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References from A New-Class Antibacterial─Almost. Lessons in Drug Discovery and Development: A Critical Analysis of More than 50 Years of Effort toward ATPase Inhibitors of DNA Gyrase and Topoisomerase IV. Local targets link to admitted publications; unresolved targets remain external evidence.
Unresolved reference
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Unresolved reference
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Clinical observations on the use of novobiocin in penicillin-resistant staphylococcal septicemia
1957 · External reference
The common identity of cathomycin and Streptonivicin
1955 · External reference
Antibacterial activity of Streptonivicin and cathomycin, two new antibiotics
1956 · External reference
Novobiocin and several of its derivatives
1956 · External reference
Two new antibiotics: antibacterial activity of novobiocin and vancomycin
10.1016/s0140-6736(56)90052-6 · 1956 · External reference
Current therapeutics. CXIV. Novobiocin
1957 · External reference
Studies on coumermycin, a new Antibiotic. I. Production, isolation and characterization of coumermycin A1
1965 · External reference
Novobiocin
10.1159/000386637 · 1957 · External reference
Some aspects of novobiocin action on Escherichia coli and Staphylococcus aureus
10.1007/bf02146985 · 1968 · External reference
Novobiocin
1959 · External reference
The current status of erythromycin, kanamycin, novobiocin, oleandomycin, ristocetin, and vancomycin, with particular reference to their use in staphylococcal disease; panel discussion
1959 · External reference
Clinical effectiveness and safety of novobiocin
1956 · External reference
Coumarin-glycoside antibiotics
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The panalba story.
1969 · External reference
FDA and Panalba: a conflict of commercial, therapeutic goals?
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Novobiocin; serum concentrations and urinary excretion following oral administration in man
1956 · External reference
A clinical evaluation of the parenteral use of novobiocin
10.1097/00000441-195809000-00007 · 1958 · External reference
Clinical and laboratory studies of novobiocin, a new antibiotic
10.1001/archinte.1956.00250250007001 · 1956 · External reference
Agranulocytosis associated with novobiocin administration: report of a case
10.7326/0003-4819-46-4-778 · 1957 · External reference
Novobiocin jaundice: demonstration of a hemolytic state
1960 · External reference
Randomized double-blinded trial of rifampin with either novobiocin or trimethoprim-sulfamethoxazole against methicillin-resistant Staphylococcus aureus colonization: prevention of antimicrobial resistance and effect of host factors on outcome
10.1128/aac.37.6.1334 · 1993 · External reference
Novobiocin in combination with high-dose chemotherapy for the treatment of advanced breast cancer: a phase 2 study
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10.1177/006947706900700119 · 1969 · External reference
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Structure-activity relationships in chemically modified coumermycin
10.1351/pac197128040571 · 1971 · External reference
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10.7164/antibiotics.42.1379 · 1989 · External reference
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10.1016/s0960-894x(01)80578-3 · 1994 · External reference
Activity of novobiocin against methicillin-resistant Staphylococcus aureus
10.1093/jac/15.4.435 · 1985 · External reference
Should novobiocin be clinically re-evaluated?
10.1016/0732-8893(89)90105-3 · 1989 · External reference
Serum inhibitory and bactericidal activity against methicillin-resistant Staphylococcus aureus in volunteers receiving novobiocin and rifampin alone and in combination
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Cyclothialidine and its congeners: A new class of DNA gyrase inhibitors
10.1016/0163-7258(93)90017-8 · 1993 · External reference
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10.1128/aac.37.12.2656 · 1993 · External reference
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From the DNA gyrase inhibitor cyclothialidine to a new class of antibacterial agents
10.2533/000942903777679505 · 2003 · External reference
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Seco-cyclothialidines: new concise synthesis, inhibitory activity toward bacterial and human DNA topoisomerases, and antibacterial properties
10.1021/jm0010623 · 2001 · External reference
GyrB mutations in Staphylococcus aureus strains resistant to cyclothialidine, coumermycin, and novobiocin
10.1128/aac.40.4.1060 · 1996 · External reference
Mode of action of GR122222X, a novel inhibitor of bacterial DNA gyrase
10.1128/aac.40.2.473 · 1996 · External reference
The nature of inhibition of DNA gyrase by the coumarins and the cyclothialidines revealed by X-ray crystallography
10.1002/j.1460-2075.1996.tb00483.x · 1996 · External reference
New antibacterial agents derived from the DNA gyrase inhibitor cyclothialidine
10.1021/jm0310232 · 2004 · External reference
A new DNA gyrase inhibitor subclass of the cyclothialidine familybased on a bicyclic dilactam-lactone scaffold. Synthesis and antibacterial properties
10.1021/jm1014023 · 2011 · External reference
DNA gyrase: an enzyme that introduces superhelical turns into DNA
10.1073/pnas.73.11.3872 · 1976 · External reference
Novobiocin and coumermycin inhibit DNA supercoiling catalyzed by DNA gyrase
10.1073/pnas.73.12.4474 · 1976 · External reference
Nalidixic acid resistance: A second genetic character involved in DNA gyrase activity
10.1073/pnas.74.11.4772 · 1977 · External reference
New topoisomerase essential for chromosome segregation in E. coli
10.1016/0092-8674(90)90172-b · 1990 · External reference
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10.1016/s0021-9258(18)35660-6 · 1992 · External reference
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10.1128/aac.32.8.1192 · 1988 · External reference
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10.1128/jb.172.6.3481-3484.1990 · 1990 · External reference
Cloning and primary structure of Staphylococcus aureus DNA topoisomerase IV: a primary target of fluoroquinolones
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DNA gyrase and topoisomerase IV are dual targets of clinafloxacin action in Streptococcus pneumoniae
10.1128/aac.42.11.2810 · 1998 · External reference
Streptococcus pneumoniae DNA gyrase and topoisomerase IV: overexpression, purification, and differential inhibition by fluoroquinolones
10.1128/aac.43.5.1129 · 1999 · External reference
In front of and behind the replication fork: bacterial type IIA topoisomerases
10.1007/s00018-010-0299-5 · 2010 · External reference
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10.1038/nsmb.1604 · 2009 · External reference
Type IIA topoisomerase inhibition by a new class of antibacterial agents
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Mechanisms of action and resistance of older and newer fluoroquinolones
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10.1073/pnas.94.25.13991 · 1997 · External reference
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10.1128/aac.00596-06 · 2007 · External reference
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10.1093/jac/dkn528 · 2009 · External reference
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Fluoroquinolone resistance: mechanisms, impact on bacteria, and role in evolutionary success
10.1016/j.tim.2014.04.007 · 2014 · External reference
Studies on mutational cross-resistance between ciprofloxacin, novobiocin and coumermycin in Escherichia coli and Staphylococcus warneri
1993 · External reference
Effects of novobiocin, coumermycin A1, clorobiocin, and their analogs on Escherichia coli DNA gyrase and bacterial growth
10.1128/aac.22.4.662 · 1982 · External reference
Escherichia coli topoisomerase IV. Purification, characterization, subunit structure, and subunit interactions
10.1016/s0021-9258(20)80551-1 · 1993 · External reference
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10.1128/aac.50.4.1228-1237.2006 · 2006 · External reference
New aminocoumarin antibiotics as gyrase inhibitors
10.1016/j.ijmm.2013.08.013 · 2014 · External reference
Emergence and maintenance of resistance to fluoroquinolones and coumarins in Staphylococcus aureus: predictions from in vitro studies
10.1093/jac/dkm191 · 2007 · External reference
Accumulation of mutations in both gyrB and parE genes is associated with high-level resistance to novobiocin in Staphylococcus aureus
10.1128/aac.49.9.3810-3815.2005 · 2005 · External reference
Discovery of kibdelomycin, a potent new class of bacterial type II topoisomerase inhibitor by chemical-genetic profiling in Staphylococcus aureus
10.1016/j.chembiol.2011.06.011 · 2011 · External reference
Quinolone-mediated bacterial death
10.1128/aac.01617-06 · 2008 · External reference
Biological evaluation of benzothiazole ethyl urea inhibitors of bacterial type II topoisomerases
10.1128/aac.00719-13 · 2013 · External reference
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10.1093/jac/dku379 · 2014 · External reference
Clinical relevance of bacteriostatic versus bactericidal mechanisms of action in the treatment of Gram-positive bacterial infections
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Crystal structure of an N-terminal fragment of the DNA gyrase B protein
10.1038/351624a0 · 1991 · External reference
The high-resolution crystal structure of a 24-kDa gyrase B fragment from E. coli complexed with one of the most potent coumarin inhibitors, clorobiocin
10.1002/(sici)1097-0134(199705)28:1<41::aid-prot4>3.3.co;2-b · 1997 · External reference
Nucleotide-dependent domain movement in the ATPase domain of a human type IIA DNA topoisomerase
10.1074/jbc.m506520200 · 2005 · External reference
GHKL, an emergent ATPase/kinase superfamily
10.1016/s0968-0004(99)01503-0 · 2000 · External reference
In vivo function of Hsp90 is dependent on ATP binding and ATP hydrolysis
10.1083/jcb.143.4.901 · 1998 · External reference
Transformation of MutL by ATP binding and hydrolysis: a switch in DNA mismatch repair
10.1016/s0092-8674(00)80717-5 · 1999 · External reference
Structure and function of the N-terminal 40 kDa fragment of human PMS2: a monomeric GHL ATPase
10.1093/emboj/20.19.5521 · 2001 · External reference
Molecular basis of bacterial outer membrane permeability revisited
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10.1128/cmr.00030-10 · 2011 · External reference
Semisynthetic coumermycins: structure-activity relationships
10.1128/am.19.1.14-26.1970 · 1970 · External reference
Novenamine is the active moiety in novobiocin
1986 · External reference
Optimization of pyrrolamide topoisomerase II inhibitors toward identification of an antibacterial clinical candidate (AZD5099)
10.1021/jm500462x · 2014 · External reference
Discovery of a novel azaindole class of antibacterial agents targeting the ATPase domains of DNA gyrase and Topoisomerase IV
10.1016/j.bmcl.2012.05.128 · 2012 · External reference
Tricyclic GyrB/ParE (TriBE) inhibitors: a new class of broad-spectrum dual-targeting antibacterial agents
10.1371/journal.pone.0084409 · 2013 · External reference
Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE). Part I: Structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity
10.1016/j.bmcl.2012.11.032 · 2013 · External reference
Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE), Part II: development of inhibitors with broad spectrum, Gram-negative antibacterial activity
10.1016/j.bmcl.2012.11.073 · 2013 · External reference
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Penetration of lipophilic agents with multiple protonation sites into bacterial cells: tetracyclines and fluoroquinolones as examples
10.1128/aac.37.7.1393 · 1993 · External reference
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10.1021/jm700967e · 2008 · External reference
Outer membrane permeability and antibiotic resistance
10.1016/j.bbapap.2008.11.005 · 2009 · External reference
Substrate specificity and kinetics of bacterial transmembrane transporters
10.4172/2155-9585.1000e105 · 2012 · External reference
Kinetic behavior of the major multidrug efflux pump AcrB of Escherichia coli
10.1073/pnas.0901695106 · 2009 · External reference
Development of a liquid chromatography/mass spectrometry-based drug acumulation assay in Pseudomonas aeruginosa
10.1016/j.ab.2008.10.041 · 2009 · External reference
General platform for systematic quantitative evaluation of small-molecule permeability in bacteria
10.1021/cb5003015 · 2014 · External reference
Molecular determinants of AcrB-mediated bacterial efflux implications for drug discovery
10.1021/jm201275d · 2012 · External reference
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Structure-activity relationship in two series of aminoalkyl substituted coumarin inhibitors of gyrase B
10.1016/s0960-894x(99)00492-8 · 1999 · External reference
Synthesis and in vitro evaluation of novel highly potent coumarin inhibitors of gyrase B
10.1016/s0960-894x(99)00329-7 · 1999 · External reference
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10.1016/s0960-894x(99)00493-x · 1999 · External reference
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10.1016/s0960-894x(99)00654-x · 2000 · External reference
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Noviose mimics of the coumarin inhibitors of gyrase B
10.1016/j.tetlet.2003.10.076 · 2003 · External reference
Synthesis of the 4′-desmethoxy analogue of RU79115
10.2298/jsc0411855m · 2004 · External reference
Fine Tuning of physico-chemical parameters to optimize a new series of novobiocin analogues
10.1016/s0960-894x(01)00257-8 · 2001 · External reference
DNA gyrase interaction with coumarin-based inhibitors: the role of the hydroxybenzoate isopentenyl moiety and the 5′-methyl group of the noviose
10.1021/bi0159837 · 2002 · External reference
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10.1039/a700647k · 1997 · External reference
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10.1016/s0079-6468(08)70097-3 · 2001 · External reference
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10.1016/s0960-894x(00)00109-8 · 2000 · External reference
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Design, synthesis, and structure–activity relationship studies of new phenolic DNA gyrase inhibitors
10.1016/j.bmcl.2006.12.065 · 2007 · External reference
Potent DNA gyrase inhibitors; novel 5-vinylpyrazole analogues with Gram-positive antibacterial activity
10.1016/j.bmcl.2004.03.045 · 2004 · External reference
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Discovery of pyrazolthiazoles as novel and potent inhibitors of bacterial gyrase
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Structure-activity relationship (SAR): effort towards blocking N-glucuronidation of indazoles (PF-03376056) by human UGT1A enzymes
10.2174/187231209787176371 · 2009 · External reference
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Novel topoisomerase inhibitors: microbiological characterisation and in vivo efficacy of pyrimidines
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Distinguishing on-target versus off-target activity in early antibacterial drug discovery using a macromolecular synthesis assay
10.1177/1087057113487208 · 2013 · External reference
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10.1128/aac.05485-11 · 2012 · External reference
Pyrrolamide DNA gyrase inhibitors: optimization of antibacterial activity and efficacy
10.1016/j.bmcl.2011.10.010 · 2011 · External reference
Novel DNA gyrase inhibitors: microbiological characterisation of pyrrolamides
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Crystal structures of Escherichia coli topoisomerase IV ParE Subunit (24 and 43 Kilodaltons): a single residue dictates differences in novobiocin potency against topoisomerase IV and DNA gyrase
10.1128/aac.48.5.1856-1864.2004 · 2004 · External reference
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Drugs for bad bugs: confronting the challenges of antibacterial discovery
10.1038/nrd2201 · 2007 · External reference
Structures of kibdelomycin bound to Staphylococcus aureus GyrB and ParE showed a novel U-shaped binding mode
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Amycolamicin: a novel broad-spectrum antibiotic inhibiting bacterial topoisomerase
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Why is big Pharma getting out of antibacterial drug discovery?
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