References

Liquid Crystals Based on Hypervalent Sulfur Fluorides: Pentafluorosulfuranyl as Polar Terminal Group

10.1002/(sici)1521-3773(19990712)38:13/14<1989::aid-anie1989>3.0.co;2-k · ExternalCitation · doi-reference

Synthesis of [2,3,3,2′,3′,5′,6′-2H7]-L-tyrosine from phenol-d6

10.1002/1099-1344(200008)43:9<917::aid-jlcr377>3.0.co;2-5 · ExternalCitation · doi-reference

Propellanes─From a Chemical Curiosity to “Explosive” Materials and Natural Products

10.1002/anie.201603951 · ExternalCitation · doi-reference

Electrochemically Enabled, Nickel-Catalyzed Amination

10.1002/anie.201707906 · ExternalCitation · doi-reference

Synthesis of BCP Benzylamines from 2-Azaallyl Anions and [1.1.1]Propellane

10.1002/anie.201810061 · ExternalCitation · doi-reference

Making the SF5 Group More Accessible: A Gas-Reagent-Free Approach to Aryl Tetrafluoro-λ6-sulfanyl Chlorides

10.1002/anie.201812356 · ExternalCitation · doi-reference

Enantioselective Copper(I)/Chiral Phosphoric Acid Catalyzed Intramolecular Amination of Allylic and Benzylic C–H Bonds

10.1002/anie.201911742 · ExternalCitation · doi-reference

Divergent Strain-Release Amino-Functionalization of [1.1.1]Propellane with Electrophilic Nitrogen-Radicals

10.1002/anie.202000140 · ExternalCitation · doi-reference

Synthesis of All-Carbon Disubstituted Bicyclo[1.1.1]pentanes by Iron-Catalyzed Kumada Cross-Coupling

10.1002/anie.202004090 · ExternalCitation · doi-reference

Flow Photochemistry for Single-Chain Polymer Nanoparticle Synthesis

10.1002/anie.202010429 · ExternalCitation · doi-reference

Visible-Light-Induced 1,3-Aminopyridylation of [1.1.1]Propellane with N-Aminopyridinium Salts

10.1002/anie.202016156 · ExternalCitation · doi-reference

Divergent, Strain-Release Reactions of Azabicyclo[1.1.0]butyl Carbinols: Semipinacol or Spiroepoxy Azetidine Formation

10.1002/anie.202100583 · ExternalCitation · doi-reference

Chemoselective Hydro(Chloro)pentafluorosulfanylation of Diazo Compounds with Pentafluorosulfanyl Chloride

10.1002/anie.202103606 · ExternalCitation · doi-reference

Electrophilic Activation of [1.1.1]Propellane for the Synthesis of Nitrogen-Substituted Bicyclo[1.1.1]pentanes

10.1002/anie.202111291 · ExternalCitation · doi-reference

Photoinitiated Anti-Hydropentafluorosulfanylation of Terminal Alkynes

10.1002/anie.202112575 · ExternalCitation · doi-reference

(Hetero)aryl-SVI Fluorides: Synthetic Development and Opportunities

10.1002/anie.202200904 · ExternalCitation · doi-reference

Metal-Free SF6 Activation: A New SF5-Based Reagent Enables Deoxyfluorination and Pentafluorosulfanylation Reactions

10.1002/anie.202204623 · ExternalCitation · doi-reference

Oxidative Fluorination of Heteroatoms Enabled by Trichloroisocyanuric Acid and Potassium Fluoride

10.1002/anie.202205088 · ExternalCitation · doi-reference

Three-Component Reaction of Pentafluorosulfanyl Chloride, Alkenes and Diazo Compounds and Synthesis of Pentafluorosulfanylfurans

10.1002/anie.202208860 · ExternalCitation · doi-reference

Strain-Release Pentafluorosulfanylation and Tetrafluoro(aryl)sulfanylation of [1.1.1]Propellane: Reactivity and Structural Insight

10.1002/anie.202211892 · ExternalCitation · doi-reference

Rapid and Scalable Halosulfonylation of Strain-Release Reagents

10.1002/anie.202213508 · ExternalCitation · doi-reference

Regio- and Stereoselective Hydroelementation of SF5-Alkynes and Further Functionalizations

10.1002/anie.202300685 · ExternalCitation · doi-reference

Palladium/Norbornene-Catalyzed Direct Vicinal Di-Carbo-Functionalization of Indoles: Reaction Development and Mechanistic Study

10.1002/anie.202310697 · ExternalCitation · doi-reference

1-Azaspiro[3.3]heptane as a Bioisostere of Piperidine

10.1002/anie.202311583 · ExternalCitation · doi-reference

Light-Driven Synthesis and Functionalization of Bicycloalkanes, Cubanes and Related Bioisosteres

10.1002/anie.202317333 · ExternalCitation · doi-reference

Overcoming a Radical Polarity Mismatch in Strain-Release Pentafluorosulfanylation of [1.1.0]Bicyclobutanes: An Entryway to Sulfone- and Carbonyl-Containing SF5–Cyclobutanes

10.1002/anie.202319930 · ExternalCitation · doi-reference

Strain-Release Diversification of 1-Azabicyclobutanes via Bromide/Nickel Relay-Catalyzed 1,3-Bis-Carbofunctionalization

10.1002/anie.202522817 · ExternalCitation · doi-reference

Strain-Release Pentafluorosulfanylation of Carbonyl-Containing Disubstituted Bicyclobutanes: A Fortuitous Path to SF5-Containing Oxa[2.1.1]bicyclohexanes

10.1002/anie.4256865 · ExternalCitation · doi-reference

Synthesis, In Silico, and In Vitro Studies of Novel Dopamine D2 and D3 Receptor Ligands

10.1002/ardp.202000486 · ExternalCitation · doi-reference

Optical Modulation of Antibiotic Resistance by Photoswitchable Cystobactamids

10.1002/chem.202201297 · ExternalCitation · doi-reference

Chemistry of Pentafluorosulfanyl Derivatives and Related Analogs: From Synthesis to Applications

10.1002/chem.202201491 · ExternalCitation · doi-reference

Synthesis and Applications of Bicyclo[1.1.0]butyl and Azabicyclo[1.1.0]butyl Organometallics

10.1002/chem.202300008 · ExternalCitation · doi-reference

Tracking SF5I in the Iodopentafluorosulfanylation of Alkynes

10.1002/chem.202302914 · ExternalCitation · doi-reference

Bicyclo[m.n.k]alkane Building Blocks as Promising Benzene and Cycloalkane Isosteres: Multigram Synthesis, Physicochemical and Structural Characterization

10.1002/chem.202303859 · ExternalCitation · doi-reference

On-Demand Continuous Flow Synthesis of Pentafluorosulfanyl Chloride (SF5Cl) Using a Custom-Made Stirring Packed-Bed Reactor

10.1002/chem.202404039 · ExternalCitation · doi-reference

Chemoselective Csp2–H Radical Alkylation of Aryl Diazonium Salts with 1-Iodo-3-Pentafluorosulfanylbicyclo[1.1.1]pentane (SF5-BCP-I)

10.1002/cjoc.70007 · ExternalCitation · doi-reference

Synthesis and Reaction of Pentafluorosulfanyl Chloride (SF5Cl)

10.1002/cjoc.70217 · ExternalCitation · doi-reference

Single-Step Photoinduced Radical Pentafluorosulfanylation and Cyclization of Alkenes for the Synthesis of SF5-Containing Cyclic Sulfinamides

10.1002/cjoc.70488 · ExternalCitation · doi-reference

Evaluation of tert-Butyl Isosteres: Case Studies of Physicochemical and Pharmacokinetic Properties, Efficacies, and Activities

10.1002/cmdc.201402502 · ExternalCitation · doi-reference

Application of the Pentafluorosulfanyl Group as a Bioisosteric Replacement

10.1002/cmdc.201700356 · ExternalCitation · doi-reference

Expanding the Repertoire of Low-Molecular-Weight Pentafluorosulfanyl-Substituted Scaffolds

10.1002/cmdc.202100641 · ExternalCitation · doi-reference

Bicyclo[1.1.1]pentane-Derived Building Blocks for Click Chemistry

10.1002/ejoc.201701296 · ExternalCitation · doi-reference

UCSF Chimera – A visualization system for exploratory research and analysis

10.1002/jcc.20084 · ExternalCitation · doi-reference

NBO 7.0: New vistas in localized and delocalized chemical bonding theory

10.1002/jcc.25873 · ExternalCitation · doi-reference

Chemistry and Mechanism of Alkene Polymerization Reactions with Metallocene Catalysts

10.1002/macp.200900229 · ExternalCitation · doi-reference

Single Crystal X-ray Structural Features of Aromatic Compounds Having a Pentafluorosulfuranyl (SF5) Functional Group

10.1007/s11224-016-0854-2 · ExternalCitation · doi-reference

Iodopentafluorosulfanylation of [1.1.1]Propellane and Further Functionalizations

10.1007/s11426-023-1715-2 · ExternalCitation · doi-reference

Recent Advances in Bioorthogonal Ligation and Bioconjugation

10.1007/s41061-023-00445-6 · ExternalCitation · doi-reference

Design, Synthesis and Biological Evaluation of Novel Bicyclo[1.1.1]pentane-Based ω-Acidic Amino Acids as Glutamate Receptor Ligands

10.1016/j.bmc.2008.11.015 · ExternalCitation · doi-reference

A Specific and Direct Comparison of the Trifluoromethyl and Pentafluorosulfanyl Groups on the Selective Dopamine D3 Antagonist 3-(3-{[4-Methyl-5-(4-methyl-1,3-oxazol-5-yl)-4H-1,2,4-triazol-3-yl]thio}propyl)-1-phenyl-3-azabicyclo[3.1.0]hexane Template

10.1016/j.bmcl.2010.06.018 · ExternalCitation · doi-reference

Novel Inhibitors of the High-affinity L-Proline Transporter as Potential Therapeutic Agents for the Treatment of Cognitive Disorders

10.1016/j.bmcl.2014.06.049 · ExternalCitation · doi-reference

Identification of Orally Bioavailable Antagonists of the TRPV4 Ion Channel

10.1016/j.bmcl.2015.06.098 · ExternalCitation · doi-reference

Recent Advances in the Applications of [1.1.1]Propellane in Organic Synthesis

10.1016/j.cclet.2020.04.023 · ExternalCitation · doi-reference

Pharmaceutical and Medicinal Significance of Sulfur (S(VI))-Containing Motifs for Drug Discovery: A Critical Review

10.1016/j.ejmech.2018.11.017 · ExternalCitation · doi-reference

Design, synthesis, and biodistribution studies of new analogues of marine alkaloids: Potent in vitro and in vivo fungicidal agents against Candida spp

10.1016/j.ejmech.2020.113048 · ExternalCitation · doi-reference

Synthetic Chemistry and Biological Activity of Pentafluorosulphanyl (SF5) Organic Molecules

10.1016/j.jfluchem.2012.06.030 · ExternalCitation · doi-reference

Recent Advances in the Trifluoromethylation Methodology and New CF3-Containing Drugs

10.1016/j.jfluchem.2014.06.026 · ExternalCitation · doi-reference

Electron Donor–Acceptor (EDA)-Complex Enabled SF5Cl Addition on Alkenes and Alkynes

10.1016/j.jfluchem.2021.109734 · ExternalCitation · doi-reference

Light-Activation of SF5Cl for the Atom Transfer Radical Addition onto Alkenes and Alkynes

10.1016/j.jfluchem.2023.110131 · ExternalCitation · doi-reference

Vardenafil: structural basis for higher potency over sildenafil in inhibiting cGMP-specific phosphodiesterase-5 (PDE5)

10.1016/j.neuint.2004.03.016 · ExternalCitation · doi-reference

Strain-Release Transformations of Bicyclo[1.1.0]butanes and [1.1.1]Propellanes

10.1016/j.tchem.2024.100070 · ExternalCitation · doi-reference

Synthesis and application of pentafluorosulfanylation reagents and derived aliphatic SF5-containing building blocks

10.1016/j.tet.2022.132656 · ExternalCitation · doi-reference

Synthesis and Further Use of SF5-Alkynes as Platforms for the Design of More Complex SF5-Containing Products

10.1016/j.tet.2022.132814 · ExternalCitation · doi-reference

Pd-catalyzed amidation of aryl(Het) halides with tert-butyl carbamate

10.1016/j.tetlet.2010.06.083 · ExternalCitation · doi-reference

Recent Advancements in the Synthesis of Pentafluorosulfanyl (SF5)-Containing Heteroaromatic Compounds

10.1016/j.tetlet.2017.11.015 · ExternalCitation · doi-reference

Bicyclo [1.1. 0] butane

10.1016/s0040-4020(01)98361-9 · ExternalCitation · doi-reference

Synthesis of 4-Substituted Phenylalanine Derivatives by Cross-Coupling Reaction of p-Boronophenylalanines

10.1016/s0040-4039(97)10082-x · ExternalCitation · doi-reference

Free Radical-Mediated Carboxylation by Radical Reaction of Alkyl Iodides with Methyl Oxalyl Chloride

10.1016/s0040-4039(98)01568-8 · ExternalCitation · doi-reference

A general and mild synthesis of thioesters and thiols from halides

10.1016/s0040-4039(98)02545-3 · ExternalCitation · doi-reference

DSM265 for Plasmodium falciparum Chemoprophylaxis: A Randomised, Double-Blinded, Phase 1 Trial with Controlled Human Malaria Infection

10.1016/s1473-3099(17)30139-1 · ExternalCitation · doi-reference

Photoinduced Organocatalyzed Atom Transfer Radical Polymerization (O-ATRP): Precision Polymer Synthesis Using Organic Photoredox Catalysis

10.1021/acs.chemrev.1c00603 · ExternalCitation · doi-reference

Synthetic Access to Persulfuranyl Scaffolds via Direct and Indirect Methods

10.1021/acs.chemrev.5c00131 · ExternalCitation · doi-reference

Smallest Bicycles in Medicinal Chemistry: Where are we now?

10.1021/acs.chemrev.5c00779 · ExternalCitation · doi-reference

The Global Threat from the Irreversible Accumulation of Trifluoroacetic Acid (TFA)

10.1021/acs.est.4c06189 · ExternalCitation · doi-reference

Generative Deep Learning for Targeted Compound Design

10.1021/acs.jcim.0c01496 · ExternalCitation · doi-reference

Validating the 1,2-Difluoro Motif As a Hybrid Bioisostere of CF3 and Et Using Matrix Metalloproteinases As Structural Probes

10.1021/acs.jmedchem.0c00648 · ExternalCitation · doi-reference

Bioisosteres of the Phenyl Ring: Recent Strategic Applications in Lead Optimization and Drug Design

10.1021/acs.jmedchem.1c01215 · ExternalCitation · doi-reference

Analysis of Past and Present Synthetic Methodologies on Medicinal Chemistry: Where Have All the New Reactions Gone?

10.1021/acs.jmedchem.5b01409 · ExternalCitation · doi-reference

Discovery of (3-(4-(2-Oxa-6-azaspiro[3.3]heptan-6-ylmethyl)phenoxy)azetidin-1-yl)(5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl)methanone (AZD1979), a Melanin Concentrating Hormone Receptor 1 (MCHr1) Antagonist with Favorable Physicochemical Properties

10.1021/acs.jmedchem.5b01654 · ExternalCitation · doi-reference

Relevance of Half-Life in Drug Design Miniperspective

10.1021/acs.jmedchem.7b00969 · ExternalCitation · doi-reference

Radical 1,5-Chloropentafluorosulfanylation of Unactivated Vinylcyclopropanes and Transformation into α-SF5 Ketones

10.1021/acs.joc.1c01886 · ExternalCitation · doi-reference

In Situ Hypoiodite-Catalyzed Oxidative Rearrangement of Chalcones: Scope and Mechanistic Investigation

10.1021/acs.joc.2c02291 · ExternalCitation · doi-reference

Two Squares in a Barrel: An Axially Disubstituted Conformationally Rigid Aliphatic Binding Motif for Cucurbit[6]uril

10.1021/acs.joc.3c01556 · ExternalCitation · doi-reference

Pentafluorosulfanylation of Acrylamides: The Synthesis of SF5-Containing Isoquinolinediones with SF5Cl

10.1021/acs.joc.4c02181 · ExternalCitation · doi-reference

Substrate-Controlled Pentafluorosulfanylation of Activated Alkenes Containing the Benzimidazole Moiety with SF5Cl

10.1021/acs.joc.5c00103 · ExternalCitation · doi-reference

Aza-Darzens Type Reaction of Azirines: Access to Highly Substituted 1-Azabicyclo[1.1.0]butanes and Azetidines

10.1021/acs.joc.5c02748 · ExternalCitation · doi-reference

Electrophilic Activation of [1.1.1]Propellane by Silyl-Triflates

10.1021/acs.joc.5c03205 · ExternalCitation · doi-reference

Practical Synthesis of (3aR, 9bR)-8-Fluoro-7-(perfluoropropan-2-yl)-9b-(phenylsulfonyl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole: An Advanced Intermediate to Access the RORγt Inverse Agonist BMT-362265

10.1021/acs.oprd.1c00019 · ExternalCitation · doi-reference

Efficient Large-Scale Process for Tecovirimat via Reactive Distillation for the Preparation of Cycloheptatriene

10.1021/acs.oprd.3c00151 · ExternalCitation · doi-reference

Reductive Transformations with Sodium Borohydride and Their Applications

10.1021/acs.oprd.5c00357 · ExternalCitation · doi-reference

Radical Addition of SF5Cl to Cyclopropenes: Synthesis of (Pentafluorosulfanyl)cyclopropanes

10.1021/acs.orglett.1c01840 · ExternalCitation · doi-reference

Copper-Catalyzed Trifluoromethylation of (Hetero)aryl Boronic Acid Pinacol Esters with YlideFluor

10.1021/acs.orglett.3c00206 · ExternalCitation · doi-reference

Rhodium-Catalyzed Intramolecular Cyclopropanation of Trifluoromethyl- and Pentafluorosulfanyl-Substituted Allylic Cyanodiazoacetates

10.1021/acs.orglett.3c00642 · ExternalCitation · doi-reference

nBu4N+[AgI(CF3)2]−: Trifluoromethylated Argentate Derived from Fluoroform and Its Reaction with (Hetero)Aryl Diazonium Salts

10.1021/acs.orglett.3c02804 · ExternalCitation · doi-reference

An Extrusion Strategy for On-Demand SF5Cl Gas Generation from a Commercial Disulfide

10.1021/acs.orglett.3c03886 · ExternalCitation · doi-reference

Expanding Radical Chloropentafluorosulfanylation of Alkynes

10.1021/acs.orglett.3c04043 · ExternalCitation · doi-reference

Synthesis of Azo-Substituted Bicyclo[1.1.1]pentanes (BCPs) via Base-Promoted Halogen Atom Transfer

10.1021/acs.orglett.4c01546 · ExternalCitation · doi-reference

Synthesis of α-SF5 Ketones by Oxypentafluorosulfanylation of Alkynes with SF5Cl and Oxygen

10.1021/acs.orglett.5c00884 · ExternalCitation · doi-reference

Strain-Release-Driven 1,3-Halo-hydroxylamination of Bicyclo[1.1.0]butanes Enabled by Anomeric Amide Reagents

10.1021/acs.orglett.5c04047 · ExternalCitation · doi-reference

Trifluoromethylation of Arenes and Heterocycles via a Bench-Stable Photocaged Trifluoromethylation Reagent

10.1021/acs.orglett.5c04296 · ExternalCitation · doi-reference

Regioselective Synthesis of Fluorosulfonyl 1,2,3-Triazoles from Bromovinylsulfonyl Fluoride

10.1021/acs.orglett.8b01309 · ExternalCitation · doi-reference

Dispersion-Controlled Regioselective Acid-Catalyzed Intramolecular Hydroindolation of cis-Methindolylstyrenes To Access Tetrahydrobenzo[cd]indoles

10.1021/acs.orglett.9b00043 · ExternalCitation · doi-reference

Copper-Catalyzed Ring Opening of [1.1.1]Propellane with Alkynes: Synthesis of Exocyclic Allenic Cyclobutanes

10.1021/acs.orglett.9b03999 · ExternalCitation · doi-reference

Kinetics of Acid-Catalyzed Dehydration of Alcohols in Mixed Solvent Modeled by Multiscale DFT/MD

10.1021/acscatal.2c03978 · ExternalCitation · doi-reference

Photocatalyzed Dual Strain Release of [1.1.1]Propellane with Diazo Compounds

10.1021/acscatal.4c00533 · ExternalCitation · doi-reference

Catalytic Vicinal Difluorination of Olefins: Creating a Hybrid, Chiral Bioisostere of the Trifluoromethyl and Ethyl Groups

10.1021/acscatal.6b02155 · ExternalCitation · doi-reference

Isolation and Reactivity of Trifluoromethyl Iodonium Salts

10.1021/acscentsci.6b00119 · ExternalCitation · doi-reference

DFT Calculation of Nonperiodic Small Molecular Systems to Predict the Reaction Mechanism of Advanced Oxidation Processes: Challenges and Perspectives

10.1021/acsestengg.3c00204 · ExternalCitation · doi-reference

Structure–Activity Study of Bioisosteric Trifluoromethyl and Pentafluorosulfanyl Indole Inhibitors of the AAA ATPase p97

10.1021/acsmedchemlett.5b00364 · ExternalCitation · doi-reference

Investigation of a Bicyclo[1.1.1]pentane as a Phenyl Replacement within an LpPLA2 Inhibitor

10.1021/acsmedchemlett.6b00281 · ExternalCitation · doi-reference

Spiro-oxindole Piperidines and 3-(Azetidin-3-yl)-1H-benzimidazol-2-ones as mGlu2 Receptor PAMs

10.1021/acsmedchemlett.9b00350 · ExternalCitation · doi-reference

Ring-Strain-Enabled Reaction Discovery: New Heterocycles from Bicyclo[1.1.0]butanes

10.1021/ar500437h · ExternalCitation · doi-reference

Small ring propellanes

10.1021/cr00095a001 · ExternalCitation · doi-reference

The Application of Cyclobutane Derivatives in Organic Synthesis

10.1021/cr010010y · ExternalCitation · doi-reference

The Chemistry of Nitrate Esters

10.1021/cr50003a001 · ExternalCitation · doi-reference

NCIPLOT: A Program for Plotting Noncovalent Interaction Regions

10.1021/ct100641a · ExternalCitation · doi-reference

Bromination of Phenols and Phenol Alcohols

10.1021/i560160a007 · ExternalCitation · doi-reference

Formation of [1.1.1]Propellane by Nucleophilic Attack on 1,3-Diiodobicyclo[1.1.1]pentane. Unrearranged Carbocation Intermediates in the Reaction of [1.1.1]Propellane with Electrophiles

10.1021/ja00023a086 · ExternalCitation · doi-reference

Toward a Molecular-Size Tinkertoy Construction Set. Preparation of Terminally Functionalized [n]Staffanes from [1.1.1]Propellane

10.1021/ja00028a029 · ExternalCitation · doi-reference

Bridgehead Carbocations: A Solvolytic Study of l-Bromobicyclo[1.1.1]pentane and Its Bridgehead-Substituted Derivatives

10.1021/ja00093a014 · ExternalCitation · doi-reference

Formation and Reactions of Bicyclo[1.1.1]pentyl-1 Cations

10.1021/ja00105a046 · ExternalCitation · doi-reference

Bicyclo [1.1.1] pentane

10.1021/ja00971a025 · ExternalCitation · doi-reference

Catalytic Hydrogenysis of Nitrate Esters

10.1021/ja01213a023 · ExternalCitation · doi-reference

Titanocene Catalyzed 4-exo Cyclizations: Mechanism, Experiment, Catalyst Design

10.1021/ja077596b · ExternalCitation · doi-reference

Synthesis and Applications of Polysubstituted Bicyclo[1.1.0]butanes

10.1021/jacs.1c11244 · ExternalCitation · doi-reference

One-Pot Synthesis of Strain-Release Reagents from Methyl Sulfones

10.1021/jacs.2c00923 · ExternalCitation · doi-reference

Dicarbofunctionalization of [1.1.1]Propellane Enabled by Nickel/Photoredox Dual Catalysis: One-Step Multicomponent Strategy for the Synthesis of BCP–Aryl Derivatives

10.1021/jacs.2c05304 · ExternalCitation · doi-reference

A General and Modular Approach to BCP Alkylamines via Multicomponent Difunctionalization of [1.1.1]Propellane

10.1021/jacs.2c13298 · ExternalCitation · doi-reference

Strain-Release Photocatalysis

10.1021/jacs.3c08206 · ExternalCitation · doi-reference

Enantioselective, Intermolecular [π2+σ2] Photocycloaddition Reactions of 2(1H)-Quinolones and Bicyclo[1.1.0]butanes

10.1021/jacs.3c08404 · ExternalCitation · doi-reference

Tetrafluoro(aryl)sulfanylated Bicyclopentane Crystals that Self-Destruct upon Cooling

10.1021/jacs.4c08867 · ExternalCitation · doi-reference

Isosteric 3D Bicyclo[1.1.1]Pentane (BCP) Core-Based Lipids for mRNA Delivery and CRISPR/Cas Gene Editing

10.1021/jacs.4c13154 · ExternalCitation · doi-reference

Direct N–SF5 and N–SF4CF3 Bond Formation through Strain-Release Functionalization of 3-Substituted [1.1.0]Azabicyclobutanes

10.1021/jacs.5c07137 · ExternalCitation · doi-reference

Strain-Release-Driven Synthesis of Pentafluorosulfanylated Four-Membered Rings under Energy Transfer Photocatalysis

10.1021/jacs.5c07138 · ExternalCitation · doi-reference

Divergent Synthesis of 1-Azabicyclo[n.1.1]alkane Bioisosteres via Photoinduced Palladium Catalysis

10.1021/jacs.5c09500 · ExternalCitation · doi-reference

Modular Access to N–SF5 Azetidines

10.1021/jacs.5c10954 · ExternalCitation · doi-reference

General Photo-Driven Chemoselective and Rapid Hydropentafluorosulfanylation of Alkenes via an Orchestrated Radical Chain Process

10.1021/jacs.5c14406 · ExternalCitation · doi-reference

Distal Stereocontrol Using Guanidinylated Peptides as Multifunctional Ligands: Desymmetrization of Diarylmethanes via Ullman Cross-Coupling

10.1021/jacs.6b03444 · ExternalCitation · doi-reference

Strain-Release Heteroatom Functionalization: Development, Scope, and Stereospecificity

10.1021/jacs.6b13229 · ExternalCitation · doi-reference

Electrophilic Aromatic Substitution Reactions: Mechanistic Landscape, Electrostatic and Electric-Field Control of Reaction Rates, and Mechanistic Crossovers

10.1021/jacs.9b04982 · ExternalCitation · doi-reference

Methylenespiro[2.3]hexanes via Nickel-Catalyzed Cyclopropanations with [1.1.1]Propellane

10.1021/jacs.9b10689 · ExternalCitation · doi-reference

Conquering the Synthesis and Functionalization of Bicyclo[1.1.1]pentanes

10.1021/jacsau.3c00014 · ExternalCitation · doi-reference

CF3-Cyclobutanes: Synthesis, Properties, and Evaluation as a Unique tert-Butyl Group Analogue

10.1021/jacsau.4c00864 · ExternalCitation · doi-reference

Synopsis of Some Recent Tactical Application of Bioisosteres in Drug Design

10.1021/jm1013693 · ExternalCitation · doi-reference

Identification and Characterization of a Novel Integrin-Linked Kinase Inhibitor

10.1021/jm2007744 · ExternalCitation · doi-reference

Application of the Bicyclo[1.1.1]pentane Motif as a Nonclassical Phenyl Ring Bioisostere in the Design of a Potent and Orally Active γ-Secretase Inhibitor

10.1021/jm300094u · ExternalCitation · doi-reference

Sulfonyl Fluoride Inhibitors of Fatty Acid Amide Hydrolase

10.1021/jm301205j · ExternalCitation · doi-reference

Discovery and Safety Profiling of a Potent Preclinical Candidate, (4-[4-[[(3R)-3-(Hydroxycarbamoyl)-8-azaspiro[4.5]decan-3-yl]sulfonyl]phenoxy]-N-methylbenzamide) (CM-352), for the Prevention and Treatment of Hemorrhage

10.1021/jm501939z · ExternalCitation · doi-reference

Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success

10.1021/jm901241e · ExternalCitation · doi-reference

Polar Substituent Effects in 1,3-Disubstituted Bicyclo[1.1.1]pentanes

10.1021/jo00146a031 · ExternalCitation · doi-reference

A Chemoselective, One-Pot Transformation of Aldehydes to Nitriles

10.1021/jo301133y · ExternalCitation · doi-reference

New and Convenient Method for Incorporation of Pentafluorosulfanyl (SF5) Substituents Into Aliphatic Organic Compounds

10.1021/ol026483o · ExternalCitation · doi-reference

TamGen: Drug Design with Target-Aware Molecule Generation through a Chemical Language Model

10.1038/s41467-024-53632-4 · ExternalCitation · doi-reference

Photo-Induced Hydroxypentafluorosulfanylation of Alkenes with SF5Cl and Oxygen Gas and Their Further Derivatization

10.1038/s41467-024-54015-5 · ExternalCitation · doi-reference

Bench-stable Reagents for Modular Access to Persulfuranyl Scaffolds

10.1038/s41467-025-63621-w · ExternalCitation · doi-reference

HFIP-Assisted Brønsted Acid-Catalyzed Ring Opening of 1-Azabicyclo[1.1.0]butane to Access Diverse C3-Quaternary Aza-Azetidines and Indole-Azetidines

10.1038/s41467-025-63680-z · ExternalCitation · doi-reference

Propellane-free Access to Bicyclo[1.1.1]pentanes

10.1038/s41467-026-68309-3 · ExternalCitation · doi-reference

Exploiting the sp2 Character of Bicyclo[1.1.1]pentyl Radicals in the Transition-Metal-Free Multicomponent Difunctionalization of [1.1.1]Propellane

10.1038/s41557-022-00979-0 · ExternalCitation · doi-reference

Catalytic undirected borylation of tertiary C–H bonds in bicyclo[1.1.1]pentanes and bicyclo[2.1.1]hexanes

10.1038/s41557-023-01159-4 · ExternalCitation · doi-reference

Enantioselective Synthesis of 2-Substituted Bicyclo[1.1.1]pentanes via Sequential Asymmetric Imine Addition of Bicyclo[1.1.0]butanes and Skeletal Editing

10.1038/s41557-024-01710-x · ExternalCitation · doi-reference

Collective Synthesis of 1,2,4-Trisubstituted, meta- and ortho-Substituted Arene Bioisosteres from Bicyclobutanes

10.1038/s41557-026-02097-7 · ExternalCitation · doi-reference

Sulfonyl Fluorides as Targets and Substrates in the Development of New Synthetic Methods

10.1038/s41570-021-00352-8 · ExternalCitation · doi-reference

Three-Dimensional Saturated C(sp3)-rich Bioisosteres for Benzene

10.1038/s41570-024-00623-0 · ExternalCitation · doi-reference

Antimalarial Drug Discovery: Progress and Approaches

10.1038/s41573-023-00772-9 · ExternalCitation · doi-reference

Synthesis of meta-Substituted Arene Bioisosteres from [3.1.1]Propellane

10.1038/s41586-022-05290-z · ExternalCitation · doi-reference

Targeted Molecular Generation with Latent Reinforcement Learning

10.1038/s41598-025-99785-0 · ExternalCitation · doi-reference

Bicyclobutanes as Unusual Building Blocks for Complexity Generation in Organic Synthesis

10.1038/s42004-022-00811-3 · ExternalCitation · doi-reference

Light-enabled scalable synthesis of bicyclo[1.1.1]pentane halides and their functionalizations

10.1038/s44160-024-00637-y · ExternalCitation · doi-reference

Ahlrichs Balanced Basis Sets of Split Valence, Triple Zeta Valence and Quadruple Zeta Valence Quality for H to Rn: Design and Assessment of Accuracy

10.1039/b508541a · ExternalCitation · doi-reference

Long-Range Corrected Hybrid Density Functionals with Damped Atom–Atom Dispersion Corrections

10.1039/b810189b · ExternalCitation · doi-reference

The Pentafluorosulfanyl Group in Cannabinoid Receptor Ligands: Synthesis and Comparison with Trifluoromethyl and tert-Butyl Analogues

10.1039/c4ra01212g · ExternalCitation · doi-reference

Copper-Catalysed Azide–Alkyne Cycloadditions (CuAAC): An Update

10.1039/c5ob01457c · ExternalCitation · doi-reference

Saturated Bioisosteres of Benzene: Where to Go Next?

10.1039/c8ob02812e · ExternalCitation · doi-reference

Strain Release – An Old Tool for New Transformations

10.1039/d0cc01771j · ExternalCitation · doi-reference

The Renaissance of Strained 1-Azabicyclo[1.1.0]butanes as Useful Reagents for the Synthesis of Functionalized Azetidines

10.1039/d0ob01251c · ExternalCitation · doi-reference

Rationalizing the Diverse Reactivity of [1.1.1]Propellane through σ–π Delocalization

10.1039/d0sc01386b · ExternalCitation · doi-reference

Bicyclobutanes: From Curiosities to Versatile Reagents and Covalent Warheads

10.1039/d2sc03948f · ExternalCitation · doi-reference

Recent Advances in Catalytic and Non-Catalytic Epoxidation of Terpenes: A Pathway to Bio-Based Polymers from Waste Biomass

10.1039/d3ra04870e · ExternalCitation · doi-reference

Recent Advances in Photochemical Strain-Release Reactions of Bicyclo[1.1.0]butanes

10.1039/d4cc05108d · ExternalCitation · doi-reference

Strain-release trifluoromethoxylation and pentafluorosulfanoxylation of [1.1.0]bicyclobutanes: expanded access to fluorinated cyclobutene hybrid bioisosteres

10.1039/d4cc06616b · ExternalCitation · doi-reference

Visible Light-Induced Strain-Release Transformations of Bicyclo[1.1.0]butanes

10.1039/d4gc03193h · ExternalCitation · doi-reference

State-of-the-Art Strategies for Lewis Acid-Catalyzed Strain-Release Cycloadditions of Bicyclo[1.1.0]butanes (BCBs)

10.1039/d4qo01741b · ExternalCitation · doi-reference

Understanding the Pentafluorosulfanyl Group and Property-Driven Design of SF5-Containing Compounds

10.1039/d5cs00566c · ExternalCitation · doi-reference

Recent Advances in the Strain-Release Driven Reactions of Bicyclobutanes: An Emerging Landscape in Organic Synthesis

10.1039/d6cs00010j · ExternalCitation · doi-reference

Recent Advances in Strain-Release Functionalization of [1.1.1]Propellanes Using Organometallic Reagents

10.1055/a-2669-6239 · ExternalCitation · doi-reference

Tecovirimat for the Treatment of Mpox

10.1056/nejmoa2506495 · ExternalCitation · doi-reference

Natural population analysis

10.1063/1.449486 · ExternalCitation · doi-reference

A New Integral Equation Formalism for the Polarizable Continuum Model: Theoretical Background and Applications to Isotropic and Anisotropic Dielectrics

10.1063/1.474659 · ExternalCitation · doi-reference

Synthesis and Solvolysis of 1-Bromobicyclo[1.1.1]pentane

10.1071/ch9900945 · ExternalCitation · doi-reference

A Practical Synthesis of 3,3-Difluorocyclobutane Carboxylic Acid

10.1081/scc-200050350 · ExternalCitation · doi-reference

The Cambridge Structural Database

10.1107/s2052520616003954 · ExternalCitation · doi-reference

Crystal Structure Refinement with SHELXL

10.1107/s2053229614024218 · ExternalCitation · doi-reference

A General Leaving Group Assisted Strategy for Synthesis of Pentafluorosulfanyl Allylic Compounds

10.1126/sciadv.adw8408 · ExternalCitation · doi-reference

Sulfonyl hydrazides as a general redox-neutral platform for radical cross-coupling

10.1126/science.adu6406 · ExternalCitation · doi-reference

Studies on Repository Compound Stability in DMSO under Various Conditions

10.1177/1087057103008003007 · ExternalCitation · doi-reference

Defining the Next Generation of Severe Malaria Treatment: A Target Product Profile

10.1186/s12936-024-04986-z · ExternalCitation · doi-reference

1H and 13C Nuclear Magnetic Resonance Studies of the Hindered Phencyclone Adducts of Some Smaller Branched N-Alkyl Maleimides: Rigorous Aryl Proton Assignments with High-Resolution Two-Dimensional (COSY45) Spectroscopy, and Anisotropic Shielding Effects and Ab Initio Geometry Optimizations

10.1366/0003702053585426 · ExternalCitation · doi-reference

Benzpyrimoxan: Design, Synthesis, and Biological Activity of a Novel Insecticide

10.1584/jpestics.d20-069 · ExternalCitation · doi-reference

Environmental properties of pentafluorosulfanyl compounds: Physical properties and photodegradation

10.1897/09-037.1 · ExternalCitation · doi-reference

Synthesis of Some Arylsulfur Pentafluoride Pesticides and Their Relative Activities Compared to the Trifluoromethyl Analogues

10.2533/000942904777678172 · ExternalCitation · doi-reference

Silyl Chloroalkenyl and Alkynyl Sulfur Pentafluorides as Versatile Reagents to Access Novel Fundamental SF5 Building Blocks

10.26434/chemrxiv-2025-jmfh6 · ExternalCitation · doi-reference

Catalytic Asymmetric Strategies for Bicyclo[1.1.0]butane Transformations: Advances and Applications

10.31635/ccschem.025.202505825 · ExternalCitation · doi-reference

Molecular Docking and Structure-Based Drug Design Strategies

10.3390/molecules200713384 · ExternalCitation · doi-reference

Synthesis and Properties of Pentafluorosulfanyl Group (SF5)-Containing Meta-Diamide Insecticides

10.3390/molecules25235536 · ExternalCitation · doi-reference

Amine–Borane Complex-Initiated SF5Cl Radical Addition on Alkenes and Alkynes

10.3762/bjoc.16.256 · ExternalCitation · doi-reference

Controlled Oligomerization of [1.1.1]Propellane through Radical Polarity Matching: Selective Synthesis of SF5- and CF3SF4-Containing [2]Staffanes

10.3762/bjoc.20.259 · ExternalCitation · doi-reference

(Bio)isosteres of ortho- and meta-Substituted Benzenes

10.3762/bjoc.20.78 · ExternalCitation · doi-reference

Molecular Drug Targets and Structure Based Drug Design: A Holistic Approach

10.6026/97320630001314 · ExternalCitation · doi-reference