Research graph
References from Chemical Genomics-Based Antifungal Drug Discovery: Targeting Glycosylphosphatidylinositol (GPI) Precursor Biosynthesis. Local targets link to admitted publications; unresolved targets remain external evidence.
Epidemiology of invasive candidiasis: a persistent public health problem
10.1128/cmr.00029-06 · 2007 · External reference
Hidden killers: human fungal infections
10.1126/scitranslmed.3004404 · 2012 · External reference
An insight into the antifungal pipeline: selected new molecules and beyond
10.1038/nrd3074 · 2010 · External reference
Antifungal drug development: challenges, unmet clinical needs, and new approaches
10.1101/cshperspect.a019703 · 2014 · External reference
Large-scale essential gene identification in Candida albicans and applications to antifungal drug discovery
10.1046/j.1365-2958.2003.03697.x · 2003 · External reference
Genome-wide fitness test and mechanism-of-action studies of inhibitory compounds in Candida albicans
10.1371/journal.ppat.0030092 · 2007 · External reference
Confronting the challenges of natural product-based antifungal discovery
10.1016/j.chembiol.2011.01.009 · 2011 · External reference
Quantitative phenotypic analysis of yeast deletion mutants using a highly parallel molecular bar-coding strategy
10.1038/ng1296-450 · 1996 · External reference
Genomic profiling of drug sensitivities via induced haploinsufficiency
10.1038/6791 · 1999 · External reference
PAP inhibitor with in vivo efficacy identified by Candida albicans genetic profiling of natural products
10.1016/j.chembiol.2008.02.016 · 2008 · External reference
Isolation, structure, and biological activities of fellutamides C and D from an undescribed Metulocladosporiella (Chaetothyriales) using the genome-wide Candida albicans fitness test
10.1021/np2001573 · 2011 · External reference
Mechanism-of-action determination of GMP synthase inhibitors and target validation in Candida albicans and Aspergillus fumigatus
10.1016/j.chembiol.2007.09.009 · 2007 · External reference
Chemical genetic profiling and characterization of small-molecule compounds that affect the biosynthesis of unsaturated fatty acids in Candida albicans
10.1074/jbc.m109.019877 · 2009 · External reference
Comprehensive analysis of glycosylphosphatidylinositol-anchored proteins in Candida albicans
10.1128/ec.00297-06 · 2007 · External reference
Biosynthesis and function of GPI proteins in the yeast Saccharomyces cerevisiae
10.1016/j.bbalip.2006.05.015 · 2007 · External reference
Covalently linked cell wall proteins of Candida albicans and their role in fitness and virulence
10.1111/j.1567-1364.2009.00541.x · 2009 · External reference
Thematic review series: Lipid posttranslational modifications. GPI anchoring of protein in yeast and mammalian cells, or: how we learned to stop worrying and love glycophospholipids
10.1194/jlr.r700002-jlr200 · 2007 · External reference
Identification of a species-specific inhibitor of glycosylphosphatidylinositol synthesis
10.1093/emboj/16.21.6374 · 1997 · External reference
A Glycosylphosphatidylinositol-anchoring inhibitor with an unusual tetracarboxocyclic sesterpene skeleton from the fungus Codinaea simplex
10.1016/s0040-4020(98)00322-6 · External reference
Pig-n, a mammalian homologue of yeast Mcd4p, is involved in transferring phosphoethanolamine to the first mannose of the glycosylphosphatidylinositol
10.1074/jbc.274.49.35099 · 1999 · External reference
In vivo characterization of the GPI assembly defect in yeast mcd4–174 mutants and bypass of the Mcd4p-dependent step in mcd4Delta cells
10.1111/j.1567-1364.2006.00139.x · 2007 · External reference
Medicinal genetics approach towards identifying the molecular target of a novel inhibitor of fungal cell wall assembly
10.1046/j.1365-2958.2003.03481.x · 2003 · External reference
MCD4 encodes a conserved endoplasmic reticulum membrane protein essential for glycosylphosphatidylinositol anchor synthesis in yeast
10.1091/mbc.10.3.627 · 1999 · External reference
The role of the beta-glucan receptor dectin-1 in control of fungal infection
10.1189/jlb.1206753 · 2007 · External reference
GWT1 gene is required for inositol acylation of glycosylphosphatidylinositol anchors in yeast
10.1074/jbc.m301044200 · 2003 · External reference
E1210, a new broad-spectrum antifungal, suppresses Candida albicans hyphal growth through inhibition of glycosylphosphatidylinositol biosynthesis
10.1128/aac.00731-11 · 2012 · External reference
Inhibiting GPI anchor biosynthesis in fungi stresses the endoplasmic reticulum and enhances immunogenicity
10.1021/cb300235m · 2012 · External reference
Bi-directional protein transport between the ER and Golgi
10.1146/annurev.cellbio.20.010403.105307 · 2004 · External reference
Sed4p stimulates Sar1p GTP hydrolysis and promotes limited coat disassembly
10.1111/j.1600-0854.2011.01173.x · 2011 · External reference
Coatomer is essential for retrieval of dilysine-tagged proteins to the endoplasmic reticulum
10.1016/0092-8674(94)90011-6 · 1994 · External reference
Rules for the recognition of dilysine retrieval motifs by coatomer
10.1038/emboj.2013.41 · 2013 · External reference
Molecular and phenotypic characterization of yeast PDR1 mutants that show hyperactive transcription of various ABC multidrug transporter genes
10.1007/s004380050584 · 1997 · External reference
Analysis of membrane topology and identification of essential residues for the yeast endoplasmic reticulum inositol acyltransferase Gwt1p
10.1074/jbc.m110.193490 · 2011 · External reference
Ethanolaminephosphate side chain added to glycosylphosphatidylinositol (GPI) anchor by mcd4p is required for ceramide remodeling and forward transport of GPI proteins from endoplasmic reticulum to Golgi
10.1074/jbc.m601425200 · 2006 · External reference
In vitro activity of E1210, a novel antifungal, against clinically important yeasts and molds
10.1128/aac.00291-11 · 2011 · External reference
Candida albicans cell wall glycans, host receptors and responses: elements for a decisive crosstalk
10.1016/j.mib.2004.06.011 · 2004 · External reference
A drug-sensitive genetic network masks fungi from the immune system
10.1371/journal.ppat.0020035 · 2006 · External reference
Role of anti-beta-glucan antibody in host defense against fungi
10.1016/j.femsim.2004.12.012 · 2005 · External reference
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Saccharomyces cerevisiae GPI10, the functional homologue of human PIG-B, is required for glycosylphosphatidylinositol-anchor synthesis
10.1042/bj3320153 · 1998 · External reference
The structure, biosynthesis and function of glycosylated phosphatidylinositols in the parasitic protozoa and higher eukaryotes
10.1042/bj2940305 · 1993 · External reference
Efficacy of oral E1210, a new broad-spectrum antifungal with a novel mechanism of action, in murine models of candidiasis, aspergillosis, and fusariosis
10.1128/aac.00366-11 · 2011 · External reference
Mapping the cellular response to small molecules using chemogenomic fitness signatures
10.1126/science.1250217 · 2014 · External reference
