Research graph
References from Integrated <i>In Silico</i> and Experimental Insights into Immunomodulatory Toll-Like Receptor 7/8 Agonists with Anticancer Potential. Local targets link to admitted publications; unresolved targets remain external evidence.
Toll-like receptor agonists as cancer therapeutics: A patent review (2014-2024)
10.1080/13543776.2025.2556819 · 2025 · External reference
Toll-Like Receptors (TLRs): Structure, Functions, Signaling, and Role of Their Polymorphisms in Colorectal Cancer Susceptibility
10.1155/2021/1157023 · 2021 · External reference
Detection of Viral Infections by Innate Immunity
10.1016/j.bcp.2020.114316 · 2021 · External reference
Targeting Toll-Like Receptor 7/8 for Immunotherapy: Recent Advances and Prospectives
10.1186/s40364-022-00436-7 · 2022 · External reference
The TLR7 Agonist Imiquimod Induces Anti-Cancer Effects via Autophagic Cell Death and Enhances Anti-Tumoral and Systemic Immunity during Radiotherapy for Melanoma
10.18632/oncotarget.15326 · 2017 · External reference
Gastric Cancer Vaccines Synthesized Using a TLR7 Agonist and Their Synergistic Antitumor Effects with 5-Fluorouracil
10.1186/s12967-018-1501-z · 2018 · External reference
Antitumor Activity and Immune Response Induction of a Dual Agonist of Toll-Like Receptors 7 and 8
10.1158/1535-7163.mct-09-1198 · 2010 · External reference
Anti-Tumor Activity of Toll-Like Receptor 7 Agonists
10.3389/fphar.2017.00304 · 2017 · External reference
A five-amino-acid motif in the undefined region of the TLR8 ectodomain is required for species-specific ligand recognition
10.1016/j.molimm.2009.11.003 · 2010 · External reference
Cutting Edge: Activation of Murine TLR8 by a Combination of Imidazoquinoline Immune Response Modifiers and PolyT Oligodeoxynucleotides
10.4049/jimmunol.177.10.6584 · 2006 · External reference
Molecular Cloning and Functional Characterization of Murine Toll-Like Receptor 8
10.3892/mmr.2015.4668 · 2016 · External reference
TLR7 and TLR8 Differentially Activate the IRF and NF-κB Pathways in Specific Cell Types to Promote Inflammation
10.4049/immunohorizons.2000002 · 2020 · External reference
Employing Drug Delivery Strategies To Overcome Challenges Using TLR7/8 Agonists for Cancer Immunotherapy
10.1208/s12248-021-00620-x · 2021 · External reference
Development of Thermosensitive Resiquimod-Loaded Liposomes for Enhanced Cancer Immunotherapy
10.1016/j.jconrel.2020.11.013 · 2021 · External reference
Delivery of Cisplatin and Resiquimod in Nanomicelles for the Chemoimmunotherapy of Ovarian Cancer
10.1186/s12645-021-00094-8 · 2022 · External reference
The Role of TLR7/8 Agonists in Cancer Therapy, with Special Emphasis on Hematologic Malignancies
10.3390/vaccines11020277 · 2023 · External reference
Design and Synthesis of Polyphenolic Imidazo[4,5-c]quinoline Derivatives to Modulate Toll-Like Receptor-7 Agonistic Activity and Adjuvanticity
10.1021/acsptsci.4c00163 · 2024 · External reference
Modulation of the Adjuvant Potential of Imidazoquinoline-Based TLR7/8 Agonists via Alum Adsorption
10.1021/acsmedchemlett.4c00200 · 2024 · External reference
Determinants of Activity at Human Toll-Like Receptors 7 and 8: Quantitative Structure-Activity Relationship (QSAR) of Diverse Heterocyclic Scaffolds
10.1021/jm500744f · 2014 · External reference
Molecular Modeling and Docking of Small Molecule Inhibitors against NEK2
10.6026/97320630012062 · 2016 · External reference
In Silico Exploration of Potential Indoleamine 2,3-Dioxygenase-1 Inhibitors: An Insight from Docking, ADME, and Molecular Dynamic Simulations
10.1016/j.jics.2024.101550 · 2025 · External reference
Using GastroPlus to Teach Complex Biopharmaceutical Concepts
10.46542/pe.2022.221.336347 · 2022 · External reference
In Silico Prediction of Bioequivalence of Atorvastatin Tablets Based on GastroPlusTM Software
10.1186/s40360-023-00689-4 · 2023 · External reference
Experimental Solubility, Thermodynamic/Computational Validations, and GastroPlus-Based In Silico Prediction for Subcutaneous Delivery of Rifampicin
10.1208/s12249-021-01987-y · 2021 · External reference
Experimental and Computational Approaches to Estimate Solubility and Permeability in Drug Discovery and Development Settings
10.1016/s0169-409x(00)00129-0 · 2001 · External reference
Synthesis Biological Evaluation and Network Pharmacology-Based Studies of 1,3,4-Oxadiazole Bearing Azaphenols as Anticancer Agents
10.1016/j.arabjc.2023.105386 · 2024 · External reference
Unresolved reference
External reference
Integrating Network Pharmacology and Experimental Validation to Decipher the Mechanism of Action of Huanglian Jiedu Decoction in Treating Atherosclerosis
2021 · External reference
Unresolved reference
External reference
Network Pharmacology-Based Investigation on the Mechanism of the JinGuanLan Formula in Treating Acne Vulgaris
10.1155/2022/6944792 · 2022 · External reference
Unresolved reference
External reference
Molecular Docking Integrated with Network Pharmacology Explores the Therapeutic Mechanism of Cannabis sativa against Type 2 Diabetes
10.3390/cimb45090457 · 2023 · External reference
Unresolved reference
External reference
SRplot: A Free Online Platform for Data Visualization and Graphing
10.1371/journal.pone.0294236 · 2023 · External reference
Unresolved reference
External reference
Unresolved reference
External reference
Portulaca oleracea Seed Oil Exerts Cytotoxic Effects on Human Liver Cancer (HepG2) and Human Lung Cancer (A-549) Cell Lines
10.7314/apjcp.2015.16.8.3383 · 2015 · External reference
Facially Amphiphilic Cholic Acid-Lysine Conjugates as Promising Antimicrobials
10.1021/acsomega.9b03425 · 2020 · External reference
Network Pharmacology: A Bright Guiding Light on the Way to Explore Personalized Precise Medication of Traditional Chinese Medicine
10.1186/s13020-023-00853-2 · 2023 · External reference
Effect of Food on the Pharmacokinetics and Bioavailability of Oral Imiquimod Relative to a Subcutaneous Dose
10.5414/cpp38476 · 2000 · External reference
Randomized Single-Blind, Placebo-Controlled Study of Topical Application of the Immune Response Modulator Resiquimod in Healthy Adults
10.1128/aac.47.12.3846-3852.2003 · 2003 · External reference
TLR7/8 Signaling Balances Cytokine Responses in Neonatal Monocytes
10.1038/s41598-026-46534-6 · 2026 · External reference
Synthesis Biological Evaluation and Network Pharmacology-Based Studies of 1,3,4-Oxadiazole Bearing Azaphenols as Anticancer Agents
10.1016/j.arabjc.2023.105386 · ExternalCitation · doi-reference
Detection of Viral Infections by Innate Immunity
10.1016/j.bcp.2020.114316 · ExternalCitation · doi-reference
Development of Thermosensitive Resiquimod-Loaded Liposomes for Enhanced Cancer Immunotherapy
10.1016/j.jconrel.2020.11.013 · ExternalCitation · doi-reference
In Silico Exploration of Potential Indoleamine 2,3-Dioxygenase-1 Inhibitors: An Insight from Docking, ADME, and Molecular Dynamic Simulations
10.1016/j.jics.2024.101550 · ExternalCitation · doi-reference
A five-amino-acid motif in the undefined region of the TLR8 ectodomain is required for species-specific ligand recognition
10.1016/j.molimm.2009.11.003 · ExternalCitation · doi-reference
Experimental and Computational Approaches to Estimate Solubility and Permeability in Drug Discovery and Development Settings
10.1016/s0169-409x(00)00129-0 · ExternalCitation · doi-reference
Modulation of the Adjuvant Potential of Imidazoquinoline-Based TLR7/8 Agonists via Alum Adsorption
10.1021/acsmedchemlett.4c00200 · ExternalCitation · doi-reference
Facially Amphiphilic Cholic Acid-Lysine Conjugates as Promising Antimicrobials
10.1021/acsomega.9b03425 · ExternalCitation · doi-reference
Design and Synthesis of Polyphenolic Imidazo[4,5-c]quinoline Derivatives to Modulate Toll-Like Receptor-7 Agonistic Activity and Adjuvanticity
10.1021/acsptsci.4c00163 · ExternalCitation · doi-reference
Determinants of Activity at Human Toll-Like Receptors 7 and 8: Quantitative Structure-Activity Relationship (QSAR) of Diverse Heterocyclic Scaffolds
10.1021/jm500744f · ExternalCitation · doi-reference
TLR7/8 Signaling Balances Cytokine Responses in Neonatal Monocytes
10.1038/s41598-026-46534-6 · ExternalCitation · doi-reference
Toll-like receptor agonists as cancer therapeutics: A patent review (2014-2024)
10.1080/13543776.2025.2556819 · ExternalCitation · doi-reference
Randomized Single-Blind, Placebo-Controlled Study of Topical Application of the Immune Response Modulator Resiquimod in Healthy Adults
10.1128/aac.47.12.3846-3852.2003 · ExternalCitation · doi-reference
Toll-Like Receptors (TLRs): Structure, Functions, Signaling, and Role of Their Polymorphisms in Colorectal Cancer Susceptibility
10.1155/2021/1157023 · ExternalCitation · doi-reference
Network Pharmacology-Based Investigation on the Mechanism of the JinGuanLan Formula in Treating Acne Vulgaris
10.1155/2022/6944792 · ExternalCitation · doi-reference
Antitumor Activity and Immune Response Induction of a Dual Agonist of Toll-Like Receptors 7 and 8
10.1158/1535-7163.mct-09-1198 · ExternalCitation · doi-reference
Delivery of Cisplatin and Resiquimod in Nanomicelles for the Chemoimmunotherapy of Ovarian Cancer
10.1186/s12645-021-00094-8 · ExternalCitation · doi-reference
Gastric Cancer Vaccines Synthesized Using a TLR7 Agonist and Their Synergistic Antitumor Effects with 5-Fluorouracil
10.1186/s12967-018-1501-z · ExternalCitation · doi-reference
Network Pharmacology: A Bright Guiding Light on the Way to Explore Personalized Precise Medication of Traditional Chinese Medicine
10.1186/s13020-023-00853-2 · ExternalCitation · doi-reference
In Silico Prediction of Bioequivalence of Atorvastatin Tablets Based on GastroPlusTM Software
10.1186/s40360-023-00689-4 · ExternalCitation · doi-reference
Targeting Toll-Like Receptor 7/8 for Immunotherapy: Recent Advances and Prospectives
10.1186/s40364-022-00436-7 · ExternalCitation · doi-reference
Employing Drug Delivery Strategies To Overcome Challenges Using TLR7/8 Agonists for Cancer Immunotherapy
10.1208/s12248-021-00620-x · ExternalCitation · doi-reference
Experimental Solubility, Thermodynamic/Computational Validations, and GastroPlus-Based In Silico Prediction for Subcutaneous Delivery of Rifampicin
10.1208/s12249-021-01987-y · ExternalCitation · doi-reference
SRplot: A Free Online Platform for Data Visualization and Graphing
10.1371/journal.pone.0294236 · ExternalCitation · doi-reference
The TLR7 Agonist Imiquimod Induces Anti-Cancer Effects via Autophagic Cell Death and Enhances Anti-Tumoral and Systemic Immunity during Radiotherapy for Melanoma
10.18632/oncotarget.15326 · ExternalCitation · doi-reference
Anti-Tumor Activity of Toll-Like Receptor 7 Agonists
10.3389/fphar.2017.00304 · ExternalCitation · doi-reference
Molecular Docking Integrated with Network Pharmacology Explores the Therapeutic Mechanism of Cannabis sativa against Type 2 Diabetes
10.3390/cimb45090457 · ExternalCitation · doi-reference
The Role of TLR7/8 Agonists in Cancer Therapy, with Special Emphasis on Hematologic Malignancies
10.3390/vaccines11020277 · ExternalCitation · doi-reference
Molecular Cloning and Functional Characterization of Murine Toll-Like Receptor 8
10.3892/mmr.2015.4668 · ExternalCitation · doi-reference
TLR7 and TLR8 Differentially Activate the IRF and NF-κB Pathways in Specific Cell Types to Promote Inflammation
10.4049/immunohorizons.2000002 · ExternalCitation · doi-reference
Cutting Edge: Activation of Murine TLR8 by a Combination of Imidazoquinoline Immune Response Modifiers and PolyT Oligodeoxynucleotides
10.4049/jimmunol.177.10.6584 · ExternalCitation · doi-reference
Using GastroPlus to Teach Complex Biopharmaceutical Concepts
10.46542/pe.2022.221.336347 · ExternalCitation · doi-reference
Effect of Food on the Pharmacokinetics and Bioavailability of Oral Imiquimod Relative to a Subcutaneous Dose
10.5414/cpp38476 · ExternalCitation · doi-reference
Molecular Modeling and Docking of Small Molecule Inhibitors against NEK2
10.6026/97320630012062 · ExternalCitation · doi-reference
Portulaca oleracea Seed Oil Exerts Cytotoxic Effects on Human Liver Cancer (HepG2) and Human Lung Cancer (A-549) Cell Lines
10.7314/apjcp.2015.16.8.3383 · ExternalCitation · doi-reference
