Research graph
References from Covalent Modification of the Mycobacterium tuberculosis FAS-II Dehydratase by Isoxyl and Thiacetazone. Local targets link to admitted publications; unresolved targets remain external evidence.
Antimycobacterial activities of isoxyl and new derivatives through the inhibition of mycolic acid synthesis
10.1128/aac.43.5.1042 · 1999 · External reference
Mutations in the essential FAS II β-hydroxyacyl ACP dehydratase complex confer resistance to thiacetazone in Mycobacterium tuberculosis and Mycobacterium kansasii
10.1111/mmi.12005 · 2012 · External reference
Ethionamide activation and sensitivity in multidrug-resistant Mycobacterium tuberculosis
10.1073/pnas.97.17.9677 · 2000 · External reference
Oxidative activation of thiacetazone by the Mycobacterium tuberculosis flavin monooxygenase EtaA and human FMO1 and FMO3
10.1021/tx050328b · 2006 · External reference
EthA, a common activator of thiocarbamide-containing drugs acting on different mycobacterial targets
10.1128/aac.01063-06 · 2007 · External reference
Isoxyl activation is required for bacteriostatic activity against Mycobacterium tuberculosis
10.1128/aac.00433-07 · 2007 · External reference
Mycolic acid methyltransferase, MmaA4, is necessary for thiacetazone susceptibility in Mycobacterium tuberculosis
10.1111/j.1365-2958.2009.06604.x · 2009 · External reference
A common mechanism of inhibition of the Mycobacterium tuberculosis mycolic acid biosynthetic pathway by isoxyl and thiacetazone
10.1074/jbc.m112.400994 · 2012 · External reference
Effects of ethionamide and isoxyl on mycolic acid synthesis in Mycobacterium tuberculosis BCG
10.1099/00221287-66-3-379 · 1971 · External reference
inhA, a gene encoding a target for isoniazid and ethionamide in Mycobacterium tuberculosis
10.1126/science.8284673 · 1994 · External reference
Point mutations within the fatty acid synthase type II dehydratase components HadA or HadC contribute to isoxyl resistance in Mycobacterium tuberculosis
10.1128/aac.01972-12 · 2013 · External reference
Synthesis, antitubercular activity and mechanism of resistance of highly effective thiacetazone analogues
10.1371/journal.pone.0053162 · 2013 · External reference
The missing piece of the type II fatty acid synthase system from Mycobacterium tuberculosis
10.1073/pnas.0704132104 · 2007 · External reference
Protein-protein interactions within the fatty acid synthase-II system of Mycobacterium tuberculosis are essential for mycobacterial viability
10.1111/j.1365-2958.2004.04334.x · 2004 · External reference
The biosynthesis of mycolic acids in Mycobacterium tuberculosis relies on multiple specialized elongation complexes interconnected by specific protein-protein interactions
10.1016/j.jmb.2005.09.016 · 2005 · External reference
The Mycobacterium tuberculosis FAS-II dehydratases and methyltransferases define the specificity of the mycolic acid elongation complexes
10.1371/journal.pone.0029564 · 2011 · External reference
Mechanism of thioamide drug action against tuberculosis and leprosy
10.1084/jem.20062100 · 2007 · External reference
The structure-activity relationship of urea derivatives as anti-tuberculosis agents
10.1016/j.bmc.2011.07.034 · 2011 · External reference
The role of KasA and KasB in the biosynthesis of meromycolic acids and isoniazid resistance in Mycobacterium tuberculosis
10.1054/tube.2002.0333 · 2002 · External reference
Benzothiazinones: prodrugs that covalently modify the decaprenylphosphoryl-β-d-ribose 2′-epimerase DprE1 of Mycobacterium tuberculosis
10.1021/ja106357w · 2010 · External reference
Benzothiazinones are suicide inhibitors of mycobacterial decaprenylphosphoryl-β-d-ribofuranose 2′-oxidase DprE1
10.1021/ja211042r · 2012 · External reference
Structural basis for benzothiazinone-mediated killing of Mycobacterium tuberculosis
10.1126/scitranslmed.3004395 · 2012 · External reference
Structural basis of inhibition of Mycobacterium tuberculosis DprE1 by benzothiazinone inhibitors
10.1073/pnas.1205735109 · 2012 · External reference
Mechanism of inhibition of Mycobacterium tuberculosis antigen 85 by ebselen
10.1038/ncomms3748 · 2013 · External reference
