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References from Development of a Novel Cell-Permeable Protein–Protein Interaction Inhibitor for the Polo-box Domain of Polo-like Kinase 1. Local targets link to admitted publications; unresolved targets remain external evidence.
Polo-like kinases and oncogenesis
10.1038/sj.onc.1208273 · 2005 · External reference
Targeting polo-like kinase 1 for cancer therapy
10.1038/nrc1841 · 2006 · External reference
Normal cells, but not cancer cells, survive severe Plk1 depletion
10.1128/mcb.26.6.2093-2108.2006 · 2006 · External reference
Polo-like kinase 1 is overexpressed in acute myeloid leukemia and its inhibition preferentially targets the proliferation of leukemic cells
10.1182/blood-2008-12-195867 · 2009 · External reference
Recent advances and new strategies in targeting Plk1 for anticancer therapy
10.1016/j.tips.2015.08.013 · 2015 · External reference
Plk1 inhibitors in cancer therapy: from laboratory to clinics
10.1158/1535-7163.mct-15-0897 · 2016 · External reference
Discovery and development of the Polo-like kinase inhibitor volasertib in cancer therapy
10.1038/leu.2014.222 · 2015 · External reference
Current progress and future perspectives in the development of anti-polo-like kinase 1 therapeutic agents
10.12688/f1000research.11398.1 · 2017 · External reference
The molecular basis for phosphodependent substrate targeting and regulation of Plks by the Polo-box domain
10.1016/s0092-8674(03)00725-6 · 2003 · External reference
Computational Analysis of Phosphopeptide Binding to the Polo-Box Domain of the Mitotic Kinase PLK1 Using Molecular Dynamics Simulation
10.1371/journal.pcbi.1000880 · 2010 · External reference
Structure of the catalytic domain of human polo-like kinase 1
10.1021/bi602474j · 2007 · External reference
The crystal structure of the human polo-like kinase-1 polo box domain and its phospho-peptide complex
10.1093/emboj/cdg558 · 2003 · External reference
From Crystal Packing to Molecular Recognition: Prediction and Discovery of a Binding Site on the Surface of Polo-Like Kinase 1
10.1002/anie.201008019 · 2011 · External reference
Serendipitous alkylation of a Plk1 ligand uncovers a new binding channel
10.1038/nchembio.614 · 2011 · External reference
A cryptic hydrophobic pocket in the polo-box domain of the polo-like kinase PLK1 regulates substrate recognition and mitotic chromosome segregation
10.1038/s41598-019-50702-2 · 2019 · External reference
Modulation of the allosteric communication between the polo-box domain and the catalytic domain in Plk1 by small compounds
10.1021/acschembio.7b01078 · 2018 · External reference
Inhibitors of the Polo-Box Domain of Polo-Like Kinase 1
10.1002/cbic.201500580 · 2016 · External reference
Deficiency in chromosome congression by the inhibition of Plk1 polo box domain-dependent recognition
10.1074/jbc.m805308200 · 2009 · External reference
Probing Binding Modes of Small Molecule Inhibitors to the Polo-Box Domain of Human Polo-like Kinase 1
10.1021/ml100020e · 2010 · External reference
Inhibition of polo-like kinase 1 by blocking polo-box domain-dependent protein-protein interactions
10.1016/j.chembiol.2008.03.013 · 2008 · External reference
A pan-specific inhibitor of the polo-box domains of polo-like kinases arrests cancer cells in mitosis
10.1002/cbic.200900059 · 2009 · External reference
Several inhibitors of the Plk1 Polo-Box Domain turn out to be non-specific protein alkylators
10.1080/15384101.2017.1325043 · 2017 · External reference
Modulating Protein-Protein Interactions of the Mitotic Polo-like Kinases to Target Mutant KRAS
10.1016/j.chembiol.2017.07.009 · 2017 · External reference
New Substructure Filters for Removal of Pan Assay Interference Compounds (PAINS) from Screening Libraries and for Their Exclusion in Bioassays
10.1021/jm901137j · 2010 · External reference
Structural and functional analyses of minimal phosphopeptides targeting the polo-box domain of polo-like kinase 1
10.1038/nsmb.1628 · 2009 · External reference
Different Plk1 functions show distinct dependencies on Polo-Box domain-mediated targeting
10.1091/mbc.e05-08-0801 · 2006 · External reference
Diversity-oriented synthesis as a tool for identifying new modulators of mitosis
10.1038/ncomms4155 · 2014 · External reference
BI 2536, a potent and selective inhibitor of polo-like kinase 1, inhibits tumor growth in vivo
10.1016/j.cub.2006.12.037 · 2007 · External reference
Use of the novel Plk1 inhibitor ZK-thiazolidinone to elucidate functions of Plk1 in early and late stages of mitosis
10.1091/mbc.e07-05-0517 · 2007 · External reference
Polo-like kinase 1 (Plk1) as a novel drug target in chronic myeloid leukemia: overriding imatinib resistance with the Plk1 inhibitor BI 2536
10.1158/0008-5472.can-09-2181 · 2010 · External reference
Sensitivity of cancer cells to Plk1 inhibitor GSK461364A is associated with loss of p53 function and chromosome instability
10.1158/1535-7163.mct-10-0095 · 2010 · External reference
A spindle checkpoint arrest and a cytokinesis failure by the dominant-negative polo-box domain of plk1 in u-2 OS cells
10.1074/jbc.m202602200 · 2002 · External reference
The influence of drug-like concepts on decision-making in medicinal chemistry
10.1038/nrd2445 · 2007 · External reference
Overcoming chemical, biological, and computational challenges in the development of inhibitors targeting protein-protein interactions
10.1016/j.chembiol.2015.04.019 · 2015 · External reference
Virtual screening - an overview
10.1016/s1359-6446(97)01163-x · 1998 · External reference
Rational methods for the selection of diverse screening compounds
10.1021/cb100420r · 2011 · External reference
iPPI-DB: A manually curated and interactive database of small non-peptide inhibitors of protein–protein interactions
10.1016/j.drudis.2013.05.003 · 2013 · External reference
Atomic Interactions and Profile of Small Molecules Disrupting Protein-Protein Interfaces: the TIMBAL Database
10.1111/j.1747-0285.2009.00889.x · 2009 · External reference
DISE: Directed Sphere Exclusion
10.1021/ci025554v · 2003 · External reference
How Similar Are Similarity Searching Methods? A Principal Component Analysis of Molecular Descriptor Space
10.1021/ci800249s · 2009 · External reference
Similarity-based virtual screening using 2D fingerprints
10.1016/j.drudis.2006.10.005 · 2006 · External reference
Allosteric modulation of AURKA kinase activity by a small-molecule inhibitor of its protein-protein interaction with TPX2
10.1038/srep28528 · 2016 · External reference
Molecular and structural basis of polo-like kinase 1 substrate recognition: Implications in centrosomal localization
10.1073/pnas.0609131104 · 2007 · External reference
Protein and ligand preparation: parameters, protocols, and influence on virtual screening enrichments
10.1007/s10822-013-9644-8 · 2013 · External reference
Glide: A new approach for rapid, accurate docking and scoring. 1. Method and assessment of docking accuracy
10.1021/jm0306430 · 2004 · External reference
Extra precision glide: docking and scoring incorporating a model of hydrophobic enclosure for protein-ligand complexes
10.1021/jm051256o · 2006 · External reference
Accurate prediction of the relative potencies of members of a series of kinase inhibitors using molecular docking and MM-GBSA scoring
10.1021/jm060522a · 2006 · External reference
