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References from Small-Molecule Modulators of HIPK4 Activity and Proteostasis. Local targets link to admitted publications; unresolved targets remain external evidence.
Intended and unintended pregnancies worldwide in 2012 and recent trends
10.1111/j.1728-4465.2014.00393.x · 2014 · External reference
Adverse events associated with testosterone administration
10.1056/nejmoa1000485 · 2010 · External reference
Male hormonal contraception: potential risks and benefits
10.1007/s11154-011-9183-3 · 2011 · External reference
Increased risk of non-fatal myocardial infarction following testosterone therapy prescription in men
10.1371/journal.pone.0085805 · 2014 · External reference
Oral administration of a retinoic Acid receptor antagonist reversibly inhibits spermatogenesis in mice
10.1210/en.2010-0941 · 2011 · External reference
Suppression of spermatogenesis by bisdichloroacetyldiamines is mediated by inhibition of testicular retinoic acid biosynthesis
10.2164/jandrol.110.010751 · 2011 · External reference
Small-molecule inhibition of BRDT for male contraception
10.1016/j.cell.2012.06.045 · 2012 · External reference
On-demand male contraception via acute inhibition of soluble adenylyl cyclase
10.1038/s41467-023-36119-6 · 2023 · External reference
Reversible male contraception by targeted inhibition of serine/threonine kinase 33
10.1126/science.adl2688 · 2024 · External reference
HIPK4 is essential for murine spermiogenesis
10.7554/elife.50209 · 2020 · External reference
Homeodomain-interacting protein kinase HIPK4 regulates phosphorylation of manchette protein RIMBP3 during spermiogenesis
10.1016/j.jbc.2022.102327 · 2022 · External reference
HIPK4 is a novel gene associated with teratozoospermia and male infertility
10.1093/hropen/hoag066 · 2026 · External reference
Novel homeodomain-interacting protein kinase family member, HIPK4, phosphorylates human p53 at serine 9
10.1016/j.febslet.2007.11.022 · 2007 · External reference
Homeodomain-interacting protein kinases, a novel family of co-repressors for homeodomain transcription factors
10.1074/jbc.273.40.25875 · 1998 · External reference
Activation of androgen receptor function by a novel nuclear protein kinase
10.1091/mbc.9.9.2527 · 1998 · External reference
Highly accurate protein structure prediction with AlphaFold
10.1038/s41586-021-03819-2 · 2021 · External reference
Effect of tyrosine autophosphorylation on catalytic activity and subcellular localisation of homeodomain-interacting protein kinases (HIPK)
10.1186/s12964-014-0082-6 · 2015 · External reference
Comprehensive kinase profile of pacritinib, a nonmyelosuppressive Janus kinase 2 inhibitor
10.2147/jep.s110702 · 2016 · External reference
Comprehensive analysis of kinase inhibitor selectivity
10.1038/nbt.1990 · 2011 · External reference
Unresolved reference
External reference
ADP-Glo: A Bioluminescent and homogeneous ADP monitoring assay for kinases
10.1089/adt.2009.0222 · 2009 · External reference
A conserved water-mediated hydrogen bond network defines bosutinib’s kinase selectivity
10.1038/nchembio.1404 · 2014 · External reference
Hybrid compound design to overcome the gatekeeper T338M mutation in cSrc
10.1021/jm9002928 · 2009 · External reference
Structure of the epidermal growth factor receptor kinase domain alone and in complex with a 4-anilinoquinazoline inhibitor
10.1074/jbc.m207135200 · 2002 · External reference
Quantitative, wide-spectrum kinase profiling in live cells for assessing the effect of cellular ATP on target engagement
10.1016/j.chembiol.2017.10.010 · 2018 · External reference
Back-pocket optimization of 2-aminopyrimidine-based macrocycles leads to potent EPHA2/GAK kinase inhibitors
10.1021/acs.jmedchem.4c00411 · 2024 · External reference
Development of pyrazolo[1,5-a]pyrimidine based macrocyclic kinase inhibitors targeting AAK1
10.1016/j.ejmech.2025.118076 · 2025 · External reference
PROTACs: past, present and future
10.1039/d2cs00193d · 2022 · External reference
Drug delivery challenges and formulation aspects of proteolysis targeting chimera (PROTACs)
10.1016/j.drudis.2022.103387 · 2023 · External reference
Quantitative Live-Cell Kinetic Degradation and Mechanistic Profiling of PROTAC Mode of Action
10.1021/acschembio.8b00692 · 2018 · External reference
Structural basis of thalidomide enantiomer binding to cereblon
10.1038/s41598-018-19202-7 · 2018 · External reference
Macrocyclization of broad-spectrum kinase inhibitor bosutinib leads to potent and selective quinoline-based HIPK4 inhibitor AZ137
10.1021/acs.jmedchem.6c01320 · 2026 · External reference
Mapping the degradable kinome provides a resource for expedited degrader development
10.1016/j.cell.2020.10.038 · 2020 · External reference
Autophagy regulates spermatid differentiation via degradation of PDLIM1
10.1080/15548627.2016.1192750 · 2016 · External reference
Autophagy core protein ATG5 is required for elongating spermatid development, sperm individualization and normal fertility in male mice
10.1080/15548627.2020.1783822 · 2021 · External reference
Structure-activity relationships for 4-anilinoquinazolines as potent inhibitors at the ATP binding site of the epidermal growth factor receptor in vitro
10.1111/j.1440-1681.1996.tb02752.x · 1996 · External reference
Inhibitors supercharge kinase turnover through native proteolytic circuits
10.1038/s41586-025-09763-9 · 2026 · External reference
Autoregulatory control of the p53 response by caspase-mediated processing of HIPK2
10.1038/sj.emboj.7601077 · 2006 · External reference
Reconstitution defines the roles of p62, NBR1 and TAX1BP1 in ubiquitin condensate formation and autophagy initiation
10.1038/s41467-021-25572-w · 2021 · External reference
Atg7 is required for acrosome biogenesis during spermatogenesis in mice
10.1038/cr.2014.70 · 2014 · External reference
Sirt1 regulates acrosome biogenesis by modulating autophagic flux during spermiogenesis in mice
10.1242/dev.147074 · 2017 · External reference
Autophagy: a multifaceted player in the fate of sperm
10.1093/humupd/dmab043 · 2022 · External reference
Autophagy core protein BECN1 is vital for spermatogenesis and male fertility in micedagger
10.1093/biolre/ioad160 · 2024 · External reference
Loss of ACTL7A causes small head sperm by defective acrosome-acroplaxome-manchette complex
10.1186/s12958-023-01130-5 · 2023 · External reference
The use of differential scanning fluorimetry to detect ligand interactions that promote protein stability
10.1038/nprot.2007.321 · 2007 · External reference
Single-plate kinome screening in live-cells to enable highly cost-efficient kinase inhibitor profiling
10.1016/j.slasd.2025.100214 · 2025 · External reference
Separation of spermatogenic cell types using STA-PUT velocity sedimentation
10.3791/50648 · 2013 · External reference