Research graph
References from Structurally Redesigned Bioorthogonal Reagents for Mitochondria-Specific Prodrug Activation. Local targets link to admitted publications; unresolved targets remain external evidence.
Constructing New Bioorthogonal Reagents and Reactions
10.1021/acs.accounts.7b00606 · 2018 · External reference
Bioorthogonal Chemistry: Fishing for Selectivity in a Sea of Functionality
10.1002/anie.200900942 · 2009 · External reference
Finding the Right (Bioorthogonal) Chemistry
10.1021/cb400828a · 2014 · External reference
Achieving Controlled Biomolecule-Biomaterial Conjugation
10.1021/acs.chemrev.8b00253 · 2018 · External reference
Advances in Chemical Protein Modification
10.1021/cr500399p · 2015 · External reference
Click Chemistry in Complex Mixtures: Bioorthogonal Bioconjugation
10.1016/j.chembiol.2014.09.002 · 2014 · External reference
Bioorthogonal labelling of biomolecules: new functional handles and ligation methods
10.1039/c3ob41329b · 2013 · External reference
Protein Organic Chemistry and Applications for Labeling and Engineering in Live-Cell Systems
10.1002/anie.201207089 · 2013 · External reference
Bioorthogonal chemistry in living organisms
10.1039/c3sc52768a · 2014 · External reference
In Vivo Applications of Bioorthogonal Chemistries
10.1002/9783527683451.ch14 · 2017 · External reference
Assessing the Mitochondrial Membrane Potential in Cells and In Vivo using Targeted Click Chemistry and Mass Spectrometry
10.1016/j.cmet.2015.11.014 · 2016 · External reference
Transition metal catalysis in the mitochondria of living cells
10.1038/ncomms12538 · 2016 · External reference
Photocatalysis Enables Visible-Light Uncaging of Bioactive Molecules in Live Cells
10.1002/anie.201811261 · 2019 · External reference
Organelle-Directed Staudinger Reaction Enabling Fluorescence-on Resolution of Mitochondrial Electropotentials via a Self-Immolative Charge Reversal Probe
10.1021/acs.analchem.7b05465 · 2018 · External reference
Enrichment-triggered prodrug activation demonstrated through mitochondria-targeted delivery of doxorubicin and carbon monoxide
10.1038/s41557-018-0055-2 · 2018 · External reference
The discovery of pyridinium 1,2,4-triazines with enhanced performance in bioconjugation reactions
10.1039/c6sc05442k · 2017 · External reference
The subcellular distribution of small molecules: a meta-analysis
10.1021/mp200093z · 2011 · External reference
Supertargeted chemistry: identifying relationships between molecular structures and their sub-cellular distribution
10.2174/1568026033452410 · 2003 · External reference
Guiding Drugs to Target-Harboring Organelles: Stretching Drug-Delivery to a Higher Level of Resolution
10.1002/anie.201906284 · 2019 · External reference
Mitochondrial form and function
10.1038/nature12985 · 2014 · External reference
Mitochondria and Cancer
10.1016/j.cell.2016.07.002 · 2016 · External reference
Mitochondria-targeted drug delivery system for cancer treatment
10.3109/1061186x.2015.1108325 · 2016 · External reference
Mitochondrial diseases: the contribution of organelle stress responses to pathology
10.1038/nrm.2017.66 · 2018 · External reference
The mitochondrial UPR: mechanisms, physiological functions and implications in ageing
10.1038/nrm.2017.110 · 2018 · External reference
Mitochondrial disorders as windows into an ancient organelle
10.1038/nature11707 · 2012 · External reference
Molecular vehicles for mitochondrial chemical biology and drug delivery
10.1021/cb400821p · 2014 · External reference
Targeting lipophilic cations to mitochondria
10.1016/j.bbabio.2008.03.029 · 2008 · External reference
Mitochondria-targeting drug conjugates for cytotoxic, anti-oxidizing and sensing purposes: current strategies and future perspectives
10.1016/j.apsb.2018.05.006 · 2018 · External reference
Development of background-free tame fluorescent probes for intracellular live cell imaging
10.1038/ncomms11964 · 2016 · External reference
Inverse electron demand Diels-Alder (iEDDA)-initiated conjugation: a (high) potential click chemistry scheme
10.1039/c3cs60049a · 2013 · External reference
Inverse electron demand Diels-Alder reactions in chemical biology
10.1039/c7cs00184c · 2017 · External reference
Bio-orthogonal Fluorescent Labelling of Biopolymers through Inverse-Electron-Demand Diels–Alder Reactions
2017 · External reference
Tetrazine ligation for chemical proteomics
10.1186/s12953-017-0121-5 · 2016 · External reference
Expanding room for tetrazine ligations in the in vivo chemistry toolbox
10.1016/j.cbpa.2013.08.004 · 2013 · External reference
Advances in Tetrazine Bioorthogonal Chemistry Driven by the Synthesis of Novel Tetrazines and Dienophiles
10.1021/acs.accounts.8b00062 · 2018 · External reference
Biomedical applications of tetrazine cycloadditions
10.1021/ar200037t · 2011 · External reference
Tetrazine-based cycloadditions: application to pretargeted live cell imaging
10.1021/bc8004446 · 2008 · External reference
Fast and sensitive pretargeted labeling of cancer cells through a tetrazine/trans-cyclooctene cycloaddition
10.1002/anie.200903233 · 2009 · External reference
Tetrazine ligation: fast bioconjugation based on inverse-electron-demand Diels-Alder reactivity
10.1021/ja8053805 · 2008 · External reference
Click to Release: Instantaneous Doxorubicin Elimination upon Tetrazine Ligation
10.1002/anie.201305969 · 2013 · External reference
Click-to-Release from trans-Cyclooctenes: Mechanistic Insights and Expansion of Scope from Established Carbamate to Remarkable Ether Cleavage
10.1002/anie.201800402 · 2018 · External reference
The Emerging Role of Tetrazines in Drug-Activation Chemistries
10.1002/cbic.201800590 · 2019 · External reference
Vinyl Ether/Tetrazine Pair for the Traceless Release of Alcohols in Cells
10.1002/anie.201609607 · 2017 · External reference
Bio-Orthogonal Chemistry and Reloadable Biomaterial Enable Local Activation of Antibiotic Prodrugs and Enhance Treatments against Staphylococcus aureus Infections
10.1021/acscentsci.8b00344 · 2018 · External reference
In Vivo Bioorthogonal Chemistry Enables Local Hydrogel and Systemic Pro-Drug To Treat Soft Tissue Sarcoma
10.1021/acscentsci.6b00150 · 2016 · External reference
Bioorthogonal tetrazine-mediated transfer reactions facilitate reaction turnover in nucleic acid-templated detection of microRNA
10.1021/ja510839r · 2014 · External reference
Chemically triggered drug release from an antibody-drug conjugate leads to potent antitumour activity in mice
10.1038/s41467-018-03880-y · 2018 · External reference
Controlled in-cell activation of RNA therapeutics using bond-cleaving bio-orthogonal chemistry
10.1039/c7sc01380a · 2017 · External reference
Chemical Control over T-Cell Activation in Vivo Using Deprotection of trans-Cyclooctene-Modified Epitopes
10.1021/acschembio.8b00155 · 2018 · External reference
Triggered Drug Release from an Antibody-Drug Conjugate Using Fast “Click-to-Release” Chemistry in Mice
10.1021/acs.bioconjchem.6b00231 · 2016 · External reference
Bioorthogonal Tetrazine Carbamate Cleavage by Highly Reactive trans-Cyclooctene
10.1021/jacs.0c00531 · 2020 · External reference
Unraveling Tetrazine-Triggered Bioorthogonal Elimination Enables Chemical Tools for Ultrafast Release and Universal Cleavage
10.1021/jacs.7b11217 · 2018 · External reference
Transition-Metal-Mediated versus Tetrazine-Triggered Bioorthogonal Release Reactions: Direct Comparison and Combinations Thereof
10.1002/cplu.202000477 · 2020 · External reference
Mitochondria-Targeted Triphenylphosphonium-Based Compounds: Syntheses, Mechanisms of Action, and Therapeutic and Diagnostic Applications
10.1021/acs.chemrev.7b00042 · 2017 · External reference
A Systematic Study of Coumarin–Tetrazine Light-Up Probes for Bioorthogonal Fluorescence Imaging
10.1002/chem.202001290 · 2020 · External reference
Mitochondrial Relocation of a Common Synthetic Antibiotic: A Non-genotoxic Approach to Cancer Therapy
10.1016/j.chempr.2020.03.004 · 2020 · External reference
Overcoming Drug Resistance by Targeting Cancer Bioenergetics with an Activatable Prodrug
10.1016/j.chempr.2018.08.002 · 2018 · External reference
Niclosamide: Comprehensive Profile
2005 · External reference
Small Molecule Mitochondrial Uncouplers and Their Therapeutic Potential
10.1021/acs.jmedchem.7b01182 · 2018 · External reference
Mechanism of Action of Reagents that uncouple Oxidative Phosphorylation
10.1038/2211016a0 · 1969 · External reference
Structure-Activity Analysis of Niclosamide Reveals Potential Role for Cytoplasmic pH in Control of Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling
10.1074/jbc.m112.359638 · 2012 · External reference
Mitochondrial uncoupling reveals a novel therapeutic opportunity for p53-defective cancers
10.1038/s41467-018-05805-1 · 2018 · External reference
Effect of mitochondrial uncouplers niclosamide ethanolamine (NEN) and oxyclozanide on hepatic metastasis of colon cancer
10.1038/s41419-017-0092-6 · 2018 · External reference
Multi-targeted therapy of cancer by niclosamide: A new application for an old drug
10.1016/j.canlet.2014.04.003 · 2014 · External reference
Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen
10.1038/nm.4184 · 2016 · External reference
Broad Spectrum Antiviral Agent Niclosamide and Its Therapeutic Potential
10.1021/acsinfecdis.0c00052 · 2020 · External reference
Plausible mechanisms of Niclosamide as an antiviral agent against COVID-19
10.1016/j.mehy.2020.109765 · 2020 · External reference
Subcellular targeting strategies for drug design and delivery
10.1038/nrd2897 · 2010 · External reference
