Research graph
References from Structure-Guided Engineering of Amine Dehydrogenase for Chiral Bulky <i>β</i> -Aryl Amine Synthesis: Dynamic Loop-to-Helix Shift and Hydrogen-Bond Network Reconstruction. Local targets link to admitted publications; unresolved targets remain external evidence.
Activation and stabilization of engineered amine dehydrogenase by fatty acids for bioprocess intensification of asymmetric reductive amination
10.1021/acscatal.4c05904 · 2025 · External reference
Direct asymmetric reductive amination for the synthesis of chiral β-arylamines
10.1002/anie.201601025 · 2016 · External reference
Asymmetric reductive amination of structurally diverse ketones with ammonia using a spectrum-extended amine dehydrogenase
10.1021/acscatal.1c04324 · 2021 · External reference
Direct synthesis of chiral β-arylamines via additive-free asymmetric reductive amination enabled by tunable bulky phosphoramidite ligands
10.1039/d4sc04416a · 2024 · External reference
Access to axially chiral biaryl benzylamines via ancestral enzyme-enabled reductive amination desymmetrization
10.1021/acscatal.4c06881 · 2025 · External reference
Organocatalytic asymmetric α-C–H functionalization of alkyl amines
10.1038/s41929-024-01230-4 · 2024 · External reference
Biocatalytic desymmetrization for the atroposelective synthesis of axially chiral biaryls using an engineered imine reductase
10.1002/anie.202416569 · 2025 · External reference
Biocatalytic formal regio- and enantioselective markovnikov hydroamination of aryl alkenes to chiral amines
10.1039/d3gc01030a · 2023 · External reference
Modular access to chiral α-(hetero)aryl amines via Ni/photoredox-catalyzed enantioselective cross-coupling
10.1021/jacs.2c0279 · 2022 · External reference
Enantioselective intramolecular α-arylation of benzylamine derivatives: Synthesis of a precursor to levocetirizine
10.1002/anie.202216758 · 2023 · External reference
Nickel-catalyzed enantioselective reductive arylation and heteroarylation of aldimines via an elementary 1,4-addition
10.1021/jacs.3c00548 · 2023 · External reference
Organocatalytic aromatization-promoted umpolung reaction of imines
10.1038/s41557-023-01384-x · 2024 · External reference
A family of native amine dehydrogenases for the asymmetric reductive amination of ketones
10.1038/s41929-019-0249-z · 2019 · External reference
An engineered imine reductase for highly diastereo- and enantioselective synthesis of β-branched amines with contiguous stereocenters
10.1002/anie.202408686 · 2024 · External reference
The combination of asymmetric hydrogenation of olefins and direct reductive amination
10.1038/s41467-020-14475-x · 2020 · External reference
Expanding chemistry through in vitro and in vivo biocatalysis
10.1038/s41586-024-07506-w · 2024 · External reference
Biocatalysis: Landmark discoveries and applications in chemical synthesis
10.1039/d3cs00689a · 2024 · External reference
From nature to industry: Harnessing enzymes for biocatalysis
10.1126/science.adh8615 · External reference
Light-driven synthesis of 2-aminoethanol from formaldehyde and ammonia
10.1021/acscatal.5c00337 · 2025 · External reference
Discovery of an imine reductase for reductive amination of carbonyl compounds with sterically challenging amines
10.1021/jacs.2c11354 · 2023 · External reference
Structure-guided design of a Zbasic2-mediated dual-enzyme nanoreactor for chiral amine synthesis
10.1016/j.ijbiomac.2024.139052 · 2025 · External reference
Amine dehydrogenases: Current status and potential value for chiral amine synthesis
10.1016/j.checat.2022.03.018 · 2022 · External reference
Integrating au catalysis and engineered amine dehydrogenase for the chemoenzymatic synthesis of chiral aliphatic amines
10.1021/jacsau.4c00222 · 2024 · External reference
Current status of amine dehydrogenases: From active site architecture to diverse applications across a broad substrate spectrum
10.1002/cctc.202400469 · 2024 · External reference
Biocatalytic reductive aminations with NAD(P)H-dependent enzymes: Enzyme discovery, engineering and synthetic applications
10.1039/d3cs00391d · 2024 · External reference
A refined picture of the native amine dehydrogenase family revealed by extensive biodiversity screening
10.1038/s41467-024-49009-2 · 2024 · External reference
Substrate-specific evolution of amine dehydrogenases for accessing structurally diverse enantiopure (R)-β-amino alcohols
10.1021/acscatal.3c04995 · 2024 · External reference
Direct asymmetric reductive amination of alkyl (hetero)aryl ketones by an engineered amine dehydrogenase
10.1002/anie.202202264 · 2022 · External reference
Shield machine-like substrate walking strategy-based pocket engineering of F-amine dehydrogenase for accessing structurally diverse fused-ring and linked-ring aryl ketones
10.1021/acscatal.4c00068 · 2024 · External reference
Unlocking the substrate acceptance of phenylalanine amine dehydrogenase enables the asymmetric synthesis of pharmaceutical n-heterocyclic primary amines
10.1021/acscatal.4c06478 · 2025 · External reference
NAD(P)H-dependent dehydrogenases for the asymmetric reductive amination of ketones: Structure, mechanism, evolution and application
10.1002/adsc.201700356 · 2017 · External reference
Engineering the substrate acceptance of L-amine dehydrogenase enables the collective biocatalytic synthesis of N-heterocyclic primary amines
10.1016/j.cej.2024.151735 · 2024 · External reference
The evolution of an amine dehydrogenase biocatalyst for the asymmetric production of chiral amines
10.1002/adsc.201201030 · 2013 · External reference
Revisiting the ramachandran plot based on statistical analysis of static and dynamic characteristics of protein structures
10.1016/j.jsb.2023.107939 · 2023 · External reference
Reshaping substrate-binding pocket of leucine dehydrogenase for bidirectionally accessing structurally diverse substrates
10.1021/acscatal.2c04735 · 2023 · External reference
Redesigning an (R)-selective transaminase for the efficient synthesis of pharmaceutical N-heterocyclic amines
10.1021/acscatal.2c05177 · 2023 · External reference
Hierarchical engineering of meso-diaminopimelate dehydrogenase for efficient synthesis of bulky D-amino acids
10.1021/acscatal.4c03164 · 2024 · External reference
Engineered cytochrome P450 for direct arylalkene-to-ketone oxidation via highly reactive carbocation intermediates
10.1038/s41929-023-00979-4 · 2023 · External reference
De novo synthesis of enzyme-embedded covalent organic frameworks (COFs) using deep eutectic solvent: Pushing the cof limits
10.1016/j.cej.2022.141058 · 2023 · External reference
Enabling sustainable chemistry with ionic liquids and deep eutectic solvents: A fad or the future?
10.1002/anie.202205609 · 2022 · External reference
Corner engineering: Tailoring enzymes for enhanced resistance and thermostability in deep eutectic solvents
10.1002/anie.202315125 · 2024 · External reference
Fenfluramine: An effective treatment for developmental epileptic encephalopathies beyond dravet and lennox–gastaut syndromes
10.1007/s00415-025-13135-8 · 2025 · External reference
Glycopyrronium/formoterol: A review in copd
10.1007/s40265-019-01186-x · 2019 · External reference
Improvement of the cardiovascular effect of methyldopa by complexation with Zn(ii): Synthesis, characterization and mechanism of action
10.1016/j.jtemb.2023.127327 · 2024 · External reference
Carbidopa ameliorates high-fat diet-induced insulin resistance by suppressing gut-derived tryptamine/phenethylamine and systemic 5-HT levels
10.1016/j.bbrc.2025.152234 · 2025 · External reference
Relevance of mexiletine in the era of evolving antiarrhythmic therapy of ventricular arrhythmias
10.1007/s00392-024-02383-9 · 2024 · External reference
The evolution of an amine dehydrogenase biocatalyst for the asymmetric production of chiral amines
10.1002/adsc.201201030 · ExternalCitation · doi-reference
NAD(P)H-dependent dehydrogenases for the asymmetric reductive amination of ketones: Structure, mechanism, evolution and application
10.1002/adsc.201700356 · ExternalCitation · doi-reference
Direct asymmetric reductive amination for the synthesis of chiral β-arylamines
10.1002/anie.201601025 · ExternalCitation · doi-reference
Direct asymmetric reductive amination of alkyl (hetero)aryl ketones by an engineered amine dehydrogenase
10.1002/anie.202202264 · ExternalCitation · doi-reference
Enabling sustainable chemistry with ionic liquids and deep eutectic solvents: A fad or the future?
10.1002/anie.202205609 · ExternalCitation · doi-reference
Enantioselective intramolecular α-arylation of benzylamine derivatives: Synthesis of a precursor to levocetirizine
10.1002/anie.202216758 · ExternalCitation · doi-reference
Corner engineering: Tailoring enzymes for enhanced resistance and thermostability in deep eutectic solvents
10.1002/anie.202315125 · ExternalCitation · doi-reference
An engineered imine reductase for highly diastereo- and enantioselective synthesis of β-branched amines with contiguous stereocenters
10.1002/anie.202408686 · ExternalCitation · doi-reference
Biocatalytic desymmetrization for the atroposelective synthesis of axially chiral biaryls using an engineered imine reductase
10.1002/anie.202416569 · ExternalCitation · doi-reference
Current status of amine dehydrogenases: From active site architecture to diverse applications across a broad substrate spectrum
10.1002/cctc.202400469 · ExternalCitation · doi-reference
Relevance of mexiletine in the era of evolving antiarrhythmic therapy of ventricular arrhythmias
10.1007/s00392-024-02383-9 · ExternalCitation · doi-reference
Fenfluramine: An effective treatment for developmental epileptic encephalopathies beyond dravet and lennox–gastaut syndromes
10.1007/s00415-025-13135-8 · ExternalCitation · doi-reference
Glycopyrronium/formoterol: A review in copd
10.1007/s40265-019-01186-x · ExternalCitation · doi-reference
Carbidopa ameliorates high-fat diet-induced insulin resistance by suppressing gut-derived tryptamine/phenethylamine and systemic 5-HT levels
10.1016/j.bbrc.2025.152234 · ExternalCitation · doi-reference
De novo synthesis of enzyme-embedded covalent organic frameworks (COFs) using deep eutectic solvent: Pushing the cof limits
10.1016/j.cej.2022.141058 · ExternalCitation · doi-reference
Engineering the substrate acceptance of L-amine dehydrogenase enables the collective biocatalytic synthesis of N-heterocyclic primary amines
10.1016/j.cej.2024.151735 · ExternalCitation · doi-reference
Amine dehydrogenases: Current status and potential value for chiral amine synthesis
10.1016/j.checat.2022.03.018 · ExternalCitation · doi-reference
Structure-guided design of a Zbasic2-mediated dual-enzyme nanoreactor for chiral amine synthesis
10.1016/j.ijbiomac.2024.139052 · ExternalCitation · doi-reference
Revisiting the ramachandran plot based on statistical analysis of static and dynamic characteristics of protein structures
10.1016/j.jsb.2023.107939 · ExternalCitation · doi-reference
Improvement of the cardiovascular effect of methyldopa by complexation with Zn(ii): Synthesis, characterization and mechanism of action
10.1016/j.jtemb.2023.127327 · ExternalCitation · doi-reference
Asymmetric reductive amination of structurally diverse ketones with ammonia using a spectrum-extended amine dehydrogenase
10.1021/acscatal.1c04324 · ExternalCitation · doi-reference
Reshaping substrate-binding pocket of leucine dehydrogenase for bidirectionally accessing structurally diverse substrates
10.1021/acscatal.2c04735 · ExternalCitation · doi-reference
Redesigning an (R)-selective transaminase for the efficient synthesis of pharmaceutical N-heterocyclic amines
10.1021/acscatal.2c05177 · ExternalCitation · doi-reference
Substrate-specific evolution of amine dehydrogenases for accessing structurally diverse enantiopure (R)-β-amino alcohols
10.1021/acscatal.3c04995 · ExternalCitation · doi-reference
Shield machine-like substrate walking strategy-based pocket engineering of F-amine dehydrogenase for accessing structurally diverse fused-ring and linked-ring aryl ketones
10.1021/acscatal.4c00068 · ExternalCitation · doi-reference
Hierarchical engineering of meso-diaminopimelate dehydrogenase for efficient synthesis of bulky D-amino acids
10.1021/acscatal.4c03164 · ExternalCitation · doi-reference
Activation and stabilization of engineered amine dehydrogenase by fatty acids for bioprocess intensification of asymmetric reductive amination
10.1021/acscatal.4c05904 · ExternalCitation · doi-reference
Unlocking the substrate acceptance of phenylalanine amine dehydrogenase enables the asymmetric synthesis of pharmaceutical n-heterocyclic primary amines
10.1021/acscatal.4c06478 · ExternalCitation · doi-reference
Access to axially chiral biaryl benzylamines via ancestral enzyme-enabled reductive amination desymmetrization
10.1021/acscatal.4c06881 · ExternalCitation · doi-reference
Light-driven synthesis of 2-aminoethanol from formaldehyde and ammonia
10.1021/acscatal.5c00337 · ExternalCitation · doi-reference
Modular access to chiral α-(hetero)aryl amines via Ni/photoredox-catalyzed enantioselective cross-coupling
10.1021/jacs.2c0279 · ExternalCitation · doi-reference
Discovery of an imine reductase for reductive amination of carbonyl compounds with sterically challenging amines
10.1021/jacs.2c11354 · ExternalCitation · doi-reference
Nickel-catalyzed enantioselective reductive arylation and heteroarylation of aldimines via an elementary 1,4-addition
10.1021/jacs.3c00548 · ExternalCitation · doi-reference
Integrating au catalysis and engineered amine dehydrogenase for the chemoenzymatic synthesis of chiral aliphatic amines
10.1021/jacsau.4c00222 · ExternalCitation · doi-reference
The combination of asymmetric hydrogenation of olefins and direct reductive amination
10.1038/s41467-020-14475-x · ExternalCitation · doi-reference
A refined picture of the native amine dehydrogenase family revealed by extensive biodiversity screening
10.1038/s41467-024-49009-2 · ExternalCitation · doi-reference
Organocatalytic aromatization-promoted umpolung reaction of imines
10.1038/s41557-023-01384-x · ExternalCitation · doi-reference
Expanding chemistry through in vitro and in vivo biocatalysis
10.1038/s41586-024-07506-w · ExternalCitation · doi-reference
A family of native amine dehydrogenases for the asymmetric reductive amination of ketones
10.1038/s41929-019-0249-z · ExternalCitation · doi-reference
Engineered cytochrome P450 for direct arylalkene-to-ketone oxidation via highly reactive carbocation intermediates
10.1038/s41929-023-00979-4 · ExternalCitation · doi-reference
Organocatalytic asymmetric α-C–H functionalization of alkyl amines
10.1038/s41929-024-01230-4 · ExternalCitation · doi-reference
Biocatalytic reductive aminations with NAD(P)H-dependent enzymes: Enzyme discovery, engineering and synthetic applications
10.1039/d3cs00391d · ExternalCitation · doi-reference
Biocatalysis: Landmark discoveries and applications in chemical synthesis
10.1039/d3cs00689a · ExternalCitation · doi-reference
Biocatalytic formal regio- and enantioselective markovnikov hydroamination of aryl alkenes to chiral amines
10.1039/d3gc01030a · ExternalCitation · doi-reference
Direct synthesis of chiral β-arylamines via additive-free asymmetric reductive amination enabled by tunable bulky phosphoramidite ligands
10.1039/d4sc04416a · ExternalCitation · doi-reference
From nature to industry: Harnessing enzymes for biocatalysis
10.1126/science.adh8615 · ExternalCitation · doi-reference
