Research graph
References from Sensor-Integrated Organ-on-a-Chip Platforms: Advances in Drug Evaluation and Disease Modeling. Local targets link to admitted publications; unresolved targets remain external evidence.
Drug Screening and Evaluative Procedures: Current Approaches Do Not Provide the Information Needed for Properly Predicting Drug Effects in Man
10.1126/science.136.3511.123 · 1962 · External reference
Animal Models of Drug-Resistant Epilepsy as Tools for Deciphering the Cellular and Molecular Mechanisms of Pharmacoresistance and Discovering More Effective Treatments
10.3390/cells12091233 · 2023 · External reference
Principles of Early Drug Discovery
10.1111/j.1476-5381.2010.01127.x · 2011 · External reference
Asthma: The Use of Animal Models and Their Translational Utility
10.3390/cells12071091 · 2023 · External reference
Animal Models of Human Disease: Challenges in Enabling Translation
10.1016/j.bcp.2013.08.006 · 2014 · External reference
Organs-on-Chips: Into the next Decade
10.1038/s41573-020-0079-3 · 2021 · External reference
Use of Animals in Experimental Research: An Ethical Dilemma?
10.1038/sj.gt.3302371 · 2004 · External reference
Human Organs-on-Chips for Disease Modelling, Drug Development and Personalized Medicine
10.1038/s41576-022-00466-9 · 2022 · External reference
Screening out Irrelevant Cell-Based Models of Disease
10.1038/nrd.2016.175 · 2016 · External reference
Lab-on-a-Chip Platforms as Tools for Drug Screening in Neuropathologies Associated with Blood-Brain Barrier Alterations
10.3390/biom11060916 · 2021 · External reference
Modelling Cancer in Microfluidic Human Organs-on-Chips
10.1038/s41568-018-0104-6 · 2019 · External reference
Drug Repurposing Screening and Mechanism Analysis Based on Human Colorectal Cancer Organoids
10.1093/procel/pwad038 · 2024 · External reference
Microphysiological Systems (“Organs-on-Chips”) for Drug Efficacy and Toxicity Testing
10.1111/cts.12444 · 2017 · External reference
Organs-on-a-Chip Module: A Review from the Development and Applications Perspective
10.3390/mi9100536 · 2018 · External reference
Organs-on-Chips Technologies – A Guide from Disease Models to Opportunities for Drug Development
10.1016/j.bios.2023.115271 · 2023 · External reference
In Vitro Metabolic Activation of Vitamin D3 by Using a Multi-Compartment Microfluidic Liver-Kidney Organ on Chip Platform
10.1038/s41598-019-40851-9 · 2019 · External reference
Microfluidic Organs-on-Chips
10.1038/nbt.2989 · 2014 · External reference
Integrating Biosensors in Organs-on-Chip Devices: A Perspective on Current Strategies to Monitor Microphysiological Systems
10.3390/bios10090110 · 2020 · External reference
Patient-Specific Organoid and Organ-on-a-Chip: 3D Cell-Culture Meets 3D Printing and Numerical Simulation
10.1002/adbi.202000024 · 2021 · External reference
Effect of Fluid Shear Stress on the Internalization of Kidney-Targeted Delivery Systems in Renal Tubular Epithelial Cells
10.1016/j.apsb.2019.11.012 · 2020 · External reference
Simulating Drug Concentrations in PDMS Microfluidic Organ Chips
10.1039/d1lc00348h · 2021 · External reference
A New 3D Cultured Liver Chip and Real-Time Monitoring System Based on Microfluidic Technology
10.3390/mi11121118 · 2020 · External reference
High-Throughput Organ-on-Chip Platform with Integrated Programmable Fluid Flow and Real-Time Sensing for Complex Tissue Models in Drug Development Workflows†
10.1039/d1lc00067e · 2021 · External reference
Collagen I Based Enzymatically Degradable Membranes for Organ-on-a-Chip Barrier Models
10.1021/acsbiomaterials.0c00297 · 2021 · External reference
Functional Integration of Synthetic Cells into 3D Microfluidic Devices for Artificial Organ-On-Chip Technologies
10.1002/adhm.202303334 · 2024 · External reference
3D Bioprinted, Vascularized Neuroblastoma Tumor Environment in Fluidic Chip Devices for Precision Medicine Drug Testing
10.1088/1758-5090/ac5fb7 · 2022 · External reference
Stiffness of Hyaluronic Acid Gels Containing Liver Extracellular Matrix Supports Human Hepatocyte Function and Alters Cell Morphology
10.1016/j.jmbbm.2015.10.016 · 2016 · External reference
Bio-Functionalization of Microfluidic Platforms Made of Thermoplastic Materials: A Review
10.1016/j.aca.2021.339283 · 2022 · External reference
A Liver-on-a-Chip Platform with Bioprinted Hepatic Spheroids
10.1088/1758-5090/8/1/014101 · 2016 · External reference
Fabrication of a Hydroxyapatite-PDMS Microfluidic Chip for Bone-Related Cell Culture and Drug Screening
10.1016/j.bioactmat.2020.07.016 · 2021 · External reference
Second-Generation Lung-on-a-Chip with an Array of Stretchable Alveoli Made with a Biological Membrane
10.1038/s42003-021-01695-0 · 2021 · External reference
Advances in Organ-on-a-Chip Materials and Devices
10.1021/acsabm.2c00041 · 2022 · External reference
SEBS Elastomers for Fabrication of Microfluidic Devices with Reduced Drug Absorption by Injection Molding and Extrusion
10.1007/s10404-017-1941-4 · 2017 · External reference
Rapid Prototyping of PMMA-Based Microfluidic Spheroid-on-a-Chip Models Using Micromilling and Vapour-Assisted Thermal Bonding
10.1038/s41598-024-53266-y · 2024 · External reference
The Use of Sensors in Blood-Brain Barrier-on-a-Chip Devices: Current Practice and Future Directions
10.3390/bios13030357 · 2023 · External reference
DNA Separation with Low-Viscosity Sieving Matrix on Microfabricated Polycarbonate Microfluidic Chips
10.1007/s00216-004-2988-0 · 2005 · External reference
Thermal Scribing to Prototype Plastic Microfluidic Devices, Applied to Study the Formation of Neutrophil Extracellular Traps
10.1039/c7lc00356k · 2017 · External reference
Polylactic Is a Sustainable, Low Absorption, Low Autofluorescence Alternative to Other Plastics for Microfluidic and Organ-on-Chip Applications
10.1021/acs.analchem.0c00651 · 2020 · External reference
Trastuzumab-Targeted Biodegradable Nanoparticles for Enhanced Delivery of Dasatinib in HER2+ Metastasic Breast Cancer
10.3390/nano9121793 · 2019 · External reference
Fabrication and Customization of Highly Porous PLGA Membranes Utilizing Near-Field Electrospinning, Thermal Transitions, and Multilayer Strategies
10.1002/adem.202400917 · 2024 · External reference
Teflon Films for Chemically-Inert Microfluidic Valves and Pumps
10.1039/b800600h · 2008 · External reference
Development of a Pancreas-Liver Organ-on-Chip Coculture Model for Organ-to-Organ Interaction Studies
10.1016/j.bej.2020.107783 · 2020 · External reference
Multiplexed Blood–Brain Barrier Organ-on-Chip
10.1039/d0lc00399a · 2020 · External reference
Photo-Curing 3D Printing Technique and Its Challenges
10.1016/j.bioactmat.2019.12.003 · 2020 · External reference
Lung on a Chip Development from Off-Stoichiometry Thiol–Ene Polymer
10.3390/mi12050546 · 2021 · External reference
A Three-Tiered Colloidosomal Microreactor for Continuous Flow Catalysis
10.1038/s41467-021-26381-x · 2021 · External reference
InVADE: Integrated Vasculature for Assessing Dynamic Events
10.1002/adfm.201703524 · 2017 · External reference
Rapid Automated Production of Tubular 3D Intestine-on-a-Chip with Diverse Cell Types Using Coaxial Bioprinting
10.1039/d4lc00731j · 2024 · External reference
Bioprinting of 3D Convoluted Renal Proximal Tubules on Perfusable Chips
10.1038/srep34845 · 2016 · External reference
Multisensor-Integrated Organs-on-Chips Platform for Automated and Continual in Situ Monitoring of Organoid Behaviors
10.1073/pnas.1612906114 · 2017 · External reference
Topography and Permeability Analyses of Vasculature-on-a-Chip Using Scanning Probe Microscopies
10.1002/adhm.202101186 · 2021 · External reference
Lubricant-Coated Organ-on-a-Chip for Enhanced Precision in Preclinical Drug Testing
10.1002/smll.202402431 · 2024 · External reference
Comprehensive Development in Organ-On-A-Chip Technology
10.1016/j.xphs.2021.07.014 · 2022 · External reference
Organ-on-a-Chip for Drug Screening: A Bright Future for Sustainability? A Critical Review
10.1021/acsbiomaterials.2c01454 · 2023 · External reference
Modeling Mucus Physiology and Pathophysiology in Human Organs-on- Chips
10.1016/j.addr.2022.114542 · 2022 · External reference
On-Chip Construction of Liver Lobules with Self-Assembled Perfusable Hepatic Sinusoid Networks
10.1021/acsami.1c00794 · 2021 · External reference
Electroacoustic Responsive Cochlea-on-a-Chip
10.1002/adma.202309002 · 2024 · External reference
Combined Effects of Electric Stimulation and Microgrooves in Cardiac Tissue-on-a-Chip for Drug Screening
10.1002/smtd.202000438 · 2020 · External reference
Personalized Glomerulus Chip Engineered from Stem Cell-Derived Epithelium and Vascular Endothelium
10.3390/mi12080967 · 2021 · External reference
Microfluidic Liver-on-a-Chip for Preclinical Drug Discovery
10.3390/pharmaceutics15041300 · 2023 · External reference
Building Three-Dimensional Lung Models for Studying Pharmacokinetics of Inhaled Drugs
10.1016/j.addr.2020.09.008 · 2021 · External reference
An Artificial Liver Sinusoid with a Microfluidic Endothelial-like Barrier for Primary Hepatocyte Culture
10.1002/bit.21360 · 2007 · External reference
Reproducing Human and Cross-Species Drug Toxicities Using a Liver-Chip
10.1126/scitranslmed.aax5516 · 2019 · External reference
Integrated in Vitro Models for Hepatic Safety and Metabolism: Evaluation of a Human Liver-Chip and Liver Spheroid
10.1007/s00204-019-02427-4 · 2019 · External reference
A 3D Bio-Printed Spheroids Based Perfusion in Vitro Liver on Chip for Drug Toxicity Assays
10.1016/j.cclet.2021.11.029 · 2022 · External reference
Liver-on-a-Chip‒Magnetic Nanoparticle Bound Synthetic Metalloporphyrin-Catalyzed Biomimetic Oxidation of a Drug in a Magnechip Reactor
10.3390/mi10100668 · 2019 · External reference
Development of Digital Organ-on-a-Chip to Assess Hepatotoxicity and Extracellular Vesicle-Based Anti-Liver Cancer Immunotherapy
10.1007/s42242-022-00188-1 · 2022 · External reference
A Human Liver Organoid Screening Platform for DILI Risk Prediction
10.1016/j.jhep.2023.01.019 · 2023 · External reference
Kidney Disease Modeling with Organoids and Organs-on-Chips
10.1146/annurev-bioeng-072623-044010 · 2024 · External reference
Efficient Drug Screening and Nephrotoxicity Assessment on Co-Culture Microfluidic Kidney Chip
10.1038/s41598-020-63096-3 · 2020 · External reference
Kidney-Based in Vitro Models for Drug-Induced Toxicity Testing
10.1007/s00204-019-02598-0 · 2019 · External reference
Pharmacokinetic Profile That Reduces Nephrotoxicity of Gentamicin in a Perfused Kidney-on-a-Chip
10.1088/1758-5090/8/1/015021 · 2016 · External reference
Implementation of a Human Renal Proximal Tubule on a Chip for Nephrotoxicity and Drug Interaction Studies
10.1016/j.xphs.2021.01.028 · 2021 · External reference
Mature Induced-Pluripotent-Stem-Cell-Derived Human Podocytes Reconstitute Kidney Glomerular-Capillary-Wall Function on a Chip
10.1038/s41551-017-0069 · 2017 · External reference
Multi-Lineage Heart-Chip Models Drug Cardiotoxicity and Enhances Maturation of Human Stem Cell-Derived Cardiovascular Cells
10.1039/d3lc00745f · 2024 · External reference
Reconstituting Organ-Level Lung Functions on a Chip
10.1126/science.1188302 · 2010 · External reference
HiPSC-Derived Multi-Organoids-on-Chip System for Safety Assessment of Antidepressant Drugs
10.1039/d0lc00921k · 2021 · External reference
Organ Chips with Integrated Multifunctional Sensors Enable Continuous Metabolic Monitoring at Controlled Oxygen Levels
10.1016/j.bios.2024.116683 · 2024 · External reference
A Closed-Loop Modular Multiorgan-on-Chips Platform for Self-Sustaining and Tightly Controlled Oxygenation
10.1073/pnas.2413684121 · 2024 · External reference
A Multi-Organ Chip with Matured Tissue Niches Linked by Vascular Flow
10.1038/s41551-022-00882-6 · 2022 · External reference
Multi-Organs-on-Chips: Towards Long-Term Biomedical Investigations
10.3390/molecules24040675 · 2019 · External reference
Chip-Based Human Liver–Intestine and Liver–Skin Co-Cultures – A First Step toward Systemic Repeated Dose Substance Testing in Vitro
10.1016/j.ejpb.2015.03.002 · 2015 · External reference
A Four-Organ-Chip for Interconnected Long-Term Co-Culture of Human Intestine, Liver, Skin and Kidney Equivalents
10.1039/c5lc00392j · 2015 · External reference
Multi-Organ Toxicity Demonstration in a Functional Human in Vitro System Composed of Four Organs
10.1038/srep20030 · 2016 · External reference
Quantitative Prediction of Human Pharmacokinetic Responses to Drugs via Fluidically Coupled Vascularized Organ Chips
10.1038/s41551-019-0498-9 · 2020 · External reference
Repeated Dose Multi-Drug Testing Using a Microfluidic Chip-Based Coculture of Human Liver and Kidney Proximal Tubules Equivalents
10.1038/s41598-020-65817-0 · 2020 · External reference
Investigation of Absorption, Metabolism and Toxicity of Ginsenosides Compound K Based on Human Organ Chips
10.1016/j.ijpharm.2020.119669 · 2020 · External reference
Multi-Tissue Interactions in an Integrated Three-Tissue Organ-on-a-Chip Platform
10.1038/s41598-017-08879-x · 2017 · External reference
Assessing Immune Hepatotoxicity of Troglitazone with a Versatile Liver-Immune-Microphysiological-System
10.3389/fphar.2024.1335836 · 2024 · External reference
Intestinal Organ Chips for Disease Modelling and Personalized Medicine
10.1038/s41575-024-00968-3 · 2024 · External reference
Direct Imaging and Automatic Analysis in Tumor-on-Chip Reveal Cooperative Antitumoral Activity of Immune Cells and Oncolytic Vaccinia Virus
10.1016/j.bios.2022.114571 · 2022 · External reference
Evaluation of Hepatic Drug-Metabolism for Glioblastoma Using Liver-Brain Chip
10.1007/s10529-020-03043-4 · 2021 · External reference
3D Microengineered Vascularized Tumor Spheroids for Drug Delivery and Efficacy Testing
10.1016/j.actbio.2022.10.009 · 2023 · External reference
Plasma-Enhanced Protein Patterning in a Microfluidic Compartmentalized Platform for Multi-Organs-on-Chip: A Liver-Tumor Model
10.1088/1748-605x/ac0454 · 2021 · External reference
Characterising a PDMS Based 3D Cell Culturing Microfluidic Platform for Screening Chemotherapeutic Drug Cytotoxic Activity
10.1038/s41598-020-72952-1 · 2020 · External reference
Organoid Cultures for Cancer Modeling
10.1016/j.stem.2023.05.012 · 2023 · External reference
Organotypic Cancer Tissue Models for Drug Screening: 3D Constructs, Bioprinting and Microfluidic Chips
10.1016/j.drudis.2020.03.002 · 2020 · External reference
Endothelial Regulation of Drug Transport in a 3D Vascularized Tumor Model
10.1002/adfm.202002444 · 2020 · External reference
A Cellular Chip-MS System for Investigation of Lactobacillus Rhamnosus GG and Irinotecan Synergistic Effects on Colorectal Cancer
10.1016/j.cclet.2021.08.041 · 2022 · External reference
Multiorgan Microfluidic Platform with Breathable Lung Chamber for Inhalation or Intravenous Drug Screening and Development
10.1002/bit.27188 · 2020 · External reference
Trained Immunity in Chronic Inflammatory Diseases and Cancer
10.1038/s41577-025-01132-x · 2025 · External reference
Small Airway-on-a-Chip Enables Analysis of Human Lung Inflammation and Drug Responses in Vitro
10.1038/nmeth.3697 · 2016 · External reference
Modeling Pulmonary Cystic Fibrosis in a Human Lung Airway-on-a-Chip
10.1016/j.jcf.2021.10.004 · 2022 · External reference
Human Mesenchymal Stem Cell-derived Miniature Joint System for Disease Modeling and Drug Testing
10.1002/advs.202105909 · 2022 · External reference
Analysis of Drug Efficacy for Inflammatory Skin on an Organ-Chip System
10.3389/fbioe.2022.939629 · 2022 · External reference
A Human-Airway-on-a-Chip for the Rapid Identification of Candidate Antiviral Therapeutics and Prophylactics
10.1038/s41551-021-00718-9 · 2021 · External reference
Biomimetic Human Disease Model of SARS-CoV-2-Induced Lung Injury and Immune Responses on Organ Chip System
10.1002/advs.202002928 · 2021 · External reference
Unresolved reference
External reference
Integrated Experimental-Computational Analysis of a HepaRG Liver-Islet Microphysiological System for Human-Centric Diabetes Research
10.1371/journal.pcbi.1010587 · 2022 · External reference
Normoglycemia and Physiological Cortisone Level Maintain Glucose Homeostasis in a Pancreas-Liver Microphysiological System
10.1038/s42003-024-06514-w · 2024 · External reference
Implantable Vascularized Liver Chip for Cross-validation of Disease Treatment with Animal Model
10.1002/adfm.201900075 · 2019 · External reference
Standard: Human Intestine-on-a-Chip
10.1186/s13619-024-00198-7 · 2024 · External reference
