Research graph
References from Using Bibliometric Analysis and Machine Learning to Identify Compounds Binding to Sialidase-1. Local targets link to admitted publications; unresolved targets remain external evidence.
Estimating cumulative point prevalence of rare diseases: analysis of the Orphanet database
10.1038/s41431-019-0508-0 · 2020 · External reference
Lysosomal storage disorders - challenges, concepts and avenues for therapy: beyond rare diseases
10.1242/jcs.221739 · 2019 · External reference
Lysosomal storage disorders: A review of the musculoskeletal features
10.1111/jpc.13122 · 2016 · External reference
Lysosomal storage diseases
10.1038/s41572-018-0037-0 · 2018 · External reference
Update on treatment of lysosomal storage diseases
2007 · External reference
Cord blood is the optimal graft source for the treatment of pediatric patients with lysosomal storage diseases: clinical outcomes and future directions
10.1016/j.jcyt.2015.03.609 · 2015 · External reference
Receptor-mediated uptake of lysosomal enzymes
1978 · External reference
Gene therapy for lysosomal storage diseases
10.1016/j.ymthe.2006.01.006 · 2006 · External reference
CNS-directed gene therapy for lysosomal storage diseases
10.1111/j.1651-2227.2008.00660.x · 2008 · External reference
Publisher Correction: Therapies for rare diseases: therapeutic modalities, progress and challenges ahead
10.1038/s41573-019-0059-7 · 2020 · External reference
Pathogenesis, Emerging therapeutic targets and Treatment in Sialidosis
10.1517/21678707.2015.1025746 · 2015 · External reference
Sialidoses
10.1684/epd.2016.0845 · 2016 · External reference
Molecular pathology of NEU1 gene in sialidosis
10.1002/humu.10268 · 2003 · External reference
Targeting macrophages with baculovirus-produced lysosomal enzymes: implications for enzyme replacement therapy of the glycoprotein storage disorder galactosialidosis
10.1096/fj.03-0941fje · 2004 · External reference
Short-term, high dose enzyme replacement therapy in sialidosis mice
10.1016/j.ymgme.2005.03.007 · 2005 · External reference
Selective Inhibitors of Human Neuraminidase 1 (NEU1)
10.1021/acs.jmedchem.8b01411 · 2018 · External reference
Preclinical dose-finding study with a liver-tropic, recombinant AAV-2/8 vector in the mouse model of galactosialidosis
10.1038/mt.2011.227 · 2012 · External reference
Exploiting machine learning for end-to-end drug discovery and development
10.1038/s41563-019-0338-z · 2019 · External reference
Unresolved reference
External reference
The ChEMBL database in 2017
10.1093/nar/gkw1074 · 2017 · External reference
Moving beyond rules: the development of a central nervous system multiparameter optimization (CNS MPO) approach to enable alignment of druglike properties
10.1021/cn100008c · 2010 · External reference
Comparing Machine Learning Algorithms for Predicting Drug-Induced Liver Injury (DILI)
10.1021/acs.molpharmaceut.0c00326 · 2020 · External reference
Comparing Multiple Machine Learning Algorithms and Metrics for Estrogen Receptor Binding Prediction
10.1021/acs.molpharmaceut.8b00546 · 2018 · External reference
Comparing and Validating Machine Learning Models for Mycobacterium tuberculosis Drug Discovery
10.1021/acs.molpharmaceut.8b00083 · 2018 · External reference
Multiple Machine Learning Comparisons of HIV Cell-based and Reverse Transcriptase Data Sets
10.1021/acs.molpharmaceut.8b01297 · 2019 · External reference
Treatment of leprosy with clofazimine, rifampicin and Bayrena
10.5935/0305-7518.19750044 · 1975 · External reference
Absorption Studies on a New Long-Active Sulfonamide, Sulfamethoxydiazine
1963 · External reference
A study of chemical light screening agents
10.1111/j.1365-2133.1975.tb03103.x · 1975 · External reference
Protective protein/cathepsin A rescues N-glycosylation defects in neuraminidase-1
10.1016/j.bbagen.2009.01.006 · 2009 · External reference
Inhibition of cytochrome C oxidase by glutathione in vitro
1990 · External reference
Sialidosis: A Review of Morphology and Molecular Biology of a Rare Pediatric Disorder
10.3390/diagnostics8020029 · 2018 · External reference
A comprehensive global genotype-phenotype database for rare diseases
10.1002/mgg3.262 · 2017 · External reference
RD-Connect: an integrated platform connecting databases, registries, biobanks and clinical bioinformatics for rare disease research
10.1007/s11606-014-2908-8 · 2014 · External reference
Representation of rare diseases in health information systems: the Orphanet approach to serve a wide range of end users
10.1002/humu.22078 · 2012 · External reference
Unresolved reference
External reference
Database identifies FDA-approved drugs with potential to be repurposed for treatment of orphan diseases
10.1093/bib/bbr006 · 2011 · External reference
Unresolved reference
External reference
Open Targets Platform: new developments and updates two years on
10.1093/nar/gky1133 · 2019 · External reference
Mining connections between chemicals, proteins, and diseases extracted from Medline annotations
10.1016/j.jbi.2010.03.008 · 2010 · External reference
Chemotext: A Publicly Available Web Server for Mining Drug-Target-Disease Relationships in PubMed
10.1021/acs.jcim.7b00589 · 2018 · External reference
Open Source Bayesian Models. 1. Application to ADME/Tox and Drug Discovery Datasets
10.1021/acs.jcim.5b00143 · 2015 · External reference
Open Source Bayesian Models. 2. Mining a “Big Dataset” To Create and Validate Models with ChEMBL
10.1021/acs.jcim.5b00144 · 2015 · External reference
The Chemistry Development Kit (CDK) v2.0: atom typing, depiction, molecular formulas, and substructure searching
10.1186/s13321-017-0231-1 · 2017 · External reference
Assessing agreement on classification tasks: The kappa statistic
1996 · External reference
A coefficient of agreement for nominal scales
10.1177/001316446002000104 · 1960 · External reference
Comparison of the predicted and observed secondary structure of T4 phage lysozyme
10.1016/0005-2795(75)90109-9 · 1975 · External reference
Naive Bayesian Models for Vero Cell Cytotoxicity
10.1007/s11095-018-2439-9 · 2018 · External reference
Central Nervous System Multiparameter Optimization Desirability: Application in Drug Discovery
10.1021/acschemneuro.6b00029 · 2016 · External reference
