Research graph
References from Synthesis and Characterization of a Click-Assembled 18-Atom Macrocycle That Displays Selective AXL Kinase Inhibitory Activity. Local targets link to admitted publications; unresolved targets remain external evidence.
Macrocycles Are Great Cycles: Applications, Opportunities, and Challenges of Synthetic Macrocycles in Drug Discovery
10.1021/jm1012374 · 2011 · External reference
Macrocyclic Drugs and Clinical Candidates: What Can Medicinal Chemists Learn from Their Properties?
10.1021/jm400887j · 2014 · External reference
Conjugated Macrocycles: Concepts and Applications
10.1002/anie.201006198 · 2011 · External reference
How Proteins Bind Macrocycles
10.1038/nchembio.1584 · 2014 · External reference
eCF309: a Potent, Selective and Cell-Permeable mTOR Inhibitor
10.1039/c5md00493d · 2016 · External reference
Synthesis of 5-Iodo-1,2,3-triazole-Containing Macrocycles Using Copper Flow Reactor Technology
10.1021/ol201567s · 2011 · External reference
Efficient Access to New Chemical Space Through Flow─Construction of Druglike Macrocycles Through Copper-Surface-Catalyzed Azide–Alkyne Cycloaddition Reactions
10.1002/chem.201002215 · 2010 · External reference
Discovery of the Macrocycle 11-(2-Pyrrolidin-1-yl-ethoxy)-14,19-dioxa-5,7,26-triaza-tetracyclo[19.3.1.1(2,6).1 (8,12)]heptacosa-1(25),2(26),3,5,8,10,12(27),16,21,23-decaene (SB1518), a Potent Janus Kinase 2/Fms-Like Tyrosine Kinase-3 (JAK2/FLT3) Inhibitor for the Treatment of Myelofibrosis and Lymphoma
10.1021/jm200326p · 2011 · External reference
Discovery of Kinase Spectrum Selective Macrocycle (16E)-14-Methyl-20-oxa-5,7,14,26-tetraazatetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3, 5,8(27),9,11,16,21,23-decaene (SB1317/TG02), a Potent Inhibitor of Cyclin Dependent Kinases (CDKs), Janus Kinase 2 (JAK2), and Fms-like Tyrosine Kinase-3 (FLT3) for the Treatment of Cancer
10.1021/jm201112g · 2012 · External reference
Design and Synthesis of Novel Macrocyclic Mer Tyrosine Kinase Inhibitors
10.1021/acsmedchemlett.6b00221 · 2016 · External reference
Discovery of Macrocyclic Pyrimidines as MerTK-Specific Inhibitors
10.1002/cmdc.201600589 · 2017 · External reference
Discovery of (10R)-7-Amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]-benzoxadiazacyclotetradecine-3-carbonitrile (PF-06463922), a Macrocyclic Inhibitor of Anaplastic Lymphoma Kinase (ALK) and c-ros Oncogene 1 (ROS1) with Preclinical Brain Exposure and Broad-Spectrum Potency against ALK-Resistant Mutations
10.1021/jm500261q · 2014 · External reference
Development of Potent Inhibitors of Receptor Tyrosine Kinases by Ligand-Based Drug Design and Target-Biased Phenotypic Screening
10.1021/acs.jmedchem.7b01605 · 2018 · External reference
Regioselective Synthesis of 9-Alkyl-6-chloropyrido [3,2-e][1,2,4]triazolo[4,3-a]pyrazines. Reactivity of Aliphatic and Aromatic Hydrazides
10.1021/jo0478398 · 2005 · External reference
Copper-Catalysed Azide–Alkyne Cycloadditions (CuAAC): an Update
10.1039/c5ob01457c · 2015 · External reference
Conformational Dynamics of a Bispyridinium Cyclophane
10.1021/jo0301292 · 2003 · External reference
Macrocycle Conformational Sampling with MacroModel
10.1021/ci5001696 · 2014 · External reference
Rapid Discovery and Structure–Activity Relationships of Pyrazolopyrimidines That Potently Suppress Breast Cancer Cell Growth via SRC Kinase Inhibition with Exceptional Selectivity over ABL Kinase
10.1021/acs.jmedchem.6b00065 · 2016 · External reference
AXL Inhibitors in Cancer: A Medicinal Chemistry Perspective
10.1021/acs.jmedchem.5b01273 · 2016 · External reference
Small Molecule Inhibitors Block Gas6-Inducible TAM Activation and Tumorigenicity
10.1038/srep43908 · 2017 · External reference
Quinolone Antibiotic Derivatives as New Selective Axl Kinase Inhibitors
10.1016/j.ejmech.2019.01.065 · 2019 · External reference
The Axl Kinase Domain in Complex with a Macrocyclic Inhibitor Offers First Structural Insights into an Active TAM Receptor Kinase
10.1074/jbc.m116.771485 · 2017 · External reference
Structure and Chemical Inhibition of the RET Tyrosine Kinase Domain
10.1074/jbc.m605604200 · 2006 · External reference
AutoDock4 and AutoDockTools4: Automated Docking with Selective Receptor Flexibility
10.1002/jcc.21256 · 2009 · External reference
Axl, a Prognostic and Therapeutic Target in Acute Myeloid Leukemia Mediates Paracrine Crosstalk of Leukemia Cells with Bone Marrow Stroma
10.1182/blood-2013-03-491431 · 2013 · External reference
Azaindole-1,2,3-triazole Conjugate as Selective Fluorometric Sensor for Dihydrogenphosphate
10.1039/c3ra42702a · 2013 · External reference
