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References from Computational Modeling Explains the Multi Sterol Ligand Specificity of the N-Terminal Domain of Niemann–Pick C1-Like 1 Protein. Local targets link to admitted publications; unresolved targets remain external evidence.
Niemann-Pick C1-Like 1 (NPC1L1) Protein in Intestinal and Hepatic Cholesterol Transport
10.1146/annurev-physiol-012110-142233 · 2011 · External reference
The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1)
10.1073/pnas.0500269102 · 2005 · External reference
Multiple plasma membrane receptors but not NPC1L1 mediate high-affinity, ezetimibe-sensitive cholesterol uptake into the intestinal brush border membrane
10.1016/j.bbalip.2007.05.011 · 2007 · External reference
Membrane topology of human NPC1L1, a key protein in enterohepatic cholesterol absorption
10.1194/jlr.m800669-jlr200 · 2009 · External reference
Kinetic imaging of NPC1L1 and sterol trafficking between plasma membrane and recycling endosomes in hepatoma cells
10.1194/jlr.m800145-jlr200 · 2008 · External reference
Cholesterol-regulated translocation of NPC1L1 to the cell surface facilitates free cholesterol uptake
10.1074/jbc.m511123200 · 2006 · External reference
Ezetimibe restores biliary cholesterol excretion in mice expressing Niemann-Pick C1-Like 1 only in liver
10.1016/j.bbalip.2011.05.013 · 2011 · External reference
Vesicular and non-vesicular sterol transport in living cells. The endocytic recycling compartment is a major sterol storage organelle
10.1074/jbc.m108861200 · 2002 · External reference
Rapid nonvesicular transport of sterol between the plasma membrane domains of polarized hepatic cells
10.1074/jbc.m202626200 · 2002 · External reference
Identification of NPC1 as the target of U18666A, an inhibitor of lysosomal cholesterol export and Ebola infection
10.7554/elife.12177 · 2015 · External reference
The sterol-sensing domain of the Niemann-Pick C1 (NPC1) protein regulates trafficking of low density lipoprotein cholesterol
10.1074/jbc.m414024200 · 2005 · External reference
The structure of the NPC1L1 N-terminal domain in a closed conformation
10.1371/journal.pone.0018722 · 2011 · External reference
Purified NPC1 protein: II. Localization of sterol binding to a 240-amino acid soluble luminal loop
10.1074/jbc.m707944200 · 2008 · External reference
Structure of N-terminal domain of NPC1 reveals distinct subdomains for binding and transfer of cholesterol
10.1016/j.cell.2009.03.049 · 2009 · External reference
N-terminal domain of the cholesterol transporter Niemann-Pick C1-like 1 (NPC1L1) is essential for alpha-tocopherol transport
10.1016/j.bbrc.2017.03.065 · 2017 · External reference
NPC1L1 is a key regulator of intestinal vitamin K absorption and a modulator of warfarin therapy
10.1126/scitranslmed.3010329 · 2015 · External reference
Multiple rare variants in NPC1L1 associated with reduced sterol absorption and plasma low-density lipoprotein levels
10.1073/pnas.0508483103 · 2006 · External reference
Inactivating mutations in NPC1L1 and protection from coronary heart disease
10.1056/nejmoa1405386 · 2014 · External reference
SWISS-MODEL: modelling protein tertiary and quaternary structure using evolutionary information
10.1093/nar/gku340 · 2014 · External reference
UniProt: the universal protein knowledgebase
10.1093/nar/gkw1099 · 2017 · External reference
Unresolved reference
External reference
Protein and ligand preparation: parameters, protocols, and influence on virtual screening enrichments
10.1007/s10822-013-9644-8 · 2013 · External reference
Very fast empirical prediction and rationalization of protein pKa values
10.1002/prot.20660 · 2005 · External reference
Development and testing of the OPLS all-atom force field on conformational energetics and properties of organic liquids
10.1021/ja9621760 · 1996 · External reference
Computational Analysis of Sterol Ligand Specificity of the Niemann Pick C2 Protein
10.1021/acs.biochem.6b00217 · 2016 · External reference
Glide: a new approach for rapid, accurate docking and scoring. 1. Method and assessment of docking accuracy
10.1021/jm0306430 · 2004 · External reference
Binding free energy based structural dynamics analysis of HIV-1 RT RNase H-inhibitor complexes
10.1039/c4ib00111g · 2014 · External reference
Unresolved reference
External reference
Unresolved reference
External reference
A new integral equation formalism for the polarizable continuum model: Theoretical background and applications to isotropic and anisotropic dielectrics
10.1063/1.474659 · 1997 · External reference
The IEF version of the PCM solvation method: an overview of a new method addressed to study molecular solutes at the QM ab initio level
10.1016/s0166-1280(98)00553-3 · 1999 · External reference
Unresolved reference
1987 · External reference
Molecular-Dynamics with Coupling to an External Bath
10.1063/1.448118 · 1984 · External reference
Numerical-Integration of Cartesian Equations of Motion of a System with Constraints - Molecular-Dynamics of N-Alkanes
10.1016/0021-9991(77)90098-5 · 1977 · External reference
The MM/PBSA and MM/GBSA methods to estimate ligand-binding affinities
10.1517/17460441.2015.1032936 · 2015 · External reference
An improved method to predict the entropy term with the MM/PBSA approach
10.1007/s10822-008-9238-z · 2009 · External reference
MMPBSA.py: An Efficient Program for End-State Free Energy Calculations
10.1021/ct300418h · 2012 · External reference
Genetic inactivation of NPC1L1 protects against sitosterolemia in mice lacking ABCG5/ABCG8
10.1194/jlr.m800439-jlr200 · 2009 · External reference
NPC1L1 (Niemann-Pick C1-like 1) mediates sterol-specific unidirectional transport of non-esterified cholesterol in McArdle-RH7777 hepatoma cells
10.1042/bj20070168 · 2007 · External reference
The N-terminal domain of NPC1L1 protein binds cholesterol and plays essential roles in cholesterol uptake
10.1074/jbc.m111.244475 · 2011 · External reference
Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: oxysterols block transport by binding to Insig
10.1073/pnas.0700899104 · 2007 · External reference
Shielded Hydrogen Bonds as Structural Determinants of Binding Kinetics: Application in Drug Design
10.1021/ja207494u · 2011 · External reference
Water access and ligand dissociation at the binding site of proteins
10.1063/1.5042491 · 2018 · External reference
Protein Binding Pocket Dynamics
10.1021/acs.accounts.5b00516 · 2016 · External reference
How cholesterol interacts with proteins and lipids during its intracellular transport
10.1016/j.bbamem.2015.05.010 · 2015 · External reference
Following intracellular cholesterol transport by linear and non-linear optical microscopy of intrinsically fluorescent sterols
10.2174/138920112799095301 · 2012 · External reference
Computational Studies of the Cholesterol Transport between NPC2 and the N-Terminal Domain of NPC1 (NPC1(NTD))
10.1021/bi4005478 · 2013 · External reference
Molecular characterization of the NPC1L1 variants identified from cholesterol low absorbers
10.1074/jbc.m110.178368 · 2011 · External reference
Identification of surface residues on Niemann-Pick C2 essential for hydrophobic handoff of cholesterol to NPC1 in lysosomes
10.1016/j.cmet.2010.05.016 · 2010 · External reference
Comparative study of the effect of disease causing and benign mutations in position Q92 on cholesterol binding by the NPC1 n-terminal domain
10.1002/prot.25597 · 2018 · External reference
Niemann-Pick C variant detection by altered sphingolipid trafficking and correlation with mutations within a specific domain of NPC1
10.1086/320599 · 2001 · External reference
Binding and intracellular transport of 25-hydroxycholesterol by Niemann-Pick C2 protein
10.1016/j.bbamem.2019.183063 · 2019 · External reference
Ezetimibe-sensitive cholesterol uptake by NPC1L1 protein does not require endocytosis
10.1091/mbc.e16-03-0154 · 2016 · External reference
