Research graph
References from Monocarbonyl Curcumin-Based Molecular Hybrids as Potent Antibacterial Agents. Local targets link to admitted publications; unresolved targets remain external evidence.
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After 2015: infectious diseases in a new era of health and development
10.1098/rstb.2013.0426 · 2014 · External reference
1,2,3-Triazole fused with pyridine/pyrimidine as new template for anti-microbial agents: Regioselective synthesis and identification of potent N-heteroarenes
10.1016/j.bmcl.2018.09.021 · 2018 · External reference
Design, synthesis, anti-microbial, antiquorum-sensing and antitumor evaluation of new series of pyrazolopyridine derivatives
10.1016/j.ejmech.2018.08.008 · 2018 · External reference
Design, synthesis and anti-mycobacterial activity evaluation of benzofuran-isatin hybrids
10.1016/j.ejmech.2018.09.049 · 2018 · External reference
Novel curcumin analogue hybrids: Synthesis and anticancer activity
10.1016/j.ejmech.2018.07.013 · 2018 · External reference
Synthesis of novel antiproliferative hybrid bis-(3-indolyl)methane phosphonate derivatives
10.1016/j.ejmech.2018.09.011 · 2018 · External reference
Pyrimidine-chloroquinoline hybrids: Synthesis and antiplasmodial activity
10.1016/j.ejmech.2018.02.021 · 2018 · External reference
Hybrid antibiotics – clinical progress and novel designs
10.1080/17460441.2016.1187597 · 2016 · External reference
Bifunctional antimicrobial conjugates and hybrid antimicrobials
10.1039/c7np00006e · 2017 · External reference
Cancer network disruption by a single molecule inhibitor targeting both histone deacetylase activity and phosphatidylinositol 3-kinase signaling
10.1158/1078-0432.ccr-12-0055 · 2012 · External reference
Human ATP-binding cassette transporter ABCG2 confers resistance to CUDC-907, a dual inhibitor of histone deacetylase and phosphatidylinositol 3-kinase
10.1021/acs.molpharmaceut.5b00687 · 2016 · External reference
CUDC-101, a multitargeted inhibitor of histone deacetylase, epidermal growth factor receptor, and human epidermal growth factor receptor 2, exerts potent anticancer activity
10.1158/0008-5472.can-09-3360 · 2010 · External reference
Phase I first-in-human study of CUDC-101, a multitargeted inhibitor of HDACs, EGFR, and HER2 in patients with advanced solid tumors
10.1158/1078-0432.ccr-14-0570 · 2014 · External reference
Potential advantages of CUDC-101, a multitargeted HDAC, EGFR, and HER2 inhibitor, in treating drug resistance and preventing cancer cell migration and invasion
10.1158/1535-7163.mct-12-1045 · 2013 · External reference
Multi-targeted hybrids based on HDAC inhibitors for anti-cancer drug discovery
10.1007/s12272-012-0221-9 · 2012 · External reference
Discovery of 7-(4-(3-ethynylphenylamino)-7-methoxyquinazolin-6-yloxy)-N-hydroxyheptanamide (CUDC-101) as a potent multi-acting HDAC, EGFR, and HER2 inhibitor for the treatment of cancer
10.1021/jm901453q · 2010 · External reference
Biological activities of curcuminoids, other biomolecules from turmeric and their derivatives – A review
10.1016/j.jtcme.2016.05.005 · 2017 · External reference
Clinical development of curcumin in neurodegenerative disease
10.1586/14737175.2015.1044981 · 2015 · External reference
Monocarbonyl curcuminoids with improved stability as Antibacterial agents against Staphylococcus aureus and their mechanistic studies
10.1021/acsomega.8b02625 · 2019 · External reference
Synthesis and anti-bacterial properties of mono-carbonyl analogues of curcumin
10.1248/cpb.56.162 · 2008 · External reference
Antiparasitic activity of synthetic curcumin monocarbonyl analogues against Trichomonas vaginalis
10.1016/j.biopha.2018.12.058 · 2019 · External reference
Monocarbonyl analogs of curcumin inhibit growth of antibiotic sensitive and resistant strains of Mycobacterium tuberculosis
10.1016/j.ejmech.2015.01.020 · 2015 · External reference
Design, synthesis and antimicrobial evaluation of propylene-tethered ciprofloxacin-isatin hybrids
10.1016/j.ejmech.2018.07.025 · 2018 · External reference
Synthesis, spectroscopic investigations, DFT studies, molecular docking and antimicrobial potential of certain new indole-isatin molecular hybrids: Experimental and theoretical approaches
10.1016/j.molstruc.2017.10.025 · 2018 · External reference
Synthesis, evaluation and structure-activity relationship of new 3-carboxamide coumarins as FXIIa inhibitors
10.1016/j.ejmech.2016.01.023 · 2016 · External reference
Synthesis of novel hybrids of pyrazole and coumarin as dual inhibitors of COX-2 and 5-LOX
10.1016/j.bmcl.2017.07.020 · 2017 · External reference
Molecular docking studies and facile synthesis of most potent biologically active N-tert-butyl-4-(4-substituted phenyl)-2-((substituted-2-oxo-2H-chromen-4-yl)methylthio)-6-oxo-1,6-dihydropyrimidine-5-carboxami de hybrids: An approach for microwave-assisted syntheses and biological evaluation
10.1016/j.bioorg.2018.03.007 · 2018 · External reference
Synthesis and antioxidant study of new polyphenolic hybrid-coumarins
10.1016/j.arabjc.2017.05.007 · 2018 · External reference
Coumarin-chalcone hybrid instigates DNA damage by minor groove binding and stabilizes p53 through post translational modifications
10.1038/srep45287 · 2017 · External reference
Synthesis of coumarin-theophylline hybrids as a new class of anti-tubercular and anti-microbial agents
10.1016/j.ejmech.2018.01.025 · 2018 · External reference
Synthesis, molecular docking studies and biological evaluation of potent coumarin–carbonodithioate hybrids via microwave irradiation
10.1016/j.cdc.2018.04.001 · 2018 · External reference
Coumarin-benzimidazole hybrids as a potent antimicrobial agent: synthesis and biological elevation
10.1038/ja.2017.70 · 2017 · External reference
Synthesis and biological evaluation of coumarin derivatives containing imidazole skeleton as potential antibacterial agents
10.1016/j.ejmech.2017.11.100 · 2018 · External reference
New thiazolyl-coumarin hybrids: Design, synthesis, characterization, X-ray crystal structure, antibacterial and antiviral evaluation
10.1016/j.molstruc.2018.04.031 · 2018 · External reference
Synthesis and antimicrobial studies on novel sulfonamides containing 4-azidomethyl coumarin
10.1016/j.ejmech.2009.12.022 · 2010 · External reference
Synthesis and Antimicrobial Evaluation of Some Novel 2-Aminothiazole Derivatives of 4-Hydroxy-chromene-2-one
10.1002/ardp.200700215 · 2008 · External reference
Synthesis, in vitro anticancer and antibacterial activities and in silico studies of new 4-substituted 1,2,3-triazole-coumarin hybrids
10.1016/j.ejmech.2016.08.062 · 2016 · External reference
Structural insights into hydroxycoumarin-induced apoptosis in U-937 cells
10.1016/j.bmc.2007.11.038 · 2008 · External reference
Discovery of novel DNA gyrase inhibitors by high-throughput virtual screening
10.1128/aac.00392-07 · 2007 · External reference
One-pot multicomponent synthesis of indole incorporated thiazolylcoumarins and their antibacterial, anticancer and DNA cleavage studies
10.1016/j.bmcl.2014.10.100 · 2015 · External reference
Synthesis and antimicrobial properties of some new thiazolyl coumarin derivatives
10.1016/j.ejmech.2011.05.044 · 2011 · External reference
Looking for new targets: simple coumarins as antibacterial agents
10.2174/157340612804075205 · 2012 · External reference
Synthesis and evaluation of a class of new coumarin triazole derivatives as potential antimicrobial agents
10.1016/j.bmcl.2010.12.059 · 2011 · External reference
Synthesis, crystal structure and antimicrobial potential of some fluorinated chalcone-1,2,3-triazole conjugates
10.1016/j.ejmech.2018.05.055 · 2018 · External reference
Dimers of coumarin-1,2,3-triazole hybrids bearing alkyl spacer: Design, microwave-assisted synthesis, molecular docking and evaluation as antimycobacterial and antimicrobial agents
10.1016/j.molstruc.2017.12.080 · 2018 · External reference
Design, synthesis, characterization, antimicrobial evaluation and molecular modeling studies of some dehydroacetic acid-chalcone-1,2,3-triazole hybrids
10.1016/j.bioorg.2018.01.016 · 2018 · External reference
Synthesis of newer 1,2,3-triazole linked chalcone and flavone hybrid compounds and evaluation of their antimicrobial and cytotoxic activities
10.1016/j.ejmech.2016.02.041 · 2016 · External reference
Design, synthesis, anticancer, antimicrobial activities and molecular docking studies of theophylline containing acetylenes and theophylline containing 1,2,3-triazoles with variant nucleoside derivatives
10.1016/j.ejmech.2016.07.024 · 2016 · External reference
Design, synthesis and biological evaluation of ciprofloxacin tethered bis-1,2,3-triazole conjugates as potent antibacterial agents
10.1016/j.ejmech.2016.08.031 · 2016 · External reference
Triazole tethered isatin-coumarin based molecular hybrids as novel antitubulin agents: Design, synthesis, biological investigation and docking studies
10.1016/j.bmcl.2017.07.069 · 2017 · External reference
Synthesis of 1,2,3-triazole tethered bifunctional hybrids by click chemistry and their cytotoxic studies
10.1007/s00044-012-0312-7 · 2013 · External reference
Synthesis and cytotoxicity studies of 3,5-diaryl N-acetyl pyrazoline-isatin hybrids
10.1007/s00044-014-1001-5 · 2014 · External reference
Synthesis and antibacterial activity of new thiazolidine-2,4-dione-based chlorophenylthiosemicarbazone hybrids
10.3390/molecules23051023 · 2018 · External reference
Identification of novel potential antibiotics against Staphylococcus using structure-based drug screening targeting dihydrofolate reductase
10.1021/ci400686d · 2014 · External reference
Triazole tethered C5-curcuminoid-coumarin based molecular hybrids as novel antitubulin agents: Design, synthesis, biological investigation and docking studies
10.1016/j.ejmech.2016.03.050 · 2016 · External reference
Triazole linked mono carbonyl curcumin-isatin bifunctional hybrids as novel anti tubulin agents: Design, synthesis, biological evaluation and molecular modeling studies
10.1016/j.bmc.2015.10.013 · 2015 · External reference
Synthesis of elastin based peptides conjugated to benzisoxazole as a new class of potent antimicrobials-A novel approach to enhance biocompatibility
10.1016/j.ejmech.2010.12.005 · 2011 · External reference
Synthesis, molecular docking, antimycobacterial and antimicrobial evaluation of new pyrrolo[3,2-c]pyridine Mannich bases
10.1016/j.ejmech.2017.03.015 · 2017 · External reference
Structure-based design of new DHFR-based antibacterial agents: 7-aryl-2,4-diaminoquinazolines
10.1016/j.bmcl.2011.07.059 · 2011 · External reference
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Host dihydrofolate reductase (DHFR)-directed cycloguanil analogues endowed with activity against influenza virus and respiratory syncytial virus
10.1016/j.ejmech.2017.04.070 · 2017 · External reference
Synthesis, in vitro antifungal activity and in silico study of 3-(1,2,4-triazol-1-yl)flavanones
10.1016/j.ejmech.2013.06.008 · 2013 · External reference
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