electron-Rich Aryl Iodides with Tertiary Alkyl Halides
10.1021/jacs.8b09473 · 2018 · External reference
Mechanisms of Nickel-Catalyzed Cross-Coupling Reactions
10.1016/j.trechm.2019.08.004 · 2019 · External reference
Nickel-catalyzed, sodium iodide-promoted reductive dimerization of alkyl halides, alkyl pseudohalides, and allylic acetates
10.1039/c0cc01716g · 2010 · External reference
Nickel-Catalyzed Carbonylation of Aromatic Halides at Atmospheric Pressure of Carbon Monoxide
10.1016/s0022-328x(00)93534-4 · 1973 · External reference
Coupling of Aryl Chlorides by Nickel and Reducing Metals
10.1021/jo00364a002 · 1986 · External reference
Nickel-Phosphine Complex-Catalyzed Homo Coupling of Aryl Halides in the Presence of Zinc Powder
10.1016/s0040-4039(01)83434-1 · 1977 · External reference
Halide Ligands-More Than Just σ-Donors? A Structural and Spectroscopic Study of Homologous Organonickel Complexes
10.1021/ic8007365 · 2008 · External reference
Nickel-catalyzed cross-coupling of unactivated alkyl halides using bis(pinacolato)diboron as reductant
10.1039/c3sc51098k · 2013 · External reference
Enantioselective Decarboxylative Arylation of α-Amino Acids via the Merger of Photoredox and Nickel Catalysis
10.1021/jacs.5b13211 · 2016 · External reference
Nickel-Catalyzed Reductive Methylation of Alkyl Halides and Acid Chlorides with Methyl p-Tosylate
10.1021/ol502682q · 2014 · External reference
Mechanistic Investigation of Carbon-Carbon Bond Formation in the Reduction of Alkyl Halides by Organonickel Complexes in Aqueous Solution
10.1021/ja00264a024 · 1986 · External reference
Evidence for a NiI Active Species in the Catalytic Cross-Coupling of Alkyl Electrophiles
10.1021/ja0483903 · 2004 · External reference
Highly nucleophilic vitamin B12-assisted nickel-catalysed reductive coupling or aryl halides and non-activated alkyl tosylates
10.1039/c7cc01932g · 2017 · External reference
Competitive C-O and S-O cleavage mechanisms in reaction of alkyl alkanesulfonates with arene anion radicals
10.1016/s0040-4039(00)89441-1 · 1970 · External reference
Electrochemical Peak Potentials of Typical Substrates Used for Coupling Reactions with Organocuprates: Effects of Solvent
10.1021/jo00167a029 · 1983 · External reference
Single Electron Transfer in the Reaction of Enolates with Alkyl Halides
10.1021/jo00218a007 · 1985 · External reference
Nickel/Cobalt-Catalyzed C(sp3)-C(sp3) Cross-Coupling of Alkyl Halides with Alkyl Tosylates
10.1021/acscatal.9b03352 · 2019 · External reference
Cobalt co-catalysis for cross-electrophile coupling: diarylmethanes from benzyl mesylates and aryl halides
10.1039/c4sc03106g · 2015 · External reference
Nickel and Nucleophilic Cobalt-Catalyzed Trideuteriomethylation of Aryl Halides Using Trideuteriomethyl p-Toluenesulfonate
10.1021/acs.orglett.8b01863 · 2018 · External reference
Ni/Co-Catalyzed Homo-Coupling of Alkyl Tosylates
10.3390/molecules24081458 · 2019 · External reference
Ni-catalyzed cross-electrophile coupling between vinyl/aryl and alkyl sulfonates: synthesis of cycloalkenes and modification of peptides
10.1039/c9sc03347e · 2019 · External reference
Reductive amidation of alkyl tosylates with isocyanates by a Ni/Co-dual catalytic system
10.1039/c9cc09377j · 2020 · External reference
Nickel-Catalyzed Alkyl-Alkyl Cross-Electrophile Coupling Reaction of 1,3-Dimesylates for the Synthesis of Alkylcyclopropanes
10.1021/jacs.0c01330 · 2020 · External reference
Cobalt-Catalyzed Cross-Coupling of 3- and 4-Iodopiperidines with Grignard Reagents
10.1002/chem.201501543 · 2015 · External reference
Copper-Catalyzed Cross-Coupling of Nonactivated Secondary Alkyl Halides and Tosylates with Secondary Alkyl Grignard Reagents
10.1021/ja304848n · 2012 · External reference
Nickel-Catalyzed Cross-Coupling Reaction of Grignard Reagents with Alkyl Halides and Tosylates: Remarkable Effect of 1,3-Butadienes
10.1021/ja025828v · 2002 · External reference
Kinetics of Radical Reactions: Radical Clocks
10.1002/9783527618293.ch16 · 2001 · External reference
Radicals and Radical Anions
2015 · External reference
Ni-Catalyzed Carbon-Carbon Bond-Forming Reductive Amination
10.1021/jacs.7b12212 · 2018 · External reference
Nickel-Catalyzed Asymmetric Reductive Cross-Coupling Between Vinyl and Benzyl Electrophiles
10.1021/ja508067c · 2014 · External reference
Nickel-Catalyzed Asymmetric Reductive Cross-Coupling To Access 1,1-Diarylalkanes
10.1021/jacs.7b01705 · 2017 · External reference
Nickel-Catalyzed Asymmetric Reductive Cross-Coupling between Heteroaryl Iodides and α-Chloronitriles
10.1021/jacs.5b06466 · 2015 · External reference
Decarboxylative Arylation of α-Amino Acids via Photoredox Catalysis: A One-Step Conversion of Biomass to Drug Pharmacophore
10.1021/ja501621q · 2014 · External reference
Merging photoredox with nickel catalysis: Coupling of α-carboxyl sp3-carbons with aryl halides
10.1126/science.1255525 · 2014 · External reference
Merging Photoredox and Nickel Catalysis: Decarboxylative Cross-Coupling of Carboxylic Acids with Vinyl Halides
10.1021/ja511913h · 2015 · External reference
Merging Photoredox and Nickel Catalysis: The Direct Synthesis of Ketones by the Decarboxylative Arylation of α-Oxo Acids
10.1002/anie.201501908 · 2015 · External reference
Nickel-Catalyzed Cross-Coupling of Redox-Active Esters with Boronic Acids
10.1002/anie.201605463 · 2016 · External reference
Practical Ni-Catalyzed Aryl-Alkyl Cross-Coupling of Secondary Redox-Active Esters
10.1021/jacs.6b00250 · 2016 · External reference
Redox-Active Esters in Fe-Catalyzed C-C Coupling
10.1021/jacs.6b07172 · 2016 · External reference
Alkyl-(Hetero)Aryl Bond Formation via Decarboxylative Cross-Coupling: A Systematic Analysis
10.1002/anie.201612314 · 2017 · External reference
Decarboxylative coupling reactions: a modern strategy for C-C-bond formation
10.1039/c1cs15093f · 2011 · External reference
Metal-Catalyzed Ionic Decarboxylative Cross-Coupling Reactions of C(sp3) Acids: Reaction Development, Mechanisms, and Application
10.1021/acscatal.9b04956 · 2020 · External reference
Recent developments in decarboxylative cross-coupling reactions between carboxylic acids and N-H compounds
10.1039/c9ra00929a · 2019 · External reference
Covalent inhibitors in drug discovey: from accidental discoveries to avoided liabilities and designed therapies
10.1016/j.drudis.2015.05.005 · 2015 · External reference
Targeted Covalent Inhibitors for Drug Design
10.1002/anie.201601091 · 2016 · External reference
The resurgence of covalent drugs
10.1038/nrd3410 · 2011 · External reference
A Perspective on the Kinetics of Covalent and Irreversible Inhibition
10.1177/1087057116671509 · 2017 · External reference
