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References from Codelivery of mRNA with α-Galactosylceramide Using a New Lipopolyplex Formulation Induces a Strong Antitumor Response upon Intravenous Administration. Local targets link to admitted publications; unresolved targets remain external evidence.
Immunology of experimental tumors
10.1146/annurev.me.15.020164.001123 · 1964 · External reference
Vaccines for established cancer: overcoming the challenges posed by immune evasion
10.1038/nrc.2016.16 · 2016 · External reference
Monoclonal antibodies in cancer therapy
2012 · External reference
Driving CAR T-cells forward
10.1038/nrclinonc.2016.36 · 2016 · External reference
Therapeutic cancer vaccines
10.1172/jci80009 · 2015 · External reference
DNA Vaccines: Developing New Strategies against Cancer
10.1155/2010/174378 · 2010 · External reference
Plasmid DNA- and messenger RNA-based anti-cancer vaccination
10.1016/j.imlet.2007.09.012 · 2008 · External reference
mRNA vaccines - a new era in vaccinology
10.1038/nrd.2017.243 · 2018 · External reference
mRNA-based therapeutics - developing a new class of drugs
10.1038/nrd4278 · 2014 · External reference
RNA-based vaccines
10.1016/j.vaccine.2012.04.060 · 2012 · External reference
Biomaterials for mRNA Delivery
10.1039/c5bm00198f · 2015 · External reference
Materials for non-viral intracellular delivery of messenger RNA therapeutics
10.1016/j.jconrel.2015.12.032 · 2016 · External reference
Viral and Synthetic RNA Vector Technologies and Applications
10.1038/mt.2016.143 · 2016 · External reference
Systemic delivery of factor IX messenger RNA for protein replacement therapy
10.1073/pnas.1619653114 · 2017 · External reference
Optimization of Lipid Nanoparticle Formulations for mRNA Delivery in Vivo with Fractional Factorial and Definitive Screening Designs
10.1021/acs.nanolett.5b02497 · 2015 · External reference
Successful reprogramming of cellular protein production through mRNA delivered by functionalized lipid nanoparticles
10.1073/pnas.1720542115 · 2018 · External reference
Charge-altering releasable transporters (CARTs) for the delivery and release of mRNA in living animals
10.1073/pnas.1614193114 · 2017 · External reference
Delivering the Messenger: Advances in Technologies for Therapeutic mRNA Delivery
10.1016/j.ymthe.2019.02.012 · 2019 · External reference
Nanoscale platforms for messenger RNA delivery
10.1002/wnan.1530 · 2019 · External reference
Lipid Nanoparticle Assisted mRNA Delivery for Potent Cancer Immunotherapy
10.1021/acs.nanolett.6b03329 · 2017 · External reference
Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy
10.1038/nature18300 · 2016 · External reference
Lipopolyplex potentiates anti-tumor immunity of mRNA-based vaccination
10.1016/j.biomaterials.2017.02.019 · 2017 · External reference
Intranasal mRNA nanoparticle vaccination induces prophylactic and therapeutic anti-tumor immunity
10.1038/srep05128 · 2015 · External reference
A Self-Assembled Non-Viral vector as Potential Platform for mRNA-Based Vaccines
10.21767/2172-0479.100119 · 2017 · External reference
mRNA vaccination with charge-altering releasable transporters elicits human T cell responses and cures established tumors in mice
10.1073/pnas.1810002115 · 2018 · External reference
Poly(β-amino ester)-co-poly(caprolactone) Terpolymers as Nonviral Vectors for mRNA Delivery In Vitro and In Vivo
10.1002/adhm.201800249 · 2018 · External reference
Polyplexes assembled from self-peptides and regulatory nucleic acids blunt toll-like receptor signaling to combat autoimmunity
10.1016/j.biomaterials.2016.11.052 · 2017 · External reference
In vivo characterization of the physicochemical properties of polymer-linked TLR agonists that enhance vaccine immunogenicity
10.1038/nbt.3371 · 2015 · External reference
Co-delivery of PLGA encapsulated invariant NKT cell agonist with antigenic protein induce strong T cell-mediated antitumor immune responses
10.1080/2162402x.2015.1068493 · 2016 · External reference
mRNA Vaccine with Antigen-Specific Checkpoint Blockade Induces an Enhanced Immune Response against Established Melanoma
10.1016/j.ymthe.2017.11.009 · 2018 · External reference
The biology of NKT cells
10.1146/annurev.immunol.25.022106.141711 · 2007 · External reference
Invariant natural killer T cells: an innate activation scheme linked to diverse effector functions
10.1038/nri3369 · 2013 · External reference
Natural Killer T Cells in Cancer Immunotherapy
10.3389/fimmu.2017.01178 · 2017 · External reference
Dendritic cell function can be modulated through cooperative actions of TLR ligands and invariant NKT cells
10.4049/jimmunol.178.5.2721 · 2007 · External reference
Co-delivery of the NKT agonist α-galactosylceramide and tumor antigens to cross-priming dendritic cells breaks tolerance to self-antigens and promotes antitumor responses
10.1080/2162402x.2017.1339855 · 2017 · External reference
Targeted Delivery of α-Galactosylceramide to CD8α+ Dendritic Cells Optimizes Type I NKT Cell-Based Antitumor Responses
10.4049/jimmunol.1303029 · 2014 · External reference
The nanoparticulation by octaarginine-modified liposome improves α-galactosylceramide-mediated antitumor therapy via systemic administration
10.1016/j.jconrel.2013.07.004 · 2013 · External reference
Nanoparticle formulated alpha-galactosylceramide activates NKT cells without inducing anergy
10.1016/j.vaccine.2009.01.047 · 2009 · External reference
Kinetics of mRNA delivery and protein translation in dendritic cells using lipid-coated PLGA nanoparticles
10.1186/s12951-018-0401-y · 2018 · External reference
Eliciting T cell immunity against poorly immunogenic tumors by immunization with dendritic cell-tumor fusion vaccines
10.4049/jimmunol.161.10.5516 · 1998 · External reference
Biodegradable Polymeric Nanoparticles Show High Efficacy and Specificity at DNA Delivery to Human Glioblastoma in Vitro and in Vivo
10.1021/nn501197v · 2014 · External reference
Porous Silicon Microparticle Potentiates Anti-Tumor Immunity by Enhancing Cross-Presentation and Inducing Type I Interferon Response
10.1016/j.celrep.2015.04.009 · 2015 · External reference
B16 as a mouse model for human melanoma
10.1002/0471142735.im2001s39 · 2001 · External reference
Evaluation of Tumor-infiltrating Leukocyte Subsets in a Subcutaneous Tumor Model
10.3791/52657 · 2015 · External reference
Nanoparticles target distinct dendritic cell populations according to their size
10.1002/eji.200737984 · 2008 · External reference
Particle size and surface charge affect particle uptake by human dendritic cells in an in vitro model
10.1016/j.ijpharm.2005.03.035 · 2005 · External reference
New multivalent cationic lipids reveal bell curve for transfection efficiency versus membrane charge density: lipid-DNA complexes for gene delivery
10.1002/jgm.717 · 2005 · External reference
Efficient Synthesis and Cell-Transfection Properties of a New Multivalent Cationic Lipid for Nonviral Gene Delivery
10.1021/jm020233w · 2002 · External reference
Cationic Liposome-Nucleic Acid Complexes for Gene Delivery and Silencing: Pathways and Mechanisms for Plasmid DNA and siRNA
10.1007/128_2010_70 · 2010 · External reference
The effect of nanoparticle size on in vivo pharmacokinetics and cellular interaction
10.2217/nnm.16.5 · 2016 · External reference
The Role of CD1d and MR1 Restricted T Cells in the Liver
10.3389/fimmu.2018.02424 · 2018 · External reference
Toll-like receptor agonists and alpha-galactosylceramide synergistically enhance the production of interferon-gamma in murine splenocytes
10.1038/srep02559 · 2013 · External reference
Co-operation of -galactosylceramide-loaded tumour cells and TLR9 agonists induce potent anti-tumour responses in a murine colon cancer model
10.1042/bj20150129 · 2016 · External reference
α-Galactosylceramide and peptide-based nano-vaccine synergistically induced a strong tumor suppressive effect in melanoma
10.1016/j.actbio.2018.06.029 · 2018 · External reference
Identification of TRP-2 as a Human Tumor Antigen Recognized by Cytotoxic T Lymphocytes
10.1084/jem.184.6.2207 · 1996 · External reference
Detection of Spontaneous CD4+ T-Cell Responses in Melanoma Patients against a Tyrosinase-Related Protein-2-Derived Epitope Identified in HLA-DRB1*0301 Transgenic Mice
10.1158/1078-0432.ccr-05-0170 · 2005 · External reference
Direct effects of type I interferons on cells of the immune system
10.1158/1078-0432.ccr-10-1114 · 2011 · External reference
Type I IFN counteracts the induction of antigen-specific immune responses by lipid-based delivery of mRNA vaccines
10.1038/mt.2012.202 · 2013 · External reference
Toll-like receptor-dependent activation of several human blood cell types by protamine-condensed mRNA
10.1002/eji.200425656 · 2005 · External reference
Ag85A DNA Vaccine Delivery by Nanoparticles: Influence of the Formulation Characteristics on Immune Responses
10.3390/vaccines4030032 · 2016 · External reference
Heterologous Prime-Boost Enhances the Antitumor Immune Response Elicited by Plant-Virus-Based Cancer Vaccine
10.1021/jacs.9b01523 · 2019 · External reference
