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References from P2X4 Receptor Antagonists Exert Anti-Inflammatory Effects via NLRP3 Inflammasome in a Murine Model of Colitis. Local targets link to admitted publications; unresolved targets remain external evidence.
Inflammatory Bowel Disease: Pathogenesis
10.3748/wjg.v20.i1.91 · 2014 · External reference
The Four Epidemiological Stages in the Global Evolution of Inflammatory Bowel Disease
10.1038/s41575-020-00360-x · 2021 · External reference
Crohn’s Disease
10.1016/s0140-6736(12)60026-9 · 2012 · External reference
Ulcerative Colitis
10.1056/nejmra1102942 · 2011 · External reference
Inflammatory Bowel Disease
10.1056/nejmra0804647 · 2009 · External reference
Visceral Hypersensitivity in Inflammatory Bowel Diseases and Irritable Bowel Syndrome: The Role of Proteases
10.3748/wjg.v22.i47.10275 · 2016 · External reference
Gastrointestinal Motility and Absorptive Disorders in Patients with Inflammatory Bowel Diseases: Prevalence, Diagnosis and Treatment
10.3748/wjg.v25.i31.4414 · 2019 · External reference
Pathogenesis of Inflammatory Bowel Disease and Recent Advances in Biologic Therapies
10.4110/in.2017.17.1.25 · 2017 · External reference
IBD in the Elderly: Management Challenges and Therapeutic Considerations
10.1007/s11894-019-0720-7 · 2019 · External reference
Approaches for Designing and Discovering Purinergic Drugs for Gastrointestinal Diseases
10.1080/17460441.2020.1743673 · 2020 · External reference
Mind the Gap: An Unmet Need for New Therapy in IBD
10.1097/mcg.0b013e318033d71d · 2007 · External reference
The Purinergic System as a Pharmacological Target for the Treatment of Immune-Mediated Inflammatory Diseases
10.1124/pr.117.014878 · 2019 · External reference
Purinergic Signaling during Intestinal Inflammation
10.1007/s00109-017-1545-1 · 2017 · External reference
Pharmacological Modulation of P2X4 in Inflammatory Bowel Diseases: The Way towards Novel Therapeutics?
10.1080/1061186x.2023.2235092 · 2023 · External reference
Electroacupuncture at He-Mu Points Reduces P2X4 Receptor Expression in Visceral Hypersensitivity
10.3969/j.issn.1673-5374.2013.22.006 · 2013 · External reference
ADOA3R as a Therapeutic Target in Experimental Colitis: Proof by Validated High-Density Oligonucleotide Microarray Analysis
10.1097/00054725-200608000-00014 · 2006 · External reference
The Pharmacological Blockade of P2X4 Receptor as a Viable Approach to Manage Visceral Pain in a Rat Model of Colitis
10.1080/1061186x.2024.2367563 · 2024 · External reference
Carbon Monoxide Decreases Interleukin-1β Levels in the Lung through the Induction of Pyrin
10.1038/cmi.2015.79 · 2017 · External reference
Dataset on the Differentiation of THP-1 Monocytes to LPS Inducible Adherent Macrophages and Their Capacity for NO/INOS Signaling
10.1016/j.dib.2021.106786 · 2021 · External reference
Hirsutella Sinensis Mycelium Suppresses Interleukin-1β and Interleukin-18 Secretion by Inhibiting Both Canonical and Non-Canonical Inflammasomes
10.1038/srep01374 · 2013 · External reference
TGFβ Upregulates PAR-1 Expression and Signalling Responses in A549 Lung Adenocarcinoma Cells
10.18632/oncotarget.11472 · 2016 · External reference
Enteric Glial NLRP3 Inflammasome Contributes to Gut Mucosal Barrier Alterations in a Mouse Model of Diet-Induced Obesity
10.1111/apha.14232 · 2025 · External reference
Prodromal Intestinal Events in Alzheimer’s Disease (AD): Colonic Dysmotility and Inflammation Are Associated with Enteric AD-Related Protein Deposition
10.3390/ijms21103523 · 2020 · External reference
A Comparative Study on the Efficacy of NLRP3 Inflammasome Signaling Inhibitors in a Pre-Clinical Model of Bowel Inflammation
10.3389/fphar.2018.01405 · 2018 · External reference
An Oral Drug Delivery System Targeting Immune-Regulating Cells Ameliorates Mucosal Injury in Trinitrobenzene Sulfonic Acid-Induced Colitis
10.1016/s0022-3565(24)29641-5 · 2001 · External reference
Colonic Dysmotility Associated with High-Fat Diet-Induced Obesity: Role of Enteric Glia
10.1096/fj.201901844r · 2020 · External reference
A Nutraceutical Strategy to Slowing down the Progression of Cone Death in an Animal Model of Retinitis Pigmentosa
10.3389/fnins.2019.00461 · 2019 · External reference
Retinal Defects in Mice Lacking the Autism-Associated Gene Engrailed-2
10.1016/j.neuroscience.2019.03.061 · 2019 · External reference
Editorial: IBD Management-Novel Targets and Therapeutic Perspectives
10.3389/fphar.2020.00448 · 2020 · External reference
Regulation of P2X7-Dependent Inflammatory Functions by P2X4 Receptor in Mouse Macrophages
10.1016/j.bbrc.2012.02.122 · 2012 · External reference
P2X4: A Fast and Sensitive Purinergic Receptor
10.1016/j.bj.2017.06.010 · 2017 · External reference
P2X4 Receptors, Immunity, and Sepsis
10.1016/j.coph.2019.02.011 · 2019 · External reference
IL-1β Mediates Chronic Intestinal Inflammation by Promoting the Accumulation of IL-17A Secreting Innate Lymphoid Cells and CD4(+) Th17 Cells
10.1084/jem.20111453 · 2012 · External reference
Exploring the Role of IL-1β in Inflammatory Bowel Disease Pathogenesis
10.3389/fmed.2024.1307394 · 2024 · External reference
Understanding the Mechanism of IL-1β Secretion
10.1016/j.cytogfr.2011.10.001 · 2011 · External reference
P2X4 Receptor-Dependent Ca2+ Influx in Model Human Monocytes and Macrophages
10.3390/ijms18112261 · 2017 · External reference
A High Concentration of Fatty Acids Induces TNF-α as Well as NO Release Mediated by the P2X4 Receptor, and the Protective Effects of Puerarin in RAW264.7 Cells
10.1039/c7fo00544j · 2017 · External reference
P2Y2 and P2X4 Receptors Mediate Ca2+ Mobilization in DH82 Canine Macrophage Cells
10.3390/ijms21228572 · 2020 · External reference
Bavachin Attenuates LPS-Induced Inflammatory Response and Inhibits the Activation of NLRP3 Inflammasome in Macrophages
10.1016/j.phymed.2018.12.008 · 2019 · External reference
Intestinal Epithelial Barrier and Neuromuscular Compartment in Health and Disease
10.3748/wjg.v26.i14.1564 · 2020 · External reference
Dynamical Changes in the Expression of GABAergic and Purinergic Components Occur during the Polarization of THP-1 Monocytes to Proinflammatory Macrophages
10.1016/j.bbrep.2023.101558 · 2023 · External reference
Recommended Tool Compounds and Drugs for Blocking P2X and P2Y Receptors
10.1007/s11302-021-09813-7 · 2021 · External reference
A Novel P2X4 Receptor-Selective Antagonist Produces Anti-Allodynic Effect in a Mouse Model of Herpetic Pain
10.1038/srep32461 · 2016 · External reference
Elevated Hydrostatic Pressure Stimulates ATP Release Which Mediates Activation of the NLRP3 Inflammasome via P2X4 in Rat Urothelial Cells
10.1007/s11255-018-1948-0 · 2018 · External reference
P2X4 Receptor Exacerbates Ischemic AKI and Induces Renal Proximal Tubular NLRP3 Inflammasome Signaling
10.1096/fj.201903287r · 2020 · External reference
P2X4 Receptors Influence Inflammasome Activation after Spinal Cord Injury
10.1523/jneurosci.4930-11.2012 · 2012 · External reference
Canonical and Non-Canonical Activation of NLRP3 Inflammasome at the Crossroad between Immune Tolerance and Intestinal Inflammation
10.3389/fimmu.2017.00036 · 2017 · External reference
Non-Canonical Inflammasome Activation Targets Caspase-11
10.1038/nature10558 · 2011 · External reference
Noncanonical Inflammasome Activation of Caspase-4/Caspase-11 Mediates Epithelial Defenses against Enteric Bacterial Pathogens
10.1016/j.chom.2014.07.002 · 2014 · External reference
Caspase-8 as an Effector and Regulator of NLRP3 Inflammasome Signaling
10.1074/jbc.m115.652321 · 2015 · External reference
Novel Roles for Caspase-8 in IL-1β and Inflammasome Regulation
10.1016/j.ajpath.2014.08.025 · 2015 · External reference
Human Caspase-4 and Caspase-5 Regulate the One-Step Non-Canonical Inflammasome Activation in Monocytes
10.1038/ncomms9761 · 2015 · External reference
Inhibition of Adenosine Deaminase Attenuates Inflammation in Experimental Colitis
10.1124/jpet.107.122762 · 2007 · External reference
Role of the A(2B) Receptor-Adenosine Deaminase Complex in Colonic Dysmotility Associated with Bowel Inflammation in Rats
10.1111/bph.12539 · 2014 · External reference
Oxazolone-Induced Colitis in BALB/C Mice: A New Method to Evaluate the Efficacy of Therapeutic Agents for Ulcerative Colitis
10.1254/jphs.fp0040214 · 2004 · External reference
ATP-P2X4 Signaling Mediates NLRP3 Inflammasome Activation: A Novel Pathway of Diabetic Nephropathy
10.1016/j.biocel.2013.02.009 · 2013 · External reference
IL-1beta Causes an Increase in Intestinal Epithelial Tight Junction Permeability
10.4049/jimmunol.178.7.4641 · 2007 · External reference
Anti-Inflammatory Effects of Novel P2X4 Receptor Antagonists, NC-2600 and NP-1815-PX, in a Murine Model of Colitis
10.1007/s10753-022-01663-8 · 2022 · External reference
Retraction Note: Anti-Inflammatory Effects of Novel P2X4 Receptor Antagonists, NC-2600 and NP-1815-PX, in a Murine Model of Colitis
10.1007/s10753-024-02143-x · 2025 · External reference
Purinergic Signaling during Intestinal Inflammation
10.1007/s00109-017-1545-1 · ExternalCitation · doi-reference
Anti-Inflammatory Effects of Novel P2X4 Receptor Antagonists, NC-2600 and NP-1815-PX, in a Murine Model of Colitis
10.1007/s10753-022-01663-8 · ExternalCitation · doi-reference
Retraction Note: Anti-Inflammatory Effects of Novel P2X4 Receptor Antagonists, NC-2600 and NP-1815-PX, in a Murine Model of Colitis
10.1007/s10753-024-02143-x · ExternalCitation · doi-reference
Elevated Hydrostatic Pressure Stimulates ATP Release Which Mediates Activation of the NLRP3 Inflammasome via P2X4 in Rat Urothelial Cells
10.1007/s11255-018-1948-0 · ExternalCitation · doi-reference
Recommended Tool Compounds and Drugs for Blocking P2X and P2Y Receptors
10.1007/s11302-021-09813-7 · ExternalCitation · doi-reference
IBD in the Elderly: Management Challenges and Therapeutic Considerations
10.1007/s11894-019-0720-7 · ExternalCitation · doi-reference
Novel Roles for Caspase-8 in IL-1β and Inflammasome Regulation
10.1016/j.ajpath.2014.08.025 · ExternalCitation · doi-reference
Regulation of P2X7-Dependent Inflammatory Functions by P2X4 Receptor in Mouse Macrophages
10.1016/j.bbrc.2012.02.122 · ExternalCitation · doi-reference
Dynamical Changes in the Expression of GABAergic and Purinergic Components Occur during the Polarization of THP-1 Monocytes to Proinflammatory Macrophages
10.1016/j.bbrep.2023.101558 · ExternalCitation · doi-reference
ATP-P2X4 Signaling Mediates NLRP3 Inflammasome Activation: A Novel Pathway of Diabetic Nephropathy
10.1016/j.biocel.2013.02.009 · ExternalCitation · doi-reference
P2X4: A Fast and Sensitive Purinergic Receptor
10.1016/j.bj.2017.06.010 · ExternalCitation · doi-reference
Noncanonical Inflammasome Activation of Caspase-4/Caspase-11 Mediates Epithelial Defenses against Enteric Bacterial Pathogens
10.1016/j.chom.2014.07.002 · ExternalCitation · doi-reference
P2X4 Receptors, Immunity, and Sepsis
10.1016/j.coph.2019.02.011 · ExternalCitation · doi-reference
Understanding the Mechanism of IL-1β Secretion
10.1016/j.cytogfr.2011.10.001 · ExternalCitation · doi-reference
Dataset on the Differentiation of THP-1 Monocytes to LPS Inducible Adherent Macrophages and Their Capacity for NO/INOS Signaling
10.1016/j.dib.2021.106786 · ExternalCitation · doi-reference
Retinal Defects in Mice Lacking the Autism-Associated Gene Engrailed-2
10.1016/j.neuroscience.2019.03.061 · ExternalCitation · doi-reference
Bavachin Attenuates LPS-Induced Inflammatory Response and Inhibits the Activation of NLRP3 Inflammasome in Macrophages
10.1016/j.phymed.2018.12.008 · ExternalCitation · doi-reference
An Oral Drug Delivery System Targeting Immune-Regulating Cells Ameliorates Mucosal Injury in Trinitrobenzene Sulfonic Acid-Induced Colitis
10.1016/s0022-3565(24)29641-5 · ExternalCitation · doi-reference
Crohn’s Disease
10.1016/s0140-6736(12)60026-9 · ExternalCitation · doi-reference
Carbon Monoxide Decreases Interleukin-1β Levels in the Lung through the Induction of Pyrin
10.1038/cmi.2015.79 · ExternalCitation · doi-reference
Non-Canonical Inflammasome Activation Targets Caspase-11
10.1038/nature10558 · ExternalCitation · doi-reference
Human Caspase-4 and Caspase-5 Regulate the One-Step Non-Canonical Inflammasome Activation in Monocytes
10.1038/ncomms9761 · ExternalCitation · doi-reference
The Four Epidemiological Stages in the Global Evolution of Inflammatory Bowel Disease
10.1038/s41575-020-00360-x · ExternalCitation · doi-reference
Hirsutella Sinensis Mycelium Suppresses Interleukin-1β and Interleukin-18 Secretion by Inhibiting Both Canonical and Non-Canonical Inflammasomes
10.1038/srep01374 · ExternalCitation · doi-reference
A Novel P2X4 Receptor-Selective Antagonist Produces Anti-Allodynic Effect in a Mouse Model of Herpetic Pain
10.1038/srep32461 · ExternalCitation · doi-reference
A High Concentration of Fatty Acids Induces TNF-α as Well as NO Release Mediated by the P2X4 Receptor, and the Protective Effects of Puerarin in RAW264.7 Cells
10.1039/c7fo00544j · ExternalCitation · doi-reference
Inflammatory Bowel Disease
10.1056/nejmra0804647 · ExternalCitation · doi-reference
Ulcerative Colitis
10.1056/nejmra1102942 · ExternalCitation · doi-reference
Caspase-8 as an Effector and Regulator of NLRP3 Inflammasome Signaling
10.1074/jbc.m115.652321 · ExternalCitation · doi-reference
Pharmacological Modulation of P2X4 in Inflammatory Bowel Diseases: The Way towards Novel Therapeutics?
10.1080/1061186x.2023.2235092 · ExternalCitation · doi-reference
The Pharmacological Blockade of P2X4 Receptor as a Viable Approach to Manage Visceral Pain in a Rat Model of Colitis
10.1080/1061186x.2024.2367563 · ExternalCitation · doi-reference
Approaches for Designing and Discovering Purinergic Drugs for Gastrointestinal Diseases
10.1080/17460441.2020.1743673 · ExternalCitation · doi-reference
IL-1β Mediates Chronic Intestinal Inflammation by Promoting the Accumulation of IL-17A Secreting Innate Lymphoid Cells and CD4(+) Th17 Cells
10.1084/jem.20111453 · ExternalCitation · doi-reference
Colonic Dysmotility Associated with High-Fat Diet-Induced Obesity: Role of Enteric Glia
10.1096/fj.201901844r · ExternalCitation · doi-reference
P2X4 Receptor Exacerbates Ischemic AKI and Induces Renal Proximal Tubular NLRP3 Inflammasome Signaling
10.1096/fj.201903287r · ExternalCitation · doi-reference
ADOA3R as a Therapeutic Target in Experimental Colitis: Proof by Validated High-Density Oligonucleotide Microarray Analysis
10.1097/00054725-200608000-00014 · ExternalCitation · doi-reference
Mind the Gap: An Unmet Need for New Therapy in IBD
10.1097/mcg.0b013e318033d71d · ExternalCitation · doi-reference
Enteric Glial NLRP3 Inflammasome Contributes to Gut Mucosal Barrier Alterations in a Mouse Model of Diet-Induced Obesity
10.1111/apha.14232 · ExternalCitation · doi-reference
Role of the A(2B) Receptor-Adenosine Deaminase Complex in Colonic Dysmotility Associated with Bowel Inflammation in Rats
10.1111/bph.12539 · ExternalCitation · doi-reference
Inhibition of Adenosine Deaminase Attenuates Inflammation in Experimental Colitis
10.1124/jpet.107.122762 · ExternalCitation · doi-reference
The Purinergic System as a Pharmacological Target for the Treatment of Immune-Mediated Inflammatory Diseases
10.1124/pr.117.014878 · ExternalCitation · doi-reference
Oxazolone-Induced Colitis in BALB/C Mice: A New Method to Evaluate the Efficacy of Therapeutic Agents for Ulcerative Colitis
10.1254/jphs.fp0040214 · ExternalCitation · doi-reference
P2X4 Receptors Influence Inflammasome Activation after Spinal Cord Injury
10.1523/jneurosci.4930-11.2012 · ExternalCitation · doi-reference
TGFβ Upregulates PAR-1 Expression and Signalling Responses in A549 Lung Adenocarcinoma Cells
10.18632/oncotarget.11472 · ExternalCitation · doi-reference
Canonical and Non-Canonical Activation of NLRP3 Inflammasome at the Crossroad between Immune Tolerance and Intestinal Inflammation
10.3389/fimmu.2017.00036 · ExternalCitation · doi-reference
Exploring the Role of IL-1β in Inflammatory Bowel Disease Pathogenesis
10.3389/fmed.2024.1307394 · ExternalCitation · doi-reference
A Nutraceutical Strategy to Slowing down the Progression of Cone Death in an Animal Model of Retinitis Pigmentosa
10.3389/fnins.2019.00461 · ExternalCitation · doi-reference
A Comparative Study on the Efficacy of NLRP3 Inflammasome Signaling Inhibitors in a Pre-Clinical Model of Bowel Inflammation
10.3389/fphar.2018.01405 · ExternalCitation · doi-reference
Editorial: IBD Management-Novel Targets and Therapeutic Perspectives
10.3389/fphar.2020.00448 · ExternalCitation · doi-reference
P2X4 Receptor-Dependent Ca2+ Influx in Model Human Monocytes and Macrophages
10.3390/ijms18112261 · ExternalCitation · doi-reference
Prodromal Intestinal Events in Alzheimer’s Disease (AD): Colonic Dysmotility and Inflammation Are Associated with Enteric AD-Related Protein Deposition
10.3390/ijms21103523 · ExternalCitation · doi-reference
P2Y2 and P2X4 Receptors Mediate Ca2+ Mobilization in DH82 Canine Macrophage Cells
10.3390/ijms21228572 · ExternalCitation · doi-reference
Inflammatory Bowel Disease: Pathogenesis
10.3748/wjg.v20.i1.91 · ExternalCitation · doi-reference
Visceral Hypersensitivity in Inflammatory Bowel Diseases and Irritable Bowel Syndrome: The Role of Proteases
10.3748/wjg.v22.i47.10275 · ExternalCitation · doi-reference
Gastrointestinal Motility and Absorptive Disorders in Patients with Inflammatory Bowel Diseases: Prevalence, Diagnosis and Treatment
10.3748/wjg.v25.i31.4414 · ExternalCitation · doi-reference
Intestinal Epithelial Barrier and Neuromuscular Compartment in Health and Disease
10.3748/wjg.v26.i14.1564 · ExternalCitation · doi-reference
Electroacupuncture at He-Mu Points Reduces P2X4 Receptor Expression in Visceral Hypersensitivity
10.3969/j.issn.1673-5374.2013.22.006 · ExternalCitation · doi-reference
IL-1beta Causes an Increase in Intestinal Epithelial Tight Junction Permeability
10.4049/jimmunol.178.7.4641 · ExternalCitation · doi-reference
Pathogenesis of Inflammatory Bowel Disease and Recent Advances in Biologic Therapies
10.4110/in.2017.17.1.25 · ExternalCitation · doi-reference
