Research graph
References from Optimizing the Hinge Length of Chimeric Antigen Receptor with a DdFP-Based Immunological Synapse Biosensor. Local targets link to admitted publications; unresolved targets remain external evidence.
CAR race to cancer immunotherapy: from CAR T, CAR NK to CAR macrophage therapy
10.1186/s13046-022-02327-z · 2022 · External reference
From concept to cure: The evolution of CAR-T cell therapy
10.1016/j.ymthe.2025.03.005 · 2025 · External reference
Chimeric Antigen Receptor T-Cells: An Overview of Concepts, Applications, Limitations, and Proposed Solutions
10.3389/fbioe.2022.797440 · 2022 · External reference
The basic principles of chimeric antigen receptor design
10.1158/2159-8290.cd-12-0548 · 2013 · External reference
The Principles of Engineering Immune Cells to Treat Cancer
10.1016/j.cell.2017.01.016 · 2017 · External reference
Comparative analysis of TCR and CAR signaling informs CAR designs with superior antigen sensitivity and in vivo function
10.1126/scisignal.abe2606 · 2021 · External reference
Challenges and future perspectives for high-throughput chimeric antigen receptor T cell discovery
10.1016/j.copbio.2024.103216 · 2024 · External reference
The affinity of antigen-binding domain on the antitumor efficacy of CAR T cells: Moderate is better
10.3389/fimmu.2022.1032403 · 2022 · External reference
Receptor affinity and extracellular domain modifications affect tumor recognition by ROR1-specific chimeric antigen receptor T cells
10.1158/1078-0432.ccr-13-0330 · 2013 · External reference
T cell receptor (TCR) clustering in the immunological synapse integrates TCR and costimulatory signaling in selected T cells
10.1073/pnas.0406867102 · 2005 · External reference
Immunological Synapse Predicts Effectiveness of Chimeric Antigen Receptor Cells
10.1016/j.ymthe.2018.01.020 · 2018 · External reference
Inefficient CAR-proximal signaling blunts antigen sensitivity
10.1038/s41590-020-0719-0 · 2020 · External reference
Function of Novel Anti-CD19 Chimeric Antigen Receptors with Human Variable Regions Is Affected by Hinge and Transmembrane Domains
10.1016/j.ymthe.2017.07.013 · 2017 · External reference
The role of extracellular spacer regions in the optimal design of chimeric immune receptors: evaluation of four different scFvs and antigens
10.1097/01.cji.0000161397.96582.59 · 2005 · External reference
A Novel Siglec-4 Derived Spacer Improves the Functionality of CAR T Cells Against Membrane-Proximal Epitopes
10.3389/fimmu.2020.01704 · 2020 · External reference
Incorporation of a hinge domain improves the expansion of chimeric antigen receptor T cells
10.1186/s13045-017-0437-8 · 2017 · External reference
The nonsignaling extracellular spacer domain of chimeric antigen receptors is decisive for in vivo antitumor activity
10.1158/2326-6066.cir-14-0127 · 2015 · External reference
Advancing Cancer Immunotherapy: Chimeric Antigen Receptor (CAR)-T Cell Engineering through Novel Screening Methods
10.4062/biomolther.2025.204 · 2026 · External reference
Genetically encoded Forster resonance energy transfer sensors for the conformation of the Src family kinase Lck
10.4049/jimmunol.0802639 · 2009 · External reference
T cell activation results in conformational changes in the Src family kinase Lck to induce its activation
10.1126/scisignal.2003607 · 2013 · External reference
De novo phosphorylation and conformational opening of the tyrosine kinase Lck act in concert to initiate T cell receptor signaling
10.1126/scisignal.aaf4736 · 2017 · External reference
Biophysical basis underlying dynamic Lck activation visualized by ZapLck FRET biosensor
10.1126/sciadv.aau2001 · 2019 · External reference
A novel ZAP-70 dependent FRET based biosensor reveals kinase activity at both the immunological synapse and the antisynapse
10.1371/journal.pone.0001521 · 2008 · External reference
ROZA-XL, an improved FRET based biosensor with an increased dynamic range for visualizing zeta associated protein 70 kD (ZAP-70) tyrosine kinase activity in live T cells
10.1016/j.bbrc.2015.02.117 · 2015 · External reference
Optical sensing and control of T cell signaling pathways
10.3389/fphys.2023.1321996 · 2023 · External reference
Genetically encoded Ca(2+) indicators: properties and evaluation
10.1016/j.bbamcr.2013.01.011 · 2013 · External reference
Fluorescent indicators for Ca2+ based on green fluorescent proteins and calmodulin
10.1038/42264 · 1997 · External reference
A high signal-to-noise Ca(2+) probe composed of a single green fluorescent protein
10.1038/84397 · 2001 · External reference
A genetically encoded fluorescent sensor of ERK activity
10.1073/pnas.0804598105 · 2008 · External reference
High-sensitivity measurements of multiple kinase activities in live single cells
10.1016/j.cell.2014.04.039 · 2014 · External reference
Assessment of costimulation and coinhibition in a triple parameter T cell reporter line: Simultaneous measurement of NF-kappaB, NFAT and AP-1
10.1016/j.jim.2016.01.007 · 2016 · External reference
A fluorogenic red fluorescent protein heterodimer
10.1016/j.chembiol.2012.01.006 · 2012 · External reference
Dimerization-dependent green and yellow fluorescent proteins
10.1021/sb300050j · 2012 · External reference
Mesothelin Expression in Human Tumors: A Tissue Microarray Study on 12,679 Tumors
10.3390/biomedicines9040397 · 2021 · External reference
Mesothelin-targeted CAR-T cell therapy for solid tumors
10.1080/14712598.2021.1843628 · 2021 · External reference
Mesothelin as a biomarker for targeted therapy
10.1186/s40364-019-0169-8 · 2019 · External reference
A Comprehensive Review of HER2 in Cancer Biology and Therapeutics
10.3390/genes15070903 · 2024 · External reference
Research progress on HER2-specific chimeric antigen receptor T cells for immunotherapy of solid tumors
10.3389/fimmu.2025.1514994 · 2025 · External reference
Humanization of a recombinant monoclonal antibody to produce a therapeutic HER dimerization inhibitor, pertuzumab
10.1007/s00262-005-0058-x · 2006 · External reference
Humanization of an anti-p185HER2 antibody for human cancer therapy
10.1073/pnas.89.10.4285 · 1992 · External reference
Novel FRET-based Immunological Synapse Biosensor for the Prediction of Chimeric Antigen Receptor-T Cell Function
10.1002/smtd.202401016 · 2025 · External reference
New high affinity monoclonal antibodies recognize non-overlapping epitopes on mesothelin for monitoring and treating mesothelioma
10.1038/srep09928 · 2015 · External reference
Modified CAR T cells targeting membrane-proximal epitope of mesothelin enhances the antitumor function against large solid tumor
10.1038/s41419-019-1711-1 · 2019 · External reference
Lck regulates the tyrosine phosphorylation of the T cell receptor subunits and ZAP-70 in murine thymocytes
10.1084/jem.183.3.1053 · 1996 · External reference
S-acylation of LCK protein tyrosine kinase is essential for its signalling function in T lymphocytes
10.1093/emboj/16.16.4983 · 1997 · External reference
Partial T cell signaling: altered phospho-zeta and lack of zap70 recruitment in APL-induced T cell anergy
10.1016/0092-8674(94)90080-9 · 1994 · External reference
Genetic evidence for differential coupling of Syk family kinases to the T-cell receptor: reconstitution studies in a ZAP-70-deficient Jurkat T-cell line
10.1128/mcb.18.3.1388 · 1998 · External reference
Lck promotes Zap70-dependent LAT phosphorylation by bridging Zap70 to LAT
10.1038/s41590-018-0131-1 · 2018 · External reference
Ratiometric biosensors based on dimerization-dependent fluorescent protein exchange
10.1038/nmeth.3261 · 2015 · External reference
Chimeric antigen receptor T cells form nonclassical and potent immune synapses driving rapid cytotoxicity
10.1073/pnas.1716266115 · 2018 · External reference
Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab
10.1038/nature01392 · 2003 · External reference
HER2 therapy. HER2 (ERBB2): functional diversity from structurally conserved building blocks
10.1186/bcr1633 · 2007 · External reference
Cryo-EM Structure of HER2-trastuzumab-pertuzumab complex
10.1371/journal.pone.0216095 · 2019 · External reference
Programmable Attenuation of Antigenic Sensitivity for a Nanobody-Based EGFR Chimeric Antigen Receptor Through Hinge Domain Truncation
10.3389/fimmu.2022.864868 · 2022 · External reference
A novel CD34-derived hinge for rapid and efficient detection and enrichment of CAR T cells
10.1016/j.omto.2021.11.003 · 2021 · External reference
T-cell receptor triggering is critically dependent on the dimensions of its peptide-MHC ligand
10.1038/nature03843 · 2005 · External reference
The kinetic-segregation model: TCR triggering and beyond
10.1038/ni1369 · 2006 · External reference
CD28 hinge used in chimeric antigen receptor (CAR) T-cells exhibits local structure and conformational exchange amidst global disorder
10.1038/s42003-024-06770-w · 2024 · External reference
The Effects of Chimeric Antigen Receptor (CAR) Hinge Domain Post-Translational Modifications on CAR-T Cell Activity
10.3390/ijms23074056 · 2022 · External reference
Hinge and Transmembrane Domains of Chimeric Antigen Receptor Regulate Receptor Expression and Signaling Threshold
10.3390/cells9051182 · 2020 · External reference
Understanding the structure and function of the immunological synapse
10.1101/cshperspect.a002311 · 2010 · External reference
Three-dimensional segregation of supramolecular activation clusters in T cells
10.1038/25764 · 1998 · External reference
The immunological synapse: a molecular machine controlling T cell activation
10.1126/science.285.5425.221 · 1999 · External reference
Signaling at neuro/immune synapses
10.1172/jci58705 · 2012 · External reference
The immune synapse clears and excludes molecules above a size threshold
10.1038/ncomms6479 · 2014 · External reference
In vitro reconstitution of T cell receptor-mediated segregation of the CD45 phosphatase
10.1073/pnas.1710358114 · 2017 · External reference
The interplay between membrane topology and mechanical forces in regulating T cell receptor activity
10.1038/s42003-021-02995-1 · 2022 · External reference
The physical landscape of CAR-T synapse
10.1016/j.bpj.2023.09.004 · 2024 · External reference
Novel FRET-based Immunological Synapse Biosensor for the Prediction of Chimeric Antigen Receptor-T Cell Function
10.1002/smtd.202401016 · ExternalCitation · doi-reference
Humanization of a recombinant monoclonal antibody to produce a therapeutic HER dimerization inhibitor, pertuzumab
10.1007/s00262-005-0058-x · ExternalCitation · doi-reference
Partial T cell signaling: altered phospho-zeta and lack of zap70 recruitment in APL-induced T cell anergy
10.1016/0092-8674(94)90080-9 · ExternalCitation · doi-reference
Genetically encoded Ca(2+) indicators: properties and evaluation
10.1016/j.bbamcr.2013.01.011 · ExternalCitation · doi-reference
ROZA-XL, an improved FRET based biosensor with an increased dynamic range for visualizing zeta associated protein 70 kD (ZAP-70) tyrosine kinase activity in live T cells
10.1016/j.bbrc.2015.02.117 · ExternalCitation · doi-reference
The physical landscape of CAR-T synapse
10.1016/j.bpj.2023.09.004 · ExternalCitation · doi-reference
High-sensitivity measurements of multiple kinase activities in live single cells
10.1016/j.cell.2014.04.039 · ExternalCitation · doi-reference
The Principles of Engineering Immune Cells to Treat Cancer
10.1016/j.cell.2017.01.016 · ExternalCitation · doi-reference
A fluorogenic red fluorescent protein heterodimer
10.1016/j.chembiol.2012.01.006 · ExternalCitation · doi-reference
Challenges and future perspectives for high-throughput chimeric antigen receptor T cell discovery
10.1016/j.copbio.2024.103216 · ExternalCitation · doi-reference
Assessment of costimulation and coinhibition in a triple parameter T cell reporter line: Simultaneous measurement of NF-kappaB, NFAT and AP-1
10.1016/j.jim.2016.01.007 · ExternalCitation · doi-reference
A novel CD34-derived hinge for rapid and efficient detection and enrichment of CAR T cells
10.1016/j.omto.2021.11.003 · ExternalCitation · doi-reference
Function of Novel Anti-CD19 Chimeric Antigen Receptors with Human Variable Regions Is Affected by Hinge and Transmembrane Domains
10.1016/j.ymthe.2017.07.013 · ExternalCitation · doi-reference
Immunological Synapse Predicts Effectiveness of Chimeric Antigen Receptor Cells
10.1016/j.ymthe.2018.01.020 · ExternalCitation · doi-reference
From concept to cure: The evolution of CAR-T cell therapy
10.1016/j.ymthe.2025.03.005 · ExternalCitation · doi-reference
Dimerization-dependent green and yellow fluorescent proteins
10.1021/sb300050j · ExternalCitation · doi-reference
Three-dimensional segregation of supramolecular activation clusters in T cells
10.1038/25764 · ExternalCitation · doi-reference
Fluorescent indicators for Ca2+ based on green fluorescent proteins and calmodulin
10.1038/42264 · ExternalCitation · doi-reference
A high signal-to-noise Ca(2+) probe composed of a single green fluorescent protein
10.1038/84397 · ExternalCitation · doi-reference
Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab
10.1038/nature01392 · ExternalCitation · doi-reference
T-cell receptor triggering is critically dependent on the dimensions of its peptide-MHC ligand
10.1038/nature03843 · ExternalCitation · doi-reference
The immune synapse clears and excludes molecules above a size threshold
10.1038/ncomms6479 · ExternalCitation · doi-reference
The kinetic-segregation model: TCR triggering and beyond
10.1038/ni1369 · ExternalCitation · doi-reference
Ratiometric biosensors based on dimerization-dependent fluorescent protein exchange
10.1038/nmeth.3261 · ExternalCitation · doi-reference
Modified CAR T cells targeting membrane-proximal epitope of mesothelin enhances the antitumor function against large solid tumor
10.1038/s41419-019-1711-1 · ExternalCitation · doi-reference
Lck promotes Zap70-dependent LAT phosphorylation by bridging Zap70 to LAT
10.1038/s41590-018-0131-1 · ExternalCitation · doi-reference
Inefficient CAR-proximal signaling blunts antigen sensitivity
10.1038/s41590-020-0719-0 · ExternalCitation · doi-reference
The interplay between membrane topology and mechanical forces in regulating T cell receptor activity
10.1038/s42003-021-02995-1 · ExternalCitation · doi-reference
CD28 hinge used in chimeric antigen receptor (CAR) T-cells exhibits local structure and conformational exchange amidst global disorder
10.1038/s42003-024-06770-w · ExternalCitation · doi-reference
New high affinity monoclonal antibodies recognize non-overlapping epitopes on mesothelin for monitoring and treating mesothelioma
10.1038/srep09928 · ExternalCitation · doi-reference
T cell receptor (TCR) clustering in the immunological synapse integrates TCR and costimulatory signaling in selected T cells
10.1073/pnas.0406867102 · ExternalCitation · doi-reference
A genetically encoded fluorescent sensor of ERK activity
10.1073/pnas.0804598105 · ExternalCitation · doi-reference
In vitro reconstitution of T cell receptor-mediated segregation of the CD45 phosphatase
10.1073/pnas.1710358114 · ExternalCitation · doi-reference
Chimeric antigen receptor T cells form nonclassical and potent immune synapses driving rapid cytotoxicity
10.1073/pnas.1716266115 · ExternalCitation · doi-reference
Humanization of an anti-p185HER2 antibody for human cancer therapy
10.1073/pnas.89.10.4285 · ExternalCitation · doi-reference
Mesothelin-targeted CAR-T cell therapy for solid tumors
10.1080/14712598.2021.1843628 · ExternalCitation · doi-reference
Lck regulates the tyrosine phosphorylation of the T cell receptor subunits and ZAP-70 in murine thymocytes
10.1084/jem.183.3.1053 · ExternalCitation · doi-reference
S-acylation of LCK protein tyrosine kinase is essential for its signalling function in T lymphocytes
10.1093/emboj/16.16.4983 · ExternalCitation · doi-reference
The role of extracellular spacer regions in the optimal design of chimeric immune receptors: evaluation of four different scFvs and antigens
10.1097/01.cji.0000161397.96582.59 · ExternalCitation · doi-reference
Understanding the structure and function of the immunological synapse
10.1101/cshperspect.a002311 · ExternalCitation · doi-reference
Biophysical basis underlying dynamic Lck activation visualized by ZapLck FRET biosensor
10.1126/sciadv.aau2001 · ExternalCitation · doi-reference
The immunological synapse: a molecular machine controlling T cell activation
10.1126/science.285.5425.221 · ExternalCitation · doi-reference
T cell activation results in conformational changes in the Src family kinase Lck to induce its activation
10.1126/scisignal.2003607 · ExternalCitation · doi-reference
De novo phosphorylation and conformational opening of the tyrosine kinase Lck act in concert to initiate T cell receptor signaling
10.1126/scisignal.aaf4736 · ExternalCitation · doi-reference
Comparative analysis of TCR and CAR signaling informs CAR designs with superior antigen sensitivity and in vivo function
10.1126/scisignal.abe2606 · ExternalCitation · doi-reference
Genetic evidence for differential coupling of Syk family kinases to the T-cell receptor: reconstitution studies in a ZAP-70-deficient Jurkat T-cell line
10.1128/mcb.18.3.1388 · ExternalCitation · doi-reference
Receptor affinity and extracellular domain modifications affect tumor recognition by ROR1-specific chimeric antigen receptor T cells
10.1158/1078-0432.ccr-13-0330 · ExternalCitation · doi-reference
The basic principles of chimeric antigen receptor design
10.1158/2159-8290.cd-12-0548 · ExternalCitation · doi-reference
The nonsignaling extracellular spacer domain of chimeric antigen receptors is decisive for in vivo antitumor activity
10.1158/2326-6066.cir-14-0127 · ExternalCitation · doi-reference
Signaling at neuro/immune synapses
10.1172/jci58705 · ExternalCitation · doi-reference
HER2 therapy. HER2 (ERBB2): functional diversity from structurally conserved building blocks
10.1186/bcr1633 · ExternalCitation · doi-reference
Incorporation of a hinge domain improves the expansion of chimeric antigen receptor T cells
10.1186/s13045-017-0437-8 · ExternalCitation · doi-reference
CAR race to cancer immunotherapy: from CAR T, CAR NK to CAR macrophage therapy
10.1186/s13046-022-02327-z · ExternalCitation · doi-reference
Mesothelin as a biomarker for targeted therapy
10.1186/s40364-019-0169-8 · ExternalCitation · doi-reference
A novel ZAP-70 dependent FRET based biosensor reveals kinase activity at both the immunological synapse and the antisynapse
10.1371/journal.pone.0001521 · ExternalCitation · doi-reference
Cryo-EM Structure of HER2-trastuzumab-pertuzumab complex
10.1371/journal.pone.0216095 · ExternalCitation · doi-reference
Chimeric Antigen Receptor T-Cells: An Overview of Concepts, Applications, Limitations, and Proposed Solutions
10.3389/fbioe.2022.797440 · ExternalCitation · doi-reference
A Novel Siglec-4 Derived Spacer Improves the Functionality of CAR T Cells Against Membrane-Proximal Epitopes
10.3389/fimmu.2020.01704 · ExternalCitation · doi-reference
The affinity of antigen-binding domain on the antitumor efficacy of CAR T cells: Moderate is better
10.3389/fimmu.2022.1032403 · ExternalCitation · doi-reference
Programmable Attenuation of Antigenic Sensitivity for a Nanobody-Based EGFR Chimeric Antigen Receptor Through Hinge Domain Truncation
10.3389/fimmu.2022.864868 · ExternalCitation · doi-reference
Research progress on HER2-specific chimeric antigen receptor T cells for immunotherapy of solid tumors
10.3389/fimmu.2025.1514994 · ExternalCitation · doi-reference
Optical sensing and control of T cell signaling pathways
10.3389/fphys.2023.1321996 · ExternalCitation · doi-reference
Mesothelin Expression in Human Tumors: A Tissue Microarray Study on 12,679 Tumors
10.3390/biomedicines9040397 · ExternalCitation · doi-reference
Hinge and Transmembrane Domains of Chimeric Antigen Receptor Regulate Receptor Expression and Signaling Threshold
10.3390/cells9051182 · ExternalCitation · doi-reference
A Comprehensive Review of HER2 in Cancer Biology and Therapeutics
10.3390/genes15070903 · ExternalCitation · doi-reference
The Effects of Chimeric Antigen Receptor (CAR) Hinge Domain Post-Translational Modifications on CAR-T Cell Activity
10.3390/ijms23074056 · ExternalCitation · doi-reference
Genetically encoded Forster resonance energy transfer sensors for the conformation of the Src family kinase Lck
10.4049/jimmunol.0802639 · ExternalCitation · doi-reference
Advancing Cancer Immunotherapy: Chimeric Antigen Receptor (CAR)-T Cell Engineering through Novel Screening Methods
10.4062/biomolther.2025.204 · ExternalCitation · doi-reference
