Research graph
References from Inhibition of Lysozyme Amyloid Fibrillation by Silybin Diastereoisomers: The Effects of Stereochemistry. Local targets link to admitted publications; unresolved targets remain external evidence.
Protein Misfolding, Amyloid Formation, and Human Disease: A Summary of Progress Over the Last Decade
10.1146/annurev-biochem-061516-045115 · 2017 · External reference
Protein misfolding, evolution and disease
10.1016/s0968-0004(99)01445-0 · 1999 · External reference
A Highly Amyloidogenic Region of Hen Lysozyme
10.1016/j.jmb.2004.05.056 · 2004 · External reference
Protein Misfolding, Functional Amyloid, and Human Disease
10.1146/annurev.biochem.75.101304.123901 · 2006 · External reference
Hereditary lysozyme amyloidosis with sicca syndrome, digestive, arterial, and tracheobronchial involvement: case-based review
10.1007/s10067-017-3839-7 · 2017 · External reference
Lysozyme amyloid: evidence for the W64R variant by proteomics in the absence of the wild type protein
10.1080/13506129.2020.1720637 · 2020 · External reference
Lysozyme amyloidosis
10.1016/j.revmed.2018.08.008 · 2019 · External reference
Renal amyloidosis: an update on diagnosis and pathogenesis
10.1007/s00709-020-01513-0 · 2020 · External reference
Natural product-based amyloid inhibitors
10.1016/j.bcp.2017.04.004 · 2017 · External reference
Curcumin and kaempferol prevent lysozyme fibril formation by modulating aggregation kinetic parameters
10.1016/j.bbapap.2014.01.009 · 2014 · External reference
Mangiferin: A multipotent natural product preventing neurodegeneration in Alzheimer’s and Parkinson’s disease models
10.1016/j.phrs.2019.104336 · 2019 · External reference
A natural product inhibits the initiation of alpha-synuclein aggregation and suppresses its toxicity
10.1073/pnas.1610586114 · 2017 · External reference
Silybin, a Major Bioactive Component of Milk Thistle (Silybum marianum L. Gaernt.)-Chemistry, Bioavailability, and Metabolism
10.3390/molecules22111942 · 2017 · External reference
Effect of silybin on the fibrillation of hen egg-white lysozyme
10.1002/jmr.2566 · 2016 · External reference
Silibinin: A novel inhibitor of A beta aggregation
10.1016/j.neuint.2010.12.017 · 2011 · External reference
Protective effects of silibinin on insulin amyloid fibrillation, cytotoxicity and mitochondrial membrane damage
10.1016/j.abb.2018.09.024 · 2018 · External reference
Silibinin ameliorates STZ-induced impairment of memory and learning by up- regulating insulin signaling pathway and attenuating apoptosis
10.1016/j.physbeh.2019.112689 · 2020 · External reference
Inhibition of Abeta Amyloid Growth and Toxicity by Silybins: The Crucial Role of Stereochemistry
10.1021/acschemneuro.7b00110 · 2017 · External reference
Natural Compounds as Beneficial Antioxidant Agents in Neurodegenerative Disorders: A Focus on Alzheimer’s Disease
10.3390/antiox8120608 · 2019 · External reference
Trehalose Conjugates of Silybin as Prodrugs for Targeting Toxic A beta Aggregates
10.1021/acschemneuro.0c00232 · 2020 · External reference
Relative Bioavailability of Silybin A and Silybin B From 2 Multiconstituent Dietary Supplement Formulations Containing Milk Thistle Extract: A Single-dose Study
10.1016/j.clinthera.2017.11.013 · 2018 · External reference
Stereoselective metabolism of silybin diastereoisomers in the glucuronidation process
10.1016/j.jpba.2003.12.002 · 2004 · External reference
Amyloid fibrillogenesis: themes and variations
10.1016/s0959-440x(99)00049-4 · 2000 · External reference
The Kinetics of Nucleated Polymerizations at High Concentrations: Amyloid Fibril Formation Near and Above the “Supercritical Concentration”
10.1529/biophysj.105.073767 · 2006 · External reference
A Three-Stage Kinetic Model of Amyloid Fibrillation
10.1529/biophysj.106.098608 · 2007 · External reference
Cholesterol catalyses Aβ42 aggregation through a heterogeneous nucleation pathway in the presence of lipid membranes
10.1038/s41557-018-0031-x · 2018 · External reference
Secondary nucleation in amyloid formation
10.1039/c8cc02204f · 2018 · External reference
Estimation of the lag time in a subsequent monomer addition model for fibril elongation
10.1039/c5cp07845h · 2016 · External reference
Absolute Correlation between Lag Time and Growth Rate in the Spontaneous Formation of Several Amyloid-like Aggregates and Fibrils
10.1016/j.jmb.2006.11.009 · 2007 · External reference
Protein Fibrillation Lag Times During Kinetic Inhibition
10.1016/j.bpj.2014.06.029 · 2014 · External reference
On the origin of the stronger binding of PIB over thioflavin T to protofibrils of the Alzheimer amyloid-beta peptide: a molecular dynamics study
10.1016/j.bpj.2011.01.058 · 2011 · External reference
Guanidine Hydrochloride Can Induce Amyloid Fibril Formation from Hen Egg-White Lysozyme
10.1021/bm0498979 · 2004 · External reference
Hydrophobic, aromatic, and electrostatic interactions play a central role in amyloid fibril formation and stability
10.1021/bi101936c · 2011 · External reference
Evidence of a two-stage thermal denaturation process in lysozyme: a Raman scattering and differential scanning calorimetry investigation
10.1063/1.2139087 · 2006 · External reference
The changes of secondary structures and properties of lysozyme along with the egg storage
10.1016/j.ijbiomac.2016.07.068 · 2016 · External reference
Microwave-radiation-induced molecular structural rearrangement of hen egg-white lysozyme
10.1103/physreve.97.052416 · 2018 · External reference
Double-edged effects of aluminium ions on amyloid fibrillation of hen egg-white lysozyme
10.1016/j.ijbiomac.2019.04.009 · 2019 · External reference
Multistate Mechanism of Lysozyme Denaturation through Synchronous Analysis of Raman Spectra
10.1021/acs.jpcb.6b07900 · 2016 · External reference
The effect of concentration, temperature and stirring on hen egg white lysozyme amyloid formation
10.1039/c3sm51671g · 2013 · External reference
The effect of concentration, temperature and stirring on hen egg white lysozyme amyloid formation
10.1039/c3sm51671g · 2013 · External reference
Physical basis for the ofloxacin-induced acceleration of lysozyme aggregation and polymorphism in amyloid fibrils
10.1016/j.abb.2016.01.005 · 2016 · External reference
Guanidine hydrochloride can induce amyloid fibril formation from hen egg-white lysozyme
10.1021/bm0498979 · 2004 · External reference
Ultrasonication-dependent acceleration of amyloid fibril formation
10.1016/j.jmb.2011.07.069 · 2011 · External reference
High-throughput analysis of ultrasonication-forced amyloid fibrillation reveals the mechanism underlying the large fluctuation in the lag time
10.1074/jbc.m114.569814 · 2014 · External reference
Ultrasonication-dependent acceleration of amyloid fibril formation
10.1016/j.jmb.2011.07.069 · 2011 · External reference
Differences in nucleation behavior underlie the contrasting aggregation kinetics of the Abeta40 and Abeta42 peptides
10.1073/pnas.1401564111 · 2014 · External reference
The length distribution of frangible biofilaments
10.1063/1.4933230 · 2015 · External reference
Distribution of Amyloid-Like and Oligomeric Species from Protein Aggregation Kinetics
10.1002/anie.201707345 · 2017 · External reference
An analytical solution to the kinetics of breakable filament assembly
10.1126/science.1178250 · 2009 · External reference
Pharmacokinetics of pure silybin diastereoisomers and identification of their metabolites in rat plasma
10.1016/j.jff.2015.02.031 · 2015 · External reference
Hepatoprotective herbal drug, silymarin from experimental pharmacology to clinical medicine
2006 · External reference
Milk thistle in liver diseases: past, present, future
10.1002/ptr.3207 · 2010 · External reference
Silybin and the liver: from basic research to clinical practice
10.3748/wjg.v17.i18.2288 · 2011 · External reference
Silymarin modulates the oxidant-antioxidant imbalance during diethylnitrosamine induced oxidative stress in rats
10.1016/j.ejphar.2006.12.023 · 2007 · External reference
Hepatoprotective role of Legalon 70 against hydrogen peroxide in chickens
2019 · External reference
Multitargeted therapy of cancer by silymarin
10.1016/j.canlet.2008.03.053 · 2008 · External reference
Large-scale separation of silybin diastereoisomers using lipases
10.1016/j.procbio.2010.06.019 · 2010 · External reference
Enzymatic kinetic resolution of silybin diastereoisomers
10.1021/np900758d · 2010 · External reference
Unravelling the inhibitory and cytoprotective potential of diuretics towards amyloid fibrillation
10.1016/j.ijbiomac.2019.10.137 · 2020 · External reference
Amyloid-Based Injectable Hydrogel Derived from Hydrolyzed Hen Egg White Lysozyme
10.1021/acsomega.8b03492 · 2019 · External reference
