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References from Biguanide Antidiabetic Drugs: Imeglimin Exhibits Higher Proton Basicity but Smaller Lithium-Cation Basicity than Metformin in Vacuo. Local targets link to admitted publications; unresolved targets remain external evidence.
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10.2337/dc16-0614 · 2016 · External reference
The 2016 global and national burden of diabetes mellitus attributable to PM2.5 air pollution
10.1016/s2542-5196(18)30140-2 · 2018 · External reference
Metformin inhibits gluconeogenesis via a redox-dependent mechanism in vivo
10.1038/s41591-018-0125-4 · 2018 · External reference
Current understanding of metformin effect on the control of hyperglycemia in diabetes
10.1530/joe-15-0447 · 2016 · External reference
Molecular action of metformin in hepatocytes: an updated insight
10.2174/1573399811666150325233108 · 2015 · External reference
Exceptionally high proton and lithium cation gas-phase basicity of the anti-diabetic drug metformin
10.1021/acs.jpca.7b09338 · 2017 · External reference
Pharmacogenomics in type 2 diabetes: oral antidiabetic drugs
10.1038/tpj.2016.54 · 2016 · External reference
Metformin - mode of action and clinical implications for diabetes and cancer
10.1038/nrendo.2013.256 · 2014 · External reference
Unresolved reference
External reference
Imeglimin - a new oral anti-diabetic that targets the three key defects of type 2 diabetes
10.4172/2155-6156.1000126 · 2011 · External reference
Imeglimin, a novel glimin oral antidiabetic, exhibits a good efficacy and safety profile in type 2 diabetic patients
10.1111/j.1463-1326.2012.01611.x · 2012 · External reference
A combination therapy of sitaglitpin with a new class of antidiabetic therapy, imeglimin shown to be beneficial in people with type 2 diabetes
10.1111/dom.12045 · 2013 · External reference
The efficacy and safety of imeglimin as add-on therapy in patients with type 2 diabetes inadequately controlled with metformin monotherapy
10.2337/dc12-0453 · 2013 · External reference
The efficacy and safety of imeglimin as add-on therapy in patients with type 2 diabetes inadequately controlled with sitagliptin monotherapy
10.2337/dc13-2349 · 2014 · External reference
Imeglimin: a potential new multi-target drug for type 2 diabetes
10.1007/s40268-015-0099-3 · 2015 · External reference
Imeglimin increases glucose-dependent insulin secretion and improves β-cell function in patients with type 2 diabetes
10.1111/dom.12452 · 2015 · External reference
Imeglimin normalizes glucose tolerance and insulin sensitivity and improves mitochondrial function in liver of a high-fat, high-sucrose diet mice model
10.2337/db14-1220 · 2015 · External reference
Imeglimin prevents human endothelial cell death by inhibiting mitochondrial permeability transition without inhibiting mitochondrial respiration
10.1038/cddiscovery.2015.72 · 2016 · External reference
Sumimoto licenses diabetes drug
10.1021/cen-09544-buscon11 · 2017 · External reference
Roivant and Poxel join for imeglimin
10.1021/cen-09608-buscon10 · 2018 · External reference
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Unresolved reference
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Advances in determining the absolute proton affinities of neutral organic molecules in the gas phase and their interpretation: A theoretical account
10.1021/cr100458v · 2012 · External reference
Basicity limits of neutral organic superbases
10.1002/anie.201503345 · 2015 · External reference
Enhanced basicity of push-pull nitrogen bases in the gas phase
10.1021/acs.chemrev.6b00224 · 2016 · External reference
What’s in a structure? The story of biguanides
10.1016/j.molstruc.2017.08.100 · 2018 · External reference
Acidic and basic drugs in medicinal chemistry: A perspective
10.1021/jm501000a · 2014 · External reference
Revised and expanded scale of the gas-phase lithium-cation basicities - an experimental and theoretical study
10.1021/jp9931399 · 2000 · External reference
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10.1007/s13361-014-0970-4 · 2014 · External reference
Unresolved reference
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Glossary of terms used in physical organic chemistry (IUPAC Recommendations, 1994)
10.1351/pac199466051077 · 1994 · External reference
Unresolved reference
External reference
Tautomeric equilibria in relations to pi-electron delocalization
10.1021/cr030087h · 2005 · External reference
Resolution of (±)-imeglimin-2,4-dichlorophenylacetate methanol solvate by preferential crystallization
10.1021/op100173r · 2010 · External reference
A Critical evaluation of the experimental and theoretical determination of lithium cation affinities
10.1016/j.ijms.2007.02.034 · 2007 · External reference
Cationic noncovalent interactions: energetics and periodic trends
10.1021/acs.chemrev.5b00688 · 2016 · External reference
Unresolved reference
2010 · External reference
Experimental gas-phase basicity scale of superbasic phosphazenes
10.1021/jp066182m · 2007 · External reference
Gas-phase structural (internal) effects in strong organic nitrogen bases
10.1002/1099-1395(200101)14:1<25::aid-poc332>3.0.co;2-e · 2001 · External reference
Ab initio calculations on formamidine-X+ (X = H, Li, Na, Mg, and Al) complexes
10.1021/j100100a018 · 1994 · External reference
Unresolved reference
External reference
Gas-phase lithium cation basicity of histamine and its agonist 2-(β-aminoethyl)-pyridine. Experimental and theoretical studies (DFT) of chelation effect
10.1016/j.ijms.2007.02.058 · 2007 · External reference
Unresolved reference
External reference
On the harmonic oscillator model of electron delocalization (HOMED) index and its application to heteroatomic π-electron systems
10.3390/sym2031485 · 2010 · External reference
Critical test of some computational chemistry methods for prediction of gas-phase acidities and basicities
10.1021/ct4003916 · 2013 · External reference
Use of DFT method for the calculation of the entropy of gas phase organic molecules: an examination of the quality of results from a simple approach
10.1021/jp010321c · 2001 · External reference
The guanylated bioamine agmatine – a theoretical investigation of its structure and exceptional high basicity in the gas phase
10.1016/j.comptc.2017.03.032 · 2017 · External reference
Evaluated gas phase basicities and proton affinities of molecules: an update
10.1063/1.556018 · 1998 · External reference
Unique features of metformin: A combined experimental, theoretical, and simulation study of its structure, dynamics, and interaction energetics with DNA grooves
10.1021/acs.jpcb.7b11928 · 2018 · External reference
Gas phase basicity of biguanides – Comparison of the equilibrium and the kinetic methods
10.1016/j.ijms.2018.10.010 · 2019 · External reference
