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References from Lipid Extraction by α-Synuclein Generates Semi-Transmembrane Defects and Lipoprotein Nanoparticles. Local targets link to admitted publications; unresolved targets remain external evidence.
Molecular pathophysiology of Parkinson’s disease
10.1146/annurev.neuro.28.061604.135718 · 2005 · External reference
Parkinson’s disease
10.1093/hmg/ddm159 · 2007 · External reference
α-synuclein in Lewy bodies
10.1038/42166 · 1997 · External reference
α-synuclein in filamentous inclusions of Lewy bodies from Parkinson’s disease and dementia with Lewy bodies
10.1073/pnas.95.11.6469 · 1998 · External reference
Mutation in the α-synuclein gene identified in families with Parkinson’s disease
10.1126/science.276.5321.2045 · 1997 · External reference
Causal relation between α-synuclein gene duplication and familial Parkinson’s disease
10.1016/s0140-6736(04)17104-3 · 2004 · External reference
α-synuclein locus triplication causes Parkinson’s disease
10.1126/science.1090278 · 2003 · External reference
Stabilization of α-synuclein secondary structure upon binding to synthetic membranes
10.1074/jbc.273.16.9443 · 1998 · External reference
α-Synuclein Oligomers with Broken Helical Conformation Form Lipoprotein Nanoparticles
10.1074/jbc.m113.476697 · 2013 · External reference
Structure and dynamics of micelle-bound human α-synuclein
10.1074/jbc.m411805200 · 2005 · External reference
Structure of membrane-bound α-synuclein from site-directed spin labeling and computational refinement
10.1073/pnas.0807826105 · 2008 · External reference
Membrane-bound α-synuclein forms an extended helix: Long-distance pulsed ESR measurements using vesicles, bicelles, and rodlike micelles
10.1021/ja804517m · 2008 · External reference
Biophysics of α-synuclein membrane interactions
10.1016/j.bbamem.2011.07.032 · 2012 · External reference
Inhibition of mitochondrial fusion by α-synuclein is rescued by PINK1, Parkin and DJ-1
10.1038/emboj.2010.223 · 2010 · External reference
Golgi fragmentation occurs in the cells with prefibrillar α-synuclein aggregates and precedes the formation of fibrillar inclusion
10.1074/jbc.m208194200 · 2002 · External reference
Endoplasmic reticulum stress and mitochondrial cell death pathways mediate A53T mutant α-synuclein-induced toxicity
10.1093/hmg/ddi396 · 2005 · External reference
Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer’s amyloid beta-peptide
10.1038/nrm2101 · 2007 · External reference
Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death
10.1038/nature02998 · 2004 · External reference
Presynaptic α-synuclein aggregates, not Lewy bodies, cause neurodegeneration in dementia with Lewy bodies
10.1523/jneurosci.4564-06.2007 · 2007 · External reference
Acceleration of oligomerization, not fibrillization, is a shared property of both α-synuclein mutations linked to early-onset Parkinson’s disease: Implications for pathogenesis and therapy
10.1073/pnas.97.2.571 · 2000 · External reference
Pathological roles of α-synuclein in neurological disorders
10.1016/s1474-4422(11)70213-7 · 2011 · External reference
Membrane remodeling and mechanics: Experiments and simulations of α-Synuclein
10.1016/j.bbamem.2016.03.012 · 2016 · External reference
Membrane Curvature Induction and Tubulation Are Common Features of Synucleins and Apolipoproteins
10.1074/jbc.m110.139576 · 2010 · External reference
Monomeric Synucleins Generate Membrane Curvature
10.1074/jbc.m112.418871 · 2013 · External reference
Membrane Remodeling by α-Synuclein and Effects on Amyloid Formation
10.1021/ja405993r · 2013 · External reference
Remodeling of Lipid Vesicles into Cylindrical Micelles by α-Synuclein in an Extended α-Helical Conformation
10.1074/jbc.m112.365817 · 2012 · External reference
Lipid regulation of the synaptic vesicle cycle
10.1038/nrn1608 · 2005 · External reference
Fluid phase lipid areas and bilayer thicknesses of commonly used phosphatidylcholines as a function of temperature
10.1016/j.bbamem.2011.07.022 · 2011 · External reference
Scattering Density Profile Model of POPG Bilayers As Determined by Molecular Dynamics Simulations and Small-Angle Neutron and X-ray Scattering Experiments
10.1021/jp208920h · 2012 · External reference
Orientation and motion of amphiphilic spin labels in membranes
10.1073/pnas.64.1.20 · 1969 · External reference
Molecular motion in spin-labeled phospholipids and membranes
10.1021/ja00731a005 · 1971 · External reference
Monomeric Fullerenes in Lipid Membranes: Effects of Molecular Shape and Polarity
10.1021/la202524r · 2011 · External reference
Interaction of hydrophobic and amphipathic antimicrobial peptides with lipid bicelles
10.1002/psc.2645 · 2014 · External reference
A collision gradient method to determine the immersion depth of nitroxides in lipid bilayers: Application to spin-labeled mutants of bacteriorhodopsin
10.1073/pnas.91.5.1667 · 1994 · External reference
Chemical properties of lipids strongly affect the kinetics of the membrane-induced aggregation of α-synuclein
10.1073/pnas.1601899113 · 2016 · External reference
α-synuclein membrane interactions and lipid specificity
10.1074/jbc.m004345200 · 2000 · External reference
The association of α-synuclein with membranes affects bilayer structure, stability, and fibril formation
10.1074/jbc.m305326200 · 2003 · External reference
Membrane Disruption Mechanism of a Prion Peptide (106-126) Investigated by Atomic Force Microscopy, Raman and Electron Paramagnetic Resonance Spectroscopy
10.1021/acs.jpcb.7b02772 · 2017 · External reference
Mechanism of the binding, insertion and destabilization of phospholipid bilayer membranes by α-helical antimicrobial and cell non-selective membrane-lytic peptides
10.1016/s0005-2736(99)00200-x · 1999 · External reference
Antimicrobial Peptides Share a Common Interaction Driven by Membrane Line Tension Reduction
10.1016/j.bpj.2016.10.003 · 2016 · External reference
Biophysics of α-synuclein induced membrane remodelling
10.1039/c4cp05883f · 2015 · External reference
The effects of α-synuclein on phospholipid vesicle integrity: a study using 31P NMR and electron microscopy
10.1080/09687680802467977 · 2008 · External reference
α-Synuclein-Induced Membrane Remodeling Is Driven by Binding Affinity, Partition Depth, and Interleaflet Order Asymmetry
10.1021/ja5016958 · 2014 · External reference
Vesicle permeabilization by protofibrillar α-synuclein: Implications for the pathogenesis and treatment of Parkinson’s disease
10.1021/bi0102398 · 2001 · External reference
Lipid bilayer disruption by oligomeric α-synuclein depends on bilayer charge and accessibility of the hydrophobic core
10.1016/j.bbamem.2009.03.010 · 2009 · External reference
Formation of a high affinity lipid-binding intermediate during the early aggregation phase of α-synuclein
10.1021/bi701522m · 2008 · External reference
Quantification of α-synuclein binding to lipid vesicles using fluorescence correlation spectroscopy
10.1529/biophysj.105.079251 · 2006 · External reference
α-synuclein and familial variants affect the chain order and the thermotropic phase behavior of anionic lipid vesicles
10.1016/j.bbapap.2016.05.003 · 2016 · External reference
Protein/Lipid Coaggregates are Formed During a-Synuclein-Induced Disruption of Lipid Bilayers
10.1021/bm500937p · 2014 · External reference
α-Synuclein Reduces Tension and Increases Undulations in Simulations of Small Unilamellar Vesicles
10.1016/j.bpj.2015.03.029 · 2015 · External reference
Interaction of human α-synuclein and Parkinson’s disease variants with phospholipids - Structural analysis using site-directed mutagenesis
10.1074/jbc.m004851200 · 2000 · External reference
Molecular anatomy of a trafficking organelle
10.1016/j.cell.2006.10.030 · 2006 · External reference
Vesicular Sterols Are Essential for Synaptic Vesicle Cycling
10.1523/jneurosci.4132-10.2010 · 2010 · External reference
Cholesterol binds to synaptophysin and is required for biogenesis of synaptic vesicles
10.1038/71366 · 2000 · External reference
Cholesterol-induced protein sorting: An analysis of energetic feasibility
10.1016/s0006-3495(03)75015-2 · 2003 · External reference
Universal behavior of membranes with sterols
10.1529/biophysj.105.067652 · 2006 · External reference
Cholesterol perturbs lipid bilayers nonuniversally
10.1103/physrevlett.100.198103 · 2008 · External reference
Dysregulation of cholesterol balance in the brain: contribution to neurodegenerative diseases
10.1242/dmm.010124 · 2012 · External reference
The fusogenic tilted peptide (67–78) of α-synuclein is a cholesterol binding domain
10.1016/j.bbamem.2011.06.017 · 2011 · External reference
α-Synuclein Regulates Neuronal Cholesterol Efflux
10.3390/molecules22101769 · 2017 · External reference
Impact of high cholesterol in a Parkinson’s disease model: Prevention of lysosomal leakage versus stimulation of α-synuclein aggregation
10.1016/j.ejcb.2017.01.002 · 2017 · External reference
Effects of Curvature and Composition on α-Synuclein Binding to Lipid Vesicles
10.1016/j.bpj.2010.07.056 · 2010 · External reference
α-synuclein has a high affinity for packing defects in a bilayer membrane - A thermodynamics study
10.1074/jbc.m401076200 · 2004 · External reference
Binding of α-synuclein affects the lipid packing in bilayers of small vesicles
10.1074/jbc.m512292200 · 2006 · External reference
Effect of cholesterol on structural and mechanical properties of membranes depends on lipid chain saturation
10.1103/physreve.80.021931 · 2009 · External reference
Depth of α-Synuclein in a Bilayer Determined by Fluorescence, Neutron Reflectometry, and Computation
10.1016/j.bpj.2011.12.051 · 2012 · External reference
Molecular Details of α-Synuclein Membrane Association Revealed by Neutrons and Photons
10.1021/jp512499r · 2015 · External reference
Thematic review series: Glycerolipids. Phosphatidylserine and phosphatidylethanolamine in mammalian cells: two metabolically related aminophospholipids
10.1194/jlr.r700020-jlr200 · 2008 · External reference
Monolayer spontaneous curvature of raft-forming membrane lipids
10.1039/c3sm51829a · 2013 · External reference
Lipid Intermolecular Hydrogen-Bonding - Influence on Structural Organization and Membrane-Function
10.1016/0304-4157(87)90017-7 · 1987 · External reference
A model of hydrogen bond formation in phosphatidylethanolamine bilayers
10.1016/s0005-2736(97)00196-x · 1998 · External reference
Molecular structures of fluid phosphatidylethanolamine bilayers obtained from simulation-to-experiment comparisons and experimental scattering density profiles
10.1021/jp511159q · 2015 · External reference
Contribution of Hydrogen-Bonding to Lipid Lipid Interactions in Membranes and the Role of Lipid Order - Effects of Cholesterol, Increased Phospholipid Unsaturation, and Ethanol
10.1021/bi00065a025 · 1993 · External reference
10.1016/j.bbamem.2018.07.013
10.1016/j.bbamem.2018.07.013 · External reference
α-Synuclein Senses Lipid Packing Defects and Induces Lateral Expansion of Lipids Leading to Membrane Remodeling
10.1074/jbc.m113.478297 · 2013 · External reference
Regulation of calcium channel activity by lipid domain formation in planar lipid bilayers
10.1016/s0006-3495(03)74532-9 · 2003 · External reference
Lipid headgroup discrimination by antimicrobial peptide LL-37: Insight into mechanism of action
10.1529/biophysj.105.067595 · 2006 · External reference
Greasing the synaptic vesicle cycle by membrane lipids
10.1016/j.tcb.2013.05.002 · 2013 · External reference
Interaction between Dopamine and Phospholipids - Studies of Substantia Nigra in Parkinson Disease Patients
10.1001/archneur.1975.00490430047006 · 1975 · External reference
Phosphatidylethanolamine deficiency disrupts α-synuclein homeostasis in yeast and worm models of Parkinson disease
10.1073/pnas.1411694111 · 2014 · External reference
Binding of α-synuclein to brain vesicles is abolished by familial Parkinson’s disease mutation
10.1074/jbc.273.41.26292 · 1998 · External reference
Kinetic Defects Induced by Melittin in Model Lipid Membranes: A Solution Atomic Force Microscopy Study
10.1021/acs.jpcb.6b02332 · 2016 · External reference
Modulation of lipid membrane structural and mechanical properties by a peptidomimetic derived from reduced amide scaffold
10.1016/j.bbamem.2017.01.026 · 2017 · External reference
Formation of supported phospholipid bilayers from unilamellar vesicles investigated by atomic force microscopy
10.1021/la9903043 · 2000 · External reference
Supported planar bilayer formation by vesicle fusion: the interaction of phospholipid vesicles with surfaces and the effect of gramicidin on bilayer properties using atomic force microscopy
10.1016/s0005-2736(00)00288-1 · 2000 · External reference
Accessibility of nitroxide side chains: Absolute Heisenberg exchange rates from power saturation EPR
10.1529/biophysj.105.059063 · 2005 · External reference
